SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fkm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 4fkm SIMILAR TO FERRIC
HYDROXAMATE RECEPTOR
1
(Staphylococcus
aureus) 		5 / 12 ALA A 264
THR A 256
PRO A 251
LEU A 190
ILE A 233
 MLY  A 263 ( 3.6A)
None
None
MLY  A 189 ( 4.5A)
MLY  A 229 ( 4.7A)
 1.04A 1cd2A-4fkmA:
undetectable		 1cd2A-4fkmA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1873_0
(FPRA)		 4fkm SIMILAR TO FERRIC
HYDROXAMATE RECEPTOR
1
(Staphylococcus
aureus) 		3 / 3 ASP A  95
ASP A 115
LYS A  99
 MLY  A  98 ( 3.7A)
MLY  A 114 ( 4.1A)
MLY  A  98 ( 2.8A)
 0.87A 1lqtB-4fkmA:
undetectable		 1lqtB-4fkmA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1430_0
(FPRA)		 4fkm SIMILAR TO FERRIC
HYDROXAMATE RECEPTOR
1
(Staphylococcus
aureus) 		3 / 3 ASP A  95
ASP A 115
LYS A  99
 MLY  A  98 ( 3.7A)
MLY  A 114 ( 4.1A)
MLY  A  98 ( 2.8A)
 0.86A 1lquB-4fkmA:
undetectable		 1lquB-4fkmA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 4fkm SIMILAR TO FERRIC
HYDROXAMATE RECEPTOR
1
(Staphylococcus
aureus) 		5 / 12 ALA A 264
THR A 256
PRO A 251
LEU A 190
ILE A 233
 MLY  A 263 ( 3.6A)
None
None
MLY  A 189 ( 4.5A)
MLY  A 229 ( 4.7A)
 1.03A 2cd2A-4fkmA:
undetectable		 2cd2A-4fkmA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J5M_A_ACTA1321_0
(CHLOROPEROXIDASE)		 4fkm SIMILAR TO FERRIC
HYDROXAMATE RECEPTOR
1
(Staphylococcus
aureus) 		4 / 6 LEU A  81
ILE A  68
VAL A  71
ALA A  58
 MLY  A  82 ( 4.3A)
None
MLY  A  90 ( 4.8A)
None
 1.02A 2j5mA-4fkmA:
undetectable		 2j5mA-4fkmA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4fkm SIMILAR TO FERRIC
HYDROXAMATE RECEPTOR
1
(Staphylococcus
aureus) 		3 / 3 ASP A 282
TYR A 284
LYS A  83
 None
MLY  A  84 ( 3.9A)
MLY  A  84 ( 1.3A)
 1.19A 2othA-4fkmA:
undetectable		 2othA-4fkmA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_B_CGEB501_1
(CYTOCHROME P450 2B4)		 4fkm SIMILAR TO FERRIC
HYDROXAMATE RECEPTOR
1
(Staphylococcus
aureus) 		4 / 8 PHE A 208
PHE A 288
VAL A 271
VAL A 273
 None
None
MLY  A 272 ( 3.1A)
MLY  A 272 ( 2.8A)
 0.90A 3me6B-4fkmA:
undetectable		 3me6B-4fkmA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_C_ECNC403_1
(FLAVOHEMOGLOBIN)		 4fkm SIMILAR TO FERRIC
HYDROXAMATE RECEPTOR
1
(Staphylococcus
aureus) 		5 / 9 PHE A 208
LEU A 297
VAL A 271
VAL A 203
LEU A 204
 None
MLY  A 296 ( 4.3A)
MLY  A 272 ( 3.1A)
None
None
 1.10A 4g1bC-4fkmA:
3.8		 4g1bC-4fkmA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XNX_A_41XA707_1
(TRANSPORTER)		 4fkm SIMILAR TO FERRIC
HYDROXAMATE RECEPTOR
1
(Staphylococcus
aureus) 		5 / 11 ALA A 275
VAL A 273
ASP A 274
GLY A 198
GLY A 276
 MLY  A 248 ( 3.9A)
MLY  A 272 ( 2.8A)
MLY  A  79 ( 3.8A)
None
None
 1.19A 4xnxA-4fkmA:
undetectable		 4xnxA-4fkmA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_A_ACRA801_2
(GLUCOAMYLASE P)		 4fkm SIMILAR TO FERRIC
HYDROXAMATE RECEPTOR
1
(Staphylococcus
aureus) 		3 / 3 TRP A 155
GLU A 160
GLU A 140
 MLY  A 156 ( 4.2A)
MLY  A 156 ( 3.8A)
MLY  A 156 ( 3.5A)
 0.93A 6fhwA-4fkmA:
undetectable		 6fhwA-4fkmA:
15.00