SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fmk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB6_0
(GRAMICIDIN A)		 4fmk POLIOVIRUS
RECEPTOR-RELATED
PROTEIN 2
(Mus
musculus) 		3 / 3 TRP A  69
ALA A  79
VAL A  77
 None
 0.95A 1bdwA-4fmkA:
undetectable
1bdwB-4fmkA:
undetectable		 1bdwA-4fmkA:
6.36
1bdwB-4fmkA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4fmk POLIOVIRUS
RECEPTOR-RELATED
PROTEIN 2
(Mus
musculus) 		4 / 8 TYR A 129
ASN A 128
GLU A 126
GLY A 127
 None
NAG  A 307 (-1.9A)
None
NAG  A 307 ( 3.9A)
 0.89A 1ykiA-4fmkA:
undetectable
1ykiB-4fmkA:
undetectable		 1ykiA-4fmkA:
21.05
1ykiB-4fmkA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_B_NFZB2219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4fmk POLIOVIRUS
RECEPTOR-RELATED
PROTEIN 2
(Mus
musculus) 		4 / 8 TYR A 129
ASN A 128
GLU A 126
GLY A 127
 None
NAG  A 307 (-1.9A)
None
NAG  A 307 ( 3.9A)
 0.89A 1ykiA-4fmkA:
undetectable
1ykiB-4fmkA:
undetectable		 1ykiA-4fmkA:
21.05
1ykiB-4fmkA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_C_NFZC3219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4fmk POLIOVIRUS
RECEPTOR-RELATED
PROTEIN 2
(Mus
musculus) 		4 / 8 TYR A 129
ASN A 128
GLU A 126
GLY A 127
 None
NAG  A 307 (-1.9A)
None
NAG  A 307 ( 3.9A)
 0.85A 1ykiC-4fmkA:
undetectable
1ykiD-4fmkA:
undetectable		 1ykiC-4fmkA:
21.05
1ykiD-4fmkA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_D_NFZD4219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4fmk POLIOVIRUS
RECEPTOR-RELATED
PROTEIN 2
(Mus
musculus) 		4 / 8 TYR A 129
ASN A 128
GLU A 126
GLY A 127
 None
NAG  A 307 (-1.9A)
None
NAG  A 307 ( 3.9A)
 0.88A 1ykiC-4fmkA:
undetectable
1ykiD-4fmkA:
undetectable		 1ykiC-4fmkA:
21.05
1ykiD-4fmkA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZR_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4fmk POLIOVIRUS
RECEPTOR-RELATED
PROTEIN 2
(Mus
musculus) 		4 / 7 GLU A 126
VAL A 149
ARG A  97
VAL A  50
 None
 1.03A 1zzrA-4fmkA:
undetectable
1zzrB-4fmkA:
undetectable		 1zzrA-4fmkA:
22.09
1zzrB-4fmkA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX2_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4fmk POLIOVIRUS
RECEPTOR-RELATED
PROTEIN 2
(Mus
musculus) 		4 / 7 VAL A 149
ARG A  97
VAL A  50
GLU A 126
 None
 1.05A 3jx2A-4fmkA:
undetectable
3jx2B-4fmkA:
undetectable		 3jx2A-4fmkA:
22.04
3jx2B-4fmkA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX5_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4fmk POLIOVIRUS
RECEPTOR-RELATED
PROTEIN 2
(Mus
musculus) 		4 / 7 VAL A 149
ARG A  97
VAL A  50
GLU A 126
 None
 1.02A 3jx5A-4fmkA:
undetectable
3jx5B-4fmkA:
undetectable		 3jx5A-4fmkA:
22.04
3jx5B-4fmkA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX6_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4fmk POLIOVIRUS
RECEPTOR-RELATED
PROTEIN 2
(Mus
musculus) 		4 / 7 VAL A 149
ARG A  97
VAL A  50
GLU A 126
 None
 1.02A 3jx6A-4fmkA:
undetectable
3jx6B-4fmkA:
undetectable		 3jx6A-4fmkA:
21.80
3jx6B-4fmkA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLJ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4fmk POLIOVIRUS
RECEPTOR-RELATED
PROTEIN 2
(Mus
musculus) 		4 / 7 VAL A 149
ARG A  97
VAL A  50
GLU A 126
 None
 1.01A 3nljA-4fmkA:
undetectable
3nljB-4fmkA:
undetectable		 3nljA-4fmkA:
21.80
3nljB-4fmkA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4fmk POLIOVIRUS
RECEPTOR-RELATED
PROTEIN 2
(Mus
musculus) 		4 / 7 VAL A 149
ARG A  97
VAL A  50
GLU A 126
 None
 1.01A 3nlpA-4fmkA:
undetectable
3nlpB-4fmkA:
undetectable		 3nlpA-4fmkA:
22.04
3nlpB-4fmkA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4fmk POLIOVIRUS
RECEPTOR-RELATED
PROTEIN 2
(Mus
musculus) 		4 / 8 VAL A 149
ARG A  97
VAL A  50
GLU A 126
 None
 0.97A 3nlqA-4fmkA:
undetectable
3nlqB-4fmkA:
undetectable		 3nlqA-4fmkA:
22.04
3nlqB-4fmkA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4fmk POLIOVIRUS
RECEPTOR-RELATED
PROTEIN 2
(Mus
musculus) 		4 / 7 GLU A 126
VAL A 149
ARG A  97
VAL A  50
 None
 0.96A 3nlqA-4fmkA:
undetectable
3nlqB-4fmkA:
undetectable		 3nlqA-4fmkA:
22.04
3nlqB-4fmkA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4fmk POLIOVIRUS
RECEPTOR-RELATED
PROTEIN 2
(Mus
musculus) 		4 / 7 VAL A 149
ARG A  97
VAL A  50
GLU A 126
 None
 0.99A 3nlrA-4fmkA:
undetectable
3nlrB-4fmkA:
undetectable		 3nlrA-4fmkA:
22.04
3nlrB-4fmkA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_2
(CYTOCHROME P450 2D6)		 4fmk POLIOVIRUS
RECEPTOR-RELATED
PROTEIN 2
(Mus
musculus) 		3 / 3 GLU A 234
ILE A 210
ALA A 151
 None
 0.64A 4wnwB-4fmkA:
undetectable		 4wnwB-4fmkA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_A_ILEA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4fmk POLIOVIRUS
RECEPTOR-RELATED
PROTEIN 2
(Mus
musculus) 		4 / 6 ALA A 134
THR A 135
VAL A  64
VAL A  36
 None
 0.95A 5eclA-4fmkA:
undetectable		 5eclA-4fmkA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_B_ACTB403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 4fmk POLIOVIRUS
RECEPTOR-RELATED
PROTEIN 2
(Mus
musculus) 		3 / 3 PHE A  93
ARG A  97
GLN A  92
 None
 1.14A 6g1pB-4fmkA:
undetectable		 6g1pB-4fmkA:
21.37