SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fhr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H77_A_T3A1_1
(THRA PROTEIN)
4fhr FLAGELLAR MOTOR
SWITCH PROTEIN FLIG

(Thermotoga
maritima)
5 / 12 ALA B 132
ALA B 201
LEU B 159
LEU B 227
ILE B 198
None
1.12A 2h77A-4fhrB:
undetectable
2h77A-4fhrB:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1604_0
(FERROCHELATASE)
4fhr FLAGELLAR MOTOR
SWITCH PROTEIN FLIG

(Thermotoga
maritima)
4 / 4 LEU B 150
PRO B 151
LEU B 154
ARG B 161
None
1.42A 2hrcB-4fhrB:
undetectable
2hrcB-4fhrB:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA803_0
(FERROCHELATASE)
4fhr FLAGELLAR MOTOR
SWITCH PROTEIN FLIG

(Thermotoga
maritima)
4 / 5 LEU B 150
PRO B 151
LEU B 154
ILE B 131
None
0.71A 2qd4A-4fhrB:
undetectable
2qd4A-4fhrB:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_2
(HIV-1 PROTEASE)
4fhr FLAGELLAR MOTOR
SWITCH PROTEIN FLIG

(Thermotoga
maritima)
3 / 3 ARG B 161
VAL B 173
THR B 168
None
0.67A 3cyxA-4fhrB:
undetectable
3cyxA-4fhrB:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)
4fhr FLAGELLAR MOTOR
SWITCH PROTEIN FLIG

(Thermotoga
maritima)
3 / 3 LEU B 150
PRO B 151
LEU B 154
None
0.40A 3w1wB-4fhrB:
undetectable
3w1wB-4fhrB:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)
4fhr FLAGELLAR MOTOR
SWITCH PROTEIN FLIG

(Thermotoga
maritima)
4 / 4 LEU B 150
PRO B 151
LEU B 154
ILE B 131
None
0.78A 4f4dB-4fhrB:
undetectable
4f4dB-4fhrB:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_D_ESTD600_1
(ESTROGEN RECEPTOR
BETA)
4fhr FLAGELLAR MOTOR
SWITCH PROTEIN FLIG

(Thermotoga
maritima)
5 / 12 ALA B 268
LEU B 261
ILE B 249
LEU B 253
LEU B 242
None
1.12A 4j24D-4fhrB:
undetectable
4j24D-4fhrB:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME
KP18CYS PEPTIDE)
4fhr FLAGELLAR MOTOR
SWITCH PROTEIN FLIG

(Thermotoga
maritima)
5 / 12 TYR B 137
GLN B 129
VAL B 173
ILE B 176
LEU B 180
None
1.50A 4k38A-4fhrB:
undetectable
4k38D-4fhrB:
undetectable
4k38A-4fhrB:
23.17
4k38D-4fhrB:
6.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)
4fhr FLAGELLAR MOTOR
SWITCH PROTEIN FLIG

(Thermotoga
maritima)
5 / 12 ALA B 132
ALA B 201
LEU B 159
LEU B 227
ILE B 198
None
1.12A 4lnwA-4fhrB:
undetectable
4lnwA-4fhrB:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)
4fhr FLAGELLAR MOTOR
SWITCH PROTEIN FLIG

(Thermotoga
maritima)
5 / 12 ALA B 132
ALA B 201
LEU B 159
LEU B 227
ILE B 198
None
1.13A 4lnxA-4fhrB:
undetectable
4lnxA-4fhrB:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)
4fhr FLAGELLAR MOTOR
SWITCH PROTEIN FLIG

(Thermotoga
maritima)
5 / 12 LEU B 261
ILE B 313
ALA B 306
ILE B 241
PHE B 238
None
1.18A 4rp8C-4fhrB:
undetectable
4rp8C-4fhrB:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)
4fhr FLAGELLAR MOTOR
SWITCH PROTEIN FLIG

(Thermotoga
maritima)
4 / 8 LEU B 288
LEU B 253
THR B 258
LEU B 261
None
0.72A 4z90F-4fhrB:
undetectable
4z90G-4fhrB:
undetectable
4z90H-4fhrB:
undetectable
4z90I-4fhrB:
undetectable
4z90J-4fhrB:
undetectable
4z90F-4fhrB:
19.76
4z90G-4fhrB:
19.76
4z90H-4fhrB:
19.76
4z90I-4fhrB:
19.76
4z90J-4fhrB:
19.76