SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fmc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4fmc RORF2
(Escherichia
coli) 		5 / 12 LEU A 105
LEU A 143
PRO A 144
ILE A 115
THR A 128
 None
 0.97A 1dhjB-4fmcA:
undetectable		 1dhjB-4fmcA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_1
(ESTROGEN RECEPTOR)		 4fmc RORF2
(Escherichia
coli) 		5 / 12 LEU A  58
LEU A 131
LEU A 130
LEU A  82
LEU A  79
 None
 1.19A 1errB-4fmcA:
undetectable		 1errB-4fmcA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		 4fmc RORF2
(Escherichia
coli) 		6 / 11 ALA A 213
LEU A 210
LEU A 215
LEU A 217
ILE A 260
ALA A 226
 None
 1.17A 1ha2A-4fmcA:
undetectable		 1ha2A-4fmcA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_B_ADNB2002_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 4fmc RORF2
(Escherichia
coli) 		4 / 6 ARG A 387
ASN A 296
PRO A 298
ALA A 299
 None
 1.18A 2ejfB-4fmcA:
undetectable		 2ejfB-4fmcA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_A_ADNA1501_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 4fmc RORF2
(Escherichia
coli) 		4 / 7 ARG A 387
ASN A 296
PRO A 298
ALA A 299
 None
 1.10A 2ejgA-4fmcA:
undetectable		 2ejgA-4fmcA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_2
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 4fmc RORF2
(Escherichia
coli) 		3 / 3 ARG A 138
GLU A 135
GLN A 141
 None
 1.07A 2p16A-4fmcA:
undetectable		 2p16A-4fmcA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_D_BEZD1221_0
(PEROXIREDOXIN 6)		 4fmc RORF2
(Escherichia
coli) 		5 / 8 VAL A  85
PRO A  84
THR A 341
SER A 366
ARG A 387
 None
 1.44A 2v32C-4fmcA:
undetectable
2v32D-4fmcA:
undetectable		 2v32C-4fmcA:
20.55
2v32D-4fmcA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YDO_A_ADNA400_1
(ADENOSINE RECEPTOR
A2A)		 4fmc RORF2
(Escherichia
coli) 		5 / 12 LEU A 163
THR A 321
GLU A 392
ILE A 307
SER A 311
 None
 1.20A 2ydoA-4fmcA:
undetectable		 2ydoA-4fmcA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJ8_C_SPMC500_1
(DIAMINE
ACETYLTRANSFERASE 1)		 4fmc RORF2
(Escherichia
coli) 		4 / 6 LEU A 140
ASP A 146
LEU A 183
HIS A 148
 None
 1.09A 3bj8C-4fmcA:
undetectable
3bj8D-4fmcA:
undetectable		 3bj8C-4fmcA:
17.19
3bj8D-4fmcA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB306_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 4fmc RORF2
(Escherichia
coli) 		4 / 6 THR A 393
THR A 362
LEU A 173
THR A 176
 None
 0.91A 3deuB-4fmcA:
undetectable		 3deuB-4fmcA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG800_0
(GLUTAMATE RECEPTOR 2)		 4fmc RORF2
(Escherichia
coli) 		4 / 6 MET A 358
ASN A 397
LEU A 395
ASP A 162
 None
 1.48A 3lslG-4fmcA:
undetectable		 3lslG-4fmcA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_A_PFLA319_1
(GLR4197 PROTEIN)		 4fmc RORF2
(Escherichia
coli) 		4 / 7 PRO A  84
LEU A 183
TYR A 339
THR A 341
 None
 0.89A 3p50A-4fmcA:
undetectable		 3p50A-4fmcA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_B_PFLB319_1
(GLR4197 PROTEIN)		 4fmc RORF2
(Escherichia
coli) 		4 / 7 PRO A  84
LEU A 183
TYR A 339
THR A 341
 None
 0.89A 3p50B-4fmcA:
undetectable		 3p50B-4fmcA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_C_PFLC319_1
(GLR4197 PROTEIN)		 4fmc RORF2
(Escherichia
coli) 		4 / 7 PRO A  84
LEU A 183
TYR A 339
THR A 341
 None
 0.89A 3p50C-4fmcA:
undetectable		 3p50C-4fmcA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_D_PFLD320_1
(GLR4197 PROTEIN)		 4fmc RORF2
(Escherichia
coli) 		4 / 7 PRO A  84
LEU A 183
TYR A 339
THR A 341
 None
 0.88A 3p50D-4fmcA:
undetectable		 3p50D-4fmcA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_E_PFLE319_1
(GLR4197 PROTEIN)		 4fmc RORF2
(Escherichia
coli) 		4 / 7 PRO A  84
LEU A 183
TYR A 339
THR A 341
 None
 0.89A 3p50E-4fmcA:
undetectable		 3p50E-4fmcA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_A_MTXA604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4fmc RORF2
(Escherichia
coli) 		5 / 12 ALA A  97
LEU A  55
LYS A  56
ILE A 115
LEU A 139
 None
 1.09A 4q0dA-4fmcA:
undetectable		 4q0dA-4fmcA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_B_MTXB604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4fmc RORF2
(Escherichia
coli) 		5 / 12 ALA A  97
LEU A  55
LYS A  56
ILE A 115
LEU A 139
 None
 1.09A 4q0dB-4fmcA:
undetectable		 4q0dB-4fmcA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_E_MTXE604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4fmc RORF2
(Escherichia
coli) 		5 / 12 ALA A  97
LEU A  55
LYS A  56
ILE A 115
LEU A 139
 None
 1.09A 4q0dE-4fmcA:
undetectable		 4q0dE-4fmcA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4fmc RORF2
(Escherichia
coli) 		5 / 11 ALA A  97
LEU A  55
SER A 108
ILE A 115
LEU A 139
 None
 1.16A 4qleB-4fmcA:
undetectable		 4qleB-4fmcA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_B_SALB801_1
(PROTEIN POLYBROMO-1)		 4fmc RORF2
(Escherichia
coli) 		4 / 5 LEU A 384
TYR A 367
ALA A 286
ILE A 338
 None
 1.15A 4y03B-4fmcA:
undetectable		 4y03B-4fmcA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 4fmc RORF2
(Escherichia
coli) 		5 / 12 VAL A 340
LEU A 234
ALA A 290
SER A 342
PHE A 291
 None
 1.28A 5hnzB-4fmcA:
undetectable		 5hnzB-4fmcA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND2_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 4fmc RORF2
(Escherichia
coli) 		5 / 12 VAL A 340
LEU A 234
ALA A 290
SER A 342
PHE A 291
 None
 1.25A 5nd2B-4fmcA:
undetectable		 5nd2B-4fmcA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA303_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4fmc RORF2
(Escherichia
coli) 		3 / 3 GLU A 312
TYR A 313
ARG A 317
 None
 0.75A 5uunA-4fmcA:
undetectable		 5uunA-4fmcA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4fmc RORF2
(Escherichia
coli) 		3 / 3 GLU A 312
TYR A 313
ARG A 317
 None
 0.70A 5uunB-4fmcA:
undetectable		 5uunB-4fmcA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_2
(TUBULIN BETA CHAIN)		 4fmc RORF2
(Escherichia
coli) 		5 / 12 ALA A 283
ASN A 218
ILE A 260
ALA A 257
ILE A 222
 None
 1.11A 5xiwD-4fmcA:
undetectable		 5xiwD-4fmcA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_BEZA401_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4fmc RORF2
(Escherichia
coli) 		5 / 9 LEU A 105
SER A 104
ARG A 120
VAL A 129
ILE A 119
 None
 0.99A 6ef6A-4fmcA:
1.4		 6ef6A-4fmcA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_1
(TUBULIN BETA CHAIN)		 4fmc RORF2
(Escherichia
coli) 		5 / 12 VAL A 340
LEU A 234
ALA A 290
SER A 342
PHE A 291
 None
 1.16A 6ew0G-4fmcA:
undetectable		 6ew0G-4fmcA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA812_0
(GEPHYRIN)		 4fmc RORF2
(Escherichia
coli) 		4 / 6 GLU A 379
ARG A 382
VAL A 369
PRO A 370
 None
 1.38A 6fgdA-4fmcA:
undetectable		 6fgdA-4fmcA:
22.67