SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fk9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JQD_A_HSMA600_1
(HISTAMINE
N-METHYLTRANSFERASE)		 4fk9 CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		4 / 7 GLU A 273
VAL A 102
TRP A  80
ASN A 177
 None
 1.32A 1jqdA-4fk9A:
undetectable		 1jqdA-4fk9A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_1
(N,N-DIMETHYLGLYCINE
OXIDASE)		 4fk9 CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		3 / 3 ASP A 137
THR A 139
GLU A 273
 None
 0.86A 1pj7A-4fk9A:
undetectable		 1pj7A-4fk9A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_A_NBVA1503_1
(GLUCOSYLCERAMIDASE)		 4fk9 CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		6 / 12 ASN A 177
GLU A 178
HIS A 244
TYR A 246
GLU A 273
ASN A 308
 None
 1.14A 2v3dA-4fk9A:
15.4		 2v3dA-4fk9A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_A_NBVA1503_1
(GLUCOSYLCERAMIDASE)		 4fk9 CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		6 / 12 ASN A 177
GLU A 178
HIS A 244
TYR A 246
GLU A 273
TRP A 303
 None
 0.65A 2v3dA-4fk9A:
15.4		 2v3dA-4fk9A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_B_NBVB1504_1
(GLUCOSYLCERAMIDASE)		 4fk9 CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		5 / 11 ASN A 177
GLU A 178
TYR A 246
GLU A 273
TRP A 303
 None
 0.72A 2v3dB-4fk9A:
2.7		 2v3dB-4fk9A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CAS_A_ASDA332_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 4fk9 CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		5 / 10 TYR A 156
ASN A 174
VAL A 172
VAL A 171
LEU A 164
 None
 1.13A 3casA-4fk9A:
9.2		 3casA-4fk9A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_B_DX2B271_1
(PTERIDINE REDUCTASE
1)		 4fk9 CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		4 / 8 PHE A 262
ASP A 218
TYR A 258
LEU A 239
 None
 1.20A 3jq7B-4fk9A:
undetectable		 3jq7B-4fk9A:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_C_SAMC226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4fk9 CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		5 / 12 LEU A 129
ASP A  90
GLY A 328
ALA A  96
GLY A  95
 None
 0.95A 3ku1C-4fk9A:
undetectable		 3ku1C-4fk9A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_A_AICA375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 4fk9 CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		5 / 11 GLY A 176
GLU A 134
LEU A 103
ASN A 112
LEU A 133
 None
 1.32A 3ndvA-4fk9A:
undetectable
3ndvB-4fk9A:
undetectable		 3ndvA-4fk9A:
24.69
3ndvB-4fk9A:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_B_AICB376_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 4fk9 CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		5 / 11 LEU A 133
GLY A 176
GLU A 134
LEU A 103
ASN A 112
 None
 1.29A 3ndvA-4fk9A:
undetectable
3ndvB-4fk9A:
undetectable		 3ndvA-4fk9A:
24.69
3ndvB-4fk9A:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_C_AICC375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 4fk9 CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		5 / 11 GLY A 176
GLU A 134
LEU A 103
ASN A 112
LEU A 133
 None
 1.31A 3ndvC-4fk9A:
undetectable
3ndvD-4fk9A:
undetectable		 3ndvC-4fk9A:
24.69
3ndvD-4fk9A:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_D_AICD374_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 4fk9 CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		5 / 11 LEU A 133
GLY A 176
GLU A 134
LEU A 103
ASN A 112
 None
 1.32A 3ndvC-4fk9A:
undetectable
3ndvD-4fk9A:
undetectable		 3ndvC-4fk9A:
24.69
3ndvD-4fk9A:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC1_1
(CYTOCHROME P450 2D6)		 4fk9 CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		5 / 12 PHE A 348
GLY A  64
LEU A  54
GLU A  63
PHE A  69
 None
 1.28A 3tbgC-4fk9A:
undetectable		 3tbgC-4fk9A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_1
(MNMC2)		 4fk9 CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		4 / 5 GLU A 178
ASP A 218
ASN A 182
GLU A 143
 None
 1.39A 3vywD-4fk9A:
undetectable		 3vywD-4fk9A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4fk9 CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		4 / 5 TYR A  81
LEU A 317
ASP A 310
VAL A 331
 None
 1.33A 4nkvA-4fk9A:
undetectable		 4nkvA-4fk9A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_B_ASCB303_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 4fk9 CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		4 / 6 TYR A 258
ARG A 224
ALA A 225
MET A 223
 None
 1.45A 4o7gB-4fk9A:
undetectable		 4o7gB-4fk9A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4fk9 CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		4 / 7 PHE A 262
ASP A 218
ILE A 243
TYR A 249
 None
 1.34A 5a06B-4fk9A:
undetectable		 5a06B-4fk9A:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 4fk9 CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		4 / 6 PHE A 348
GLU A  63
PHE A  69
VAL A 172
 None
 1.33A 5h4dA-4fk9A:
undetectable		 5h4dA-4fk9A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		 4fk9 CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		5 / 12 PRO A 114
VAL A 117
ILE A 121
ALA A 122
LYS A 125
 None
 0.50A 5j2tC-4fk9A:
undetectable		 5j2tC-4fk9A:
21.71