SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fms'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 4fms PROBABLE PORIN
(Pseudomonas
aeruginosa) 		3 / 3 GLU B  38
HIS B  25
HIS B  23
 None
C8E  B 405 (-4.3A)
None
 0.64A 1oe2A-4fmsB:
undetectable		 1oe2A-4fmsB:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1502_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 4fms PROBABLE PORIN
(Pseudomonas
aeruginosa) 		4 / 5 TRP B 116
PRO B 118
GLY B 137
GLY B 157
 None
 1.08A 1zlqA-4fmsB:
undetectable		 1zlqA-4fmsB:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_A_NCAA1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 4fms PROBABLE PORIN
(Pseudomonas
aeruginosa) 		4 / 7 ARG B 387
PHE B 383
ARG B  26
GLU B 349
 None
 1.27A 2c8aA-4fmsB:
undetectable		 2c8aA-4fmsB:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_A_NCAA1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 4fms PROBABLE PORIN
(Pseudomonas
aeruginosa) 		4 / 7 ARG B 387
PHE B 383
GLN B 373
GLU B 349
 None
 1.25A 2c8aA-4fmsB:
undetectable		 2c8aA-4fmsB:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_C_NCAC1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 4fms PROBABLE PORIN
(Pseudomonas
aeruginosa) 		4 / 6 ARG B 387
PHE B 383
ARG B  26
GLU B 349
 None
 1.29A 2c8aC-4fmsB:
undetectable		 2c8aC-4fmsB:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 4fms PROBABLE PORIN
(Pseudomonas
aeruginosa) 		3 / 3 ASP B 163
ASN B 162
THR B  41
 None
SO4  B 402 (-3.0A)
None
 0.74A 2pymB-4fmsB:
undetectable		 2pymB-4fmsB:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA1_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 4fms PROBABLE PORIN
(Pseudomonas
aeruginosa) 		3 / 3 GLY B 128
ASP B 126
SER B 285
 BDP  B 401 ( 4.4A)
BDP  B 401 (-2.8A)
BDP  B 401 (-3.3A)
 0.61A 3brfA-4fmsB:
undetectable		 3brfA-4fmsB:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA270_0
(PROTEIN SSM1)		 4fms PROBABLE PORIN
(Pseudomonas
aeruginosa) 		4 / 5 LEU B  66
SER B  43
LEU B 131
PRO B 132
 None
 1.35A 3onnA-4fmsB:
undetectable		 3onnA-4fmsB:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 4fms PROBABLE PORIN
(Pseudomonas
aeruginosa) 		5 / 12 GLY B 128
ASN B 282
SER B 159
PRO B 118
LEU B 123
 BDP  B 401 ( 4.4A)
None
None
None
None
 1.05A 4fzvA-4fmsB:
undetectable		 4fzvA-4fmsB:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_1
(ADENOSINE KINASE)		 4fms PROBABLE PORIN
(Pseudomonas
aeruginosa) 		5 / 12 ASP B 292
GLY B 287
PHE B 172
GLY B 128
ASP B 126
 BDP  B 401 (-2.9A)
None
None
BDP  B 401 ( 4.4A)
BDP  B 401 (-2.8A)
 1.02A 4n09B-4fmsB:
undetectable		 4n09B-4fmsB:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 4fms PROBABLE PORIN
(Pseudomonas
aeruginosa) 		5 / 12 LEU B  64
SER B 391
GLN B 133
ARG B 369
GLY B 128
 None
None
None
None
BDP  B 401 ( 4.4A)
 1.33A 5m50E-4fmsB:
undetectable		 5m50E-4fmsB:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 4fms PROBABLE PORIN
(Pseudomonas
aeruginosa) 		4 / 5 PHE B 324
THR B 264
GLU B 351
ASN B 365
 C8E  B 407 (-3.9A)
None
None
None
 1.38A 5ybbA-4fmsB:
undetectable		 5ybbA-4fmsB:
22.96