SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fin'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA8_0
(GRAMICIDIN A)		 4fin ETTA (YJJK) ABCF
FAMILY PROTEIN
(Escherichia
coli) 		4 / 4 GLY A  32
VAL A 212
TRP A 228
GLY A 227
 None
 1.30A 1ng8A-4finA:
undetectable		 1ng8A-4finA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB8_0
(GRAMICIDIN A)		 4fin ETTA (YJJK) ABCF
FAMILY PROTEIN
(Escherichia
coli) 		4 / 4 GLY A  32
VAL A 212
TRP A 228
GLY A 227
 None
 1.30A 1ng8B-4finA:
undetectable		 1ng8B-4finA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4fin ETTA (YJJK) ABCF
FAMILY PROTEIN
(Escherichia
coli) 		5 / 11 ILE A 229
VAL A  37
ALA A 214
LEU A 185
PHE A  29
 None
 1.22A 1uduA-4finA:
undetectable		 1uduA-4finA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XL6_B_SPMB3001_1
(INWARD RECTIFIER
POTASSIUM CHANNEL)		 4fin ETTA (YJJK) ABCF
FAMILY PROTEIN
(Escherichia
coli) 		4 / 5 ALA A 109
TYR A 108
ALA A 112
TYR A 111
 None
 0.99A 1xl6A-4finA:
undetectable
1xl6B-4finA:
undetectable		 1xl6A-4finA:
18.13
1xl6B-4finA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4fin ETTA (YJJK) ABCF
FAMILY PROTEIN
(Escherichia
coli) 		5 / 12 LEU A 230
ILE A  35
ALA A  53
ILE A  71
PHE A  29
 None
 1.00A 2h42C-4finA:
undetectable		 2h42C-4finA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLK_B_SPMB1302_1
(ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 10)		 4fin ETTA (YJJK) ABCF
FAMILY PROTEIN
(Escherichia
coli) 		4 / 4 ALA A 109
TYR A 108
ALA A 112
TYR A 111
 None
 1.00A 2wlkA-4finA:
undetectable
2wlkB-4finA:
undetectable		 2wlkA-4finA:
18.13
2wlkB-4finA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_E_RTLE177_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4fin ETTA (YJJK) ABCF
FAMILY PROTEIN
(Escherichia
coli) 		5 / 11 LEU A 178
ALA A 150
ALA A 147
LEU A 140
PHE A 204
 None
 1.20A 3bszE-4finA:
undetectable		 3bszE-4finA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA802_1
(CATALASE-PEROXIDASE)		 4fin ETTA (YJJK) ABCF
FAMILY PROTEIN
(Escherichia
coli) 		4 / 8 LYS A 534
LEU A 543
GLY A 356
ILE A 355
 None
 0.88A 3wxoA-4finA:
undetectable		 3wxoA-4finA:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_A_UEGA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4fin ETTA (YJJK) ABCF
FAMILY PROTEIN
(Escherichia
coli) 		5 / 11 ALA A 350
GLY A 349
VAL A 323
HIS A 510
CYH A 493
 None
 0.87A 4c5lA-4finA:
undetectable		 4c5lA-4finA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4fin ETTA (YJJK) ABCF
FAMILY PROTEIN
(Escherichia
coli) 		5 / 9 ALA A 350
GLY A 349
VAL A 323
HIS A 510
CYH A 493
 None
 0.84A 4c5lB-4finA:
undetectable		 4c5lB-4finA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_C_UEGC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4fin ETTA (YJJK) ABCF
FAMILY PROTEIN
(Escherichia
coli) 		5 / 10 ALA A 350
GLY A 349
VAL A 323
HIS A 510
CYH A 493
 None
 0.86A 4c5lC-4finA:
undetectable		 4c5lC-4finA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4fin ETTA (YJJK) ABCF
FAMILY PROTEIN
(Escherichia
coli) 		5 / 10 ALA A 350
GLY A 349
VAL A 323
HIS A 510
CYH A 493
 None
 0.88A 4c5lD-4finA:
undetectable		 4c5lD-4finA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4fin ETTA (YJJK) ABCF
FAMILY PROTEIN
(Escherichia
coli) 		5 / 10 ALA A 350
GLY A 349
VAL A 323
HIS A 510
CYH A 493
 None
 0.86A 4c5nB-4finA:
undetectable		 4c5nB-4finA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4fin ETTA (YJJK) ABCF
FAMILY PROTEIN
(Escherichia
coli) 		5 / 10 ALA A 350
GLY A 349
VAL A 323
HIS A 510
CYH A 493
 None
 0.95A 4c5nD-4finA:
undetectable		 4c5nD-4finA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 4fin ETTA (YJJK) ABCF
FAMILY PROTEIN
(Escherichia
coli) 		4 / 6 LEU A 230
LEU A  48
ILE A  51
MET A   8
 None
 0.95A 4do3B-4finA:
undetectable		 4do3B-4finA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		 4fin ETTA (YJJK) ABCF
FAMILY PROTEIN
(Escherichia
coli) 		5 / 12 LEU A 176
PRO A 189
ILE A  71
LEU A  49
GLY A  54
 None
 1.22A 4l9qB-4finA:
undetectable		 4l9qB-4finA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_A_ML1A302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4fin ETTA (YJJK) ABCF
FAMILY PROTEIN
(Escherichia
coli) 		4 / 8 PHE A 344
ILE A 346
PHE A 522
GLY A 353
 None
 0.95A 4qogA-4finA:
undetectable
4qogB-4finA:
undetectable		 4qogA-4finA:
17.03
4qogB-4finA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_A_ADNA303_1
(5'/3'-NUCLEOTIDASE
SURE)		 4fin ETTA (YJJK) ABCF
FAMILY PROTEIN
(Escherichia
coli) 		6 / 10 GLY A  44
ASP A  56
ALA A  63
ILE A  25
LEU A  48
LEU A  22
 SO4  A 601 (-3.1A)
None
None
None
None
None
 1.40A 4xj7A-4finA:
undetectable
4xj7B-4finA:
undetectable		 4xj7A-4finA:
18.85
4xj7B-4finA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_D_ADND303_1
(5'/3'-NUCLEOTIDASE
SURE)		 4fin ETTA (YJJK) ABCF
FAMILY PROTEIN
(Escherichia
coli) 		6 / 10 LEU A  48
LEU A  22
GLY A  44
ASP A  56
ALA A  63
ILE A  25
 None
None
SO4  A 601 (-3.1A)
None
None
None
 1.39A 4xj7C-4finA:
undetectable
4xj7D-4finA:
undetectable		 4xj7C-4finA:
18.85
4xj7D-4finA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_2
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 4fin ETTA (YJJK) ABCF
FAMILY PROTEIN
(Escherichia
coli) 		3 / 3 GLU A 274
TRP A 275
ASN A 485
 None
 1.08A 5dv4A-4finA:
undetectable		 5dv4A-4finA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_B_FUAB1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4fin ETTA (YJJK) ABCF
FAMILY PROTEIN
(Escherichia
coli) 		4 / 5 ILE A 313
LEU A 475
HIS A 454
VAL A 391
 None
 1.22A 5jmnB-4finA:
0.0		 5jmnB-4finA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_1
(PROTEASE PR5-SQV)		 4fin ETTA (YJJK) ABCF
FAMILY PROTEIN
(Escherichia
coli) 		5 / 9 ALA A 494
ILE A 507
GLY A 353
ILE A 354
THR A 472
 None
 1.23A 5kr2C-4finA:
undetectable		 5kr2C-4finA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_B_TRPB403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 4fin ETTA (YJJK) ABCF
FAMILY PROTEIN
(Escherichia
coli) 		4 / 7 ARG A 305
GLU A 307
THR A 300
PRO A 315
 None
 1.16A 6a4iB-4finA:
undetectable		 6a4iB-4finA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4fin ETTA (YJJK) ABCF
FAMILY PROTEIN
(Escherichia
coli) 		5 / 10 LEU A 365
THR A 364
GLY A 359
ILE A 354
ILE A 497
 None
None
SO4  A 603 (-3.3A)
None
None
 1.09A 6ebpD-4finA:
undetectable		 6ebpD-4finA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4fin ETTA (YJJK) ABCF
FAMILY PROTEIN
(Escherichia
coli) 		5 / 11 LEU A 365
THR A 364
GLY A 359
ILE A 354
ILE A 497
 None
None
SO4  A 603 (-3.3A)
None
None
 1.07A 6ebzA-4finA:
undetectable		 6ebzA-4finA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4fin ETTA (YJJK) ABCF
FAMILY PROTEIN
(Escherichia
coli) 		5 / 11 LEU A 365
THR A 364
GLY A 359
ILE A 354
ILE A 497
 None
None
SO4  A 603 (-3.3A)
None
None
 1.09A 6ebzD-4finA:
undetectable		 6ebzD-4finA:
10.24