SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fln'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		 4fln PROTEASE DO-LIKE 2,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		3 / 3 ASN A 157
PHE A 147
VAL A 282
 None
 0.66A 1kijA-4flnA:
undetectable		 1kijA-4flnA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 4fln PROTEASE DO-LIKE 2,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 LEU A 327
ASP A 366
SER A 356
VAL A 352
ILE A 409
 None
 1.42A 1uobA-4flnA:
undetectable		 1uobA-4flnA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_2
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 4fln PROTEASE DO-LIKE 2,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 6 GLN A 483
ASN A 517
ASN A 504
LEU A 468
 None
 1.24A 2nyrA-4flnA:
undetectable		 2nyrA-4flnA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 4fln PROTEASE DO-LIKE 2,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 4 PRO A 424
ASP A 188
ASP A 190
ASP A 310
 None
 1.13A 2nyuA-4flnA:
undetectable		 2nyuA-4flnA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 4fln PROTEASE DO-LIKE 2,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 5 PRO A 424
ALA A 401
ASP A 188
ASP A 190
ASP A 310
 None
 1.26A 2nyuB-4flnA:
undetectable		 2nyuB-4flnA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4fln PROTEASE DO-LIKE 2,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 6 PHE A 371
ILE A 407
PHE A 392
GLY A 324
 None
 0.70A 2qx6A-4flnA:
undetectable
2qx6B-4flnA:
undetectable		 2qx6A-4flnA:
18.68
2qx6B-4flnA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLD_A_ASCA130_0
(CYTOCHROME C')		 4fln PROTEASE DO-LIKE 2,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 5 ALA A 283
GLY A 144
CYH A 160
HIS A 159
 None
 1.32A 2yldA-4flnA:
undetectable		 2yldA-4flnA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFL_A_5CHA693_1
(LACTOTRANSFERRIN)		 4fln PROTEASE DO-LIKE 2,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 4 THR A 235
VAL A 298
GLY A 269
THR A 156
 None
 1.09A 3cflA-4flnA:
undetectable		 3cflA-4flnA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_1
(PROTEASE)		 4fln PROTEASE DO-LIKE 2,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 10 ASP A 218
VAL A 220
ILE A 280
ILE A 299
ILE A 259
 None
 0.97A 3nu6A-4flnA:
undetectable		 3nu6A-4flnA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_1
(PROTEASE)		 4fln PROTEASE DO-LIKE 2,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 10 ASP A 218
VAL A 220
ILE A 280
ILE A 299
ILE A 259
 None
 1.02A 3nujA-4flnA:
undetectable		 3nujA-4flnA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_A_XRAA233_2
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4fln PROTEASE DO-LIKE 2,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 5 VAL A 421
PHE A 371
ILE A 407
PHE A 392
 None
 0.88A 3owxB-4flnA:
undetectable		 3owxB-4flnA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4fln PROTEASE DO-LIKE 2,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 HIS A 159
VAL A 187
ASP A 190
GLY A 266
SER A 268
 None
 0.57A 3sueC-4flnA:
5.0		 3sueC-4flnA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4fln PROTEASE DO-LIKE 2,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 HIS A 159
VAL A 187
ASP A 190
GLY A 266
SER A 268
 None
 0.53A 3sufD-4flnA:
12.0		 3sufD-4flnA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VKX_A_T3A301_1
(PROLIFERATING CELL
NUCLEAR ANTIGEN)		 4fln PROTEASE DO-LIKE 2,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 6 LEU A 455
PRO A 450
GLN A 483
PRO A 430
 None
 1.14A 3vkxA-4flnA:
undetectable		 3vkxA-4flnA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZWI_A_ASCA156_0
(CYTOCHROME C')		 4fln PROTEASE DO-LIKE 2,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 5 ALA A 283
GLY A 144
CYH A 160
HIS A 159
 None
 1.32A 3zwiA-4flnA:
undetectable		 3zwiA-4flnA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_B_IMNB201_1
(TRANSTHYRETIN)		 4fln PROTEASE DO-LIKE 2,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 8 THR A 235
ALA A 261
SER A 240
VAL A 222
 None
 0.83A 4ik7B-4flnA:
undetectable		 4ik7B-4flnA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_E_CAME502_0
(CAMPHOR
5-MONOOXYGENASE)		 4fln PROTEASE DO-LIKE 2,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 5 PHE A 384
TYR A 394
THR A 245
ILE A 242
 None
 1.22A 4jx1E-4flnA:
undetectable		 4jx1E-4flnA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_B_017B101_1
(PROTEASE)		 4fln PROTEASE DO-LIKE 2,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 11 ASP A 218
VAL A 220
ILE A 280
ILE A 299
ILE A 259
 None
 0.96A 4njtA-4flnA:
undetectable		 4njtA-4flnA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4fln PROTEASE DO-LIKE 2,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 8 LEU A 395
VAL A 244
LEU A 255
ILE A 390
 None
 0.79A 4r38A-4flnA:
undetectable		 4r38A-4flnA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_B_478B101_1
(HIV-1 PROTEASE)		 4fln PROTEASE DO-LIKE 2,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 11 ASP A 218
VAL A 220
ILE A 280
ILE A 299
ILE A 259
 None
 0.95A 4rvjA-4flnA:
undetectable		 4rvjA-4flnA:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_D_478D101_1
(HIV-1 PROTEASE)		 4fln PROTEASE DO-LIKE 2,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 11 ASP A 218
VAL A 220
ILE A 280
ILE A 299
ILE A 259
 None
 0.96A 4rvjC-4flnA:
undetectable		 4rvjC-4flnA:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_2_BEZ2801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4fln PROTEASE DO-LIKE 2,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 4 LEU A 524
ARG A 567
ILE A 525
ILE A 441
 None
 1.28A 5dzk2-4flnA:
undetectable
5dzkM-4flnA:
undetectable
5dzkN-4flnA:
undetectable		 5dzk2-4flnA:
2.30
5dzkM-4flnA:
16.35
5dzkN-4flnA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_V_BEZV801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4fln PROTEASE DO-LIKE 2,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 4 ILE A 525
ILE A 441
ARG A 567
LEU A 524
 None
 1.18A 5dzkh-4flnA:
undetectable
5dzkn-4flnA:
undetectable
5dzkv-4flnA:
undetectable		 5dzkh-4flnA:
16.35
5dzkn-4flnA:
16.35
5dzkv-4flnA:
2.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JO9_A_SORA302_0
(RIBITOL
2-DEHYDROGENASE)		 4fln PROTEASE DO-LIKE 2,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 GLY A 270
PRO A 271
VAL A 222
PHE A 147
LEU A 155
 None
 1.20A 5jo9A-4flnA:
undetectable		 5jo9A-4flnA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 4fln PROTEASE DO-LIKE 2,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 9 LEU A 327
VAL A 325
VAL A 349
ILE A 409
ILE A 407
 None
 1.24A 5yf9X-4flnA:
undetectable		 5yf9X-4flnA:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_0
(NS3 PROTEASE)		 4fln PROTEASE DO-LIKE 2,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 HIS A 159
VAL A 187
ASP A 190
GLY A 266
SER A 268
 None
 0.60A 6c2mC-4flnA:
5.8		 6c2mC-4flnA:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4fln PROTEASE DO-LIKE 2,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 6 SER A 452
TYR A 130
ASP A 434
GLN A 483
 None
 1.39A 6djzA-4flnA:
undetectable		 6djzA-4flnA:
18.68