SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fn6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_B_SCKB951_1
(ACETYLCHOLINESTERASE)		 4fn6 THIAMINASE-2
(Staphylococcus
aureus) 		4 / 8 TYR A 167
TYR A 141
TRP A 163
TYR A  47
 None
CME  A 137 ( 3.5A)
None
ACT  A 302 (-4.5A)
 1.50A 2ha2B-4fn6A:
undetectable		 2ha2B-4fn6A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_G_ASDG1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4fn6 THIAMINASE-2
(Staphylococcus
aureus) 		4 / 7 PHE A   3
LEU A 202
PRO A 136
ALA A 132
 None
None
CME  A 137 ( 3.2A)
None
 0.93A 2vcvG-4fn6A:
undetectable		 2vcvG-4fn6A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8Y_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4fn6 THIAMINASE-2
(Staphylococcus
aureus) 		5 / 12 GLU A 179
ASN A 176
ASP A 173
ILE A 174
PHE A  51
 None
 1.07A 4u8yB-4fn6A:
undetectable		 4u8yB-4fn6A:
11.82