SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fmt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4fmt CHPT PROTEIN
(Caulobacter
vibrioides) 		5 / 10 PHE A 105
ALA A 101
PHE A  78
VAL A 174
ILE A 219
 None
 1.32A 1claA-4fmtA:
undetectable		 1claA-4fmtA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_2
(TUBULIN BETA-2B
CHAIN)		 4fmt CHPT PROTEIN
(Caulobacter
vibrioides) 		5 / 12 LEU A 112
ALA A 101
ALA A 161
ALA A 146
ILE A 219
 None
 0.87A 4o2bD-4fmtA:
undetectable		 4o2bD-4fmtA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_B_LOCB502_1
(TUBULIN BETA CHAIN)		 4fmt CHPT PROTEIN
(Caulobacter
vibrioides) 		5 / 12 LEU A 112
ALA A 101
ALA A 161
ALA A 146
ILE A 219
 None
 0.97A 4x20B-4fmtA:
undetectable		 4x20B-4fmtA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_B_LOCB504_2
(TUBULIN BETA CHAIN)		 4fmt CHPT PROTEIN
(Caulobacter
vibrioides) 		5 / 12 LEU A 112
ALA A 101
ALA A 161
ALA A 146
ILE A 219
 None
 1.00A 5xiwB-4fmtA:
undetectable		 5xiwB-4fmtA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4fmt CHPT PROTEIN
(Caulobacter
vibrioides) 		5 / 12 LEU A 170
ILE A 135
LEU A 200
ILE A 208
LEU A  97
 None
 1.00A 5ycnA-4fmtA:
undetectable		 5ycnA-4fmtA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECE_C_DVAC3010_0
(VLM2
DODECADEPSIPEPTIDE)		 4fmt CHPT PROTEIN
(Caulobacter
vibrioides) 		3 / 3 ALA A 153
PHE A 157
GLN A 119
 None
 0.79A 6eceA-4fmtA:
undetectable		 6eceA-4fmtA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA205_0
(N-ACETYLTRANSFERASE)		 4fmt CHPT PROTEIN
(Caulobacter
vibrioides) 		4 / 4 ALA A 136
ALA A 139
ALA A 163
ALA A 161
 None
 0.81A 6gtqA-4fmtA:
undetectable
6gtqB-4fmtA:
undetectable		 6gtqA-4fmtA:
20.47
6gtqB-4fmtA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA205_0
(N-ACETYLTRANSFERASE)		 4fmt CHPT PROTEIN
(Caulobacter
vibrioides) 		4 / 4 ALA A 163
ALA A 161
ALA A 136
ALA A 139
 None
 0.82A 6gtqA-4fmtA:
undetectable
6gtqB-4fmtA:
undetectable		 6gtqA-4fmtA:
20.47
6gtqB-4fmtA:
20.47