SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fkz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_E_ADNE1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4fkz UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Bacillus
subtilis) 		5 / 11 THR A 152
GLY A 122
GLU A 120
GLU A 289
ASN A 158
 None
 1.33A 1odiE-4fkzA:
undetectable		 1odiE-4fkzA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1301_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 4fkz UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Bacillus
subtilis) 		4 / 6 LEU A 107
PHE A 110
ALA A 109
LEU A  78
 None
 0.89A 1ukbA-4fkzA:
7.3		 1ukbA-4fkzA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOS_A_VIAA1_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 4fkz UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Bacillus
subtilis) 		5 / 12 TYR A 237
ASP A 283
LEU A 301
PHE A 253
ILE A 326
 None
 1.50A 1xosA-4fkzA:
undetectable		 1xosA-4fkzA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_A_PXLA1003_1
(PYRIDOXINE KINASE)		 4fkz UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Bacillus
subtilis) 		4 / 8 VAL A  23
VAL A  36
LEU A  24
ASP A  58
 None
 0.93A 2ddwA-4fkzA:
5.8		 2ddwA-4fkzA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_B_ACTB653_0
(ACETYL-COENZYME A
SYNTHETASE)		 4fkz UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Bacillus
subtilis) 		4 / 4 VAL A 300
THR A 282
VAL A 287
GLY A 286
 None
None
UDP  A 402 ( 4.9A)
UDP  A 402 (-3.5A)
 1.16A 2p2fB-4fkzA:
4.7		 2p2fB-4fkzA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_A_ACTA1397_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 4fkz UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Bacillus
subtilis) 		3 / 3 PRO A 292
GLY A 310
TYR A 350
 None
 0.72A 2vouA-4fkzA:
3.5		 2vouA-4fkzA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_B_ACTB1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 4fkz UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Bacillus
subtilis) 		3 / 3 PRO A 292
GLY A 310
TYR A 350
 None
 0.63A 2vouB-4fkzA:
3.6		 2vouB-4fkzA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_C_ACTC1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 4fkz UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Bacillus
subtilis) 		3 / 3 PRO A 292
GLY A 310
TYR A 350
 None
 0.63A 2vouC-4fkzA:
3.6		 2vouC-4fkzA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4fkz UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Bacillus
subtilis) 		5 / 12 ASN A 211
THR A 282
VAL A 300
LEU A 318
SER A 130
 None
 1.46A 2xrlA-4fkzA:
undetectable		 2xrlA-4fkzA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)		 4fkz UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Bacillus
subtilis) 		4 / 7 GLU A 134
ARG A 138
GLU A 210
SER A 130
 UD1  A 401 (-3.6A)
None
None
None
 1.28A 2zt7A-4fkzA:
2.1		 2zt7A-4fkzA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_D_VDYD6178_1
(VITAMIN D
HYDROXYLASE)		 4fkz UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Bacillus
subtilis) 		5 / 12 ASN A 158
THR A 282
VAL A 298
PRO A 292
LEU A 316
 None
 1.17A 3a51D-4fkzA:
undetectable		 3a51D-4fkzA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_B_TP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 4fkz UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Bacillus
subtilis) 		5 / 12 PHE A 253
VAL A 259
PHE A 279
LEU A 334
ALA A 222
 None
 1.33A 3apvB-4fkzA:
undetectable		 3apvB-4fkzA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4fkz UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Bacillus
subtilis) 		3 / 3 ASP A  47
LEU A  46
GLN A  68
 None
None
UD1  A 401 (-3.9A)
 0.76A 3g4lA-4fkzA:
undetectable		 3g4lA-4fkzA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4fkz UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Bacillus
subtilis) 		5 / 12 ALA A 222
LEU A 281
LEU A 299
ILE A 326
MET A 343
 None
 1.13A 3uvvA-4fkzA:
undetectable		 3uvvA-4fkzA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4fkz UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Bacillus
subtilis) 		5 / 12 SER A  34
VAL A  36
ILE A  55
PHE A  10
HIS A  96
 None
 1.42A 4c49B-4fkzA:
undetectable		 4c49B-4fkzA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		 4fkz UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Bacillus
subtilis) 		4 / 5 LEU A  50
ILE A  17
ALA A  52
PHE A  53
 None
UDP  A 402 (-3.7A)
None
None
 1.04A 4dc3B-4fkzA:
9.3		 4dc3B-4fkzA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIM_A_CELA711_1
(LACTOTRANSFERRIN)		 4fkz UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Bacillus
subtilis) 		5 / 9 GLY A 153
VAL A 171
PRO A 151
PRO A 292
GLY A 351
 None
 1.36A 4fimA-4fkzA:
undetectable		 4fimA-4fkzA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIM_A_CELA711_1
(LACTOTRANSFERRIN)		 4fkz UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Bacillus
subtilis) 		5 / 9 GLY A 153
VAL A 171
PRO A 292
TYR A 350
GLY A 351
 None
 1.16A 4fimA-4fkzA:
undetectable		 4fimA-4fkzA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4fkz UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Bacillus
subtilis) 		3 / 3 SER A 344
TYR A 340
PRO A 292
 None
 0.97A 4lbgA-4fkzA:
8.1		 4lbgA-4fkzA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_A_STRA601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4fkz UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Bacillus
subtilis) 		4 / 6 ALA A 274
ILE A 177
SER A 284
ILE A 280
 None
None
UDP  A 402 (-2.7A)
None
 0.77A 4r21A-4fkzA:
undetectable		 4r21A-4fkzA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WAN_C_ACTC303_0
(BRANCHPOINT-BRIDGING
PROTEIN)		 4fkz UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Bacillus
subtilis) 		3 / 3 ASP A  98
ARG A 302
PRO A 131
 UD1  A 401 ( 4.9A)
None
None
 1.06A 4wanC-4fkzA:
undetectable		 4wanC-4fkzA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X61_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 4fkz UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Bacillus
subtilis) 		5 / 12 LEU A  22
GLY A 173
GLY A 351
PRO A 349
GLU A 289
 None
 1.12A 4x61A-4fkzA:
3.8		 4x61A-4fkzA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB3_A_UEGA202_1
(YFIR)		 4fkz UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Bacillus
subtilis) 		4 / 4 LEU A 265
ILE A 262
PRO A 191
LEU A 193
 UDP  A 402 (-4.5A)
None
None
None
 0.97A 5eb3A-4fkzA:
3.6		 5eb3A-4fkzA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4fkz UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Bacillus
subtilis) 		4 / 5 THR A 205
ALA A 206
THR A 282
HIS A 207
 UDP  A 402 ( 4.8A)
None
None
UD1  A 401 ( 4.0A)
 1.27A 5ecmA-4fkzA:
1.9		 5ecmA-4fkzA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWZ_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4fkz UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Bacillus
subtilis) 		3 / 3 MET A 140
GLN A 139
ARG A 138
 None
 1.05A 5ewzB-4fkzA:
2.2		 5ewzB-4fkzA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 4fkz UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Bacillus
subtilis) 		3 / 3 ALA A 155
ASN A 158
LEU A 159
 None
 0.36A 5i1nB-4fkzA:
undetectable		 5i1nB-4fkzA:
6.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 4fkz UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Bacillus
subtilis) 		5 / 11 THR A 205
ALA A 206
VAL A 298
GLY A 286
GLY A 285
 UDP  A 402 ( 4.8A)
None
None
UDP  A 402 (-3.5A)
UDP  A 402 (-3.6A)
 0.79A 5lf7K-4fkzA:
undetectable
5lf7L-4fkzA:
undetectable		 5lf7K-4fkzA:
19.79
5lf7L-4fkzA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_Y_6V8Y306_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 4fkz UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Bacillus
subtilis) 		5 / 11 THR A 205
ALA A 206
VAL A 298
GLY A 286
GLY A 285
 UDP  A 402 ( 4.8A)
None
None
UDP  A 402 (-3.5A)
UDP  A 402 (-3.6A)
 0.79A 5lf7Y-4fkzA:
undetectable
5lf7Z-4fkzA:
undetectable		 5lf7Y-4fkzA:
19.79
5lf7Z-4fkzA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M35_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4fkz UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Bacillus
subtilis) 		3 / 3 MET A 140
GLN A 139
ARG A 138
 None
 1.04A 5m35B-4fkzA:
undetectable		 5m35B-4fkzA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M36_A_BEZA303_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4fkz UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Bacillus
subtilis) 		3 / 3 MET A 140
GLN A 139
ARG A 138
 None
 1.07A 5m36A-4fkzA:
undetectable		 5m36A-4fkzA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M78_A_SALA304_1
(CARBONIC ANHYDRASE 2)		 4fkz UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Bacillus
subtilis) 		4 / 7 VAL A  93
PHE A  85
THR A 102
THR A 101
 None
 0.86A 5m78A-4fkzA:
undetectable		 5m78A-4fkzA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FN9_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4fkz UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Bacillus
subtilis) 		3 / 3 MET A 140
GLN A 139
ARG A 138
 None
 1.06A 6fn9A-4fkzA:
undetectable		 6fn9A-4fkzA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNA_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4fkz UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Bacillus
subtilis) 		3 / 3 MET A 140
GLN A 139
ARG A 138
 None
 1.07A 6fnaB-4fkzA:
undetectable		 6fnaB-4fkzA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNB_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4fkz UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Bacillus
subtilis) 		3 / 3 MET A 140
GLN A 139
ARG A 138
 None
 1.06A 6fnbA-4fkzA:
undetectable		 6fnbA-4fkzA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_N_PCFN606_0
(CYTOCHROME B)		 4fkz UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Bacillus
subtilis) 		5 / 12 PHE A 220
MET A 219
ALA A 222
TYR A 327
VAL A 259
 None
 1.32A 6hu9N-4fkzA:
undetectable		 6hu9N-4fkzA:
22.55