SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fir'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_A_BEZA349_0
(D-AMINO ACID OXIDASE)		 4fir PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Pyrococcus
horikoshii) 		4 / 5 TYR A 123
TYR A 223
ILE A 231
GLY A 148
 None
 1.09A 1kifA-4firA:
undetectable		 1kifA-4firA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_B_BEZB349_0
(D-AMINO ACID OXIDASE)		 4fir PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Pyrococcus
horikoshii) 		4 / 5 TYR A 123
TYR A 223
ILE A 231
GLY A 148
 None
 1.09A 1kifB-4firA:
undetectable		 1kifB-4firA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_C_BEZC349_0
(D-AMINO ACID OXIDASE)		 4fir PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Pyrococcus
horikoshii) 		4 / 5 TYR A 123
TYR A 223
ILE A 231
GLY A 148
 None
 1.09A 1kifC-4firA:
undetectable		 1kifC-4firA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_D_BEZD349_0
(D-AMINO ACID OXIDASE)		 4fir PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Pyrococcus
horikoshii) 		4 / 5 TYR A 123
TYR A 223
ILE A 231
GLY A 148
 None
 1.09A 1kifD-4firA:
undetectable		 1kifD-4firA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_E_BEZE349_0
(D-AMINO ACID OXIDASE)		 4fir PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Pyrococcus
horikoshii) 		4 / 5 TYR A 123
TYR A 223
ILE A 231
GLY A 148
 None
 1.09A 1kifE-4firA:
undetectable		 1kifE-4firA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_F_BEZF349_0
(D-AMINO ACID OXIDASE)		 4fir PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Pyrococcus
horikoshii) 		4 / 5 TYR A 123
TYR A 223
ILE A 231
GLY A 148
 None
 1.09A 1kifF-4firA:
undetectable		 1kifF-4firA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_G_BEZG349_0
(D-AMINO ACID OXIDASE)		 4fir PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Pyrococcus
horikoshii) 		4 / 5 TYR A 123
TYR A 223
ILE A 231
GLY A 148
 None
 1.09A 1kifG-4firA:
undetectable		 1kifG-4firA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_H_BEZH349_0
(D-AMINO ACID OXIDASE)		 4fir PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Pyrococcus
horikoshii) 		4 / 5 TYR A 123
TYR A 223
ILE A 231
GLY A 148
 None
 1.09A 1kifH-4firA:
undetectable		 1kifH-4firA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE9_A_BEZA352_0
(D-AMINO ACID OXIDASE)		 4fir PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Pyrococcus
horikoshii) 		4 / 5 TYR A 123
TYR A 223
ILE A 231
GLY A 148
 None
 1.05A 1ve9A-4firA:
undetectable		 1ve9A-4firA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_G_BEZG2352_0
(D-AMINO-ACID OXIDASE)		 4fir PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Pyrococcus
horikoshii) 		4 / 5 TYR A 123
TYR A 223
ILE A 231
GLY A 148
 None
 1.09A 2du8G-4firA:
undetectable		 2du8G-4firA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_J_BEZJ3352_0
(D-AMINO-ACID OXIDASE)		 4fir PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Pyrococcus
horikoshii) 		4 / 5 TYR A 123
TYR A 223
ILE A 231
GLY A 148
 None
 0.99A 2du8J-4firA:
undetectable		 2du8J-4firA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB927_0
(FERROCHELATASE)		 4fir PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Pyrococcus
horikoshii) 		3 / 3 LEU A 248
PRO A 249
ARG A 144
 None
 0.58A 2qd4B-4firA:
1.7		 2qd4B-4firA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 4fir PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Pyrococcus
horikoshii) 		5 / 12 ALA A 254
ILE A 163
THR A 260
LEU A 307
PRO A 304
 None
 1.27A 3cl9A-4firA:
undetectable		 3cl9A-4firA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_B_V2HB602_0
(CYTOCHROME P450 2R1)		 4fir PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Pyrococcus
horikoshii) 		5 / 12 VAL A  48
ALA A  45
THR A  32
ILE A  39
MET A  29
 None
 1.29A 3dl9B-4firA:
undetectable		 3dl9B-4firA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 4fir PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Pyrococcus
horikoshii) 		5 / 12 VAL A 167
ASN A 252
ILE A 152
VAL A 173
ILE A 177
 None
 1.21A 4eb6B-4firA:
undetectable
4eb6C-4firA:
undetectable		 4eb6B-4firA:
20.09
4eb6C-4firA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 4fir PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Pyrococcus
horikoshii) 		4 / 4 PHE A  19
VAL A  23
ALA A  20
PHE A 253
 None
 1.38A 4f3tA-4firA:
undetectable		 4f3tA-4firA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J5J_B_478B401_2
(PROTEASE)		 4fir PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Pyrococcus
horikoshii) 		5 / 10 ALA A  45
ILE A  28
VAL A  23
GLY A  25
VAL A 277
 None
None
None
None
R5P  A 401 ( 4.4A)
 1.00A 4j5jB-4firA:
undetectable		 4j5jB-4firA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN)		 4fir PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Pyrococcus
horikoshii) 		3 / 3 ARG A 143
GLU A 109
TYR A 199
 None
 0.85A 4r29D-4firA:
undetectable		 4r29D-4firA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_E_ACTE403_0
(PROTON-GATED ION
CHANNEL)		 4fir PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Pyrococcus
horikoshii) 		3 / 3 ARG A 144
TYR A 223
GLU A 147
 None
 0.69A 4zzbE-4firA:
undetectable		 4zzbE-4firA:
22.01