SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fio'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4fio METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE
(Methanobrevibact
er
ruminantium) 		5 / 12 ILE A 283
VAL A 272
ASP A 275
MET A 225
GLY A 277
 None
 1.15A 1kiaB-4fioA:
undetectable		 1kiaB-4fioA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 4fio METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE
(Methanobrevibact
er
ruminantium) 		4 / 8 SER A 317
ALA A 224
ILE A 182
THR A 173
 None
None
IPA  A 402 (-4.6A)
None
 0.90A 3bpxA-4fioA:
undetectable
3bpxB-4fioA:
undetectable		 3bpxA-4fioA:
17.80
3bpxB-4fioA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_1
(CYTOCHROME P450 2R1)		 4fio METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE
(Methanobrevibact
er
ruminantium) 		4 / 5 ALA A 291
LEU A 257
GLY A 190
THR A  84
 None
 0.78A 3dl9A-4fioA:
undetectable		 3dl9A-4fioA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4fio METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE
(Methanobrevibact
er
ruminantium) 		4 / 6 ILE A  89
ALA A  88
ALA A 208
THR A  84
 None
 0.64A 3mdrB-4fioA:
undetectable		 3mdrB-4fioA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4fio METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE
(Methanobrevibact
er
ruminantium) 		5 / 12 GLY A 184
GLY A 236
ALA A 212
ALA A 215
SER A 317
 None
 1.05A 3sudB-4fioA:
undetectable		 3sudB-4fioA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYE_B_YTZB902_1
(DIHYDROPTEROATE
SYNTHASE)		 4fio METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE
(Methanobrevibact
er
ruminantium) 		3 / 3 PHE A 167
LYS A  28
SER A  27
 None
 1.27A 3tyeB-4fioA:
undetectable		 3tyeB-4fioA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZS3_A_ACTA1224_0
(THAUMATIN-LIKE
PROTEIN)		 4fio METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE
(Methanobrevibact
er
ruminantium) 		4 / 5 SER A 111
GLU A 142
THR A 140
TYR A  52
 None
 1.34A 3zs3A-4fioA:
undetectable		 3zs3A-4fioA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4fio METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE
(Methanobrevibact
er
ruminantium) 		4 / 7 GLU A 123
GLU A 127
TYR A 125
GLY A  98
 None
 1.05A 4fgzA-4fioA:
undetectable		 4fgzA-4fioA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		 4fio METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE
(Methanobrevibact
er
ruminantium) 		4 / 8 SER A 118
LEU A 117
CYH A 159
PRO A 113
 None
 1.10A 4j7uD-4fioA:
undetectable		 4j7uD-4fioA:
25.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LJ0_A_ACTA505_0
(NAB2)		 4fio METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE
(Methanobrevibact
er
ruminantium) 		3 / 3 LEU A  57
LYS A  54
THR A  53
 None
 0.53A 4lj0A-4fioA:
undetectable		 4lj0A-4fioA:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OQR_A_2UOA502_1
(CYP105AS1)		 4fio METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE
(Methanobrevibact
er
ruminantium) 		5 / 9 VAL A  12
ILE A  82
ALA A  61
VAL A   4
ALA A   8
 None
 1.10A 4oqrA-4fioA:
undetectable		 4oqrA-4fioA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_2
(NUPC FAMILY PROTEIN)		 4fio METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE
(Methanobrevibact
er
ruminantium) 		3 / 3 THR A 124
ASN A 189
PHE A 288
 None
IPA  A 402 (-3.0A)
EEE  A 401 (-4.1A)
 0.73A 4pd9A-4fioA:
undetectable		 4pd9A-4fioA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FEP_A_SAMA407_0
([FEFE] HYDROGENASE
MATURASE SUBUNIT
HYDE)		 4fio METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE
(Methanobrevibact
er
ruminantium) 		5 / 12 CYH A  56
SER A 175
LEU A 176
MET A  15
ILE A 138
 None
 1.43A 5fepA-4fioA:
undetectable		 5fepA-4fioA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_B_SAMB501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 4fio METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE
(Methanobrevibact
er
ruminantium) 		5 / 12 ALA A 289
PRO A 290
GLY A 236
ASP A 263
GLY A 264
 None
 1.18A 5wwsB-4fioA:
undetectable		 5wwsB-4fioA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F8C_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 4fio METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE
(Methanobrevibact
er
ruminantium) 		4 / 6 ALA A 231
SER A 179
THR A  53
ILE A  82
 None
 0.90A 6f8cA-4fioA:
undetectable		 6f8cA-4fioA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_1
(-)		 4fio METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE
(Methanobrevibact
er
ruminantium) 		5 / 12 ASP A 275
ASP A 230
ASN A 229
PHE A 269
GLU A 142
 None
None
IPA  A 402 (-4.1A)
None
None
 1.33A 6gnfA-4fioA:
undetectable		 6gnfA-4fioA:
23.57