SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fm9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		 4fm9 DNA TOPOISOMERASE
2-ALPHA
(Homo
sapiens) 		3 / 3 GLN A 933
TYR A 957
ARG A 958
 None
 0.88A 1gtbA-4fm9A:
undetectable		 1gtbA-4fm9A:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KLM_A_SPPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 4fm9 DNA TOPOISOMERASE
2-ALPHA
(Homo
sapiens) 		5 / 11 LEU A 730
LYS A 728
PRO A 716
LEU A 722
PRO A 724
 None
 1.38A 1klmA-4fm9A:
2.8		 1klmA-4fm9A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 4fm9 DNA TOPOISOMERASE
2-ALPHA
(Homo
sapiens) 		4 / 6 TYR A 612
ASP A 832
ASN A 833
GLU A 597
 None
 1.19A 1rjdA-4fm9A:
undetectable		 1rjdA-4fm9A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 4fm9 DNA TOPOISOMERASE
2-ALPHA
(Homo
sapiens) 		4 / 6 TYR A 612
ASP A 832
ASN A 833
GLU A 597
 None
 1.20A 1rjdB-4fm9A:
undetectable		 1rjdB-4fm9A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 4fm9 DNA TOPOISOMERASE
2-ALPHA
(Homo
sapiens) 		4 / 6 TYR A 612
ASP A 832
ASN A 833
GLU A 597
 None
 1.22A 1rjdC-4fm9A:
undetectable		 1rjdC-4fm9A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AM9_A_TESA1000_1
(ANDROGEN RECEPTOR)		 4fm9 DNA TOPOISOMERASE
2-ALPHA
(Homo
sapiens) 		5 / 12 ASN A 782
LEU A 771
GLN A 726
MET A 847
LEU A 817
 None
 1.41A 2am9A-4fm9A:
undetectable		 2am9A-4fm9A:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4fm9 DNA TOPOISOMERASE
2-ALPHA
(Homo
sapiens) 		5 / 11 ALA A 447
LEU A 457
ASP A 443
LEU A 441
ILE A 435
 None
 1.05A 2w9sA-4fm9A:
undetectable		 2w9sA-4fm9A:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4fm9 DNA TOPOISOMERASE
2-ALPHA
(Homo
sapiens) 		4 / 6 TYR A 907
PRO A 865
ILE A1018
ASN A 905
 None
 1.25A 2wekB-4fm9A:
undetectable		 2wekB-4fm9A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_B_J01B600_1
(ORF12)		 4fm9 DNA TOPOISOMERASE
2-ALPHA
(Homo
sapiens) 		5 / 11 ALA A 752
THR A 732
ALA A 748
GLY A 749
SER A 750
 None
 1.21A 2xfsB-4fm9A:
undetectable		 2xfsB-4fm9A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1437_1
(ORF12)		 4fm9 DNA TOPOISOMERASE
2-ALPHA
(Homo
sapiens) 		5 / 11 SER A 750
THR A 732
ALA A 752
GLY A 749
ALA A 748
 None
 1.29A 2xh9A-4fm9A:
undetectable		 2xh9A-4fm9A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_B_J01B1437_1
(ORF12)		 4fm9 DNA TOPOISOMERASE
2-ALPHA
(Homo
sapiens) 		5 / 10 SER A 750
THR A 732
ALA A 752
GLY A 749
ALA A 748
 None
 1.32A 2xh9B-4fm9A:
undetectable		 2xh9B-4fm9A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA1_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 4fm9 DNA TOPOISOMERASE
2-ALPHA
(Homo
sapiens) 		3 / 3 GLY A 796
ASP A 799
SER A 800
 None
 0.51A 3brfA-4fm9A:
undetectable		 3brfA-4fm9A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 4fm9 DNA TOPOISOMERASE
2-ALPHA
(Homo
sapiens) 		5 / 12 THR A 460
THR A 540
LEU A 553
ILE A 513
ILE A 510
 None
 1.23A 3gwxA-4fm9A:
undetectable		 3gwxA-4fm9A:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4fm9 DNA TOPOISOMERASE
2-ALPHA
(Homo
sapiens) 		6 / 12 GLY A 551
PHE A 706
SER A 707
ASP A 545
ILE A 549
LEU A 552
 None
 1.49A 3iv6A-4fm9A:
undetectable		 3iv6A-4fm9A:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_B_SAMB301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4fm9 DNA TOPOISOMERASE
2-ALPHA
(Homo
sapiens) 		5 / 12 GLY A 551
PHE A 706
ASP A 545
ILE A 549
LEU A 552
 None
 1.20A 3iv6B-4fm9A:
undetectable		 3iv6B-4fm9A:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_D_SAMD301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4fm9 DNA TOPOISOMERASE
2-ALPHA
(Homo
sapiens) 		6 / 12 GLY A 551
PHE A 706
SER A 707
ASP A 545
ILE A 549
LEU A 552
 None
 1.46A 3iv6D-4fm9A:
undetectable		 3iv6D-4fm9A:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4fm9 DNA TOPOISOMERASE
2-ALPHA
(Homo
sapiens) 		5 / 10 VAL A 483
ASP A 442
LEU A 616
THR A 620
ARG A 478
 None
 1.24A 3j6gB-4fm9A:
3.3		 3j6gB-4fm9A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_D_TA1D502_1
(TUBULIN BETA CHAIN)		 4fm9 DNA TOPOISOMERASE
2-ALPHA
(Homo
sapiens) 		5 / 10 VAL A 483
ASP A 442
LEU A 616
THR A 620
ARG A 478
 None
 1.24A 3j6gD-4fm9A:
3.3		 3j6gD-4fm9A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_F_TA1F502_1
(TUBULIN BETA CHAIN)		 4fm9 DNA TOPOISOMERASE
2-ALPHA
(Homo
sapiens) 		5 / 10 VAL A 483
ASP A 442
LEU A 616
THR A 620
ARG A 478
 None
 1.25A 3j6gF-4fm9A:
3.3		 3j6gF-4fm9A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_H_TA1H502_1
(TUBULIN BETA CHAIN)		 4fm9 DNA TOPOISOMERASE
2-ALPHA
(Homo
sapiens) 		5 / 10 VAL A 483
ASP A 442
LEU A 616
THR A 620
ARG A 478
 None
 1.25A 3j6gH-4fm9A:
3.6		 3j6gH-4fm9A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_J_TA1J502_1
(TUBULIN BETA CHAIN)		 4fm9 DNA TOPOISOMERASE
2-ALPHA
(Homo
sapiens) 		5 / 10 VAL A 483
ASP A 442
LEU A 616
THR A 620
ARG A 478
 None
 1.24A 3j6gJ-4fm9A:
4.1		 3j6gJ-4fm9A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_L_TA1L502_1
(TUBULIN BETA CHAIN)		 4fm9 DNA TOPOISOMERASE
2-ALPHA
(Homo
sapiens) 		5 / 10 VAL A 483
ASP A 442
LEU A 616
THR A 620
ARG A 478
 None
 1.24A 3j6gL-4fm9A:
3.3		 3j6gL-4fm9A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_N_TA1N502_1
(TUBULIN BETA CHAIN)		 4fm9 DNA TOPOISOMERASE
2-ALPHA
(Homo
sapiens) 		5 / 10 VAL A 483
ASP A 442
LEU A 616
THR A 620
ARG A 478
 None
 1.24A 3j6gN-4fm9A:
3.3		 3j6gN-4fm9A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_P_TA1P502_1
(TUBULIN BETA CHAIN)		 4fm9 DNA TOPOISOMERASE
2-ALPHA
(Homo
sapiens) 		5 / 10 VAL A 483
ASP A 442
LEU A 616
THR A 620
ARG A 478
 None
 1.24A 3j6gP-4fm9A:
3.3		 3j6gP-4fm9A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_R_TA1R502_1
(TUBULIN BETA CHAIN)		 4fm9 DNA TOPOISOMERASE
2-ALPHA
(Homo
sapiens) 		5 / 10 VAL A 483
ASP A 442
LEU A 616
THR A 620
ARG A 478
 None
 1.24A 3j6gR-4fm9A:
3.2		 3j6gR-4fm9A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 4fm9 DNA TOPOISOMERASE
2-ALPHA
(Homo
sapiens) 		5 / 12 GLY A 448
GLY A 449
VAL A 483
ASP A 442
ASP A 446
 None
 1.06A 3m6vA-4fm9A:
undetectable		 3m6vA-4fm9A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 4fm9 DNA TOPOISOMERASE
2-ALPHA
(Homo
sapiens) 		6 / 12 ALA A 444
GLY A 448
GLY A 449
VAL A 483
ASP A 442
ASP A 446
 None
 1.46A 3m6vB-4fm9A:
undetectable		 3m6vB-4fm9A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU3_B_478B401_1
(PROTEASE)		 4fm9 DNA TOPOISOMERASE
2-ALPHA
(Homo
sapiens) 		5 / 12 LEU A 570
GLY A 534
ILE A 513
GLY A 515
ILE A 536
 None
 0.93A 3nu3A-4fm9A:
undetectable		 3nu3A-4fm9A:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU5_B_478B401_2
(PROTEASE)		 4fm9 DNA TOPOISOMERASE
2-ALPHA
(Homo
sapiens) 		5 / 12 LEU A 570
GLY A 534
ILE A 513
GLY A 515
ILE A 536
 None
 1.02A 3nu5B-4fm9A:
undetectable		 3nu5B-4fm9A:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_2
(HIV-1 PROTEASE)		 4fm9 DNA TOPOISOMERASE
2-ALPHA
(Homo
sapiens) 		5 / 11 ARG A 635
ALA A 469
GLY A 474
VAL A 475
ILE A 458
 None
 1.03A 3oxvD-4fm9A:
undetectable		 3oxvD-4fm9A:
8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_1
(HIV-1 PROTEASE)		 4fm9 DNA TOPOISOMERASE
2-ALPHA
(Homo
sapiens) 		5 / 12 LEU A 570
GLY A 534
ILE A 513
GLY A 515
ILE A 536
 None
 0.90A 3oxxC-4fm9A:
undetectable		 3oxxC-4fm9A:
8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_A_DSFA319_1
(GLR4197 PROTEIN)		 4fm9 DNA TOPOISOMERASE
2-ALPHA
(Homo
sapiens) 		5 / 9 TYR A 518
ILE A 507
ILE A 510
VAL A 493
ILE A 557
 None
 1.44A 3p4wA-4fm9A:
1.7		 3p4wA-4fm9A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_1
(PROTEASE)		 4fm9 DNA TOPOISOMERASE
2-ALPHA
(Homo
sapiens) 		5 / 12 LEU A 570
GLY A 534
ILE A 513
GLY A 515
ILE A 536
 None
 0.98A 3pwrA-4fm9A:
undetectable		 3pwrA-4fm9A:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEO_B_LLTB261_1
(DEOXYCYTIDINE KINASE)		 4fm9 DNA TOPOISOMERASE
2-ALPHA
(Homo
sapiens) 		4 / 7 VAL A 514
LEU A 531
TYR A 522
PHE A 556
 None
 1.02A 3qeoB-4fm9A:
3.2		 3qeoB-4fm9A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_B_ROCB801_2
(PROTEASE)		 4fm9 DNA TOPOISOMERASE
2-ALPHA
(Homo
sapiens) 		5 / 12 LEU A 570
GLY A 534
ILE A 513
GLY A 515
ILE A 536
 None
 1.02A 3tkgB-4fm9A:
undetectable		 3tkgB-4fm9A:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7H_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 4fm9 DNA TOPOISOMERASE
2-ALPHA
(Homo
sapiens) 		3 / 3 ARG A 793
THR A 934
TRP A 931
 None
 1.08A 4d7hA-4fm9A:
undetectable		 4d7hA-4fm9A:
20.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G0V_A_MIXA1301_1
(DNA TOPOISOMERASE
2-BETA)		 4fm9 DNA TOPOISOMERASE
2-ALPHA
(Homo
sapiens) 		4 / 7 GLY A 488
ASN A 504
GLU A 506
MET A 762
 None
 1.01A 4g0vA-4fm9A:
50.0		 4g0vA-4fm9A:
79.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G0V_D_MIXD101_1
(DNA TOPOISOMERASE
2-BETA)		 4fm9 DNA TOPOISOMERASE
2-ALPHA
(Homo
sapiens) 		4 / 6 GLY A 488
ASN A 504
GLU A 506
MET A 762
 None
 1.01A 4g0vB-4fm9A:
49.5		 4g0vB-4fm9A:
79.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_2
(HIV-1 PROTEASE)		 4fm9 DNA TOPOISOMERASE
2-ALPHA
(Homo
sapiens) 		5 / 12 LEU A 570
GLY A 534
ILE A 513
GLY A 515
ILE A 536
 None
 0.92A 4jecB-4fm9A:
undetectable		 4jecB-4fm9A:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KSZ_A_CYSA620_0
(LACTOPEROXIDASE)		 4fm9 DNA TOPOISOMERASE
2-ALPHA
(Homo
sapiens) 		3 / 3 ARG A 713
GLU A 712
PHE A1003
 None
 0.98A 4kszA-4fm9A:
undetectable		 4kszA-4fm9A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD4_C_AOQC4003_1
(CYTOCHROME B)		 4fm9 DNA TOPOISOMERASE
2-ALPHA
(Homo
sapiens) 		5 / 12 PHE A 569
GLY A 534
ILE A 536
LEU A 516
ILE A 507
 None
 1.07A 4pd4C-4fm9A:
undetectable		 4pd4C-4fm9A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4fm9 DNA TOPOISOMERASE
2-ALPHA
(Homo
sapiens) 		5 / 12 LEU A 552
SER A 654
PHE A 653
GLY A 551
GLY A 546
 None
 0.98A 4rzvA-4fm9A:
undetectable		 4rzvA-4fm9A:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UG5_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 4fm9 DNA TOPOISOMERASE
2-ALPHA
(Homo
sapiens) 		3 / 3 ARG A 793
THR A 934
TRP A 931
 None
 1.09A 4ug5A-4fm9A:
undetectable		 4ug5A-4fm9A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGL_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 4fm9 DNA TOPOISOMERASE
2-ALPHA
(Homo
sapiens) 		3 / 3 ARG A 793
THR A 934
TRP A 931
 None
 1.04A 4uglA-4fm9A:
undetectable		 4uglA-4fm9A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6C_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 4fm9 DNA TOPOISOMERASE
2-ALPHA
(Homo
sapiens) 		3 / 3 ARG A 793
THR A 934
TRP A 931
 None
 1.07A 5g6cA-4fm9A:
undetectable		 5g6cA-4fm9A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 4fm9 DNA TOPOISOMERASE
2-ALPHA
(Homo
sapiens) 		5 / 12 VAL A 483
ASP A 442
LEU A 616
THR A 620
ARG A 478
 None
 1.18A 5m5cB-4fm9A:
3.1		 5m5cB-4fm9A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO8_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4fm9 DNA TOPOISOMERASE
2-ALPHA
(Homo
sapiens) 		4 / 6 SER A 601
TRP A 598
PHE A 595
GLU A 597
 None
 1.48A 5uo8A-4fm9A:
undetectable
5uo8B-4fm9A:
undetectable		 5uo8A-4fm9A:
21.14
5uo8B-4fm9A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA402_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4fm9 DNA TOPOISOMERASE
2-ALPHA
(Homo
sapiens) 		5 / 11 SER A 641
HIS A 558
ILE A 699
ASN A 696
ILE A 554
 None
 1.29A 5y80A-4fm9A:
3.3		 5y80A-4fm9A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4fm9 DNA TOPOISOMERASE
2-ALPHA
(Homo
sapiens) 		4 / 7 ILE A 510
VAL A 514
ILE A 536
THR A 456
 None
 0.84A 6cduF-4fm9A:
undetectable
6cduG-4fm9A:
2.6		 6cduF-4fm9A:
17.77
6cduG-4fm9A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH3_A_017A101_1
(PROTEASE)		 4fm9 DNA TOPOISOMERASE
2-ALPHA
(Homo
sapiens) 		5 / 12 LEU A 570
GLY A 534
ILE A 513
GLY A 515
ILE A 536
 None
 0.93A 6dh3B-4fm9A:
undetectable		 6dh3B-4fm9A:
8.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH6_A_017A104_1
(PROTEASE)		 4fm9 DNA TOPOISOMERASE
2-ALPHA
(Homo
sapiens) 		5 / 12 LEU A 570
GLY A 534
ILE A 513
GLY A 515
ILE A 536
 None
 0.88A 6dh6B-4fm9A:
undetectable		 6dh6B-4fm9A:
8.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_1
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 4fm9 DNA TOPOISOMERASE
2-ALPHA
(Homo
sapiens) 		4 / 7 ILE A 501
TRP A 561
HIS A 559
VAL A 493
 None
 1.17A 6j20A-4fm9A:
undetectable		 6j20A-4fm9A:
18.77