SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fn5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_B_ESTB354_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 4fn5 ELONGATION FACTOR G
1
(Pseudomonas
aeruginosa) 		4 / 8 VAL A 330
LEU A 333
PRO A 328
MET A 366
 None
 1.00A 1fduB-4fn5A:
undetectable		 1fduB-4fn5A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXH_B_PACB1001_0
(PENICILLIN ACYLASE)		 4fn5 ELONGATION FACTOR G
1
(Pseudomonas
aeruginosa) 		4 / 7 PHE A 667
SER A 417
ALA A 419
ILE A 457
 None
 1.04A 1fxhA-4fn5A:
undetectable
1fxhB-4fn5A:
undetectable		 1fxhA-4fn5A:
11.66
1fxhB-4fn5A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4fn5 ELONGATION FACTOR G
1
(Pseudomonas
aeruginosa) 		4 / 7 THR A 256
VAL A 110
GLY A 108
ILE A  13
 None
 0.70A 1gtnC-4fn5A:
undetectable
1gtnD-4fn5A:
1.0		 1gtnC-4fn5A:
7.39
1gtnD-4fn5A:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRQ_A_STRA501_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 4fn5 ELONGATION FACTOR G
1
(Pseudomonas
aeruginosa) 		5 / 11 LEU A 252
VAL A 169
ILE A 186
LEU A 233
LEU A 243
 None
 1.23A 1mrqA-4fn5A:
undetectable		 1mrqA-4fn5A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4fn5 ELONGATION FACTOR G
1
(Pseudomonas
aeruginosa) 		4 / 8 ARG A  29
ASN A 272
ASN A 142
ASP A 145
 None
 1.33A 1rs6A-4fn5A:
undetectable		 1rs6A-4fn5A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RTS_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 4fn5 ELONGATION FACTOR G
1
(Pseudomonas
aeruginosa) 		4 / 8 PHE A 522
ILE A 560
LEU A 574
GLY A 576
 None
 0.86A 1rtsA-4fn5A:
undetectable		 1rtsA-4fn5A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_CCSB417_0
(ESTROGEN RECEPTOR)		 4fn5 ELONGATION FACTOR G
1
(Pseudomonas
aeruginosa) 		3 / 3 GLN A 646
LYS A 621
VAL A 661
 None
 0.91A 2jfaB-4fn5A:
undetectable		 2jfaB-4fn5A:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		 4fn5 ELONGATION FACTOR G
1
(Pseudomonas
aeruginosa) 		5 / 12 ARG A 521
ILE A 560
LEU A 577
GLY A 536
ALA A 579
 None
 0.86A 2oc8A-4fn5A:
undetectable		 2oc8A-4fn5A:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_B_REAB1445_1
(PUTATIVE CYTOCHROME
P450 120)		 4fn5 ELONGATION FACTOR G
1
(Pseudomonas
aeruginosa) 		5 / 12 PHE A 179
ALA A  17
VAL A 275
GLY A 274
GLN A 182
 None
 1.14A 2ve3B-4fn5A:
undetectable		 2ve3B-4fn5A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z71_A_PNVA903_1
(PENICILLIN ACYLASE)		 4fn5 ELONGATION FACTOR G
1
(Pseudomonas
aeruginosa) 		5 / 10 ASN A  37
GLU A 204
ASP A 280
GLY A  77
GLN A  78
 None
 1.45A 2z71A-4fn5A:
0.0
2z71C-4fn5A:
0.0		 2z71A-4fn5A:
20.82
2z71C-4fn5A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 4fn5 ELONGATION FACTOR G
1
(Pseudomonas
aeruginosa) 		5 / 12 ASN A   8
GLU A 291
VAL A 110
ILE A  13
ASN A  12
 None
 1.36A 3jayA-4fn5A:
undetectable		 3jayA-4fn5A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4fn5 ELONGATION FACTOR G
1
(Pseudomonas
aeruginosa) 		3 / 3 VAL A 673
VAL A 622
SER A 684
 None
 0.62A 3n8xB-4fn5A:
undetectable		 3n8xB-4fn5A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4fn5 ELONGATION FACTOR G
1
(Pseudomonas
aeruginosa) 		4 / 8 ARG A  29
ASN A 272
ASN A 142
ASP A 145
 None
 1.12A 4d33A-4fn5A:
undetectable		 4d33A-4fn5A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4fn5 ELONGATION FACTOR G
1
(Pseudomonas
aeruginosa) 		4 / 7 ARG A  29
ASN A 272
ASN A 142
ASP A 145
 None
 1.13A 4d33B-4fn5A:
undetectable		 4d33B-4fn5A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FR0_A_SAMA401_0
(ARSENIC
METHYLTRANSFERASE)		 4fn5 ELONGATION FACTOR G
1
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  14
ASP A 107
ILE A 138
VAL A 282
LEU A 279
 None
 1.12A 4fr0A-4fn5A:
2.0		 4fr0A-4fn5A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_B_HFGB1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 4fn5 ELONGATION FACTOR G
1
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 343
GLU A 358
VAL A 349
THR A 326
GLY A 331
 None
 1.25A 4hvcB-4fn5A:
2.8		 4hvcB-4fn5A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		 4fn5 ELONGATION FACTOR G
1
(Pseudomonas
aeruginosa) 		4 / 8 SER A  75
TRP A 193
TYR A 202
GLN A 170
 None
 1.22A 4j7uD-4fn5A:
undetectable		 4j7uD-4fn5A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6T_A_SAMA201_0
(RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1)		 4fn5 ELONGATION FACTOR G
1
(Pseudomonas
aeruginosa) 		4 / 4 ILE A  13
VAL A  68
VAL A  84
ARG A  11
 None
 1.21A 4m6tA-4fn5A:
undetectable		 4m6tA-4fn5A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		 4fn5 ELONGATION FACTOR G
1
(Pseudomonas
aeruginosa) 		4 / 6 ASP A 672
ALA A 670
TYR A 683
ASP A 637
 None
 1.13A 4mdaA-4fn5A:
undetectable		 4mdaA-4fn5A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 4fn5 ELONGATION FACTOR G
1
(Pseudomonas
aeruginosa) 		4 / 6 ASP A 672
ALA A 670
TYR A 683
ASP A 637
 None
 1.12A 4mdbA-4fn5A:
undetectable		 4mdbA-4fn5A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4fn5 ELONGATION FACTOR G
1
(Pseudomonas
aeruginosa) 		4 / 4 GLY A 611
VAL A 499
PHE A 539
ILE A 520
 None
 1.13A 4xv2B-4fn5A:
undetectable		 4xv2B-4fn5A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4fn5 ELONGATION FACTOR G
1
(Pseudomonas
aeruginosa) 		4 / 4 VAL A 581
ALA A 600
PHE A 522
THR A 604
 None
 1.45A 4z4fA-4fn5A:
5.0		 4z4fA-4fn5A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4fn5 ELONGATION FACTOR G
1
(Pseudomonas
aeruginosa) 		4 / 4 VAL A 581
ALA A 600
PHE A 522
THR A 604
 None
 1.47A 4z4hA-4fn5A:
5.0		 4z4hA-4fn5A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 4fn5 ELONGATION FACTOR G
1
(Pseudomonas
aeruginosa) 		4 / 6 TRP A 193
PRO A 276
ILE A  15
VAL A 110
 None
 1.00A 4zj8A-4fn5A:
5.5		 4zj8A-4fn5A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_2
(PROTEASE PR5-DRV)		 4fn5 ELONGATION FACTOR G
1
(Pseudomonas
aeruginosa) 		4 / 8 GLY A 571
ALA A 570
VAL A 698
GLY A 613
 None
 0.64A 5kr1B-4fn5A:
undetectable		 5kr1B-4fn5A:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_MTLA805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4fn5 ELONGATION FACTOR G
1
(Pseudomonas
aeruginosa) 		4 / 8 ARG A  29
ASN A 272
ASN A 142
ASP A 145
 None
 1.27A 5vunA-4fn5A:
undetectable		 5vunA-4fn5A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4fn5 ELONGATION FACTOR G
1
(Pseudomonas
aeruginosa) 		4 / 8 ARG A  29
ASN A 272
ASN A 142
ASP A 145
 None
 1.27A 5vunB-4fn5A:
undetectable		 5vunB-4fn5A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4fn5 ELONGATION FACTOR G
1
(Pseudomonas
aeruginosa) 		4 / 8 ARG A  29
ASN A 272
ASN A 142
ASP A 145
 None
 1.25A 5vuoB-4fn5A:
undetectable		 5vuoB-4fn5A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 4fn5 ELONGATION FACTOR G
1
(Pseudomonas
aeruginosa) 		4 / 7 PHE A 522
ILE A 560
LEU A 574
GLY A 576
 None
 0.81A 5x5qC-4fn5A:
undetectable		 5x5qC-4fn5A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_E_D16E402_1
(THYMIDYLATE SYNTHASE)		 4fn5 ELONGATION FACTOR G
1
(Pseudomonas
aeruginosa) 		4 / 6 PHE A 522
ILE A 560
LEU A 574
GLY A 576
 None
 0.86A 5x5qE-4fn5A:
undetectable		 5x5qE-4fn5A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_F_D16F402_1
(THYMIDYLATE SYNTHASE)		 4fn5 ELONGATION FACTOR G
1
(Pseudomonas
aeruginosa) 		4 / 8 PHE A 522
ILE A 560
LEU A 574
GLY A 576
 None
 0.81A 5x5qF-4fn5A:
undetectable		 5x5qF-4fn5A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_C_HFGC1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 4fn5 ELONGATION FACTOR G
1
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 343
GLU A 358
VAL A 349
THR A 326
GLY A 331
 None
 1.21A 5xipC-4fn5A:
undetectable		 5xipC-4fn5A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_A_HFGA1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4fn5 ELONGATION FACTOR G
1
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 343
GLU A 358
VAL A 349
THR A 326
GLY A 331
 None
 1.26A 5xiqA-4fn5A:
3.2		 5xiqA-4fn5A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4fn5 ELONGATION FACTOR G
1
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 343
GLU A 358
VAL A 349
THR A 326
GLY A 331
 None
 1.28A 5xiqD-4fn5A:
2.9		 5xiqD-4fn5A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9A_A_AR3A201_1
(PEPTIDYL-TRNA
HYDROLASE)		 4fn5 ELONGATION FACTOR G
1
(Pseudomonas
aeruginosa) 		4 / 6 ALA A 603
GLN A 606
LYS A 610
GLN A 609
 None
 1.39A 5y9aA-4fn5A:
3.9		 5y9aA-4fn5A:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_B_P2EB1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 4fn5 ELONGATION FACTOR G
1
(Pseudomonas
aeruginosa) 		4 / 5 PRO A 618
VAL A 488
GLY A 567
VAL A 615
 None
 0.95A 6ak3B-4fn5A:
undetectable		 6ak3B-4fn5A:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4fn5 ELONGATION FACTOR G
1
(Pseudomonas
aeruginosa) 		4 / 8 ARG A  29
ASN A 272
ASN A 142
ASP A 145
 None
 1.27A 6auuB-4fn5A:
undetectable		 6auuB-4fn5A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		 4fn5 ELONGATION FACTOR G
1
(Pseudomonas
aeruginosa) 		5 / 9 SER A 102
ALA A 109
VAL A 126
ALA A 130
VAL A  99
 None
 0.98A 6bklA-4fn5A:
undetectable
6bklB-4fn5A:
undetectable
6bklC-4fn5A:
undetectable
6bklD-4fn5A:
undetectable		 6bklA-4fn5A:
3.55
6bklB-4fn5A:
3.55
6bklC-4fn5A:
3.55
6bklD-4fn5A:
3.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 4fn5 ELONGATION FACTOR G
1
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 262
ALA A 109
PHE A 113
GLU A 156
VAL A 119
 None
 1.17A 6bqgA-4fn5A:
undetectable		 6bqgA-4fn5A:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4fn5 ELONGATION FACTOR G
1
(Pseudomonas
aeruginosa) 		4 / 6 TYR A 285
ASP A 184
GLN A  78
ALA A 226
 None
 1.10A 6djzB-4fn5A:
undetectable		 6djzB-4fn5A:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 4fn5 ELONGATION FACTOR G
1
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 418
SER A 417
GLY A 462
PHE A 445
VAL A 447
 None
 1.14A 6drzA-4fn5A:
undetectable		 6drzA-4fn5A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F32_B_ACTB602_0
(AMINE OXIDASE LKCE)		 4fn5 ELONGATION FACTOR G
1
(Pseudomonas
aeruginosa) 		4 / 6 VAL A 353
LYS A 354
VAL A 391
THR A 392
 None
 1.41A 6f32B-4fn5A:
undetectable		 6f32B-4fn5A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_HFGA603_0
(UNCHARACTERIZED
PROTEIN)		 4fn5 ELONGATION FACTOR G
1
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 343
GLU A 358
VAL A 349
THR A 326
GLY A 331
 None
 1.36A 6mn8A-4fn5A:
2.2		 6mn8A-4fn5A:
22.08