SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fk8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_A_TESA325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 4fk8 FERREDOXIN--NADP
REDUCTASE
(Burkholderia
thailandensis) 		4 / 7 LEU A 181
TYR A 147
ASN A  49
TYR A  75
 None
 1.25A 1afsA-4fk8A:
undetectable		 1afsA-4fk8A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_B_TESB325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 4fk8 FERREDOXIN--NADP
REDUCTASE
(Burkholderia
thailandensis) 		4 / 7 LEU A 181
TYR A 147
ASN A  49
TYR A  75
 None
 1.26A 1afsB-4fk8A:
undetectable		 1afsB-4fk8A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4fk8 FERREDOXIN--NADP
REDUCTASE
(Burkholderia
thailandensis) 		4 / 8 TYR A 167
TYR A 170
SER A  72
ARG A 142
 None
 1.18A 2vmyA-4fk8A:
undetectable
2vmyB-4fk8A:
undetectable		 2vmyA-4fk8A:
21.95
2vmyB-4fk8A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 4fk8 FERREDOXIN--NADP
REDUCTASE
(Burkholderia
thailandensis) 		5 / 12 PHE A  82
LEU A  34
GLU A 164
ALA A 268
SER A 129
 None
 1.34A 3apvA-4fk8A:
undetectable		 3apvA-4fk8A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_B_DP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 4fk8 FERREDOXIN--NADP
REDUCTASE
(Burkholderia
thailandensis) 		5 / 12 PHE A  82
LEU A  34
GLU A 164
ALA A 268
SER A 129
 None
 1.42A 3apwB-4fk8A:
undetectable		 3apwB-4fk8A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 4fk8 FERREDOXIN--NADP
REDUCTASE
(Burkholderia
thailandensis) 		5 / 11 GLY A 204
ILE A 210
THR A 156
LEU A 128
THR A 243
 None
 1.10A 3bexC-4fk8A:
3.3
3bexD-4fk8A:
3.4		 3bexC-4fk8A:
22.45
3bexD-4fk8A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 4fk8 FERREDOXIN--NADP
REDUCTASE
(Burkholderia
thailandensis) 		5 / 11 THR A 156
LEU A 128
THR A 243
GLY A 204
ILE A 210
 None
 1.09A 3bexE-4fk8A:
3.6
3bexF-4fk8A:
2.9		 3bexE-4fk8A:
22.45
3bexF-4fk8A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_A_PAUA248_0
(TYPE III
PANTOTHENATE KINASE)		 4fk8 FERREDOXIN--NADP
REDUCTASE
(Burkholderia
thailandensis) 		5 / 11 GLY A 204
ILE A 210
THR A 156
LEU A 128
THR A 243
 None
 1.14A 3bf1A-4fk8A:
undetectable
3bf1B-4fk8A:
3.5		 3bf1A-4fk8A:
22.45
3bf1B-4fk8A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_B_PAUB248_0
(TYPE III
PANTOTHENATE KINASE)		 4fk8 FERREDOXIN--NADP
REDUCTASE
(Burkholderia
thailandensis) 		5 / 12 THR A 156
LEU A 128
THR A 243
GLY A 204
ILE A 210
 None
 1.11A 3bf1A-4fk8A:
3.4
3bf1B-4fk8A:
3.4		 3bf1A-4fk8A:
22.45
3bf1B-4fk8A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 4fk8 FERREDOXIN--NADP
REDUCTASE
(Burkholderia
thailandensis) 		5 / 11 GLY A 204
ILE A 210
THR A 156
LEU A 128
THR A 243
 None
 1.09A 3bf1E-4fk8A:
3.5
3bf1F-4fk8A:
3.7		 3bf1E-4fk8A:
22.45
3bf1F-4fk8A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 4fk8 FERREDOXIN--NADP
REDUCTASE
(Burkholderia
thailandensis) 		5 / 11 THR A 156
LEU A 128
THR A 243
GLY A 204
ILE A 210
 None
 1.10A 3bf1E-4fk8A:
3.5
3bf1F-4fk8A:
3.7		 3bf1E-4fk8A:
22.45
3bf1F-4fk8A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_C_C2FC1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 4fk8 FERREDOXIN--NADP
REDUCTASE
(Burkholderia
thailandensis) 		3 / 3 ARG A  46
PRO A  73
PHE A  47
 None
 0.91A 3thrC-4fk8A:
undetectable		 3thrC-4fk8A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4fk8 FERREDOXIN--NADP
REDUCTASE
(Burkholderia
thailandensis) 		4 / 5 GLU A  80
PHE A  82
TYR A 170
HIS A 173
 None
 1.47A 4a97J-4fk8A:
undetectable		 4a97J-4fk8A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 4fk8 FERREDOXIN--NADP
REDUCTASE
(Burkholderia
thailandensis) 		5 / 12 GLY A 131
GLY A 133
PHE A 137
LEU A 233
GLY A 235
 None
 0.85A 4o33A-4fk8A:
undetectable		 4o33A-4fk8A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 4fk8 FERREDOXIN--NADP
REDUCTASE
(Burkholderia
thailandensis) 		5 / 12 GLY A 131
GLY A 133
PHE A 137
LEU A 233
GLY A 235
 None
 0.88A 4o3fA-4fk8A:
2.1		 4o3fA-4fk8A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 4fk8 FERREDOXIN--NADP
REDUCTASE
(Burkholderia
thailandensis) 		6 / 9 SER A  69
THR A 132
GLY A 133
ALA A 135
CYH A 234
GLU A 266
 FAD  A 301 (-3.8A)
FAD  A 301 (-3.0A)
None
FAD  A 301 (-3.4A)
None
FAD  A 301 ( 3.9A)
 0.64A 5vw4A-4fk8A:
17.9		 5vw4A-4fk8A:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 4fk8 FERREDOXIN--NADP
REDUCTASE
(Burkholderia
thailandensis) 		6 / 9 THR A 132
GLY A 133
ALA A 135
CYH A 234
GLY A 235
GLU A 266
 FAD  A 301 (-3.0A)
None
FAD  A 301 (-3.4A)
None
None
FAD  A 301 ( 3.9A)
 0.82A 5vw4A-4fk8A:
17.9		 5vw4A-4fk8A:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW5_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 4fk8 FERREDOXIN--NADP
REDUCTASE
(Burkholderia
thailandensis) 		5 / 8 SER A  69
THR A 132
GLY A 133
CYH A 234
GLU A 266
 FAD  A 301 (-3.8A)
FAD  A 301 (-3.0A)
None
None
FAD  A 301 ( 3.9A)
 0.64A 5vw5A-4fk8A:
18.1		 5vw5A-4fk8A:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4fk8 FERREDOXIN--NADP
REDUCTASE
(Burkholderia
thailandensis) 		4 / 8 TRP A  30
ARG A 142
ASP A 174
GLU A  76
 None
 1.19A 6mn4D-4fk8A:
undetectable		 6mn4D-4fk8A:
23.00