SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4flx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_B_SAMB105_0
(PROTEIN (MET
REPRESSOR))		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		5 / 11 GLU A 376
GLU A 378
LEU A 381
ALA A 501
GLY A 499
 GLU  A 376 ( 0.6A)
GLU  A 378 ( 0.6A)
LEU  A 381 ( 0.6A)
ALA  A 501 ( 0.0A)
GLY  A 499 ( 0.0A)
 1.23A 1cmaA-4flxA:
undetectable
1cmaB-4flxA:
undetectable		 1cmaA-4flxA:
10.19
1cmaB-4flxA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4002_1
(SERUM ALBUMIN)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		4 / 6 PHE A 258
LEU A 322
VAL A 278
VAL A 263
 PHE  A 258 ( 1.3A)
LEU  A 322 ( 0.6A)
VAL  A 278 ( 0.6A)
VAL  A 263 ( 0.6A)
 0.89A 1e7aB-4flxA:
undetectable		 1e7aB-4flxA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2200_0
(PROTEIN (METHIONINE
REPRESSOR))		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		5 / 12 ALA A 501
GLY A 499
GLU A 376
GLU A 378
LEU A 381
 ALA  A 501 ( 0.0A)
GLY  A 499 ( 0.0A)
GLU  A 376 ( 0.6A)
GLU  A 378 ( 0.6A)
LEU  A 381 ( 0.6A)
 1.22A 1mj2A-4flxA:
undetectable
1mj2B-4flxA:
undetectable		 1mj2A-4flxA:
10.36
1mj2B-4flxA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_C_SAMC200_0
(METHIONINE REPRESSOR)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		5 / 12 ALA A 501
GLY A 499
GLU A 376
GLU A 378
LEU A 381
 ALA  A 501 ( 0.0A)
GLY  A 499 ( 0.0A)
GLU  A 376 ( 0.6A)
GLU  A 378 ( 0.6A)
LEU  A 381 ( 0.6A)
 1.27A 1mjoC-4flxA:
undetectable
1mjoD-4flxA:
undetectable		 1mjoC-4flxA:
10.36
1mjoD-4flxA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_C_SAMC199_0
(METHIONINE REPRESSOR)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		5 / 10 GLU A 376
GLU A 378
LEU A 381
ALA A 501
GLY A 499
 GLU  A 376 ( 0.6A)
GLU  A 378 ( 0.6A)
LEU  A 381 ( 0.6A)
ALA  A 501 ( 0.0A)
GLY  A 499 ( 0.0A)
 1.22A 1mjqC-4flxA:
undetectable
1mjqD-4flxA:
undetectable		 1mjqC-4flxA:
10.36
1mjqD-4flxA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_I_SAMI199_0
(METHIONINE REPRESSOR)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		5 / 11 GLU A 376
GLU A 378
LEU A 381
ALA A 501
GLY A 499
 GLU  A 376 ( 0.6A)
GLU  A 378 ( 0.6A)
LEU  A 381 ( 0.6A)
ALA  A 501 ( 0.0A)
GLY  A 499 ( 0.0A)
 1.21A 1mjqI-4flxA:
undetectable
1mjqJ-4flxA:
undetectable		 1mjqI-4flxA:
10.36
1mjqJ-4flxA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK2_A_ACAA91_1
(TISSUE-TYPE
PLASMINOGEN
ACTIVATOR)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		4 / 8 TYR A 538
ASP A 540
ASP A 542
LEU A 608
 TYR  A 538 ( 1.3A)
ASP  A 540 (-0.5A)
ASP  A 542 ( 0.5A)
LEU  A 608 ( 0.5A)
 1.19A 1pk2A-4flxA:
undetectable		 1pk2A-4flxA:
6.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_C_CHDC3271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		4 / 8 ARG A 266
LEU A 352
PHE A 356
LEU A 333
 ARG  A 266 ( 0.6A)
LEU  A 352 ( 0.6A)
PHE  A 356 ( 1.3A)
LEU  A 333 ( 0.6A)
 0.91A 1v54C-4flxA:
2.6
1v54J-4flxA:
undetectable		 1v54C-4flxA:
13.49
1v54J-4flxA:
6.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		4 / 8 ARG A 266
LEU A 352
PHE A 356
LEU A 333
 ARG  A 266 ( 0.6A)
LEU  A 352 ( 0.6A)
PHE  A 356 ( 1.3A)
LEU  A 333 ( 0.6A)
 0.91A 1v54P-4flxA:
undetectable
1v54W-4flxA:
undetectable		 1v54P-4flxA:
13.49
1v54W-4flxA:
6.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_C_CHDC3271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		4 / 7 ARG A 266
LEU A 352
PHE A 356
LEU A 333
 ARG  A 266 ( 0.6A)
LEU  A 352 ( 0.6A)
PHE  A 356 ( 1.3A)
LEU  A 333 ( 0.6A)
 0.95A 1v55C-4flxA:
2.6
1v55J-4flxA:
undetectable		 1v55C-4flxA:
13.49
1v55J-4flxA:
6.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XQL_A_4AXA605_1
(ALANINE RACEMASE)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		4 / 8 LYS A 592
TYR A 594
ARG A 407
TYR A 545
 LYS  A 592 (-0.0A)
TYR  A 594 (-1.3A)
ARG  A 407 ( 0.6A)
TYR  A 545 ( 1.3A)
 1.35A 1xqlA-4flxA:
undetectable
1xqlB-4flxA:
undetectable		 1xqlA-4flxA:
21.34
1xqlB-4flxA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XQL_B_4AXB505_1
(ALANINE RACEMASE)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		4 / 8 LYS A 592
TYR A 594
ARG A 407
TYR A 545
 LYS  A 592 (-0.0A)
TYR  A 594 (-1.3A)
ARG  A 407 ( 0.6A)
TYR  A 545 ( 1.3A)
 1.39A 1xqlA-4flxA:
undetectable
1xqlB-4flxA:
undetectable		 1xqlA-4flxA:
21.34
1xqlB-4flxA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		4 / 8 ARG A 266
LEU A 352
PHE A 356
LEU A 333
 ARG  A 266 ( 0.6A)
LEU  A 352 ( 0.6A)
PHE  A 356 ( 1.3A)
LEU  A 333 ( 0.6A)
 0.91A 2dyrP-4flxA:
2.6
2dyrW-4flxA:
undetectable		 2dyrP-4flxA:
13.49
2dyrW-4flxA:
6.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_P_CHDP310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		4 / 7 ARG A 266
LEU A 352
PHE A 356
LEU A 333
 ARG  A 266 ( 0.6A)
LEU  A 352 ( 0.6A)
PHE  A 356 ( 1.3A)
LEU  A 333 ( 0.6A)
 0.98A 2dysP-4flxA:
2.6
2dysW-4flxA:
undetectable		 2dysP-4flxA:
13.49
2dysW-4flxA:
6.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		4 / 7 ARG A 266
LEU A 352
PHE A 356
LEU A 333
 ARG  A 266 ( 0.6A)
LEU  A 352 ( 0.6A)
PHE  A 356 ( 1.3A)
LEU  A 333 ( 0.6A)
 0.94A 2eijC-4flxA:
2.6
2eijJ-4flxA:
undetectable		 2eijC-4flxA:
13.49
2eijJ-4flxA:
6.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		4 / 7 ARG A 266
LEU A 352
PHE A 356
LEU A 333
 ARG  A 266 ( 0.6A)
LEU  A 352 ( 0.6A)
PHE  A 356 ( 1.3A)
LEU  A 333 ( 0.6A)
 0.95A 2eikC-4flxA:
2.6
2eikJ-4flxA:
undetectable		 2eikC-4flxA:
13.49
2eikJ-4flxA:
6.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		4 / 7 ARG A 266
LEU A 352
PHE A 356
LEU A 333
 ARG  A 266 ( 0.6A)
LEU  A 352 ( 0.6A)
PHE  A 356 ( 1.3A)
LEU  A 333 ( 0.6A)
 0.97A 2eimP-4flxA:
2.6
2eimW-4flxA:
undetectable		 2eimP-4flxA:
13.49
2eimW-4flxA:
6.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		4 / 7 ARG A 266
LEU A 352
PHE A 356
LEU A 333
 ARG  A 266 ( 0.6A)
LEU  A 352 ( 0.6A)
PHE  A 356 ( 1.3A)
LEU  A 333 ( 0.6A)
 0.99A 2einC-4flxA:
2.4
2einJ-4flxA:
undetectable		 2einC-4flxA:
13.49
2einJ-4flxA:
6.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		4 / 6 ARG A 266
LEU A 352
PHE A 356
LEU A 333
 ARG  A 266 ( 0.6A)
LEU  A 352 ( 0.6A)
PHE  A 356 ( 1.3A)
LEU  A 333 ( 0.6A)
 1.04A 2einP-4flxA:
2.4
2einW-4flxA:
undetectable		 2einP-4flxA:
13.49
2einW-4flxA:
6.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		4 / 6 LEU A 650
VAL A 636
VAL A 741
ILE A 642
 LEU  A 650 ( 0.6A)
VAL  A 636 ( 0.5A)
VAL  A 741 ( 0.5A)
ILE  A 642 ( 0.6A)
 0.90A 2hyyA-4flxA:
undetectable		 2hyyA-4flxA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		4 / 6 LEU A 650
VAL A 636
VAL A 741
ILE A 642
 LEU  A 650 ( 0.6A)
VAL  A 636 ( 0.5A)
VAL  A 741 ( 0.5A)
ILE  A 642 ( 0.6A)
 0.84A 2hyyB-4flxA:
undetectable		 2hyyB-4flxA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_2
(ESTROGEN RECEPTOR)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		4 / 5 LEU A 232
ASP A 235
LEU A 138
HIS A 257
 LEU  A 232 ( 0.5A)
ASP  A 235 ( 0.5A)
LEU  A 138 ( 0.5A)
HIS  A 257 ( 1.0A)
 1.22A 2jfaA-4flxA:
undetectable		 2jfaA-4flxA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_0
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		5 / 12 GLY A 400
TYR A 583
GLY A 586
TRP A 398
GLU A 554
 GLY  A 400 ( 0.0A)
TYR  A 583 ( 1.3A)
GLY  A 586 ( 0.0A)
TRP  A 398 ( 0.5A)
GLU  A 554 ( 0.5A)
 1.02A 2plwA-4flxA:
undetectable		 2plwA-4flxA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1104_0
(FERROCHELATASE)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		3 / 3 LEU A 571
PRO A 572
LEU A 575
 LEU  A 571 ( 0.5A)
PRO  A 572 ( 1.1A)
LEU  A 575 ( 0.6A)
 0.47A 2qd5B-4flxA:
undetectable		 2qd5B-4flxA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_2
(ESTROGEN RECEPTOR)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		4 / 5 LEU A 232
ASP A 235
LEU A 138
HIS A 257
 LEU  A 232 ( 0.5A)
ASP  A 235 ( 0.5A)
LEU  A 138 ( 0.5A)
HIS  A 257 ( 1.0A)
 1.23A 2qxsA-4flxA:
undetectable		 2qxsA-4flxA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_2
(ESTROGEN RECEPTOR)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		4 / 5 LEU A 232
ASP A 235
LEU A 138
HIS A 257
 LEU  A 232 ( 0.5A)
ASP  A 235 ( 0.5A)
LEU  A 138 ( 0.5A)
HIS  A 257 ( 1.0A)
 1.20A 2qxsB-4flxA:
undetectable		 2qxsB-4flxA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YZQ_A_SAMA6075_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		5 / 12 ILE A 256
ASP A   4
VAL A 205
ILE A 206
GLU A 251
 ILE  A 256 ( 0.7A)
ASP  A   4 ( 0.6A)
VAL  A 205 ( 0.5A)
ILE  A 206 ( 0.7A)
GLU  A 251 ( 0.6A)
 1.16A 2yzqA-4flxA:
undetectable		 2yzqA-4flxA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		3 / 3 ASP A 212
PHE A 216
LEU A 220
 ASP  A 212 ( 0.6A)
PHE  A 216 ( 1.3A)
LEU  A 220 ( 0.6A)
 0.69A 2zi9A-4flxA:
undetectable		 2zi9A-4flxA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		3 / 3 SER A 493
GLU A 330
ASP A 259
 SER  A 493 ( 0.0A)
GLU  A 330 ( 0.5A)
ASP  A 259 ( 0.6A)
 0.71A 2zulA-4flxA:
undetectable		 2zulA-4flxA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		4 / 7 ARG A 266
LEU A 352
PHE A 356
LEU A 333
 ARG  A 266 ( 0.6A)
LEU  A 352 ( 0.6A)
PHE  A 356 ( 1.3A)
LEU  A 333 ( 0.6A)
 0.96A 2zxwC-4flxA:
2.6
2zxwJ-4flxA:
undetectable		 2zxwC-4flxA:
13.49
2zxwJ-4flxA:
6.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		4 / 6 ARG A 266
LEU A 352
PHE A 356
LEU A 333
 ARG  A 266 ( 0.6A)
LEU  A 352 ( 0.6A)
PHE  A 356 ( 1.3A)
LEU  A 333 ( 0.6A)
 0.97A 2zxwP-4flxA:
2.6
2zxwW-4flxA:
undetectable		 2zxwP-4flxA:
13.49
2zxwW-4flxA:
6.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		4 / 6 ARG A 266
LEU A 352
PHE A 356
LEU A 333
 ARG  A 266 ( 0.6A)
LEU  A 352 ( 0.6A)
PHE  A 356 ( 1.3A)
LEU  A 333 ( 0.6A)
 0.86A 3abkP-4flxA:
undetectable
3abkW-4flxA:
undetectable		 3abkP-4flxA:
13.49
3abkW-4flxA:
6.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		4 / 6 ARG A 266
LEU A 352
PHE A 356
LEU A 333
 ARG  A 266 ( 0.6A)
LEU  A 352 ( 0.6A)
PHE  A 356 ( 1.3A)
LEU  A 333 ( 0.6A)
 0.91A 3ag1C-4flxA:
2.5
3ag1J-4flxA:
undetectable		 3ag1C-4flxA:
13.49
3ag1J-4flxA:
6.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		4 / 7 ARG A 266
LEU A 352
PHE A 356
LEU A 333
 ARG  A 266 ( 0.6A)
LEU  A 352 ( 0.6A)
PHE  A 356 ( 1.3A)
LEU  A 333 ( 0.6A)
 0.95A 3ag2C-4flxA:
2.6		 3ag2C-4flxA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		4 / 7 ARG A 266
LEU A 352
PHE A 356
LEU A 333
 ARG  A 266 ( 0.6A)
LEU  A 352 ( 0.6A)
PHE  A 356 ( 1.3A)
LEU  A 333 ( 0.6A)
 0.93A 3ag2P-4flxA:
2.6
3ag2W-4flxA:
undetectable		 3ag2P-4flxA:
13.49
3ag2W-4flxA:
6.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		4 / 8 ARG A 266
LEU A 352
PHE A 356
LEU A 333
 ARG  A 266 ( 0.6A)
LEU  A 352 ( 0.6A)
PHE  A 356 ( 1.3A)
LEU  A 333 ( 0.6A)
 0.90A 3ag4C-4flxA:
2.6
3ag4J-4flxA:
undetectable		 3ag4C-4flxA:
13.49
3ag4J-4flxA:
6.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		4 / 7 ARG A 266
LEU A 352
PHE A 356
LEU A 333
 ARG  A 266 ( 0.6A)
LEU  A 352 ( 0.6A)
PHE  A 356 ( 1.3A)
LEU  A 333 ( 0.6A)
 0.89A 3ag4P-4flxA:
2.6
3ag4W-4flxA:
undetectable		 3ag4P-4flxA:
13.49
3ag4W-4flxA:
6.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		4 / 7 ARG A 266
LEU A 352
PHE A 356
LEU A 333
 ARG  A 266 ( 0.6A)
LEU  A 352 ( 0.6A)
PHE  A 356 ( 1.3A)
LEU  A 333 ( 0.6A)
 0.92A 3asnC-4flxA:
2.6
3asnJ-4flxA:
undetectable		 3asnC-4flxA:
13.49
3asnJ-4flxA:
6.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		4 / 7 ARG A 266
LEU A 352
PHE A 356
LEU A 333
 ARG  A 266 ( 0.6A)
LEU  A 352 ( 0.6A)
PHE  A 356 ( 1.3A)
LEU  A 333 ( 0.6A)
 0.91A 3asnP-4flxA:
2.4
3asnW-4flxA:
undetectable		 3asnP-4flxA:
13.49
3asnW-4flxA:
6.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_P_CHDP1271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		4 / 7 ARG A 266
LEU A 352
PHE A 356
LEU A 333
 ARG  A 266 ( 0.6A)
LEU  A 352 ( 0.6A)
PHE  A 356 ( 1.3A)
LEU  A 333 ( 0.6A)
 0.91A 3asoP-4flxA:
2.6
3asoW-4flxA:
undetectable		 3asoP-4flxA:
13.49
3asoW-4flxA:
6.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		3 / 3 SER A 493
GLU A 330
ASP A 259
 SER  A 493 ( 0.0A)
GLU  A 330 ( 0.5A)
ASP  A 259 ( 0.6A)
 0.72A 3dmhA-4flxA:
undetectable		 3dmhA-4flxA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGX_A_SALA102_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		4 / 7 VAL A 682
ILE A 702
TYR A 701
ILE A 717
 VAL  A 682 ( 0.6A)
ILE  A 702 ( 0.7A)
TYR  A 701 ( 1.3A)
ILE  A 717 ( 0.7A)
 1.00A 3hgxA-4flxA:
1.6		 3hgxA-4flxA:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		4 / 6 LEU A 650
VAL A 636
VAL A 741
ILE A 642
 LEU  A 650 ( 0.6A)
VAL  A 636 ( 0.5A)
VAL  A 741 ( 0.5A)
ILE  A 642 ( 0.6A)
 0.82A 3k5vA-4flxA:
undetectable		 3k5vA-4flxA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		4 / 6 LEU A 650
VAL A 636
VAL A 741
ILE A 642
 LEU  A 650 ( 0.6A)
VAL  A 636 ( 0.5A)
VAL  A 741 ( 0.5A)
ILE  A 642 ( 0.6A)
 0.87A 3k5vB-4flxA:
undetectable		 3k5vB-4flxA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A2000_1
(P38A)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		5 / 12 ASP A   6
ILE A  18
VAL A 344
ALA A 117
TYR A 120
 ASP  A   6 (-0.5A)
ILE  A  18 ( 0.5A)
VAL  A 344 ( 0.5A)
ALA  A 117 ( 0.0A)
TYR  A 120 ( 1.3A)
 1.25A 3ohtA-4flxA:
2.2
3ohtB-4flxA:
undetectable		 3ohtA-4flxA:
19.16
3ohtB-4flxA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		3 / 3 LEU A 571
PRO A 572
LEU A 575
 LEU  A 571 ( 0.5A)
PRO  A 572 ( 1.1A)
LEU  A 575 ( 0.6A)
 0.46A 3w1wB-4flxA:
undetectable		 3w1wB-4flxA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		4 / 6 ARG A 266
LEU A 352
PHE A 356
LEU A 333
 ARG  A 266 ( 0.6A)
LEU  A 352 ( 0.6A)
PHE  A 356 ( 1.3A)
LEU  A 333 ( 0.6A)
 0.92A 3wg7C-4flxA:
2.6
3wg7J-4flxA:
undetectable		 3wg7C-4flxA:
13.49
3wg7J-4flxA:
6.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		4 / 6 ARG A 266
LEU A 352
PHE A 356
LEU A 333
 ARG  A 266 ( 0.6A)
LEU  A 352 ( 0.6A)
PHE  A 356 ( 1.3A)
LEU  A 333 ( 0.6A)
 0.89A 3wg7P-4flxA:
2.4
3wg7W-4flxA:
undetectable		 3wg7P-4flxA:
13.49
3wg7W-4flxA:
6.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		4 / 7 ARG A 266
LEU A 352
PHE A 356
LEU A 333
 ARG  A 266 ( 0.6A)
LEU  A 352 ( 0.6A)
PHE  A 356 ( 1.3A)
LEU  A 333 ( 0.6A)
 0.89A 3x2qC-4flxA:
2.7
3x2qJ-4flxA:
undetectable		 3x2qC-4flxA:
13.49
3x2qJ-4flxA:
6.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		4 / 7 ARG A 266
LEU A 352
PHE A 356
LEU A 333
 ARG  A 266 ( 0.6A)
LEU  A 352 ( 0.6A)
PHE  A 356 ( 1.3A)
LEU  A 333 ( 0.6A)
 0.90A 3x2qP-4flxA:
undetectable
3x2qW-4flxA:
undetectable		 3x2qP-4flxA:
13.49
3x2qW-4flxA:
6.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		5 / 9 LEU A 322
ILE A 198
LEU A 194
ILE A 160
ILE A 142
 LEU  A 322 ( 0.6A)
ILE  A 198 ( 0.7A)
LEU  A 194 ( 0.5A)
ILE  A 160 ( 0.7A)
ILE  A 142 (-0.7A)
 1.25A 3zosB-4flxA:
undetectable		 3zosB-4flxA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		5 / 11 GLN A 665
PHE A 152
GLY A 696
ALA A 215
GLY A 211
 GLN  A 665 ( 0.6A)
PHE  A 152 ( 1.3A)
GLY  A 696 ( 0.0A)
ALA  A 215 ( 0.0A)
GLY  A 211 ( 0.0A)
 1.24A 4a6nA-4flxA:
undetectable		 4a6nA-4flxA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		4 / 7 TYR A  37
ILE A 109
ARG A  97
ILE A 100
 TYR  A  37 ( 1.3A)
ILE  A 109 ( 0.6A)
ARG  A  97 ( 0.6A)
ILE  A 100 ( 0.6A)
 0.92A 4lv9B-4flxA:
undetectable		 4lv9B-4flxA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		3 / 3 LEU A 358
ARG A 359
MET A 129
 LEU  A 358 (-0.5A)
ARG  A 359 ( 0.6A)
MET  A 129 ( 0.0A)
 1.00A 4m11C-4flxA:
undetectable		 4m11C-4flxA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		5 / 12 ILE A 666
LEU A 670
GLY A 677
SER A 711
ASN A 735
 ILE  A 666 ( 0.7A)
LEU  A 670 ( 0.5A)
GLY  A 677 ( 0.0A)
SER  A 711 ( 0.0A)
ASN  A 735 ( 0.6A)
 1.20A 4o1eA-4flxA:
undetectable		 4o1eA-4flxA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		5 / 12 ILE A 702
ILE A 666
LEU A 670
GLY A 677
ASN A 735
 ILE  A 702 ( 0.7A)
ILE  A 666 ( 0.7A)
LEU  A 670 ( 0.5A)
GLY  A 677 ( 0.0A)
ASN  A 735 ( 0.6A)
 1.09A 4o1eA-4flxA:
undetectable		 4o1eA-4flxA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA304_1
(CHITOSANASE)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		4 / 4 TYR A 673
ILE A 666
THR A 667
TYR A 701
 TYR  A 673 ( 1.3A)
ILE  A 666 ( 0.7A)
THR  A 667 ( 0.8A)
TYR  A 701 ( 1.3A)
 1.34A 4oltA-4flxA:
undetectable		 4oltA-4flxA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB304_1
(CHITOSANASE)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		4 / 5 TYR A 673
ILE A 666
THR A 667
TYR A 701
 TYR  A 673 ( 1.3A)
ILE  A 666 ( 0.7A)
THR  A 667 ( 0.8A)
TYR  A 701 ( 1.3A)
 1.36A 4oltB-4flxA:
undetectable		 4oltB-4flxA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_D_PARD500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		4 / 8 PHE A 283
THR A 319
GLU A 143
ASP A 141
 PHE  A 283 ( 1.3A)
THR  A 319 ( 0.8A)
GLU  A 143 (-0.6A)
ASP  A 141 (-0.5A)
 0.94A 4qb9D-4flxA:
undetectable		 4qb9D-4flxA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		4 / 8 ILE A 567
PHE A 406
LEU A 577
LEU A 544
 ILE  A 567 ( 0.4A)
PHE  A 406 ( 1.3A)
LEU  A 577 ( 0.5A)
LEU  A 544 ( 0.6A)
 0.90A 4qopC-4flxA:
undetectable		 4qopC-4flxA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA303_1
(CHITOSANASE)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		4 / 6 TYR A 673
ILE A 666
THR A 667
TYR A 701
 TYR  A 673 ( 1.3A)
ILE  A 666 ( 0.7A)
THR  A 667 ( 0.8A)
TYR  A 701 ( 1.3A)
 1.36A 4qwpA-4flxA:
undetectable		 4qwpA-4flxA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_A_15UA301_1
(THROMBIN HEAVY CHAIN)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		5 / 10 TYR A 594
LEU A 596
LEU A 404
ALA A 560
GLY A 581
 TYR  A 594 (-1.3A)
LEU  A 596 ( 0.6A)
LEU  A 404 (-0.6A)
ALA  A 560 ( 0.0A)
GLY  A 581 ( 0.0A)
 1.50A 4rn6A-4flxA:
undetectable		 4rn6A-4flxA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		4 / 7 ARG A 266
LEU A 352
PHE A 356
LEU A 333
 ARG  A 266 ( 0.6A)
LEU  A 352 ( 0.6A)
PHE  A 356 ( 1.3A)
LEU  A 333 ( 0.6A)
 0.95A 5b1bP-4flxA:
2.7
5b1bW-4flxA:
undetectable		 5b1bP-4flxA:
13.49
5b1bW-4flxA:
6.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		5 / 12 GLY A 586
LEU A 397
VAL A 643
GLY A 634
LEU A 596
 GLY  A 586 ( 0.0A)
LEU  A 397 ( 0.5A)
VAL  A 643 ( 0.6A)
GLY  A 634 ( 0.0A)
LEU  A 596 ( 0.6A)
 1.18A 5hg0A-4flxA:
undetectable		 5hg0A-4flxA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		4 / 8 ILE A 228
GLY A 227
PHE A 152
PHE A 214
 ILE  A 228 ( 0.7A)
GLY  A 227 ( 0.0A)
PHE  A 152 ( 1.3A)
PHE  A 214 ( 1.3A)
 0.94A 5hieD-4flxA:
undetectable		 5hieD-4flxA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQB_D_KAND600_1
(BIFUNCTIONAL AAC/APH)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		5 / 12 ASP A 315
ASP A 141
TYR A 311
GLU A 294
TYR A 291
 ASP  A 315 (-0.5A)
ASP  A 141 (-0.5A)
TYR  A 311 ( 1.3A)
GLU  A 294 ( 0.6A)
TYR  A 291 ( 1.3A)
 1.29A 5iqbD-4flxA:
1.3		 5iqbD-4flxA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQE_B_NMYB600_1
(BIFUNCTIONAL AAC/APH)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		5 / 10 ASP A 315
ASP A 141
TYR A 311
GLU A 294
TYR A 291
 ASP  A 315 (-0.5A)
ASP  A 141 (-0.5A)
TYR  A 311 ( 1.3A)
GLU  A 294 ( 0.6A)
TYR  A 291 ( 1.3A)
 1.46A 5iqeB-4flxA:
2.5		 5iqeB-4flxA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQE_D_NMYD600_1
(BIFUNCTIONAL AAC/APH)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		5 / 12 ASP A 315
ASP A 141
TYR A 311
GLU A 294
TYR A 291
 ASP  A 315 (-0.5A)
ASP  A 141 (-0.5A)
TYR  A 311 ( 1.3A)
GLU  A 294 ( 0.6A)
TYR  A 291 ( 1.3A)
 1.32A 5iqeD-4flxA:
2.5		 5iqeD-4flxA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQG_B_51GB600_1
(BIFUNCTIONAL AAC/APH)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		5 / 10 ASP A 315
ASP A 141
TYR A 311
GLU A 294
TYR A 291
 ASP  A 315 (-0.5A)
ASP  A 141 (-0.5A)
TYR  A 311 ( 1.3A)
GLU  A 294 ( 0.6A)
TYR  A 291 ( 1.3A)
 1.47A 5iqgB-4flxA:
0.0		 5iqgB-4flxA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		4 / 5 ARG A 266
LEU A 352
PHE A 356
LEU A 333
 ARG  A 266 ( 0.6A)
LEU  A 352 ( 0.6A)
PHE  A 356 ( 1.3A)
LEU  A 333 ( 0.6A)
 0.94A 5iy5P-4flxA:
2.6
5iy5W-4flxA:
undetectable		 5iy5P-4flxA:
13.43
5iy5W-4flxA:
6.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_1
(CYTOCHROME P450 3A4)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		5 / 12 ASP A 614
LEU A 745
ILE A 642
ALA A 629
ILE A 603
 ASP  A 614 ( 0.6A)
LEU  A 745 ( 0.5A)
ILE  A 642 ( 0.6A)
ALA  A 629 ( 0.0A)
ILE  A 603 ( 0.6A)
 1.15A 5vc0A-4flxA:
undetectable		 5vc0A-4flxA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		4 / 6 ARG A 266
LEU A 352
PHE A 356
LEU A 333
 ARG  A 266 ( 0.6A)
LEU  A 352 ( 0.6A)
PHE  A 356 ( 1.3A)
LEU  A 333 ( 0.6A)
 0.95A 5w97C-4flxA:
undetectable
5w97J-4flxA:
undetectable		 5w97C-4flxA:
13.49
5w97J-4flxA:
6.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		4 / 6 ARG A 266
LEU A 352
PHE A 356
LEU A 333
 ARG  A 266 ( 0.6A)
LEU  A 352 ( 0.6A)
PHE  A 356 ( 1.3A)
LEU  A 333 ( 0.6A)
 0.90A 5x19P-4flxA:
2.7		 5x19P-4flxA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		4 / 5 ARG A 266
LEU A 352
PHE A 356
LEU A 333
 ARG  A 266 ( 0.6A)
LEU  A 352 ( 0.6A)
PHE  A 356 ( 1.3A)
LEU  A 333 ( 0.6A)
 0.92A 5x1bP-4flxA:
1.3		 5x1bP-4flxA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		4 / 5 ARG A 266
LEU A 352
PHE A 356
LEU A 333
 ARG  A 266 ( 0.6A)
LEU  A 352 ( 0.6A)
PHE  A 356 ( 1.3A)
LEU  A 333 ( 0.6A)
 0.95A 5x1fC-4flxA:
undetectable
5x1fJ-4flxA:
undetectable		 5x1fC-4flxA:
13.49
5x1fJ-4flxA:
6.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_P_CHDP304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		4 / 7 ARG A 266
LEU A 352
PHE A 356
LEU A 333
 ARG  A 266 ( 0.6A)
LEU  A 352 ( 0.6A)
PHE  A 356 ( 1.3A)
LEU  A 333 ( 0.6A)
 0.91A 5x1fP-4flxA:
undetectable
5x1fW-4flxA:
undetectable		 5x1fP-4flxA:
13.49
5x1fW-4flxA:
6.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		4 / 5 ARG A 266
LEU A 352
PHE A 356
LEU A 333
 ARG  A 266 ( 0.6A)
LEU  A 352 ( 0.6A)
PHE  A 356 ( 1.3A)
LEU  A 333 ( 0.6A)
 0.93A 5xdxC-4flxA:
2.6
5xdxJ-4flxA:
undetectable		 5xdxC-4flxA:
13.37
5xdxJ-4flxA:
6.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		4 / 5 ARG A 266
LEU A 352
PHE A 356
LEU A 333
 ARG  A 266 ( 0.6A)
LEU  A 352 ( 0.6A)
PHE  A 356 ( 1.3A)
LEU  A 333 ( 0.6A)
 0.95A 5xdxP-4flxA:
2.6
5xdxW-4flxA:
undetectable		 5xdxP-4flxA:
13.37
5xdxW-4flxA:
6.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_B_LOCB504_2
(TUBULIN BETA CHAIN)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		5 / 12 LEU A 220
LEU A 232
ILE A 191
LYS A 229
ALA A 223
 LEU  A 220 ( 0.6A)
LEU  A 232 ( 0.5A)
ILE  A 191 ( 0.7A)
LYS  A 229 ( 0.0A)
ALA  A 223 ( 0.0A)
 1.00A 5xiwB-4flxA:
undetectable		 5xiwB-4flxA:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		4 / 7 ARG A 266
LEU A 352
PHE A 356
LEU A 333
 ARG  A 266 ( 0.6A)
LEU  A 352 ( 0.6A)
PHE  A 356 ( 1.3A)
LEU  A 333 ( 0.6A)
 0.93A 5z85C-4flxA:
undetectable
5z85J-4flxA:
undetectable		 5z85C-4flxA:
13.49
5z85J-4flxA:
6.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		4 / 7 ARG A 266
LEU A 352
PHE A 356
LEU A 333
 ARG  A 266 ( 0.6A)
LEU  A 352 ( 0.6A)
PHE  A 356 ( 1.3A)
LEU  A 333 ( 0.6A)
 0.88A 5zcoC-4flxA:
2.6
5zcoJ-4flxA:
undetectable		 5zcoC-4flxA:
13.49
5zcoJ-4flxA:
6.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		4 / 7 ARG A 266
LEU A 352
PHE A 356
LEU A 333
 ARG  A 266 ( 0.6A)
LEU  A 352 ( 0.6A)
PHE  A 356 ( 1.3A)
LEU  A 333 ( 0.6A)
 0.91A 5zcqC-4flxA:
undetectable
5zcqJ-4flxA:
undetectable		 5zcqC-4flxA:
13.49
5zcqJ-4flxA:
6.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		4 / 7 ARG A 266
LEU A 352
PHE A 356
LEU A 333
 ARG  A 266 ( 0.6A)
LEU  A 352 ( 0.6A)
PHE  A 356 ( 1.3A)
LEU  A 333 ( 0.6A)
 0.93A 5zcqP-4flxA:
2.6
5zcqW-4flxA:
undetectable		 5zcqP-4flxA:
13.49
5zcqW-4flxA:
6.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNA_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		3 / 3 ARG A 504
LYS A 502
TYR A 497
 ARG  A 504 (-0.6A)
LYS  A 502 ( 0.0A)
TYR  A 497 ( 1.3A)
 1.33A 6gnaA-4flxA:
1.3		 6gnaA-4flxA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNB_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		3 / 3 ARG A 504
LYS A 502
TYR A 497
 ARG  A 504 (-0.6A)
LYS  A 502 ( 0.0A)
TYR  A 497 ( 1.3A)
 1.33A 6gnbA-4flxA:
1.3		 6gnbA-4flxA:
17.55