SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fjo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4fjo MITOTIC SPINDLE
ASSEMBLY CHECKPOINT
PROTEIN MAD2B
(Mus
musculus) 		3 / 3 HIS C 180
ASP C  89
ASN C 210
 PO4  C 302 ( 3.8A)
None
None
 0.81A 1wg8B-4fjoC:
undetectable		 1wg8B-4fjoC:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF211_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4fjo MITOTIC SPINDLE
ASSEMBLY CHECKPOINT
PROTEIN MAD2B
(Mus
musculus) 		4 / 7 LEU C  23
PHE C 126
LEU C  75
SER C 194
 None
None
None
PO4  C 303 (-4.8A)
 0.99A 1wrlE-4fjoC:
undetectable
1wrlF-4fjoC:
undetectable		 1wrlE-4fjoC:
15.74
1wrlF-4fjoC:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMA_D_ADND604_1
(PYRUVATE KINASE)		 4fjo MITOTIC SPINDLE
ASSEMBLY CHECKPOINT
PROTEIN MAD2B
(Mus
musculus) 		3 / 3 ARG C 158
GLU C 154
ASN C 159
 None
 0.84A 4imaD-4fjoC:
undetectable		 4imaD-4fjoC:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IP7_D_ADND604_1
(PYRUVATE KINASE
ISOZYMES L)		 4fjo MITOTIC SPINDLE
ASSEMBLY CHECKPOINT
PROTEIN MAD2B
(Mus
musculus) 		3 / 3 ARG C 158
GLU C 154
ASN C 159
 None
 0.80A 4ip7D-4fjoC:
undetectable		 4ip7D-4fjoC:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA601_1
(SERUM ALBUMIN)		 4fjo MITOTIC SPINDLE
ASSEMBLY CHECKPOINT
PROTEIN MAD2B
(Mus
musculus) 		5 / 11 LEU C  29
VAL C  25
PHE C 100
LEU C 201
SER C 131
 None
 1.30A 4zbqA-4fjoC:
undetectable		 4zbqA-4fjoC:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA503_1
(CYTOCHROME P450 2C9)		 4fjo DNA POLYMERASE ZETA
CATALYTIC SUBUNIT
MITOTIC SPINDLE
ASSEMBLY CHECKPOINT
PROTEIN MAD2B
(Mus
musculus) 		5 / 12 ILE C  64
PHE C 146
LEU C  88
LEU D1878
PRO D1881
 None
 1.17A 5xxiA-4fjoC:
undetectable		 5xxiA-4fjoC:
18.61