SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fle'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_A_VIBA502_1
(THIAMIN
PYROPHOSPHOKINASE)		 4fle ESTERASE
(Yersinia
enterocolitica) 		4 / 8 LEU A 118
SER A  13
ASN A  12
GLN A  40
 None
 0.98A 1ig3A-4fleA:
undetectable
1ig3B-4fleA:
undetectable		 1ig3A-4fleA:
21.29
1ig3B-4fleA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_B_VIBB501_1
(THIAMIN
PYROPHOSPHOKINASE)		 4fle ESTERASE
(Yersinia
enterocolitica) 		4 / 7 GLN A  40
LEU A 118
SER A  13
ASN A  12
 None
 0.96A 1ig3A-4fleA:
undetectable
1ig3B-4fleA:
undetectable		 1ig3A-4fleA:
21.29
1ig3B-4fleA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4fle ESTERASE
(Yersinia
enterocolitica) 		5 / 12 ALA A  49
MET A 129
LEU A  71
ILE A 123
LEU A 118
 None
 1.09A 1rx3A-4fleA:
undetectable		 1rx3A-4fleA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_0
(HEMK PROTEIN)		 4fle ESTERASE
(Yersinia
enterocolitica) 		5 / 12 ILE A   8
ILE A  38
SER A  54
PHE A  75
PRO A  42
 None
 0.92A 1sg9A-4fleA:
undetectable		 1sg9A-4fleA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 4fle ESTERASE
(Yersinia
enterocolitica) 		5 / 9 GLY A  10
SER A  70
LEU A  71
LEU A 100
HIS A 173
 None
 1.00A 1y7iA-4fleA:
13.9		 1y7iA-4fleA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB160_0
(HEME-BINDING PROTEIN
HUTZ)		 4fle ESTERASE
(Yersinia
enterocolitica) 		4 / 4 LEU A 104
GLY A 105
LEU A 118
GLU A 119
 None
 1.12A 3tgvB-4fleA:
undetectable		 3tgvB-4fleA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC0_A_MIYA1204_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS B FROM
TRANSPOSON TN1 0)		 4fle ESTERASE
(Yersinia
enterocolitica) 		5 / 12 PRO A  92
GLN A 144
LEU A 142
GLN A 165
LEU A 134
 None
 1.22A 4ac0A-4fleA:
undetectable		 4ac0A-4fleA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4fle ESTERASE
(Yersinia
enterocolitica) 		5 / 12 ALA A  49
MET A 129
LEU A  71
ILE A 123
LEU A 118
 None
 1.09A 4gh8A-4fleA:
undetectable		 4gh8A-4fleA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_B_KANB201_2
(BIFUNCTIONAL AAC/APH)		 4fle ESTERASE
(Yersinia
enterocolitica) 		3 / 3 LEU A  99
ASP A 102
TYR A 103
 None
 0.57A 4qc6B-4fleA:
undetectable		 4qc6B-4fleA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4fle ESTERASE
(Yersinia
enterocolitica) 		4 / 6 TRP A  78
GLY A  65
ALA A  76
LEU A  79
 None
 0.94A 6fosA-4fleA:
undetectable		 6fosA-4fleA:
14.92