SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fn4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAY_A_ADNA1001_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 4fn4 SHORT CHAIN
DEHYDROGENASE
(Sulfolobus
acidocaldarius) 		7 / 11 GLY A  15
SER A  18
LEU A  40
ASP A  65
VAL A  66
ALA A  93
VAL A 116
 NAD  A 501 (-3.2A)
NAD  A 501 (-2.7A)
NAD  A 501 (-3.8A)
NAD  A 501 (-3.6A)
NAD  A 501 (-3.6A)
NAD  A 501 (-3.8A)
NAD  A 501 ( 4.1A)
 0.60A 1uayA-4fn4A:
28.3		 1uayA-4fn4A:
31.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAY_B_ADNB1002_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 4fn4 SHORT CHAIN
DEHYDROGENASE
(Sulfolobus
acidocaldarius) 		6 / 10 GLY A  15
LEU A  40
ASP A  65
VAL A  66
ALA A  93
VAL A 116
 NAD  A 501 (-3.2A)
NAD  A 501 (-3.8A)
NAD  A 501 (-3.6A)
NAD  A 501 (-3.6A)
NAD  A 501 (-3.8A)
NAD  A 501 ( 4.1A)
 0.54A 1uayB-4fn4A:
28.9		 1uayB-4fn4A:
31.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAY_B_ADNB1002_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 4fn4 SHORT CHAIN
DEHYDROGENASE
(Sulfolobus
acidocaldarius) 		6 / 10 GLY A  15
SER A  18
ASP A  65
VAL A  66
ALA A  93
VAL A 116
 NAD  A 501 (-3.2A)
NAD  A 501 (-2.7A)
NAD  A 501 (-3.6A)
NAD  A 501 (-3.6A)
NAD  A 501 (-3.8A)
NAD  A 501 ( 4.1A)
 0.54A 1uayB-4fn4A:
28.9		 1uayB-4fn4A:
31.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_B_SAMB4001_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 4fn4 SHORT CHAIN
DEHYDROGENASE
(Sulfolobus
acidocaldarius) 		5 / 12 GLY A  15
GLY A  17
LEU A  40
ASP A  65
VAL A  66
 NAD  A 501 (-3.2A)
NAD  A 501 ( 4.0A)
NAD  A 501 (-3.8A)
NAD  A 501 (-3.6A)
NAD  A 501 (-3.6A)
 0.77A 1zq9B-4fn4A:
6.3		 1zq9B-4fn4A:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 4fn4 SHORT CHAIN
DEHYDROGENASE
(Sulfolobus
acidocaldarius) 		4 / 8 THR A  82
VAL A  62
GLY A  61
ILE A  12
 None
 0.79A 2a1mB-4fn4A:
undetectable		 2a1mB-4fn4A:
18.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JAP_A_J01A1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 4fn4 SHORT CHAIN
DEHYDROGENASE
(Sulfolobus
acidocaldarius) 		5 / 12 LEU A 210
SER A 145
ILE A 146
ALA A 147
THR A 190
 None
NAD  A 501 (-3.6A)
None
None
None
 1.00A 2japA-4fn4A:
34.2		 2japA-4fn4A:
31.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JAP_A_J01A1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 4fn4 SHORT CHAIN
DEHYDROGENASE
(Sulfolobus
acidocaldarius) 		5 / 12 SER A 145
ILE A 146
ALA A 147
TYR A 158
THR A 190
 NAD  A 501 (-3.6A)
None
None
GOL  A 502 ( 4.3A)
None
 0.61A 2japA-4fn4A:
34.2		 2japA-4fn4A:
31.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JAP_B_J01B1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 4fn4 SHORT CHAIN
DEHYDROGENASE
(Sulfolobus
acidocaldarius) 		5 / 12 LEU A 210
SER A 145
ILE A 146
ALA A 147
THR A 190
 None
NAD  A 501 (-3.6A)
None
None
None
 0.99A 2japB-4fn4A:
34.3		 2japB-4fn4A:
31.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JAP_B_J01B1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 4fn4 SHORT CHAIN
DEHYDROGENASE
(Sulfolobus
acidocaldarius) 		5 / 12 MET A  96
SER A 145
ILE A 146
ALA A 147
TYR A 158
 GOL  A 502 (-3.5A)
NAD  A 501 (-3.6A)
None
None
GOL  A 502 ( 4.3A)
 0.79A 2japB-4fn4A:
34.3		 2japB-4fn4A:
31.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JAP_B_J01B1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 4fn4 SHORT CHAIN
DEHYDROGENASE
(Sulfolobus
acidocaldarius) 		5 / 12 SER A 145
ILE A 146
ALA A 147
TYR A 158
THR A 190
 NAD  A 501 (-3.6A)
None
None
GOL  A 502 ( 4.3A)
None
 0.62A 2japB-4fn4A:
34.3		 2japB-4fn4A:
31.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JAP_C_J01C1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 4fn4 SHORT CHAIN
DEHYDROGENASE
(Sulfolobus
acidocaldarius) 		5 / 12 LEU A 210
SER A 145
ILE A 146
ALA A 147
THR A 190
 None
NAD  A 501 (-3.6A)
None
None
None
 0.97A 2japC-4fn4A:
34.1		 2japC-4fn4A:
31.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JAP_C_J01C1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 4fn4 SHORT CHAIN
DEHYDROGENASE
(Sulfolobus
acidocaldarius) 		5 / 12 SER A 145
ILE A 146
ALA A 147
TYR A 158
THR A 190
 NAD  A 501 (-3.6A)
None
None
GOL  A 502 ( 4.3A)
None
 0.65A 2japC-4fn4A:
34.1		 2japC-4fn4A:
31.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JAP_D_J01D1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 4fn4 SHORT CHAIN
DEHYDROGENASE
(Sulfolobus
acidocaldarius) 		5 / 12 LEU A 210
SER A 145
ILE A 146
ALA A 147
THR A 190
 None
NAD  A 501 (-3.6A)
None
None
None
 0.96A 2japD-4fn4A:
34.2		 2japD-4fn4A:
31.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JAP_D_J01D1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 4fn4 SHORT CHAIN
DEHYDROGENASE
(Sulfolobus
acidocaldarius) 		5 / 12 SER A 145
ILE A 146
ALA A 147
TYR A 158
THR A 190
 NAD  A 501 (-3.6A)
None
None
GOL  A 502 ( 4.3A)
None
 0.64A 2japD-4fn4A:
34.2		 2japD-4fn4A:
31.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA502_1
(CYTOCHROME P450 2C8)		 4fn4 SHORT CHAIN
DEHYDROGENASE
(Sulfolobus
acidocaldarius) 		5 / 12 ILE A  20
ILE A 230
VAL A 141
VAL A  11
ILE A  48
 NAD  A 501 (-4.0A)
None
None
None
None
 0.91A 2nnhA-4fn4A:
undetectable		 2nnhA-4fn4A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 4fn4 SHORT CHAIN
DEHYDROGENASE
(Sulfolobus
acidocaldarius) 		5 / 12 ILE A  24
ALA A  23
GLY A  19
ILE A 226
GLY A  15
 None
None
NAD  A 501 (-3.3A)
None
NAD  A 501 (-3.2A)
 0.85A 2qe6A-4fn4A:
6.6		 2qe6A-4fn4A:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 4fn4 SHORT CHAIN
DEHYDROGENASE
(Sulfolobus
acidocaldarius) 		5 / 12 ILE A  24
ALA A  23
GLY A  19
ILE A 226
GLY A  15
 None
None
NAD  A 501 (-3.3A)
None
NAD  A 501 (-3.2A)
 0.97A 2qe6B-4fn4A:
6.4		 2qe6B-4fn4A:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMF_A_SAMA388_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4fn4 SHORT CHAIN
DEHYDROGENASE
(Sulfolobus
acidocaldarius) 		5 / 12 GLY A  15
ALA A  23
ASP A  65
VAL A  66
VAL A 116
 NAD  A 501 (-3.2A)
None
NAD  A 501 (-3.6A)
NAD  A 501 (-3.6A)
NAD  A 501 ( 4.1A)
 0.99A 3dmfA-4fn4A:
7.1		 3dmfA-4fn4A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMF_A_SAMA388_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4fn4 SHORT CHAIN
DEHYDROGENASE
(Sulfolobus
acidocaldarius) 		5 / 12 GLY A  15
GLY A  17
ASP A  65
VAL A  66
VAL A 116
 NAD  A 501 (-3.2A)
NAD  A 501 ( 4.0A)
NAD  A 501 (-3.6A)
NAD  A 501 (-3.6A)
NAD  A 501 ( 4.1A)
 0.96A 3dmfA-4fn4A:
7.1		 3dmfA-4fn4A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_A_PXLA400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 4fn4 SHORT CHAIN
DEHYDROGENASE
(Sulfolobus
acidocaldarius) 		5 / 11 SER A 203
VAL A  99
LEU A 205
THR A 209
ASP A  97
 None
 1.10A 3mbhA-4fn4A:
6.7		 3mbhA-4fn4A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_B_PXLB400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 4fn4 SHORT CHAIN
DEHYDROGENASE
(Sulfolobus
acidocaldarius) 		5 / 12 SER A 203
VAL A  99
LEU A 205
THR A 209
ASP A  97
 None
 1.10A 3mbhB-4fn4A:
6.7		 3mbhB-4fn4A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_C_PXLC400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 4fn4 SHORT CHAIN
DEHYDROGENASE
(Sulfolobus
acidocaldarius) 		5 / 12 SER A 203
VAL A  99
LEU A 205
THR A 209
ASP A  97
 None
 1.11A 3mbhC-4fn4A:
6.8		 3mbhC-4fn4A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_F_PXLF400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 4fn4 SHORT CHAIN
DEHYDROGENASE
(Sulfolobus
acidocaldarius) 		5 / 11 SER A 203
VAL A  99
LEU A 205
THR A 209
ASP A  97
 None
 1.12A 3mbhF-4fn4A:
6.6		 3mbhF-4fn4A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q87_B_SAMB300_0
(N6 ADENINE SPECIFIC
DNA METHYLASE)		 4fn4 SHORT CHAIN
DEHYDROGENASE
(Sulfolobus
acidocaldarius) 		5 / 12 GLY A  15
SER A  18
ILE A  24
LEU A  40
ASP A  65
 NAD  A 501 (-3.2A)
NAD  A 501 (-2.7A)
None
NAD  A 501 (-3.8A)
NAD  A 501 (-3.6A)
 0.97A 3q87B-4fn4A:
7.2		 3q87B-4fn4A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EOH_A_TEPA402_1
(PYRIDOXAL KINASE)		 4fn4 SHORT CHAIN
DEHYDROGENASE
(Sulfolobus
acidocaldarius) 		4 / 5 SER A 203
GLY A  98
THR A 209
ASP A  97
 None
 0.98A 4eohA-4fn4A:
6.4		 4eohA-4fn4A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_A_SAMA301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 4fn4 SHORT CHAIN
DEHYDROGENASE
(Sulfolobus
acidocaldarius) 		5 / 12 ALA A 185
GLY A 164
GLY A 167
ALA A 144
TYR A 119
 None
 1.08A 4lg1A-4fn4A:
7.6		 4lg1A-4fn4A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_B_SAMB301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 4fn4 SHORT CHAIN
DEHYDROGENASE
(Sulfolobus
acidocaldarius) 		5 / 12 ALA A 185
GLY A 164
GLY A 167
ALA A 144
TYR A 119
 None
 1.07A 4lg1B-4fn4A:
7.6		 4lg1B-4fn4A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_C_SAMC301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 4fn4 SHORT CHAIN
DEHYDROGENASE
(Sulfolobus
acidocaldarius) 		5 / 12 ALA A 185
GLY A 164
GLY A 167
ALA A 144
TYR A 119
 None
 1.05A 4lg1C-4fn4A:
3.9		 4lg1C-4fn4A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 4fn4 SHORT CHAIN
DEHYDROGENASE
(Sulfolobus
acidocaldarius) 		5 / 9 THR A  14
THR A 143
ALA A 144
ALA A 185
ALA A 121
 None
NAD  A 501 (-4.1A)
None
None
None
 0.90A 5l5zK-4fn4A:
undetectable
5l5zL-4fn4A:
undetectable		 5l5zK-4fn4A:
26.59
5l5zL-4fn4A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 4fn4 SHORT CHAIN
DEHYDROGENASE
(Sulfolobus
acidocaldarius) 		5 / 9 THR A  14
THR A 143
ALA A 144
ALA A 185
ALA A 121
 None
NAD  A 501 (-4.1A)
None
None
None
 0.90A 5l5zY-4fn4A:
undetectable
5l5zZ-4fn4A:
undetectable		 5l5zY-4fn4A:
26.59
5l5zZ-4fn4A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XU8_A_DX4A701_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2)		 4fn4 SHORT CHAIN
DEHYDROGENASE
(Sulfolobus
acidocaldarius) 		4 / 8 GLY A 164
LEU A 165
SER A 145
ALA A 147
 None
None
NAD  A 501 (-3.6A)
None
 0.95A 5xu8A-4fn4A:
undetectable		 5xu8A-4fn4A:
21.41