SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fie'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		5 / 12 ILE A 327
ALA A 348
LEU A 321
PHE A 324
ILE A 337
 None
ANP  A1001 (-3.6A)
None
None
None
 1.19A 1g5yB-4fieA:
undetectable		 1g5yB-4fieA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_A_NIOA604_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		4 / 5 SER A 443
THR A 404
GLU A 507
GLY A 511
 None
 0.95A 1icrA-4fieA:
undetectable
1icrB-4fieA:
undetectable		 1icrA-4fieA:
19.67
1icrB-4fieA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_B_NIOB602_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		4 / 5 GLU A 507
GLY A 511
SER A 443
THR A 404
 None
 0.96A 1icrA-4fieA:
undetectable
1icrB-4fieA:
undetectable		 1icrA-4fieA:
19.67
1icrB-4fieA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_A_NIOA221_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		4 / 6 SER A 443
THR A 404
GLU A 507
GLY A 511
 None
 0.99A 1icuA-4fieA:
undetectable
1icuB-4fieA:
undetectable		 1icuA-4fieA:
19.67
1icuB-4fieA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_B_NIOB219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		4 / 6 GLU A 507
GLY A 511
SER A 443
THR A 404
 None
 0.99A 1icuA-4fieA:
undetectable
1icuB-4fieA:
undetectable		 1icuA-4fieA:
19.67
1icuB-4fieA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_C_NIOC225_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		4 / 6 SER A 443
THR A 404
GLU A 507
GLY A 511
 None
 0.98A 1icuC-4fieA:
undetectable
1icuD-4fieA:
undetectable		 1icuC-4fieA:
19.67
1icuD-4fieA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_C_NIOC708_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		4 / 5 SER A 443
THR A 404
GLU A 507
GLY A 511
 None
 0.97A 1icvC-4fieA:
undetectable
1icvD-4fieA:
undetectable		 1icvC-4fieA:
19.67
1icvD-4fieA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_D_NIOD706_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		4 / 5 GLU A 507
GLY A 511
SER A 443
THR A 404
 None
 1.02A 1icvC-4fieA:
undetectable
1icvD-4fieA:
undetectable		 1icvC-4fieA:
19.67
1icvD-4fieA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_A_BEZA524_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		4 / 6 SER A 443
THR A 404
GLU A 507
GLY A 511
 None
 0.98A 1kqbA-4fieA:
undetectable
1kqbB-4fieA:
undetectable		 1kqbA-4fieA:
20.09
1kqbB-4fieA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_B_BEZB525_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		4 / 5 GLU A 507
GLY A 511
SER A 443
THR A 404
 None
 1.00A 1kqbA-4fieA:
undetectable
1kqbB-4fieA:
undetectable		 1kqbA-4fieA:
20.09
1kqbB-4fieA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_C_BEZC522_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		4 / 6 SER A 443
THR A 404
GLU A 507
GLY A 511
 None
 0.95A 1kqbC-4fieA:
undetectable
1kqbD-4fieA:
undetectable		 1kqbC-4fieA:
20.09
1kqbD-4fieA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_D_BEZD523_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		4 / 6 GLU A 507
GLY A 511
SER A 443
THR A 404
 None
 0.96A 1kqbC-4fieA:
undetectable
1kqbD-4fieA:
undetectable		 1kqbC-4fieA:
20.09
1kqbD-4fieA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MOG_A_RBFA200_1
(DODECIN)		 4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		3 / 3 PHE A 324
TRP A 392
GLU A 390
 None
 0.89A 1mogA-4fieA:
undetectable		 1mogA-4fieA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_B_THAB2_1
(LIVER
CARBOXYLESTERASE I)		 4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		5 / 11 PHE A 548
VAL A 407
LEU A 403
LEU A 552
LEU A 501
 None
 1.28A 1mx1B-4fieA:
undetectable		 1mx1B-4fieA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		6 / 12 VAL A 335
ALA A 348
GLU A 366
VAL A 379
PHE A 397
GLY A 401
 ANP  A1001 (-4.7A)
ANP  A1001 (-3.6A)
ANP  A1001 (-3.6A)
None
ANP  A1001 ( 4.6A)
None
 0.86A 1opjB-4fieA:
21.5		 1opjB-4fieA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_E_REAE176_1
(RETINOL BINDING
PROTEIN)		 4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		5 / 10 ALA A 419
ALA A 423
VAL A 379
LEU A 447
ASP A 451
 None
None
None
ANP  A1001 (-4.7A)
None
 1.29A 1rlbE-4fieA:
undetectable		 1rlbE-4fieA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		6 / 12 ILE A 327
VAL A 335
ALA A 348
GLU A 366
LEU A 431
HIS A 438
 None
ANP  A1001 (-4.7A)
ANP  A1001 (-3.6A)
ANP  A1001 (-3.6A)
None
None
 0.82A 1uwjB-4fieA:
7.5		 1uwjB-4fieA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_B_STRB402_1
(MINERALOCORTICOID
RECEPTOR)		 4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		5 / 12 ASN A 377
LEU A 456
ALA A 427
LEU A 501
LEU A 572
 None
 1.14A 2aa6B-4fieA:
undetectable		 2aa6B-4fieA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CC8_A_RBFA1067_1
(VNG1446H)		 4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		3 / 3 PHE A 324
VAL A 349
TRP A 392
 None
 0.90A 2cc8A-4fieA:
undetectable		 2cc8A-4fieA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CCB_A_RBFA1067_1
(VNG1446H)		 4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		3 / 3 PHE A 324
VAL A 349
TRP A 392
 None
 0.90A 2ccbA-4fieA:
undetectable		 2ccbA-4fieA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		6 / 11 GLY A 328
GLY A 330
VAL A 335
ALA A 348
MET A 395
LEU A 447
 ANP  A1001 (-4.4A)
ANP  A1001 (-3.2A)
ANP  A1001 (-4.7A)
ANP  A1001 (-3.6A)
ANP  A1001 (-4.8A)
ANP  A1001 (-4.7A)
 0.58A 2evaA-4fieA:
25.2		 2evaA-4fieA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		6 / 12 VAL A 335
ALA A 348
GLU A 366
PHE A 397
GLY A 401
LEU A 447
 ANP  A1001 (-4.7A)
ANP  A1001 (-3.6A)
ANP  A1001 (-3.6A)
ANP  A1001 ( 4.6A)
None
ANP  A1001 (-4.7A)
 0.84A 2hyyB-4fieA:
17.8		 2hyyB-4fieA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		7 / 12 VAL A 335
ALA A 348
GLU A 366
VAL A 379
PHE A 397
GLY A 401
LEU A 447
 ANP  A1001 (-4.7A)
ANP  A1001 (-3.6A)
ANP  A1001 (-3.6A)
None
ANP  A1001 ( 4.6A)
None
ANP  A1001 (-4.7A)
 0.80A 2hyyC-4fieA:
22.3		 2hyyC-4fieA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		8 / 12 GLY A 328
VAL A 335
ALA A 348
LYS A 350
GLU A 366
MET A 370
GLY A 401
LEU A 447
 ANP  A1001 (-4.4A)
ANP  A1001 (-4.7A)
ANP  A1001 (-3.6A)
ANP  A1001 (-3.0A)
ANP  A1001 (-3.6A)
None
None
ANP  A1001 (-4.7A)
 0.82A 2ityA-4fieA:
23.6		 2ityA-4fieA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_1
(MINERALOCORTICOID
RECEPTOR)		 4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		5 / 12 ASN A 377
LEU A 456
ALA A 427
LEU A 501
LEU A 572
 None
 1.14A 2oaxD-4fieA:
undetectable		 2oaxD-4fieA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_E_SNLE5001_1
(MINERALOCORTICOID
RECEPTOR)		 4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		5 / 12 ASN A 377
LEU A 456
ALA A 427
LEU A 501
LEU A 572
 None
 1.17A 2oaxE-4fieA:
undetectable		 2oaxE-4fieA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VX9_A_RBFA1064_1
(DODECIN)		 4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		3 / 3 PHE A 324
VAL A 349
TRP A 392
 None
 0.88A 2vx9A-4fieA:
undetectable		 2vx9A-4fieA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)		 4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		7 / 12 ILE A 327
ALA A 348
LYS A 350
GLU A 366
GLY A 401
LEU A 447
SER A 457
 None
ANP  A1001 (-3.6A)
ANP  A1001 (-3.0A)
ANP  A1001 (-3.6A)
None
ANP  A1001 (-4.7A)
ANP  A1001 ( 4.4A)
 1.01A 2y6oA-4fieA:
22.6		 2y6oA-4fieA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)		 4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		7 / 12 ILE A 327
ALA A 348
LYS A 350
MET A 370
GLY A 401
LEU A 447
SER A 457
 None
ANP  A1001 (-3.6A)
ANP  A1001 (-3.0A)
None
None
ANP  A1001 (-4.7A)
ANP  A1001 ( 4.4A)
 1.01A 2y6oA-4fieA:
22.6		 2y6oA-4fieA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		7 / 12 GLY A 328
ALA A 348
LYS A 350
VAL A 379
PHE A 397
GLY A 401
LEU A 447
 ANP  A1001 (-4.4A)
ANP  A1001 (-3.6A)
ANP  A1001 (-3.0A)
None
ANP  A1001 ( 4.6A)
None
ANP  A1001 (-4.7A)
 0.61A 3c7qA-4fieA:
20.8		 3c7qA-4fieA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		7 / 11 ILE A 327
ALA A 348
LYS A 350
VAL A 379
PHE A 397
LEU A 447
SER A 457
 None
ANP  A1001 (-3.6A)
ANP  A1001 (-3.0A)
None
ANP  A1001 ( 4.6A)
ANP  A1001 (-4.7A)
ANP  A1001 ( 4.4A)
 0.80A 3miyA-4fieA:
23.1		 3miyA-4fieA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		7 / 11 ILE A 327
LYS A 350
VAL A 379
PHE A 397
GLY A 401
LEU A 447
SER A 457
 None
ANP  A1001 (-3.0A)
None
ANP  A1001 ( 4.6A)
None
ANP  A1001 (-4.7A)
ANP  A1001 ( 4.4A)
 0.79A 3miyA-4fieA:
23.1		 3miyA-4fieA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		6 / 9 ILE A 327
ALA A 348
LYS A 350
PHE A 397
LEU A 447
SER A 457
 None
ANP  A1001 (-3.6A)
ANP  A1001 (-3.0A)
ANP  A1001 ( 4.6A)
ANP  A1001 (-4.7A)
ANP  A1001 ( 4.4A)
 0.77A 3miyB-4fieA:
22.9		 3miyB-4fieA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		6 / 9 ILE A 327
LYS A 350
PHE A 397
GLY A 401
LEU A 447
SER A 457
 None
ANP  A1001 (-3.0A)
ANP  A1001 ( 4.6A)
None
ANP  A1001 (-4.7A)
ANP  A1001 ( 4.4A)
 0.77A 3miyB-4fieA:
22.9		 3miyB-4fieA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)		 4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		5 / 9 ILE A 327
ALA A 348
VAL A 379
PHE A 397
LEU A 447
 None
ANP  A1001 (-3.6A)
None
ANP  A1001 ( 4.6A)
ANP  A1001 (-4.7A)
 0.69A 3ti1A-4fieA:
24.2		 3ti1A-4fieA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		7 / 12 ALA A 348
LYS A 350
GLU A 366
VAL A 379
PHE A 397
GLY A 401
LEU A 447
 ANP  A1001 (-3.6A)
ANP  A1001 (-3.0A)
ANP  A1001 (-3.6A)
None
ANP  A1001 ( 4.6A)
None
ANP  A1001 (-4.7A)
 0.84A 3ue4A-4fieA:
25.4		 3ue4A-4fieA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		7 / 12 VAL A 335
ALA A 348
GLU A 366
MET A 370
PHE A 397
GLY A 401
LEU A 447
 ANP  A1001 (-4.7A)
ANP  A1001 (-3.6A)
ANP  A1001 (-3.6A)
None
ANP  A1001 ( 4.6A)
None
ANP  A1001 (-4.7A)
 0.94A 3ue4B-4fieA:
24.8		 3ue4B-4fieA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		7 / 12 VAL A 335
ALA A 348
GLU A 366
VAL A 379
PHE A 397
GLY A 401
LEU A 447
 ANP  A1001 (-4.7A)
ANP  A1001 (-3.6A)
ANP  A1001 (-3.6A)
None
ANP  A1001 ( 4.6A)
None
ANP  A1001 (-4.7A)
 0.76A 3ue4B-4fieA:
24.8		 3ue4B-4fieA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		9 / 12 GLY A 330
GLY A 333
VAL A 335
ALA A 348
LYS A 350
VAL A 379
LEU A 447
SER A 457
ASP A 458
 ANP  A1001 (-3.2A)
None
ANP  A1001 (-4.7A)
ANP  A1001 (-3.6A)
ANP  A1001 (-3.0A)
None
ANP  A1001 (-4.7A)
ANP  A1001 ( 4.4A)
ANP  A1001 (-2.7A)
 0.86A 3v5wA-4fieA:
10.7		 3v5wA-4fieA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		8 / 12 ILE A 327
GLY A 330
GLY A 333
VAL A 335
ALA A 348
LYS A 350
SER A 457
ASP A 458
 None
ANP  A1001 (-3.2A)
None
ANP  A1001 (-4.7A)
ANP  A1001 (-3.6A)
ANP  A1001 (-3.0A)
ANP  A1001 ( 4.4A)
ANP  A1001 (-2.7A)
 0.85A 3v5wA-4fieA:
10.7		 3v5wA-4fieA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		5 / 11 LEU A 535
ILE A 527
ILE A 503
VAL A 505
VAL A 407
 None
 1.02A 3w67A-4fieA:
undetectable		 3w67A-4fieA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		8 / 12 VAL A 335
ALA A 348
LYS A 350
GLU A 366
VAL A 379
PHE A 397
GLY A 401
LEU A 447
 ANP  A1001 (-4.7A)
ANP  A1001 (-3.6A)
ANP  A1001 (-3.0A)
ANP  A1001 (-3.6A)
None
ANP  A1001 ( 4.6A)
None
ANP  A1001 (-4.7A)
 0.74A 4ag8A-4fieA:
21.3		 4ag8A-4fieA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		6 / 11 ALA A 348
LYS A 350
VAL A 379
PHE A 397
GLY A 401
LEU A 447
 ANP  A1001 (-3.6A)
ANP  A1001 (-3.0A)
None
ANP  A1001 ( 4.6A)
None
ANP  A1001 (-4.7A)
 0.72A 4agdA-4fieA:
20.7		 4agdA-4fieA:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B9Z_A_ACRA1818_1
(ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B)		 4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		5 / 12 ILE A 446
LEU A 398
GLU A 396
PHE A 459
HIS A 438
 None
ANP  A1001 (-4.6A)
None
None
None
 1.15A 4b9zA-4fieA:
undetectable		 4b9zA-4fieA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		5 / 12 VAL A 509
THR A 408
ILE A 581
VAL A 420
ILE A 446
 None
 1.26A 4eb6B-4fieA:
undetectable
4eb6C-4fieA:
undetectable		 4eb6B-4fieA:
22.91
4eb6C-4fieA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		5 / 12 VAL A 582
THR A 410
ILE A 446
VAL A 420
ILE A 417
 None
 1.36A 4eb6B-4fieA:
undetectable
4eb6C-4fieA:
undetectable		 4eb6B-4fieA:
22.91
4eb6C-4fieA:
20.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		 4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		10 / 10 ILE A 327
ALA A 348
VAL A 379
MET A 395
PHE A 397
LEU A 398
GLY A 401
LEU A 447
SER A 457
ASP A 458
 None
ANP  A1001 (-3.6A)
None
ANP  A1001 (-4.8A)
ANP  A1001 ( 4.6A)
ANP  A1001 (-4.6A)
None
ANP  A1001 (-4.7A)
ANP  A1001 ( 4.4A)
ANP  A1001 (-2.7A)
 0.67A 4ks8A-4fieA:
43.6		 4ks8A-4fieA:
52.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		 4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		6 / 10 VAL A 379
MET A 395
PHE A 397
LEU A 398
GLY A 400
SER A 457
 None
ANP  A1001 (-4.8A)
ANP  A1001 ( 4.6A)
ANP  A1001 (-4.6A)
None
ANP  A1001 ( 4.4A)
 1.18A 4ks8A-4fieA:
43.6		 4ks8A-4fieA:
52.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0U_A_ADNA501_1
(AURORA KINASE A)		 4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		4 / 6 VAL A 335
ALA A 348
LYS A 350
LEU A 447
 ANP  A1001 (-4.7A)
ANP  A1001 (-3.6A)
ANP  A1001 (-3.0A)
ANP  A1001 (-4.7A)
 0.54A 4o0uA-4fieA:
8.2		 4o0uA-4fieA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		7 / 12 ILE A 327
GLY A 328
VAL A 335
ALA A 348
MET A 395
LEU A 398
LEU A 447
 None
ANP  A1001 (-4.4A)
ANP  A1001 (-4.7A)
ANP  A1001 (-3.6A)
ANP  A1001 (-4.8A)
ANP  A1001 (-4.6A)
ANP  A1001 (-4.7A)
 0.63A 4qmzA-4fieA:
36.7		 4qmzA-4fieA:
28.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		7 / 12 VAL A 335
ALA A 348
LYS A 350
MET A 370
PHE A 397
GLY A 401
LEU A 447
 ANP  A1001 (-4.7A)
ANP  A1001 (-3.6A)
ANP  A1001 (-3.0A)
None
ANP  A1001 ( 4.6A)
None
ANP  A1001 (-4.7A)
 0.81A 4xeyA-4fieA:
24.6		 4xeyA-4fieA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		7 / 12 VAL A 335
ALA A 348
LYS A 350
VAL A 379
PHE A 397
GLY A 401
LEU A 447
 ANP  A1001 (-4.7A)
ANP  A1001 (-3.6A)
ANP  A1001 (-3.0A)
None
ANP  A1001 ( 4.6A)
None
ANP  A1001 (-4.7A)
 0.55A 4xeyA-4fieA:
24.6		 4xeyA-4fieA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		7 / 12 VAL A 335
ALA A 348
LYS A 350
VAL A 379
PHE A 397
GLY A 401
LEU A 447
 ANP  A1001 (-4.7A)
ANP  A1001 (-3.6A)
ANP  A1001 (-3.0A)
None
ANP  A1001 ( 4.6A)
None
ANP  A1001 (-4.7A)
 0.56A 4xeyB-4fieA:
24.1		 4xeyB-4fieA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CU6_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		4 / 6 TYR A 492
VAL A 496
PRO A 557
ALA A 483
 SEP  A 474 ( 4.4A)
None
None
None
 0.81A 5cu6A-4fieA:
25.2		 5cu6A-4fieA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		7 / 12 ILE A 327
ALA A 348
LYS A 350
MET A 370
GLY A 401
LEU A 447
SER A 457
 None
ANP  A1001 (-3.6A)
ANP  A1001 (-3.0A)
None
None
ANP  A1001 (-4.7A)
ANP  A1001 ( 4.4A)
 0.84A 5i9yA-4fieA:
22.4		 5i9yA-4fieA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IM2_A_BEZA401_0
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)		 4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		5 / 12 VAL A 407
ILE A 503
PRO A 533
LEU A 535
VAL A 509
 None
 1.26A 5im2A-4fieA:
undetectable		 5im2A-4fieA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JCN_B_ASCB502_0
(OS09G0567300 PROTEIN)		 4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		4 / 6 GLU A 495
PRO A 557
GLY A 493
ARG A 471
 None
 1.20A 5jcnB-4fieA:
undetectable		 5jcnB-4fieA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_B_ADNB401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		5 / 9 ILE A 327
GLY A 328
VAL A 335
ALA A 348
MET A 395
 None
ANP  A1001 (-4.4A)
ANP  A1001 (-4.7A)
ANP  A1001 (-3.6A)
ANP  A1001 (-4.8A)
 0.67A 5lw1B-4fieA:
23.4		 5lw1B-4fieA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OTR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		4 / 5 TYR A 492
VAL A 496
PRO A 557
ALA A 483
 SEP  A 474 ( 4.4A)
None
None
None
 0.76A 5otrA-4fieA:
24.9		 5otrA-4fieA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)		 4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		6 / 12 VAL A 335
ALA A 348
LYS A 350
GLY A 401
LEU A 447
SER A 457
 ANP  A1001 (-4.7A)
ANP  A1001 (-3.6A)
ANP  A1001 (-3.0A)
None
ANP  A1001 (-4.7A)
ANP  A1001 ( 4.4A)
 0.79A 5p9iA-4fieA:
23.6		 5p9iA-4fieA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		6 / 12 ALA A 348
GLU A 366
VAL A 379
PHE A 397
GLY A 401
LEU A 447
 ANP  A1001 (-3.6A)
ANP  A1001 (-3.6A)
None
ANP  A1001 ( 4.6A)
None
ANP  A1001 (-4.7A)
 0.72A 5te0A-4fieA:
25.5		 5te0A-4fieA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		6 / 12 ALA A 348
MET A 370
VAL A 379
PHE A 397
GLY A 401
LEU A 447
 ANP  A1001 (-3.6A)
None
None
ANP  A1001 ( 4.6A)
None
ANP  A1001 (-4.7A)
 0.76A 5te0A-4fieA:
25.5		 5te0A-4fieA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_C_HFGC1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		5 / 12 PRO A 479
THR A 478
TRP A 481
THR A 404
SER A 445
 None
 1.34A 5xiqC-4fieA:
undetectable		 5xiqC-4fieA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		6 / 12 GLY A 328
VAL A 335
ALA A 348
LYS A 350
LEU A 447
ASP A 458
 ANP  A1001 (-4.4A)
ANP  A1001 (-4.7A)
ANP  A1001 (-3.6A)
ANP  A1001 (-3.0A)
ANP  A1001 (-4.7A)
ANP  A1001 (-2.7A)
 0.84A 5yu9B-4fieA:
21.8		 5yu9B-4fieA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		6 / 12 VAL A 335
ALA A 348
LYS A 350
GLY A 401
LEU A 447
ASP A 458
 ANP  A1001 (-4.7A)
ANP  A1001 (-3.6A)
ANP  A1001 (-3.0A)
None
ANP  A1001 (-4.7A)
ANP  A1001 (-2.7A)
 0.86A 5yu9D-4fieA:
22.0		 5yu9D-4fieA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNM_A_1N1A1001_1
(-)		 4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		7 / 12 ILE A 327
VAL A 335
ALA A 348
LYS A 350
MET A 370
GLY A 401
LEU A 447
 None
ANP  A1001 (-4.7A)
ANP  A1001 (-3.6A)
ANP  A1001 (-3.0A)
None
None
ANP  A1001 (-4.7A)
 0.87A 6fnmA-4fieA:
23.2		 6fnmA-4fieA:
23.04