SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fmw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI9_X_SAMX501_0
(UPF0217 PROTEIN
MJ1640)		 4fmw RNA
(GUANINE-9-)-METHYLT
RANSFERASE
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 9 LEU A 186
ILE A 205
GLY A 206
LEU A 232
LEU A 246
 SAH  A 301 (-4.1A)
SAH  A 301 (-4.5A)
SAH  A 301 (-3.3A)
SAH  A 301 (-3.8A)
SAH  A 301 (-4.1A)
 0.62A 3ai9X-4fmwA:
7.3		 3ai9X-4fmwA:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)		 4fmw RNA
(GUANINE-9-)-METHYLT
RANSFERASE
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		4 / 6 ILE A 227
TYR A 203
LYS A 201
ILE A 178
 None
 1.19A 3eteA-4fmwA:
undetectable
3eteE-4fmwA:
undetectable		 3eteA-4fmwA:
16.30
3eteE-4fmwA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI202_1
(PROTEIN S100-A4)		 4fmw RNA
(GUANINE-9-)-METHYLT
RANSFERASE
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 12 SER A  99
ILE A 255
GLU A 199
LEU A 197
ASP A 198
 None
 1.25A 3ko0G-4fmwA:
undetectable
3ko0H-4fmwA:
undetectable
3ko0I-4fmwA:
undetectable
3ko0J-4fmwA:
undetectable		 3ko0G-4fmwA:
22.22
3ko0H-4fmwA:
22.22
3ko0I-4fmwA:
22.22
3ko0J-4fmwA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_A_ADNA401_1
(APH(2'')-ID)		 4fmw RNA
(GUANINE-9-)-METHYLT
RANSFERASE
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 10 ALA A 130
ILE A 105
HIS A 122
LEU A 143
ILE A 125
 None
 1.10A 4dtaA-4fmwA:
undetectable		 4dtaA-4fmwA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA306_1
(CHITOSANASE)		 4fmw RNA
(GUANINE-9-)-METHYLT
RANSFERASE
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		3 / 3 SER A 145
ASP A 106
GLN A 221
 None
 0.64A 4oltA-4fmwA:
undetectable
4oltB-4fmwA:
undetectable		 4oltA-4fmwA:
20.15
4oltB-4fmwA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB304_1
(CHITOSANASE)		 4fmw RNA
(GUANINE-9-)-METHYLT
RANSFERASE
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		3 / 3 GLN A 221
SER A 145
ASP A 106
 None
 0.65A 4qwpA-4fmwA:
undetectable
4qwpB-4fmwA:
undetectable		 4qwpA-4fmwA:
19.25
4qwpB-4fmwA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 4fmw RNA
(GUANINE-9-)-METHYLT
RANSFERASE
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		6 / 12 LEU A 186
ILE A 205
GLY A 206
LEU A 232
LEU A 234
LEU A 246
 SAH  A 301 (-4.1A)
SAH  A 301 (-4.5A)
SAH  A 301 (-3.3A)
SAH  A 301 (-3.8A)
SAH  A 301 (-4.8A)
SAH  A 301 (-4.1A)
 0.37A 5nfjB-4fmwA:
25.8		 5nfjB-4fmwA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_C_SAMC501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 4fmw RNA
(GUANINE-9-)-METHYLT
RANSFERASE
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		6 / 12 LEU A 186
ILE A 205
GLY A 206
LEU A 232
LEU A 234
LEU A 246
 SAH  A 301 (-4.1A)
SAH  A 301 (-4.5A)
SAH  A 301 (-3.3A)
SAH  A 301 (-3.8A)
SAH  A 301 (-4.8A)
SAH  A 301 (-4.1A)
 0.39A 5nfjC-4fmwA:
26.2		 5nfjC-4fmwA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_B_SAMB501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4fmw RNA
(GUANINE-9-)-METHYLT
RANSFERASE
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 9 LEU A 186
ILE A 205
GLY A 206
LEU A 232
LEU A 246
 SAH  A 301 (-4.1A)
SAH  A 301 (-4.5A)
SAH  A 301 (-3.3A)
SAH  A 301 (-3.8A)
SAH  A 301 (-4.1A)
 0.54A 5o96A-4fmwA:
5.7
5o96B-4fmwA:
9.8		 5o96A-4fmwA:
21.05
5o96B-4fmwA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4fmw RNA
(GUANINE-9-)-METHYLT
RANSFERASE
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		6 / 12 LEU A 186
ILE A 205
GLY A 206
LEU A 232
LEU A 246
VAL A 251
 SAH  A 301 (-4.1A)
SAH  A 301 (-4.5A)
SAH  A 301 (-3.3A)
SAH  A 301 (-3.8A)
SAH  A 301 (-4.1A)
SAH  A 301 (-4.9A)
 0.40A 5twjA-4fmwA:
5.4		 5twjA-4fmwA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_B_SAMB201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4fmw RNA
(GUANINE-9-)-METHYLT
RANSFERASE
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		6 / 10 LEU A 186
ILE A 205
GLY A 206
LEU A 232
LEU A 246
VAL A 251
 SAH  A 301 (-4.1A)
SAH  A 301 (-4.5A)
SAH  A 301 (-3.3A)
SAH  A 301 (-3.8A)
SAH  A 301 (-4.1A)
SAH  A 301 (-4.9A)
 0.44A 5twjB-4fmwA:
5.2		 5twjB-4fmwA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_C_SAMC201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4fmw RNA
(GUANINE-9-)-METHYLT
RANSFERASE
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		6 / 12 LEU A 186
ILE A 205
GLY A 206
LEU A 232
LEU A 246
VAL A 251
 SAH  A 301 (-4.1A)
SAH  A 301 (-4.5A)
SAH  A 301 (-3.3A)
SAH  A 301 (-3.8A)
SAH  A 301 (-4.1A)
SAH  A 301 (-4.9A)
 0.41A 5twjC-4fmwA:
5.7		 5twjC-4fmwA:
20.38