SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fl3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTX_A_CVIA200_0
(HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR IN QACA
5'REGION)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		5 / 12 THR A 135
ILE A 147
TYR A  47
GLU A 155
ALA A 159
 None
 1.29A 1jtxA-4fl3A:
undetectable		 1jtxA-4fl3A:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		7 / 12 LEU A 377
ALA A 400
LYS A 402
LEU A 446
GLY A 454
LEU A 501
ASP A 512
 ANP  A 701 ( 4.6A)
ANP  A 701 (-3.3A)
ANP  A 701 (-2.7A)
None
ANP  A 701 ( 4.2A)
ANP  A 701 (-4.5A)
MG  A 702 ( 3.1A)
 0.87A 1m17A-4fl3A:
29.4		 1m17A-4fl3A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		6 / 9 LEU A 377
GLY A 378
VAL A 385
ALA A 400
ALA A 451
LEU A 501
 ANP  A 701 ( 4.6A)
ANP  A 701 ( 4.0A)
ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 (-4.1A)
ANP  A 701 (-4.5A)
 0.73A 1muoA-4fl3A:
8.9		 1muoA-4fl3A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		4 / 5 GLU A 452
LEU A 502
LEU A 453
LEU A 501
 None
None
None
ANP  A 701 (-4.5A)
 1.12A 1np1A-4fl3A:
undetectable		 1np1A-4fl3A:
14.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		9 / 9 LEU A 377
VAL A 385
ALA A 400
MET A 448
MET A 450
ALA A 451
GLY A 454
PRO A 455
LEU A 501
 ANP  A 701 ( 4.6A)
ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 ( 3.7A)
ANP  A 701 (-3.5A)
ANP  A 701 (-4.1A)
ANP  A 701 ( 4.2A)
ANP  A 701 (-4.0A)
ANP  A 701 (-4.5A)
 0.49A 1xbbA-4fl3A:
35.3		 1xbbA-4fl3A:
44.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		6 / 12 ALA A 400
MET A 424
GLY A 454
LEU A 501
ASP A 512
PHE A 513
 ANP  A 701 (-3.3A)
None
ANP  A 701 ( 4.2A)
ANP  A 701 (-4.5A)
MG  A 702 ( 3.1A)
None
 0.96A 1xkkA-4fl3A:
21.9		 1xkkA-4fl3A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		5 / 9 LEU A 377
VAL A 385
LYS A 402
LEU A 446
LEU A 515
 ANP  A 701 ( 4.6A)
ANP  A 701 (-4.1A)
ANP  A 701 (-2.7A)
None
None
 0.44A 1xkkA-4fl3A:
21.9		 1xkkA-4fl3A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		7 / 11 GLY A 378
GLY A 380
VAL A 385
ALA A 400
MET A 448
ALA A 451
LEU A 501
 ANP  A 701 ( 4.0A)
ANP  A 701 (-3.5A)
ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 ( 3.7A)
ANP  A 701 (-4.1A)
ANP  A 701 (-4.5A)
 0.61A 2evaA-4fl3A:
26.1		 2evaA-4fl3A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		7 / 11 GLY A 378
VAL A 385
ALA A 400
MET A 448
ALA A 451
LEU A 501
ASP A 512
 ANP  A 701 ( 4.0A)
ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 ( 3.7A)
ANP  A 701 (-4.1A)
ANP  A 701 (-4.5A)
MG  A 702 ( 3.1A)
 0.70A 2evaA-4fl3A:
26.1		 2evaA-4fl3A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		6 / 12 LEU A 377
VAL A 385
ALA A 400
MET A 448
ASN A 499
ASP A 512
 ANP  A 701 ( 4.6A)
ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 ( 3.7A)
MG  A 702 ( 3.0A)
MG  A 702 ( 3.1A)
 0.72A 2fumC-4fl3A:
24.3		 2fumC-4fl3A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		6 / 12 LEU A 377
GLY A 378
GLY A 380
VAL A 385
ALA A 400
MET A 448
 ANP  A 701 ( 4.6A)
ANP  A 701 ( 4.0A)
ANP  A 701 (-3.5A)
ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 ( 3.7A)
 0.46A 2fumD-4fl3A:
24.4		 2fumD-4fl3A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		7 / 12 LEU A 377
GLY A 380
VAL A 385
ALA A 400
MET A 448
ASN A 499
ASP A 512
 ANP  A 701 ( 4.6A)
ANP  A 701 (-3.5A)
ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 ( 3.7A)
MG  A 702 ( 3.0A)
MG  A 702 ( 3.1A)
 0.83A 2fumD-4fl3A:
24.4		 2fumD-4fl3A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		6 / 12 LEU A 377
ALA A 400
LYS A 402
LEU A 446
GLY A 454
LEU A 501
 ANP  A 701 ( 4.6A)
ANP  A 701 (-3.3A)
ANP  A 701 (-2.7A)
None
ANP  A 701 ( 4.2A)
ANP  A 701 (-4.5A)
 0.43A 2itoA-4fl3A:
29.7		 2itoA-4fl3A:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		8 / 12 LEU A 377
GLY A 378
VAL A 385
ALA A 400
LYS A 402
LEU A 446
GLY A 454
LEU A 501
 ANP  A 701 ( 4.6A)
ANP  A 701 ( 4.0A)
ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 (-2.7A)
None
ANP  A 701 ( 4.2A)
ANP  A 701 (-4.5A)
 0.69A 2ityA-4fl3A:
30.0		 2ityA-4fl3A:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		7 / 12 LEU A 377
GLY A 378
VAL A 385
LYS A 402
ALA A 451
LEU A 501
ASP A 512
 ANP  A 701 ( 4.6A)
ANP  A 701 ( 4.0A)
ANP  A 701 (-4.1A)
ANP  A 701 (-2.7A)
ANP  A 701 (-4.1A)
ANP  A 701 (-4.5A)
MG  A 702 ( 3.1A)
 0.78A 2ivuA-4fl3A:
30.2		 2ivuA-4fl3A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		7 / 12 LEU A 377
GLY A 378
VAL A 385
LYS A 402
LEU A 446
ALA A 451
LEU A 501
 ANP  A 701 ( 4.6A)
ANP  A 701 ( 4.0A)
ANP  A 701 (-4.1A)
ANP  A 701 (-2.7A)
None
ANP  A 701 (-4.1A)
ANP  A 701 (-4.5A)
 0.36A 2ivuA-4fl3A:
30.2		 2ivuA-4fl3A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD36_0
(GCN4 LEUCINE ZIPPER)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		3 / 3 SER A  84
TYR A  74
HIS A  82
 None
 0.81A 2r2vD-4fl3A:
undetectable		 2r2vD-4fl3A:
4.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		6 / 10 LEU A 377
ALA A 400
LYS A 402
VAL A 433
GLY A 454
LEU A 501
 ANP  A 701 ( 4.6A)
ANP  A 701 (-3.3A)
ANP  A 701 (-2.7A)
ANP  A 701 (-4.8A)
ANP  A 701 ( 4.2A)
ANP  A 701 (-4.5A)
 0.60A 3aoxA-4fl3A:
20.4		 3aoxA-4fl3A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		8 / 12 VAL A 385
ALA A 400
MET A 424
GLY A 454
LEU A 501
ASP A 512
PHE A 513
LEU A 515
 ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
None
ANP  A 701 ( 4.2A)
ANP  A 701 (-4.5A)
MG  A 702 ( 3.1A)
None
None
 0.61A 3bbtB-4fl3A:
32.9		 3bbtB-4fl3A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		9 / 12 VAL A 385
ALA A 400
LYS A 402
LEU A 446
GLY A 454
LEU A 501
ASP A 512
PHE A 513
LEU A 515
 ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 (-2.7A)
None
ANP  A 701 ( 4.2A)
ANP  A 701 (-4.5A)
MG  A 702 ( 3.1A)
None
None
 0.82A 3bbtD-4fl3A:
24.6		 3bbtD-4fl3A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		7 / 12 LEU A 377
GLY A 378
ALA A 400
LYS A 402
VAL A 433
GLY A 454
LEU A 501
 ANP  A 701 ( 4.6A)
ANP  A 701 ( 4.0A)
ANP  A 701 (-3.3A)
ANP  A 701 (-2.7A)
ANP  A 701 (-4.8A)
ANP  A 701 ( 4.2A)
ANP  A 701 (-4.5A)
 0.83A 3c7qA-4fl3A:
29.0		 3c7qA-4fl3A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		8 / 12 LEU A 377
GLY A 378
GLY A 380
GLY A 383
VAL A 385
ALA A 400
LYS A 402
MET A 448
 ANP  A 701 ( 4.6A)
ANP  A 701 ( 4.0A)
ANP  A 701 (-3.5A)
None
ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 (-2.7A)
ANP  A 701 ( 3.7A)
 0.47A 3eygA-4fl3A:
28.3		 3eygA-4fl3A:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		8 / 12 LEU A 377
GLY A 378
GLY A 380
GLY A 383
VAL A 385
ALA A 400
MET A 448
LEU A 501
 ANP  A 701 ( 4.6A)
ANP  A 701 ( 4.0A)
ANP  A 701 (-3.5A)
None
ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 ( 3.7A)
ANP  A 701 (-4.5A)
 0.58A 3eygA-4fl3A:
28.3		 3eygA-4fl3A:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		8 / 12 LEU A 377
GLY A 378
GLY A 380
GLY A 383
VAL A 385
ALA A 400
LYS A 402
MET A 448
 ANP  A 701 ( 4.6A)
ANP  A 701 ( 4.0A)
ANP  A 701 (-3.5A)
None
ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 (-2.7A)
ANP  A 701 ( 3.7A)
 0.52A 3fupA-4fl3A:
29.0		 3fupA-4fl3A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		8 / 12 LEU A 377
GLY A 378
GLY A 380
GLY A 383
VAL A 385
ALA A 400
MET A 448
LEU A 501
 ANP  A 701 ( 4.6A)
ANP  A 701 ( 4.0A)
ANP  A 701 (-3.5A)
None
ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 ( 3.7A)
ANP  A 701 (-4.5A)
 0.65A 3fupA-4fl3A:
29.0		 3fupA-4fl3A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		8 / 12 LEU A 377
GLY A 378
GLY A 380
VAL A 385
ALA A 400
LYS A 402
VAL A 433
MET A 448
 ANP  A 701 ( 4.6A)
ANP  A 701 ( 4.0A)
ANP  A 701 (-3.5A)
ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 (-2.7A)
ANP  A 701 (-4.8A)
ANP  A 701 ( 3.7A)
 0.61A 3fupB-4fl3A:
28.7		 3fupB-4fl3A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		5 / 12 ALA A 521
SER A 516
LEU A 501
GLY A 380
PHE A 382
 None
None
ANP  A 701 (-4.5A)
ANP  A 701 (-3.5A)
None
 1.09A 3k2hA-4fl3A:
undetectable		 3k2hA-4fl3A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		5 / 12 ALA A 521
SER A 516
LEU A 501
GLY A 380
PHE A 382
 None
None
ANP  A 701 (-4.5A)
ANP  A 701 (-3.5A)
None
 1.07A 3k2hB-4fl3A:
undetectable		 3k2hB-4fl3A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		7 / 12 LEU A 377
GLY A 378
VAL A 385
ALA A 400
LYS A 402
VAL A 433
MET A 448
 ANP  A 701 ( 4.6A)
ANP  A 701 ( 4.0A)
ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 (-2.7A)
ANP  A 701 (-4.8A)
ANP  A 701 ( 3.7A)
 0.65A 3lxkA-4fl3A:
28.6		 3lxkA-4fl3A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		7 / 11 ALA A 400
LYS A 402
VAL A 433
GLY A 454
LEU A 501
SER A 511
ASP A 512
 ANP  A 701 (-3.3A)
ANP  A 701 (-2.7A)
ANP  A 701 (-4.8A)
ANP  A 701 ( 4.2A)
ANP  A 701 (-4.5A)
MG  A 702 ( 4.2A)
MG  A 702 ( 3.1A)
 1.00A 3miyA-4fl3A:
31.3		 3miyA-4fl3A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_1
(TYROSINE-PROTEIN
KINASE BTK)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		7 / 12 LEU A 377
VAL A 385
ALA A 400
LYS A 402
VAL A 433
GLY A 454
LEU A 501
 ANP  A 701 ( 4.6A)
ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 (-2.7A)
ANP  A 701 (-4.8A)
ANP  A 701 ( 4.2A)
ANP  A 701 (-4.5A)
 0.63A 3octA-4fl3A:
28.5		 3octA-4fl3A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		5 / 12 LEU A 365
TYR A 364
ALA A 421
GLY A 437
LEU A 446
 None
 1.13A 3ou6A-4fl3A:
undetectable		 3ou6A-4fl3A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		5 / 12 LEU A 365
TYR A 364
ALA A 421
GLY A 437
LEU A 446
 None
 1.11A 3ou6B-4fl3A:
undetectable		 3ou6B-4fl3A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		5 / 12 LEU A 365
TYR A 364
ALA A 421
GLY A 437
LEU A 446
 None
 1.10A 3ou6C-4fl3A:
undetectable		 3ou6C-4fl3A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		5 / 12 LEU A 365
TYR A 364
ALA A 421
GLY A 437
LEU A 446
 None
 1.11A 3ou6D-4fl3A:
undetectable		 3ou6D-4fl3A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		5 / 12 LEU A 365
TYR A 364
GLU A 420
ALA A 421
LEU A 446
 None
 1.17A 3ou6D-4fl3A:
undetectable		 3ou6D-4fl3A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		5 / 12 LEU A 365
TYR A 364
ALA A 421
GLY A 437
LEU A 446
 None
 1.12A 3ou7A-4fl3A:
undetectable		 3ou7A-4fl3A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		5 / 12 LEU A 365
TYR A 364
ALA A 421
GLY A 437
LEU A 446
 None
 1.11A 3ou7C-4fl3A:
undetectable		 3ou7C-4fl3A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		5 / 12 LEU A 365
TYR A 364
ALA A 421
GLY A 437
LEU A 446
 None
 1.11A 3ou7D-4fl3A:
undetectable		 3ou7D-4fl3A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		7 / 12 LEU A 377
VAL A 385
ALA A 400
VAL A 433
GLY A 454
LEU A 501
ASP A 512
 ANP  A 701 ( 4.6A)
ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 (-4.8A)
ANP  A 701 ( 4.2A)
ANP  A 701 (-4.5A)
MG  A 702 ( 3.1A)
 0.47A 3qlgB-4fl3A:
29.4		 3qlgB-4fl3A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXR_B_1N1B2_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		6 / 12 LEU A 377
VAL A 385
ALA A 400
VAL A 433
GLY A 454
LEU A 501
 ANP  A 701 ( 4.6A)
ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 (-4.8A)
ANP  A 701 ( 4.2A)
ANP  A 701 (-4.5A)
 0.47A 3sxrB-4fl3A:
29.2		 3sxrB-4fl3A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UZZ_B_ASDB501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		4 / 8 TYR A 131
LEU A 341
MET A 343
TRP A 136
 None
 1.43A 3uzzB-4fl3A:
undetectable		 3uzzB-4fl3A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		8 / 12 GLY A 380
GLY A 383
VAL A 385
ALA A 400
VAL A 433
LEU A 501
SER A 511
ASP A 512
 ANP  A 701 (-3.5A)
None
ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 (-4.8A)
ANP  A 701 (-4.5A)
MG  A 702 ( 4.2A)
MG  A 702 ( 3.1A)
 0.78A 3v5wA-4fl3A:
8.9		 3v5wA-4fl3A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		7 / 12 GLY A 383
VAL A 385
ALA A 400
LEU A 404
VAL A 433
LEU A 501
ASP A 512
 None
ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
None
ANP  A 701 (-4.8A)
ANP  A 701 (-4.5A)
MG  A 702 ( 3.1A)
 0.82A 3v5wA-4fl3A:
8.9		 3v5wA-4fl3A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		7 / 12 VAL A 385
ALA A 400
LYS A 402
LEU A 404
VAL A 433
LEU A 501
ASP A 512
 ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 (-2.7A)
None
ANP  A 701 (-4.8A)
ANP  A 701 (-4.5A)
MG  A 702 ( 3.1A)
 1.04A 3v5wA-4fl3A:
8.9		 3v5wA-4fl3A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		7 / 12 VAL A 385
ALA A 400
LYS A 402
VAL A 433
LEU A 501
SER A 511
ASP A 512
 ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 (-2.7A)
ANP  A 701 (-4.8A)
ANP  A 701 (-4.5A)
MG  A 702 ( 4.2A)
MG  A 702 ( 3.1A)
 0.93A 3v5wA-4fl3A:
8.9		 3v5wA-4fl3A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		7 / 12 LEU A 377
VAL A 385
ALA A 400
LYS A 402
VAL A 433
GLY A 454
LEU A 501
 ANP  A 701 ( 4.6A)
ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 (-2.7A)
ANP  A 701 (-4.8A)
ANP  A 701 ( 4.2A)
ANP  A 701 (-4.5A)
 0.78A 4ag8A-4fl3A:
29.6		 4ag8A-4fl3A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		5 / 11 LEU A 377
ALA A 400
VAL A 433
GLY A 454
LEU A 501
 ANP  A 701 ( 4.6A)
ANP  A 701 (-3.3A)
ANP  A 701 (-4.8A)
ANP  A 701 ( 4.2A)
ANP  A 701 (-4.5A)
 0.49A 4agdA-4fl3A:
28.5		 4agdA-4fl3A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		5 / 12 LYS A 402
MET A 448
ASN A 499
ASP A 512
GLY A 514
 ANP  A 701 (-2.7A)
ANP  A 701 ( 3.7A)
MG  A 702 ( 3.0A)
MG  A 702 ( 3.1A)
None
 0.56A 4an2A-4fl3A:
25.8		 4an2A-4fl3A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		6 / 9 LEU A 377
VAL A 385
ALA A 400
MET A 448
GLY A 454
LEU A 501
 ANP  A 701 ( 4.6A)
ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 ( 3.7A)
ANP  A 701 ( 4.2A)
ANP  A 701 (-4.5A)
 0.42A 4ansA-4fl3A:
29.4		 4ansA-4fl3A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		6 / 10 LEU A 377
GLY A 378
VAL A 385
ALA A 400
ALA A 451
LEU A 501
 ANP  A 701 ( 4.6A)
ANP  A 701 ( 4.0A)
ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 (-4.1A)
ANP  A 701 (-4.5A)
 0.37A 4ckjA-4fl3A:
29.7		 4ckjA-4fl3A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		5 / 11 GLN A 477
ALA A 508
LEU A 502
PHE A 566
ILE A 472
 None
 1.34A 4claA-4fl3A:
undetectable		 4claA-4fl3A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		7 / 12 LEU A 377
VAL A 385
ALA A 400
LYS A 402
GLY A 454
LEU A 501
ASP A 512
 ANP  A 701 ( 4.6A)
ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 (-2.7A)
ANP  A 701 ( 4.2A)
ANP  A 701 (-4.5A)
MG  A 702 ( 3.1A)
 0.56A 4hjoA-4fl3A:
32.8		 4hjoA-4fl3A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		9 / 12 LEU A 377
GLY A 378
VAL A 385
ALA A 400
LYS A 402
LEU A 446
MET A 448
GLY A 454
LEU A 501
 ANP  A 701 ( 4.6A)
ANP  A 701 ( 4.0A)
ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 (-2.7A)
None
ANP  A 701 ( 3.7A)
ANP  A 701 ( 4.2A)
ANP  A 701 (-4.5A)
 0.70A 4i22A-4fl3A:
24.6		 4i22A-4fl3A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		7 / 12 GLY A 378
VAL A 385
ALA A 400
LYS A 402
LEU A 446
LEU A 501
LEU A 515
 ANP  A 701 ( 4.0A)
ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 (-2.7A)
None
ANP  A 701 (-4.5A)
None
 0.54A 4ifgA-4fl3A:
23.8		 4ifgA-4fl3A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		6 / 10 ALA A 400
VAL A 433
GLY A 454
LEU A 501
SER A 511
ASP A 512
 ANP  A 701 (-3.3A)
ANP  A 701 (-4.8A)
ANP  A 701 ( 4.2A)
ANP  A 701 (-4.5A)
MG  A 702 ( 4.2A)
MG  A 702 ( 3.1A)
 1.00A 4ks8A-4fl3A:
23.5		 4ks8A-4fl3A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		6 / 10 ALA A 400
VAL A 433
MET A 448
GLY A 454
LEU A 501
SER A 511
 ANP  A 701 (-3.3A)
ANP  A 701 (-4.8A)
ANP  A 701 ( 3.7A)
ANP  A 701 ( 4.2A)
ANP  A 701 (-4.5A)
MG  A 702 ( 4.2A)
 0.79A 4ks8A-4fl3A:
23.5		 4ks8A-4fl3A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		6 / 12 LYS A 402
MET A 448
ASN A 499
ASP A 512
GLY A 514
LEU A 519
 ANP  A 701 (-2.7A)
ANP  A 701 ( 3.7A)
MG  A 702 ( 3.0A)
MG  A 702 ( 3.1A)
None
None
 1.01A 4lmnA-4fl3A:
24.6		 4lmnA-4fl3A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		6 / 12 LYS A 402
MET A 448
ASN A 499
ASP A 512
PHE A 513
GLY A 514
 ANP  A 701 (-2.7A)
ANP  A 701 ( 3.7A)
MG  A 702 ( 3.0A)
MG  A 702 ( 3.1A)
None
None
 0.72A 4lmnA-4fl3A:
24.6		 4lmnA-4fl3A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		4 / 8 SER A 350
ASP A 428
GLU A 349
ARG A 359
 None
 0.99A 4lnwA-4fl3A:
undetectable		 4lnwA-4fl3A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		7 / 12 LEU A 377
VAL A 385
ALA A 400
LYS A 402
VAL A 433
GLY A 454
LEU A 501
 ANP  A 701 ( 4.6A)
ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 (-2.7A)
ANP  A 701 (-4.8A)
ANP  A 701 ( 4.2A)
ANP  A 701 (-4.5A)
 0.77A 4mxxB-4fl3A:
28.7		 4mxxB-4fl3A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		8 / 11 LEU A 377
GLY A 378
VAL A 385
ALA A 400
LYS A 402
ASN A 499
LEU A 501
ASP A 512
 ANP  A 701 ( 4.6A)
ANP  A 701 ( 4.0A)
ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 (-2.7A)
MG  A 702 ( 3.0A)
ANP  A 701 (-4.5A)
MG  A 702 ( 3.1A)
 0.95A 4o0sA-4fl3A:
23.6		 4o0sA-4fl3A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0U_A_ADNA501_1
(AURORA KINASE A)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		4 / 6 VAL A 385
ALA A 400
LYS A 402
LEU A 501
 ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 (-2.7A)
ANP  A 701 (-4.5A)
 0.60A 4o0uA-4fl3A:
8.9		 4o0uA-4fl3A:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		5 / 6 LEU A 377
GLY A 378
VAL A 385
ALA A 400
LEU A 501
 ANP  A 701 ( 4.6A)
ANP  A 701 ( 4.0A)
ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 (-4.5A)
 0.66A 4o0wA-4fl3A:
23.7		 4o0wA-4fl3A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		8 / 12 LEU A 377
GLY A 378
GLY A 380
GLY A 383
VAL A 385
ALA A 400
VAL A 433
ASP A 512
 ANP  A 701 ( 4.6A)
ANP  A 701 ( 4.0A)
ANP  A 701 (-3.5A)
None
ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 (-4.8A)
MG  A 702 ( 3.1A)
 0.56A 4otiA-4fl3A:
20.0		 4otiA-4fl3A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		5 / 6 LEU A 377
VAL A 385
ILE A 432
ARG A 493
ILE A 510
 ANP  A 701 ( 4.6A)
ANP  A 701 (-4.1A)
None
None
None
 0.73A 4tyjA-4fl3A:
23.6		 4tyjA-4fl3A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		7 / 10 LEU A 377
VAL A 385
LEU A 427
ILE A 432
VAL A 433
ARG A 493
ILE A 510
 ANP  A 701 ( 4.6A)
ANP  A 701 (-4.1A)
None
None
ANP  A 701 (-4.8A)
None
None
 0.79A 4u0iA-4fl3A:
28.6		 4u0iA-4fl3A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		4 / 7 VAL A 385
ALA A 451
ARG A 493
ILE A 510
 ANP  A 701 (-4.1A)
ANP  A 701 (-4.1A)
None
None
 0.75A 4uxqA-4fl3A:
29.3		 4uxqA-4fl3A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		6 / 12 VAL A 385
ALA A 400
ALA A 451
LEU A 485
HIS A 492
GLY A 514
 ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 (-4.1A)
None
None
None
 0.88A 4v04A-4fl3A:
29.1		 4v04A-4fl3A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		6 / 10 LEU A 377
VAL A 385
ARG A 493
LEU A 501
ILE A 510
LEU A 515
 ANP  A 701 ( 4.6A)
ANP  A 701 (-4.1A)
None
ANP  A 701 (-4.5A)
None
None
 0.86A 4v04B-4fl3A:
29.4		 4v04B-4fl3A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		5 / 12 ALA A 400
ALA A 451
LEU A 485
HIS A 492
GLY A 514
 ANP  A 701 (-3.3A)
ANP  A 701 (-4.1A)
None
None
None
 0.93A 4v04B-4fl3A:
29.4		 4v04B-4fl3A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_B_ANWB601_0
(RHODOPSIN KINASE)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		5 / 8 LEU A 377
ALA A 400
MET A 448
LEU A 501
SER A 511
 ANP  A 701 ( 4.6A)
ANP  A 701 (-3.3A)
ANP  A 701 ( 3.7A)
ANP  A 701 (-4.5A)
MG  A 702 ( 4.2A)
 0.54A 4wboB-4fl3A:
20.9		 4wboB-4fl3A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		4 / 6 LEU A 377
ALA A 400
MET A 448
LEU A 501
 ANP  A 701 ( 4.6A)
ANP  A 701 (-3.3A)
ANP  A 701 ( 3.7A)
ANP  A 701 (-4.5A)
 0.47A 4wboC-4fl3A:
21.2		 4wboC-4fl3A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_E_CHDE104_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		5 / 11 ALA A 204
LEU A 205
TYR A 216
LEU A 255
LEU A 251
 None
 1.00A 4wg0C-4fl3A:
undetectable
4wg0D-4fl3A:
undetectable
4wg0E-4fl3A:
undetectable		 4wg0C-4fl3A:
2.77
4wg0D-4fl3A:
2.77
4wg0E-4fl3A:
2.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_G_CHDG103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		5 / 11 ALA A 204
LEU A 205
TYR A 216
LEU A 255
LEU A 251
 None
 0.99A 4wg0E-4fl3A:
undetectable
4wg0F-4fl3A:
undetectable
4wg0G-4fl3A:
undetectable		 4wg0E-4fl3A:
2.77
4wg0F-4fl3A:
2.77
4wg0G-4fl3A:
2.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		6 / 12 LEU A 377
ALA A 400
LYS A 402
LEU A 446
GLY A 454
LEU A 501
 ANP  A 701 ( 4.6A)
ANP  A 701 (-3.3A)
ANP  A 701 (-2.7A)
None
ANP  A 701 ( 4.2A)
ANP  A 701 (-4.5A)
 0.49A 4wkqA-4fl3A:
29.4		 4wkqA-4fl3A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		7 / 12 LEU A 377
VAL A 385
ALA A 400
LYS A 402
VAL A 433
GLY A 454
LEU A 501
 ANP  A 701 ( 4.6A)
ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 (-2.7A)
ANP  A 701 (-4.8A)
ANP  A 701 ( 4.2A)
ANP  A 701 (-4.5A)
 0.49A 4xeyA-4fl3A:
30.7		 4xeyA-4fl3A:
27.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		7 / 12 LEU A 377
VAL A 385
ALA A 400
LYS A 402
VAL A 433
GLY A 454
LEU A 501
 ANP  A 701 ( 4.6A)
ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 (-2.7A)
ANP  A 701 (-4.8A)
ANP  A 701 ( 4.2A)
ANP  A 701 (-4.5A)
 0.48A 4xeyB-4fl3A:
30.2		 4xeyB-4fl3A:
27.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJQ_D_ERYD1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		5 / 12 ASN A  19
THR A  21
ILE A 147
GLU A 121
GLU A 242
 None
 1.44A 4zjqD-4fl3A:
0.5		 4zjqD-4fl3A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		4 / 6 LEU A 453
ALA A 451
LEU A 502
VAL A 347
 None
ANP  A 701 (-4.1A)
None
None
 1.28A 5a6iA-4fl3A:
undetectable		 5a6iA-4fl3A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		5 / 12 LEU A 377
VAL A 385
ALA A 400
GLY A 454
LEU A 501
 ANP  A 701 ( 4.6A)
ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 ( 4.2A)
ANP  A 701 (-4.5A)
 0.40A 5h2uA-4fl3A:
33.0		 5h2uA-4fl3A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		6 / 12 LEU A 377
VAL A 385
ALA A 400
GLY A 454
LEU A 501
ASP A 512
 ANP  A 701 ( 4.6A)
ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 ( 4.2A)
ANP  A 701 (-4.5A)
MG  A 702 ( 3.1A)
 0.49A 5h2uB-4fl3A:
33.2		 5h2uB-4fl3A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		6 / 12 LEU A 377
VAL A 385
LYS A 402
GLY A 454
LEU A 501
ASP A 512
 ANP  A 701 ( 4.6A)
ANP  A 701 (-4.1A)
ANP  A 701 (-2.7A)
ANP  A 701 ( 4.2A)
ANP  A 701 (-4.5A)
MG  A 702 ( 3.1A)
 0.86A 5h2uB-4fl3A:
33.2		 5h2uB-4fl3A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		6 / 12 LEU A 377
ALA A 400
LYS A 402
GLY A 454
LEU A 501
ASP A 512
 ANP  A 701 ( 4.6A)
ANP  A 701 (-3.3A)
ANP  A 701 (-2.7A)
ANP  A 701 ( 4.2A)
ANP  A 701 (-4.5A)
MG  A 702 ( 3.1A)
 0.58A 5h2uC-4fl3A:
33.0		 5h2uC-4fl3A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A211_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		4 / 6 VAL A 500
ALA A 508
GLN A 477
VAL A 478
 None
 0.88A 5i8fA-4fl3A:
undetectable		 5i8fA-4fl3A:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		7 / 11 LEU A 377
GLY A 378
VAL A 385
ALA A 400
VAL A 433
ALA A 451
LEU A 501
 ANP  A 701 ( 4.6A)
ANP  A 701 ( 4.0A)
ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 (-4.8A)
ANP  A 701 (-4.1A)
ANP  A 701 (-4.5A)
 0.53A 5lvnA-4fl3A:
22.5		 5lvnA-4fl3A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		6 / 10 LEU A 377
VAL A 385
ALA A 400
VAL A 433
MET A 448
LEU A 501
 ANP  A 701 ( 4.6A)
ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 (-4.8A)
ANP  A 701 ( 3.7A)
ANP  A 701 (-4.5A)
 0.78A 5n3hA-4fl3A:
21.1		 5n3hA-4fl3A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		8 / 12 VAL A 385
ALA A 400
LYS A 402
MET A 424
GLY A 454
LEU A 501
SER A 511
PHE A 513
 ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 (-2.7A)
None
ANP  A 701 ( 4.2A)
ANP  A 701 (-4.5A)
MG  A 702 ( 4.2A)
None
 0.80A 5p9iA-4fl3A:
32.9		 5p9iA-4fl3A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA406_0
(THIOREDOXIN
REDUCTASE)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		3 / 3 HIS A 492
SER A 511
ARG A 498
 None
MG  A 702 ( 4.2A)
ANP  A 701 (-4.2A)
 0.88A 5u63A-4fl3A:
undetectable		 5u63A-4fl3A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		4 / 4 LEU A 205
LEU A 251
SER A 245
ALA A 248
 None
 1.12A 5uunA-4fl3A:
undetectable		 5uunA-4fl3A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		9 / 12 LEU A 377
GLY A 378
VAL A 385
ALA A 400
LYS A 402
MET A 424
LEU A 446
LEU A 501
ASP A 512
 ANP  A 701 ( 4.6A)
ANP  A 701 ( 4.0A)
ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 (-2.7A)
None
None
ANP  A 701 (-4.5A)
MG  A 702 ( 3.1A)
 0.59A 5yu9A-4fl3A:
31.4		 5yu9A-4fl3A:
7.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		8 / 12 LEU A 377
GLY A 378
VAL A 385
ALA A 400
LYS A 402
MET A 448
LEU A 501
ASP A 512
 ANP  A 701 ( 4.6A)
ANP  A 701 ( 4.0A)
ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 (-2.7A)
ANP  A 701 ( 3.7A)
ANP  A 701 (-4.5A)
MG  A 702 ( 3.1A)
 0.79A 5yu9A-4fl3A:
31.4		 5yu9A-4fl3A:
7.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		8 / 12 GLY A 378
VAL A 385
ALA A 400
LYS A 402
MET A 424
LEU A 446
LEU A 501
ASP A 512
 ANP  A 701 ( 4.0A)
ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 (-2.7A)
None
None
ANP  A 701 (-4.5A)
MG  A 702 ( 3.1A)
 0.59A 5yu9B-4fl3A:
24.8		 5yu9B-4fl3A:
7.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		7 / 12 GLY A 378
VAL A 385
ALA A 400
LYS A 402
MET A 448
LEU A 501
ASP A 512
 ANP  A 701 ( 4.0A)
ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 (-2.7A)
ANP  A 701 ( 3.7A)
ANP  A 701 (-4.5A)
MG  A 702 ( 3.1A)
 0.84A 5yu9B-4fl3A:
24.8		 5yu9B-4fl3A:
7.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		7 / 12 VAL A 385
ALA A 400
LYS A 402
MET A 424
LEU A 446
GLY A 454
ASP A 512
 ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 (-2.7A)
None
None
ANP  A 701 ( 4.2A)
MG  A 702 ( 3.1A)
 0.55A 5yu9C-4fl3A:
31.3		 5yu9C-4fl3A:
7.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		6 / 12 VAL A 385
ALA A 400
LYS A 402
MET A 448
GLY A 454
ASP A 512
 ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 (-2.7A)
ANP  A 701 ( 3.7A)
ANP  A 701 ( 4.2A)
MG  A 702 ( 3.1A)
 0.84A 5yu9C-4fl3A:
31.3		 5yu9C-4fl3A:
7.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		8 / 12 VAL A 385
ALA A 400
LYS A 402
MET A 424
GLY A 454
LEU A 501
ASP A 512
LEU A 515
 ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 (-2.7A)
None
ANP  A 701 ( 4.2A)
ANP  A 701 (-4.5A)
MG  A 702 ( 3.1A)
None
 0.61A 5yu9D-4fl3A:
32.2		 5yu9D-4fl3A:
7.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		8 / 12 VAL A 385
ALA A 400
LYS A 402
MET A 448
GLY A 454
LEU A 501
ASP A 512
LEU A 515
 ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 (-2.7A)
ANP  A 701 ( 3.7A)
ANP  A 701 ( 4.2A)
ANP  A 701 (-4.5A)
MG  A 702 ( 3.1A)
None
 0.83A 5yu9D-4fl3A:
32.2		 5yu9D-4fl3A:
7.85