SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fl0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCN_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
PEPTIDE
N-ACETYL-D-HIS-L-PRO
-NH2)		 4fl0 AMINOTRANSFERASE
ALD1
(Arabidopsis
thaliana) 		3 / 3 PHE A 409
TYR A 378
PRO A 224
 None
 1.01A 1mcnA-4fl0A:
undetectable
1mcnB-4fl0A:
undetectable
1mcnP-4fl0A:
undetectable		 1mcnA-4fl0A:
20.35
1mcnB-4fl0A:
20.35
1mcnP-4fl0A:
2.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4fl0 AMINOTRANSFERASE
ALD1
(Arabidopsis
thaliana) 		5 / 9 LEU A 152
LEU A 149
ILE A 249
LEU A 302
ILE A 310
 None
 1.19A 2f78A-4fl0A:
undetectable		 2f78A-4fl0A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4fl0 AMINOTRANSFERASE
ALD1
(Arabidopsis
thaliana) 		5 / 9 LEU A 152
LEU A 149
ILE A 249
LEU A 302
ILE A 310
 None
 1.18A 2f78B-4fl0A:
undetectable		 2f78B-4fl0A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4fl0 AMINOTRANSFERASE
ALD1
(Arabidopsis
thaliana) 		5 / 9 LEU A 152
LEU A 149
ILE A 249
LEU A 302
ILE A 310
 None
 1.17A 2f7aB-4fl0A:
undetectable		 2f7aB-4fl0A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_B_SAMB500_0
(HYPOTHETICAL PROTEIN)		 4fl0 AMINOTRANSFERASE
ALD1
(Arabidopsis
thaliana) 		4 / 6 ASP A 171
VAL A 174
PRO A 167
THR A 165
 None
 1.29A 2q6oB-4fl0A:
undetectable		 2q6oB-4fl0A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		 4fl0 AMINOTRANSFERASE
ALD1
(Arabidopsis
thaliana) 		4 / 5 VAL A 192
TYR A 189
VAL A 174
ASP A 171
 None
 1.08A 2x45A-4fl0A:
undetectable		 2x45A-4fl0A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		 4fl0 AMINOTRANSFERASE
ALD1
(Arabidopsis
thaliana) 		4 / 5 VAL A 192
TYR A 189
VAL A 174
ASP A 171
 None
 1.07A 2x45C-4fl0A:
undetectable		 2x45C-4fl0A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4fl0 AMINOTRANSFERASE
ALD1
(Arabidopsis
thaliana) 		4 / 8 TYR A 378
SER A 220
CYH A 219
GLN A 162
 None
None
PLP  A 501 (-3.6A)
None
 0.96A 2xz5B-4fl0A:
undetectable
2xz5E-4fl0A:
undetectable		 2xz5B-4fl0A:
18.98
2xz5E-4fl0A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4fl0 AMINOTRANSFERASE
ALD1
(Arabidopsis
thaliana) 		4 / 8 GLN A 162
TYR A 378
SER A 220
CYH A 219
 None
None
None
PLP  A 501 (-3.6A)
 0.91A 2xz5C-4fl0A:
undetectable
2xz5D-4fl0A:
undetectable		 2xz5C-4fl0A:
18.98
2xz5D-4fl0A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_2
(DIHYDROFOLATE
REDUCTASE)		 4fl0 AMINOTRANSFERASE
ALD1
(Arabidopsis
thaliana) 		4 / 4 ILE A  84
PHE A 288
ILE A  88
THR A  80
 None
 0.90A 3ia4A-4fl0A:
undetectable		 3ia4A-4fl0A:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG801_0
(GLUTAMATE RECEPTOR 2)		 4fl0 AMINOTRANSFERASE
ALD1
(Arabidopsis
thaliana) 		3 / 3 PRO A 377
SER A 420
ASN A 223
 None
None
PLP  A 501 (-3.9A)
 0.67A 3lslG-4fl0A:
undetectable		 3lslG-4fl0A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFG_B_LEUB289_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 4fl0 AMINOTRANSFERASE
ALD1
(Arabidopsis
thaliana) 		3 / 3 PHE A 217
SER A 172
SER A 173
 None
 0.91A 3ufgB-4fl0A:
undetectable		 3ufgB-4fl0A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BVA_A_T3A1314_1
(THIOMORPHOLINE-CARBO
XYLATE DEHYDROGENASE)		 4fl0 AMINOTRANSFERASE
ALD1
(Arabidopsis
thaliana) 		5 / 12 ARG A 292
VAL A 291
GLY A 290
PHE A 282
SER A 139
 PLP  A 501 (-3.1A)
None
None
None
None
 1.44A 4bvaA-4fl0A:
undetectable		 4bvaA-4fl0A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_A_ADNA401_1
(APH(2'')-ID)		 4fl0 AMINOTRANSFERASE
ALD1
(Arabidopsis
thaliana) 		5 / 10 ILE A 345
PRO A  85
ILE A  84
HIS A  91
ILE A  88
 None
 1.16A 4dtaA-4fl0A:
undetectable		 4dtaA-4fl0A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)		 4fl0 AMINOTRANSFERASE
ALD1
(Arabidopsis
thaliana) 		5 / 12 PRO A 405
GLY A 406
GLY A 408
LEU A  75
GLY A 421
 None
 1.04A 4fp9A-4fl0A:
2.8		 4fp9A-4fl0A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)		 4fl0 AMINOTRANSFERASE
ALD1
(Arabidopsis
thaliana) 		5 / 12 PRO A 405
GLY A 406
GLY A 408
LEU A  75
GLY A 421
 None
 1.04A 4fp9C-4fl0A:
2.7		 4fp9C-4fl0A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)		 4fl0 AMINOTRANSFERASE
ALD1
(Arabidopsis
thaliana) 		5 / 12 PRO A 405
GLY A 406
GLY A 408
LEU A  75
GLY A 421
 None
 1.04A 4fp9D-4fl0A:
2.9		 4fp9D-4fl0A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)		 4fl0 AMINOTRANSFERASE
ALD1
(Arabidopsis
thaliana) 		5 / 12 PRO A 405
GLY A 406
GLY A 408
LEU A  75
GLY A 421
 None
 1.04A 4fp9F-4fl0A:
2.8		 4fp9F-4fl0A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 4fl0 AMINOTRANSFERASE
ALD1
(Arabidopsis
thaliana) 		5 / 12 PRO A 405
GLY A 406
GLY A 408
LEU A  75
GLY A 421
 None
 1.08A 4fzvA-4fl0A:
2.9		 4fzvA-4fl0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI506_0
(RNA POLYMERASE
3D-POL)		 4fl0 AMINOTRANSFERASE
ALD1
(Arabidopsis
thaliana) 		3 / 3 ARG A 356
LYS A 357
LYS A 353
 None
 1.32A 4k50I-4fl0A:
undetectable		 4k50I-4fl0A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_2
(SUGAR KINASE)		 4fl0 AMINOTRANSFERASE
ALD1
(Arabidopsis
thaliana) 		3 / 3 SER A 265
TYR A 126
PRO A 221
 None
 0.83A 4k8cA-4fl0A:
2.9		 4k8cA-4fl0A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4fl0 AMINOTRANSFERASE
ALD1
(Arabidopsis
thaliana) 		3 / 3 SER A 265
TYR A 126
PRO A 221
 None
 0.82A 4kahA-4fl0A:
undetectable		 4kahA-4fl0A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4fl0 AMINOTRANSFERASE
ALD1
(Arabidopsis
thaliana) 		3 / 3 SER A 265
TYR A 126
PRO A 221
 None
 0.83A 4kahB-4fl0A:
undetectable		 4kahB-4fl0A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4fl0 AMINOTRANSFERASE
ALD1
(Arabidopsis
thaliana) 		3 / 3 SER A 265
TYR A 126
PRO A 221
 None
 0.84A 4kanA-4fl0A:
undetectable		 4kanA-4fl0A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4fl0 AMINOTRANSFERASE
ALD1
(Arabidopsis
thaliana) 		3 / 3 SER A 265
TYR A 126
PRO A 221
 None
 0.84A 4kanB-4fl0A:
undetectable		 4kanB-4fl0A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4fl0 AMINOTRANSFERASE
ALD1
(Arabidopsis
thaliana) 		3 / 3 SER A 265
TYR A 126
PRO A 221
 None
 0.84A 4kbeA-4fl0A:
2.8		 4kbeA-4fl0A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4fl0 AMINOTRANSFERASE
ALD1
(Arabidopsis
thaliana) 		3 / 3 SER A 265
TYR A 126
PRO A 221
 None
 0.87A 4kbeB-4fl0A:
2.8		 4kbeB-4fl0A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4fl0 AMINOTRANSFERASE
ALD1
(Arabidopsis
thaliana) 		3 / 3 SER A 265
TYR A 126
PRO A 221
 None
 0.79A 4lbgA-4fl0A:
2.8		 4lbgA-4fl0A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4fl0 AMINOTRANSFERASE
ALD1
(Arabidopsis
thaliana) 		3 / 3 SER A 265
TYR A 126
PRO A 221
 None
 0.81A 4lbgB-4fl0A:
undetectable		 4lbgB-4fl0A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MS4_A_2C0A501_1
(GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1)		 4fl0 AMINOTRANSFERASE
ALD1
(Arabidopsis
thaliana) 		4 / 8 SER A 252
SER A 280
TYR A 126
ILE A 121
 None
 1.34A 4ms4A-4fl0A:
3.0		 4ms4A-4fl0A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN)		 4fl0 AMINOTRANSFERASE
ALD1
(Arabidopsis
thaliana) 		5 / 12 ALA A 253
SER A 280
GLY A 294
ILE A  88
GLY A 287
 PLP  A 501 (-3.5A)
None
None
None
None
 0.82A 4r29D-4fl0A:
undetectable		 4r29D-4fl0A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4fl0 AMINOTRANSFERASE
ALD1
(Arabidopsis
thaliana) 		4 / 7 ILE A 345
LEU A 342
GLY A 340
GLY A 341
 None
 0.87A 5a06B-4fl0A:
undetectable		 5a06B-4fl0A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_2_BEZ2801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4fl0 AMINOTRANSFERASE
ALD1
(Arabidopsis
thaliana) 		4 / 4 LEU A 396
ARG A 434
ILE A 401
ILE A  73
 None
 1.23A 5dzk2-4fl0A:
undetectable
5dzkM-4fl0A:
undetectable
5dzkN-4fl0A:
undetectable		 5dzk2-4fl0A:
1.32
5dzkM-4fl0A:
18.34
5dzkN-4fl0A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_E_FK5E201_1
(FK506-BINDING
PROTEIN 1)		 4fl0 AMINOTRANSFERASE
ALD1
(Arabidopsis
thaliana) 		5 / 11 TYR A 169
ASP A 251
VAL A 215
ILE A 216
ILE A 266
 None
PLP  A 501 (-2.8A)
None
None
None
 1.16A 5hw8E-4fl0A:
undetectable		 5hw8E-4fl0A:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4fl0 AMINOTRANSFERASE
ALD1
(Arabidopsis
thaliana) 		6 / 12 ILE A 121
ALA A 120
GLY A 141
PHE A 282
GLY A 333
LEU A 334
 None
None
PLP  A 501 (-3.4A)
None
None
None
 1.32A 5i73A-4fl0A:
undetectable		 5i73A-4fl0A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 4fl0 AMINOTRANSFERASE
ALD1
(Arabidopsis
thaliana) 		3 / 3 ASP A 251
ASN A 223
PHE A 282
 PLP  A 501 (-2.8A)
PLP  A 501 (-3.9A)
None
 0.90A 5jglB-4fl0A:
2.9		 5jglB-4fl0A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 4fl0 AMINOTRANSFERASE
ALD1
(Arabidopsis
thaliana) 		3 / 3 THR A 179
SER A 173
ASP A 214
 None
 0.82A 5kvaA-4fl0A:
undetectable		 5kvaA-4fl0A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 4fl0 AMINOTRANSFERASE
ALD1
(Arabidopsis
thaliana) 		5 / 10 PRO A 299
LEU A 149
ILE A 247
ILE A 249
ILE A 266
 None
 0.98A 5mvmD-4fl0A:
undetectable
5mvmE-4fl0A:
undetectable		 5mvmD-4fl0A:
13.47
5mvmE-4fl0A:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJY_A_BEZA304_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 4fl0 AMINOTRANSFERASE
ALD1
(Arabidopsis
thaliana) 		3 / 3 MET A 360
GLU A 259
ARG A 356
 None
 1.00A 5tjyA-4fl0A:
3.7		 5tjyA-4fl0A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJZ_A_BEZA302_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 4fl0 AMINOTRANSFERASE
ALD1
(Arabidopsis
thaliana) 		3 / 3 MET A 360
GLU A 259
ARG A 356
 None
 1.05A 5tjzA-4fl0A:
3.8		 5tjzA-4fl0A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V1T_A_SAMA605_0
(RADICAL SAM)		 4fl0 AMINOTRANSFERASE
ALD1
(Arabidopsis
thaliana) 		5 / 12 LEU A 337
THR A 124
VAL A 136
SER A 139
GLU A 278
 None
 1.41A 5v1tA-4fl0A:
undetectable		 5v1tA-4fl0A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4fl0 AMINOTRANSFERASE
ALD1
(Arabidopsis
thaliana) 		4 / 5 GLY A 423
ASN A 355
ARG A 424
ARG A 425
 None
 1.28A 6dwdB-4fl0A:
undetectable
6dwdD-4fl0A:
undetectable		 6dwdB-4fl0A:
24.19
6dwdD-4fl0A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4fl0 AMINOTRANSFERASE
ALD1
(Arabidopsis
thaliana) 		4 / 5 ARG A 424
ARG A 425
GLY A 423
ASN A 355
 None
 1.31A 6dwjB-4fl0A:
undetectable
6dwjD-4fl0A:
undetectable		 6dwjB-4fl0A:
24.19
6dwjD-4fl0A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		 4fl0 AMINOTRANSFERASE
ALD1
(Arabidopsis
thaliana) 		4 / 8 GLY A 287
THR A 289
PHE A 257
TYR A 254
 None
None
None
PLP  A 501 (-4.5A)
 1.06A 6eqpA-4fl0A:
undetectable		 6eqpA-4fl0A:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		 4fl0 AMINOTRANSFERASE
ALD1
(Arabidopsis
thaliana) 		5 / 12 GLY A 332
GLY A 333
LEU A 334
GLY A  98
ASN A 114
 None
 0.98A 6gngB-4fl0A:
undetectable		 6gngB-4fl0A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		 4fl0 AMINOTRANSFERASE
ALD1
(Arabidopsis
thaliana) 		5 / 12 GLY A 332
GLY A 333
LEU A 334
GLY A 104
ASN A 114
 None
 0.93A 6gngB-4fl0A:
undetectable		 6gngB-4fl0A:
20.77