SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fk1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_A_FFOA1002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4fk1 PUTATIVE THIOREDOXIN
REDUCTASE
(Bacillus
anthracis) 		4 / 5 GLU C 114
TYR C 126
PHE C 231
PRO C 275
 FAD  C 500 (-3.7A)
FAD  C 500 (-4.3A)
None
None
 1.26A 1dfoB-4fk1C:
undetectable		 1dfoB-4fk1C:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_B_FFOB2002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4fk1 PUTATIVE THIOREDOXIN
REDUCTASE
(Bacillus
anthracis) 		4 / 5 GLU C 114
TYR C 126
PHE C 231
PRO C 275
 FAD  C 500 (-3.7A)
FAD  C 500 (-4.3A)
None
None
 1.26A 1dfoA-4fk1C:
undetectable		 1dfoA-4fk1C:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_C_FFOC3002_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4fk1 PUTATIVE THIOREDOXIN
REDUCTASE
(Bacillus
anthracis) 		4 / 5 GLU C 114
TYR C 126
PHE C 231
PRO C 275
 FAD  C 500 (-3.7A)
FAD  C 500 (-4.3A)
None
None
 1.26A 1dfoD-4fk1C:
undetectable		 1dfoD-4fk1C:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_D_FFOD4002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4fk1 PUTATIVE THIOREDOXIN
REDUCTASE
(Bacillus
anthracis) 		4 / 5 GLU C 114
TYR C 126
PHE C 231
PRO C 275
 FAD  C 500 (-3.7A)
FAD  C 500 (-4.3A)
None
None
 1.26A 1dfoC-4fk1C:
undetectable		 1dfoC-4fk1C:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 4fk1 PUTATIVE THIOREDOXIN
REDUCTASE
(Bacillus
anthracis) 		5 / 9 GLY C  15
ALA C  11
SER C  19
LEU C  16
LEU C  64
 None
None
None
None
MSO  C  68 ( 4.2A)
 1.03A 1y7iA-4fk1C:
undetectable		 1y7iA-4fk1C:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4fk1 PUTATIVE THIOREDOXIN
REDUCTASE
(Bacillus
anthracis) 		5 / 12 GLY C 111
GLY C 285
GLY C  15
GLY C  12
LEU C  22
 FAD  C 500 (-3.5A)
None
None
FAD  C 500 (-3.2A)
None
 0.82A 2oxtB-4fk1C:
undetectable		 2oxtB-4fk1C:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4fk1 PUTATIVE THIOREDOXIN
REDUCTASE
(Bacillus
anthracis) 		4 / 6 GLU C 114
TYR C 126
PHE C 231
PRO C 275
 FAD  C 500 (-3.7A)
FAD  C 500 (-4.3A)
None
None
 1.35A 2vmyA-4fk1C:
undetectable		 2vmyA-4fk1C:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLK_B_SPMB1302_1
(ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 10)		 4fk1 PUTATIVE THIOREDOXIN
REDUCTASE
(Bacillus
anthracis) 		4 / 4 ALA C   7
TYR C  76
ALA C 103
TYR C 101
 None
 1.25A 2wlkA-4fk1C:
undetectable
2wlkB-4fk1C:
undetectable		 2wlkA-4fk1C:
23.45
2wlkB-4fk1C:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SM2_A_478A126_2
(GAG-PRO-POL
POLYPROTEIN)		 4fk1 PUTATIVE THIOREDOXIN
REDUCTASE
(Bacillus
anthracis) 		6 / 11 ALA C  18
VAL C   8
VAL C  73
GLY C  23
ALA C  25
LEU C  31
 None
 1.35A 3sm2B-4fk1C:
undetectable		 3sm2B-4fk1C:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SM2_A_478A126_2
(GAG-PRO-POL
POLYPROTEIN)		 4fk1 PUTATIVE THIOREDOXIN
REDUCTASE
(Bacillus
anthracis) 		6 / 11 VAL C   8
VAL C  73
GLY C  23
ALA C  25
LEU C  31
TYR C 265
 None
 1.39A 3sm2B-4fk1C:
undetectable		 3sm2B-4fk1C:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_A_MIYA2001_1
(TETX2 PROTEIN)		 4fk1 PUTATIVE THIOREDOXIN
REDUCTASE
(Bacillus
anthracis) 		5 / 11 GLN C 284
SER C 276
PRO C  13
GLY C  10
ASN C  37
 None
FAD  C 500 ( 4.1A)
FAD  C 500 (-3.5A)
FAD  C 500 (-3.2A)
FAD  C 500 (-4.6A)
 1.29A 3v3nA-4fk1C:
13.3		 3v3nA-4fk1C:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B53_B_ACTB1445_0
(IG GAMMA-4 CHAIN C
REGION)		 4fk1 PUTATIVE THIOREDOXIN
REDUCTASE
(Bacillus
anthracis) 		3 / 3 GLU C 261
GLY C 242
SER C 260
 None
 0.69A 4b53B-4fk1C:
undetectable		 4b53B-4fk1C:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4fk1 PUTATIVE THIOREDOXIN
REDUCTASE
(Bacillus
anthracis) 		5 / 9 GLY C  15
ALA C 288
GLY C 285
VAL C   8
VAL C  21
 None
 1.26A 4c5lB-4fk1C:
2.1		 4c5lB-4fk1C:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4fk1 PUTATIVE THIOREDOXIN
REDUCTASE
(Bacillus
anthracis) 		5 / 10 GLY C  15
ALA C 288
GLY C 285
VAL C   8
VAL C  21
 None
 1.26A 4c5nB-4fk1C:
3.2		 4c5nB-4fk1C:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4fk1 PUTATIVE THIOREDOXIN
REDUCTASE
(Bacillus
anthracis) 		5 / 10 GLY C  15
ALA C 288
GLY C 285
VAL C   8
VAL C  21
 None
 1.36A 4c5nD-4fk1C:
2.7		 4c5nD-4fk1C:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 4fk1 PUTATIVE THIOREDOXIN
REDUCTASE
(Bacillus
anthracis) 		4 / 8 SER C 277
SER C 276
THR C 272
GLY C 111
 FAD  C 500 (-4.3A)
FAD  C 500 ( 4.1A)
None
FAD  C 500 (-3.5A)
 0.89A 4fo4A-4fk1C:
undetectable		 4fo4A-4fk1C:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 4fk1 PUTATIVE THIOREDOXIN
REDUCTASE
(Bacillus
anthracis) 		5 / 12 GLY C  15
GLY C  12
LEU C 278
ILE C   9
ALA C 267
 None
FAD  C 500 (-3.2A)
FAD  C 500 (-3.7A)
None
None
 0.99A 4qtuB-4fk1C:
3.1		 4qtuB-4fk1C:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G08_A_Z80A1187_1
(FREQUENIN 2)		 4fk1 PUTATIVE THIOREDOXIN
REDUCTASE
(Bacillus
anthracis) 		4 / 6 ILE C 227
TYR C 126
PHE C 131
PHE C 231
 None
FAD  C 500 (-4.3A)
None
None
 1.31A 5g08A-4fk1C:
undetectable		 5g08A-4fk1C:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_1
(METHYLTRANSFERASE)		 4fk1 PUTATIVE THIOREDOXIN
REDUCTASE
(Bacillus
anthracis) 		4 / 7 GLY C 111
PHE C 231
GLU C 269
ASN C  37
 FAD  C 500 (-3.5A)
None
FAD  C 500 (-3.2A)
FAD  C 500 (-4.6A)
 1.10A 5n5dB-4fk1C:
3.6		 5n5dB-4fk1C:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA816_0
(UNCHARACTERIZED
PROTEIN)		 4fk1 PUTATIVE THIOREDOXIN
REDUCTASE
(Bacillus
anthracis) 		3 / 3 ARG C 105
ARG C 258
ASP C 295
 None
 0.79A 6d8pA-4fk1C:
undetectable		 6d8pA-4fk1C:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_D_AQ4D602_0
(CYTOCHROME P450 1A1)		 4fk1 PUTATIVE THIOREDOXIN
REDUCTASE
(Bacillus
anthracis) 		5 / 12 ILE C 227
PHE C 131
GLY C 224
ILE C 199
LEU C 202
 None
 0.99A 6dwnD-4fk1C:
undetectable		 6dwnD-4fk1C:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_H_BO2H301_0
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4fk1 PUTATIVE THIOREDOXIN
REDUCTASE
(Bacillus
anthracis) 		5 / 12 GLN C 284
ALA C 288
ALA C  11
GLY C  12
ALA C 109
 None
None
None
FAD  C 500 (-3.2A)
None
 1.06A 6hwdH-4fk1C:
undetectable
6hwdI-4fk1C:
undetectable		 6hwdH-4fk1C:
12.59
6hwdI-4fk1C:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_V_BO2V301_0
(PROTEASOME SUBUNIT
BETA TYPE-2)		 4fk1 PUTATIVE THIOREDOXIN
REDUCTASE
(Bacillus
anthracis) 		5 / 11 GLN C 284
ALA C 288
ALA C  11
GLY C  12
ALA C 109
 None
None
None
FAD  C 500 (-3.2A)
None
 1.05A 6hwdV-4fk1C:
undetectable		 6hwdV-4fk1C:
12.59