SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fme'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4fme ADP-RIBOSYLATION
FACTOR 6
(Homo
sapiens) 		3 / 3 ASN C  60
TRP C  62
GLN C  82
 None
 0.96A 1xoqA-4fmeC:
undetectable		 1xoqA-4fmeC:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRH_A_NIOA200_1
(PROTEIN HP0721)		 4fme ADP-RIBOSYLATION
FACTOR 6
(Homo
sapiens) 		4 / 7 GLY C 165
ILE C  85
MET C  14
LEU C 166
 None
 0.91A 2xrhA-4fmeC:
undetectable		 2xrhA-4fmeC:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_0
(WBDD)		 4fme ADP-RIBOSYLATION
FACTOR 6
(Homo
sapiens) 		5 / 12 GLY C  25
ALA C  23
ILE C  29
VAL C  87
ILE C  85
 GTP  C 201 (-3.0A)
GTP  C 201 (-4.5A)
None
None
None
 0.89A 4ax8A-4fmeC:
undetectable		 4ax8A-4fmeC:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_0
(METHYLTRANSFERASE
WBDD)		 4fme ADP-RIBOSYLATION
FACTOR 6
(Homo
sapiens) 		5 / 12 GLY C  25
ALA C  23
ILE C  29
VAL C  87
ILE C  85
 GTP  C 201 (-3.0A)
GTP  C 201 (-4.5A)
None
None
None
 0.91A 4aztA-4fmeC:
undetectable		 4aztA-4fmeC:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_0
(WBDD)		 4fme ADP-RIBOSYLATION
FACTOR 6
(Homo
sapiens) 		5 / 12 GLY C  25
ALA C  23
ILE C  29
VAL C  87
ILE C  85
 GTP  C 201 (-3.0A)
GTP  C 201 (-4.5A)
None
None
None
 0.89A 4azvA-4fmeC:
undetectable		 4azvA-4fmeC:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA8_C_Z80C301_1
(MAJOR PRION PROTEIN)		 4fme ADP-RIBOSYLATION
FACTOR 6
(Homo
sapiens) 		4 / 5 LEU C 166
GLY C 165
ILE C  29
LYS C  32
 None
 1.07A 4ma8C-4fmeC:
undetectable		 4ma8C-4fmeC:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		 4fme ADP-RIBOSYLATION
FACTOR 6
(Homo
sapiens) 		5 / 12 GLY C  25
ALA C  23
ILE C  29
VAL C  87
ILE C  85
 GTP  C 201 (-3.0A)
GTP  C 201 (-4.5A)
None
None
None
 0.98A 4uw0A-4fmeC:
2.3		 4uw0A-4fmeC:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_B_NIZB808_1
(CATALASE-PEROXIDASE)		 4fme ADP-RIBOSYLATION
FACTOR 6
(Homo
sapiens) 		4 / 8 VAL C  61
GLY C 165
LEU C 169
THR C 167
 None
 0.99A 5sxqB-4fmeC:
undetectable		 5sxqB-4fmeC:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_A_NIZA807_1
(CATALASE-PEROXIDASE)		 4fme ADP-RIBOSYLATION
FACTOR 6
(Homo
sapiens) 		4 / 8 VAL C  61
GLY C 165
LEU C 169
THR C 167
 None
 1.00A 5sxtA-4fmeC:
undetectable		 5sxtA-4fmeC:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_B_NIZB808_1
(CATALASE-PEROXIDASE)		 4fme ADP-RIBOSYLATION
FACTOR 6
(Homo
sapiens) 		4 / 8 VAL C  61
GLY C 165
LEU C 169
THR C 167
 None
 0.99A 5sxtB-4fmeC:
undetectable		 5sxtB-4fmeC:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA809_1
(CATALASE-PEROXIDASE)		 4fme ADP-RIBOSYLATION
FACTOR 6
(Homo
sapiens) 		4 / 8 VAL C  61
GLY C 165
LEU C 169
THR C 167
 None
 0.99A 5syjA-4fmeC:
undetectable		 5syjA-4fmeC:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB809_1
(CATALASE-PEROXIDASE)		 4fme ADP-RIBOSYLATION
FACTOR 6
(Homo
sapiens) 		4 / 8 VAL C  61
GLY C 165
LEU C 169
THR C 167
 None
 0.98A 5syjB-4fmeC:
undetectable		 5syjB-4fmeC:
12.59