SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fn7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 4fn7 ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN
(Mycobacterium
tuberculosis) 		4 / 8 ASP A  20
ASN A  54
GLY A 102
GLY A  61
 None
 0.80A 1jr1B-4fn7A:
undetectable		 1jr1B-4fn7A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		 4fn7 ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 PHE A 110
PHE A  58
LEU A  89
LEU A  26
PHE A  83
 None
 1.21A 1og5A-4fn7A:
undetectable		 1og5A-4fn7A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI517_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4fn7 ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN
(Mycobacterium
tuberculosis) 		4 / 7 TYR A 154
ILE A 137
PHE A 174
ALA A 157
 None
 1.11A 1oniG-4fn7A:
undetectable
1oniI-4fn7A:
undetectable		 1oniG-4fn7A:
23.81
1oniI-4fn7A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_A_SAMA301_0
(RRNA
METHYLTRANSFERASE)		 4fn7 ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN
(Mycobacterium
tuberculosis) 		5 / 11 GLY A 221
GLY A 224
ILE A 137
MET A 135
ALA A 141
 None
 1.01A 1x7pA-4fn7A:
undetectable
1x7pB-4fn7A:
undetectable		 1x7pA-4fn7A:
21.00
1x7pB-4fn7A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_A_BEZA11_0
(CES1 PROTEIN)		 4fn7 ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN
(Mycobacterium
tuberculosis) 		4 / 4 LEU A  34
SER A  59
LEU A  89
LEU A  85
 None
 1.14A 1yajA-4fn7A:
undetectable		 1yajA-4fn7A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_1
(POL PROTEIN)		 4fn7 ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 ARG A 148
ALA A 140
GLY A  81
GLY A  82
ILE A 218
 None
 0.82A 2fxeA-4fn7A:
undetectable		 2fxeA-4fn7A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		 4fn7 ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN
(Mycobacterium
tuberculosis) 		4 / 6 SER A  91
ARG A 211
ARG A 148
ILE A 144
 None
 1.28A 2qeiA-4fn7A:
undetectable		 2qeiA-4fn7A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)		 4fn7 ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 GLN A  31
GLY A  82
VAL A  57
ALA A 109
ALA A 104
 None
 1.06A 3keeB-4fn7A:
undetectable		 3keeB-4fn7A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 4fn7 ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN
(Mycobacterium
tuberculosis) 		5 / 11 GLY A  61
ALA A  25
ILE A 105
PHE A  58
ALA A 109
 None
 1.14A 3nmuB-4fn7A:
1.1
3nmuJ-4fn7A:
undetectable		 3nmuB-4fn7A:
21.74
3nmuJ-4fn7A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FR0_A_SAMA401_0
(ARSENIC
METHYLTRANSFERASE)		 4fn7 ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  81
LEU A  26
GLN A  31
ILE A 144
LEU A  89
 None
 1.12A 4fr0A-4fn7A:
undetectable		 4fr0A-4fn7A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_D_MIXD101_1
(DNA TOPOISOMERASE
2-BETA)		 4fn7 ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN
(Mycobacterium
tuberculosis) 		4 / 6 ARG A  80
GLY A  81
GLU A  84
MET A 135
 None
 1.27A 4g0vB-4fn7A:
undetectable		 4g0vB-4fn7A:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LS7_B_1X9B503_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 4fn7 ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 137
ALA A 106
PHE A  83
GLY A  61
PHE A  62
 None
 0.89A 4ls7A-4fn7A:
undetectable
4ls7B-4fn7A:
undetectable		 4ls7A-4fn7A:
21.94
4ls7B-4fn7A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		 4fn7 ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  79
GLY A  82
GLN A  31
ILE A 137
PHE A 110
 None
 1.43A 4p6xA-4fn7A:
undetectable		 4p6xA-4fn7A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		 4fn7 ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  79
GLY A  82
GLN A  31
ILE A 137
PHE A 110
 None
 1.45A 4p6xE-4fn7A:
undetectable		 4p6xE-4fn7A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		 4fn7 ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  79
GLY A  82
GLN A  31
ILE A 137
PHE A 110
 None
 1.47A 4p6xI-4fn7A:
undetectable		 4p6xI-4fn7A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_1
(GLUCOCORTICOID
RECEPTOR)		 4fn7 ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  79
GLY A  82
GLN A  31
ILE A 137
PHE A 110
 None
 1.41A 4udcA-4fn7A:
undetectable		 4udcA-4fn7A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4fn7 ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  81
GLY A  82
MET A 107
ILE A 225
ILE A 218
 None
 1.08A 4zvmA-4fn7A:
undetectable
4zvmB-4fn7A:
undetectable		 4zvmA-4fn7A:
22.43
4zvmB-4fn7A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_U_BEZU801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4fn7 ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN
(Mycobacterium
tuberculosis) 		4 / 6 PHE A 110
SER A  59
ALA A 104
LEU A 111
 None
 1.28A 5dzkg-4fn7A:
13.9
5dzku-4fn7A:
undetectable		 5dzkg-4fn7A:
26.48
5dzku-4fn7A:
1.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4fn7 ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN
(Mycobacterium
tuberculosis) 		4 / 5 THR A  52
ALA A  99
THR A 101
TYR A 124
 None
 1.28A 5ecmA-4fn7A:
undetectable		 5ecmA-4fn7A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4fn7 ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 TYR A 154
ILE A  76
PHE A  62
VAL A 131
GLY A  81
 None
 0.99A 5esgA-4fn7A:
undetectable		 5esgA-4fn7A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4fn7 ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  47
ALA A 191
SER A  17
ILE A  16
TYR A   7
 None
 1.24A 5igvA-4fn7A:
undetectable		 5igvA-4fn7A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM2_A_SALA601_1
(SALICYLATE-AMP
LIGASE)		 4fn7 ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN
(Mycobacterium
tuberculosis) 		5 / 9 HIS A 103
CYH A 100
GLY A  60
GLY A 108
LEU A 112
 None
 1.13A 5wm2A-4fn7A:
undetectable		 5wm2A-4fn7A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 4fn7 ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 178
VAL A  50
VAL A  96
SER A 186
GLU A 182
 None
 1.16A 6bzoC-4fn7A:
undetectable		 6bzoC-4fn7A:
11.43