SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fl4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4fl4 CELLULOSOME
ANCHORING PROTEIN
COHESIN REGION
GLYCOSIDE HYDROLASE
FAMILY 9
(Ruminiclostridiu
m
thermocellum) 		5 / 11 THR A  34
SER A  33
PHE C  43
VAL C  33
VAL C 138
 None
 1.29A 1q23J-4fl4A:
undetectable		 1q23J-4fl4A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 4fl4 GLYCOSIDE HYDROLASE
FAMILY 9
CELLULOSOME
ANCHORING PROTEIN
COHESIN REGION
(Ruminiclostridiu
m
thermocellum;
Ruminiclostridiu
m
thermocellum) 		4 / 8 PHE C  87
THR A  37
GLY C  94
ILE C  98
 None
 0.82A 2a1mB-4fl4C:
undetectable		 2a1mB-4fl4C:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_A_CQAA403_0
(HISTAMINE
N-METHYLTRANSFERASE)		 4fl4 GLYCOSIDE HYDROLASE
FAMILY 9
CELLULOSOME
ANCHORING PROTEIN
COHESIN REGION
(Ruminiclostridiu
m
thermocellum;
Ruminiclostridiu
m
thermocellum) 		4 / 8 ASP A  35
GLY C  41
PHE C  87
ASP C  73
 CA  A 101 (-2.4A)
None
None
None
 0.89A 2aouA-4fl4A:
undetectable		 2aouA-4fl4A:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA501_0
(FERROCHELATASE)		 4fl4 CELLULOSOME
ANCHORING PROTEIN
COHESIN REGION
(Ruminiclostridiu
m
thermocellum) 		5 / 11 LEU C  30
LEU C  11
LEU C 142
ILE C  98
VAL C 138
 None
 1.33A 2qd3A-4fl4C:
undetectable		 2qd3A-4fl4C:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_B_DX2B271_1
(PTERIDINE REDUCTASE
1)		 4fl4 CELLULOSOME
ANCHORING PROTEIN
COHESIN REGION
(Ruminiclostridiu
m
thermocellum) 		4 / 8 ARG C 219
PHE C 168
ASP C 295
LEU C 177
 SO4  C 404 (-3.5A)
None
CA  C 402 (-2.3A)
None
 1.08A 3jq7B-4fl4C:
undetectable		 3jq7B-4fl4C:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA505_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4fl4 GLYCOSIDE HYDROLASE
FAMILY 9
CELLULOSOME
ANCHORING PROTEIN
COHESIN REGION
(Ruminiclostridiu
m
thermocellum;
Ruminiclostridiu
m
thermocellum) 		3 / 3 THR A  34
ASN A  26
GLU C 137
 None
CA  A 101 (-2.9A)
None
 0.76A 3v4tA-4fl4A:
undetectable
3v4tC-4fl4A:
undetectable		 3v4tA-4fl4A:
11.86
3v4tC-4fl4A:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4fl4 CELLULOSOME
ANCHORING PROTEIN
COHESIN REGION
GLYCOSIDE HYDROLASE
FAMILY 9
(Ruminiclostridiu
m
thermocellum) 		4 / 7 ASP A  35
ASN A  26
GLU C 137
ASP A  27
 CA  A 101 (-2.4A)
CA  A 101 (-2.9A)
None
None
 1.21A 4fevD-4fl4A:
undetectable		 4fevD-4fl4A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4fl4 CELLULOSOME
ANCHORING PROTEIN
COHESIN REGION
GLYCOSIDE HYDROLASE
FAMILY 9
(Ruminiclostridiu
m
thermocellum) 		4 / 8 ASP A  35
ASN A  26
GLU C 137
ASP A  27
 CA  A 101 (-2.4A)
CA  A 101 (-2.9A)
None
None
 1.19A 4fewD-4fl4A:
undetectable		 4fewD-4fl4A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4fl4 CELLULOSOME
ANCHORING PROTEIN
COHESIN REGION
GLYCOSIDE HYDROLASE
FAMILY 9
(Ruminiclostridiu
m
thermocellum) 		4 / 8 ASP A  35
ASN A  26
GLU C 137
ASP A  27
 CA  A 101 (-2.4A)
CA  A 101 (-2.9A)
None
None
 1.18A 4fewF-4fl4A:
undetectable		 4fewF-4fl4A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEX_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4fl4 CELLULOSOME
ANCHORING PROTEIN
COHESIN REGION
GLYCOSIDE HYDROLASE
FAMILY 9
(Ruminiclostridiu
m
thermocellum) 		4 / 7 ASP A  35
ASN A  26
GLU C 137
ASP A  27
 CA  A 101 (-2.4A)
CA  A 101 (-2.9A)
None
None
 1.19A 4fexB-4fl4A:
undetectable		 4fexB-4fl4A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4fl4 CELLULOSOME
ANCHORING PROTEIN
COHESIN REGION
GLYCOSIDE HYDROLASE
FAMILY 9
(Ruminiclostridiu
m
thermocellum) 		4 / 8 ASP A  35
ASN A  26
GLU C 137
ASP A  27
 CA  A 101 (-2.4A)
CA  A 101 (-2.9A)
None
None
 1.19A 4gkhB-4fl4A:
undetectable		 4gkhB-4fl4A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4fl4 CELLULOSOME
ANCHORING PROTEIN
COHESIN REGION
GLYCOSIDE HYDROLASE
FAMILY 9
(Ruminiclostridiu
m
thermocellum) 		4 / 7 ASP A  35
ASN A  26
GLU C 137
ASP A  27
 CA  A 101 (-2.4A)
CA  A 101 (-2.9A)
None
None
 1.19A 4gkhG-4fl4A:
undetectable		 4gkhG-4fl4A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4fl4 CELLULOSOME
ANCHORING PROTEIN
COHESIN REGION
GLYCOSIDE HYDROLASE
FAMILY 9
(Ruminiclostridiu
m
thermocellum) 		4 / 8 ASP A  35
ASN A  26
GLU C 137
ASP A  27
 CA  A 101 (-2.4A)
CA  A 101 (-2.9A)
None
None
 1.20A 4gkiA-4fl4A:
undetectable		 4gkiA-4fl4A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_D_QDND602_1
(CYTOCHROME P450 2D6)		 4fl4 CELLULOSOME
ANCHORING PROTEIN
COHESIN REGION
(Ruminiclostridiu
m
thermocellum) 		5 / 10 GLY C 128
GLU C 137
ALA C  88
SER C  40
ALA C  39
 None
 1.27A 4wnuD-4fl4C:
undetectable		 4wnuD-4fl4C:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXF_A_BEZA601_0
(EUGENOL OXIDASE)		 4fl4 GLYCOSIDE HYDROLASE
FAMILY 9
CELLULOSOME
ANCHORING PROTEIN
COHESIN REGION
(Ruminiclostridiu
m
thermocellum;
Ruminiclostridiu
m
thermocellum) 		5 / 9 VAL A  82
ILE A  80
VAL C  84
TYR C  77
ARG C  80
 None
 1.49A 5fxfA-4fl4A:
undetectable		 5fxfA-4fl4A:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXF_B_BEZB601_0
(EUGENOL OXIDASE)		 4fl4 GLYCOSIDE HYDROLASE
FAMILY 9
CELLULOSOME
ANCHORING PROTEIN
COHESIN REGION
(Ruminiclostridiu
m
thermocellum;
Ruminiclostridiu
m
thermocellum) 		5 / 10 VAL A  82
ILE A  80
VAL C  84
TYR C  77
ARG C  80
 None
 1.46A 5fxfB-4fl4A:
undetectable		 5fxfB-4fl4A:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC902_0
(MRNA CAPPING ENZYME
P5)		 4fl4 CELLULOSOME
ANCHORING PROTEIN
COHESIN REGION
(Ruminiclostridiu
m
thermocellum) 		5 / 12 GLY C 199
PRO C 176
ALA C 175
GLU C 202
PHE C 201
 None
 1.32A 5x6yC-4fl4C:
undetectable		 5x6yC-4fl4C:
18.54