SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4flc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		 4flc ADENYLOSUCCINATE
LYASE
(Homo
sapiens) 		5 / 12 ALA A 127
ILE A 123
PHE A  30
LEU A 252
LEU A 193
 None
 1.15A 1dtlA-4flcA:
undetectable		 1dtlA-4flcA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 4flc ADENYLOSUCCINATE
LYASE
(Homo
sapiens) 		3 / 3 ASP A 129
LYS A 134
ARG A 137
 None
 1.18A 1ra8A-4flcA:
undetectable		 1ra8A-4flcA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_C_TFPC208_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4flc ADENYLOSUCCINATE
LYASE
(Homo
sapiens) 		4 / 5 LEU A 311
PHE A  30
MET A  26
SER A  23
 None
 0.84A 1wrlC-4flcA:
undetectable		 1wrlC-4flcA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_E_TFPE212_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4flc ADENYLOSUCCINATE
LYASE
(Homo
sapiens) 		4 / 7 LEU A 311
PHE A  30
MET A  26
SER A  23
 None
 0.78A 1wrlE-4flcA:
undetectable		 1wrlE-4flcA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 4flc ADENYLOSUCCINATE
LYASE
(Homo
sapiens) 		5 / 11 LEU A 128
LEU A 131
SER A 261
LEU A 258
LEU A 186
 None
 0.96A 2ceoA-4flcA:
undetectable		 2ceoA-4flcA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_H_CPFH1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 4flc ADENYLOSUCCINATE
LYASE
(Homo
sapiens) 		3 / 3 ARG A 149
GLU A 148
SER A 301
 None
 0.92A 2xctD-4flcA:
2.2		 2xctD-4flcA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 4flc ADENYLOSUCCINATE
LYASE
(Homo
sapiens) 		5 / 12 ILE A 351
LEU A 186
VAL A 254
VAL A 189
LEU A 128
 None
 1.02A 3gwxB-4flcA:
undetectable		 3gwxB-4flcA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_0
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 4flc ADENYLOSUCCINATE
LYASE
(Homo
sapiens) 		5 / 12 TYR A  34
ALA A 342
ILE A 123
ASP A 120
LEU A  17
 None
 1.17A 3lcvB-4flcA:
undetectable		 3lcvB-4flcA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 4flc ADENYLOSUCCINATE
LYASE
(Homo
sapiens) 		5 / 12 LEU A 142
ALA A 146
GLU A 148
LEU A 362
ILE A 265
 None
 1.05A 3olsB-4flcA:
2.4		 3olsB-4flcA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA402_1
(HIV-1 PROTEASE)		 4flc ADENYLOSUCCINATE
LYASE
(Homo
sapiens) 		4 / 5 ARG A 190
LEU A 132
PRO A 471
ASP A 191
 None
 0.98A 3ufnA-4flcA:
undetectable
3ufnB-4flcA:
undetectable		 3ufnA-4flcA:
10.53
3ufnB-4flcA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7H_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 4flc ADENYLOSUCCINATE
LYASE
(Homo
sapiens) 		3 / 3 ARG A 338
THR A 119
TRP A  39
 None
 1.13A 4d7hA-4flcA:
undetectable		 4d7hA-4flcA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 4flc ADENYLOSUCCINATE
LYASE
(Homo
sapiens) 		5 / 11 LEU A 186
LEU A 128
PHE A  30
LEU A 352
LEU A 311
 None
 1.17A 4dm8A-4flcA:
2.1		 4dm8A-4flcA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4flc ADENYLOSUCCINATE
LYASE
(Homo
sapiens) 		5 / 10 LEU A 121
ASP A 117
THR A 239
THR A 244
ASP A 248
 None
 1.23A 4n9uA-4flcA:
2.4		 4n9uA-4flcA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4flc ADENYLOSUCCINATE
LYASE
(Homo
sapiens) 		5 / 12 LEU A 121
ASP A 117
THR A 239
THR A 244
ASP A 248
 None
 1.20A 4ng6A-4flcA:
undetectable		 4ng6A-4flcA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCU_A_SAMA603_0
(CYSTATHIONINE
BETA-SYNTHASE)		 4flc ADENYLOSUCCINATE
LYASE
(Homo
sapiens) 		4 / 7 PHE A  36
THR A 119
ILE A 123
ASP A 120
 None
 0.80A 4pcuA-4flcA:
undetectable		 4pcuA-4flcA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCU_B_SAMB603_0
(CYSTATHIONINE
BETA-SYNTHASE)		 4flc ADENYLOSUCCINATE
LYASE
(Homo
sapiens) 		5 / 9 PHE A  36
VAL A 115
THR A 119
ILE A 123
ASP A 120
 None
 1.08A 4pcuA-4flcA:
undetectable
4pcuB-4flcA:
undetectable		 4pcuA-4flcA:
22.47
4pcuB-4flcA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UG5_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 4flc ADENYLOSUCCINATE
LYASE
(Homo
sapiens) 		3 / 3 ARG A 338
THR A 119
TRP A  39
 None
 1.13A 4ug5A-4flcA:
undetectable		 4ug5A-4flcA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGL_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 4flc ADENYLOSUCCINATE
LYASE
(Homo
sapiens) 		3 / 3 ARG A 338
THR A 119
TRP A  39
 None
 1.21A 4uglA-4flcA:
undetectable		 4uglA-4flcA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 4flc ADENYLOSUCCINATE
LYASE
(Homo
sapiens) 		5 / 12 VAL A 198
GLY A 203
ARG A 329
VAL A 247
LEU A 121
 None
 1.18A 5ergB-4flcA:
undetectable		 5ergB-4flcA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6C_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 4flc ADENYLOSUCCINATE
LYASE
(Homo
sapiens) 		3 / 3 ARG A 338
THR A 119
TRP A  39
 None
 1.13A 5g6cA-4flcA:
undetectable		 5g6cA-4flcA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_G_IPHG101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4flc ADENYLOSUCCINATE
LYASE
(Homo
sapiens) 		4 / 6 HIS A 310
LEU A 311
CYH A 340
LEU A 252
 None
 1.50A 5hrqD-4flcA:
undetectable
5hrqG-4flcA:
undetectable
5hrqH-4flcA:
undetectable		 5hrqD-4flcA:
6.20
5hrqG-4flcA:
3.49
5hrqH-4flcA:
6.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIH_A_8CVA201_1
(DIHYDROFOLATE
REDUCTASE)		 4flc ADENYLOSUCCINATE
LYASE
(Homo
sapiens) 		4 / 8 ILE A 237
ALA A 235
ASP A 223
ILE A 238
 None
 0.85A 5uihA-4flcA:
undetectable		 5uihA-4flcA:
11.14