SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fnm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AX9_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE
(Lucilia
cuprina) 		4 / 8 GLY A 136
GLU A 217
SER A 218
HIS A 471
 DPF  A 601 (-3.4A)
DPF  A 601 ( 4.2A)
DPF  A 601 (-1.5A)
DPF  A 601 (-4.2A)
 0.75A 1ax9A-4fnmA:
38.9		 1ax9A-4fnmA:
30.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		 4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE
(Lucilia
cuprina) 		6 / 12 GLY A 135
GLY A 136
GLY A 137
SER A 218
PHE A 354
HIS A 471
 DPF  A 601 ( 3.8A)
DPF  A 601 (-3.4A)
DPF  A 601 (-3.7A)
DPF  A 601 (-1.5A)
None
DPF  A 601 (-4.2A)
 1.12A 1dx6A-4fnmA:
39.3		 1dx6A-4fnmA:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		 4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE
(Lucilia
cuprina) 		7 / 12 GLY A 135
GLY A 136
GLY A 137
SER A 218
TRP A 251
PHE A 309
HIS A 471
 DPF  A 601 ( 3.8A)
DPF  A 601 (-3.4A)
DPF  A 601 (-3.7A)
DPF  A 601 (-1.5A)
DPF  A 601 ( 3.7A)
None
DPF  A 601 (-4.2A)
 0.69A 1dx6A-4fnmA:
39.3		 1dx6A-4fnmA:
30.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE
(Lucilia
cuprina) 		5 / 12 GLY A 184
GLY A 312
PRO A 313
PHE A 172
VAL A 192
 None
 1.12A 1fduC-4fnmA:
2.3		 1fduC-4fnmA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE
(Lucilia
cuprina) 		5 / 12 GLU A 142
LEU A 475
TYR A 457
GLY A 136
GLY A 141
 None
None
DPF  A 601 (-3.2A)
DPF  A 601 (-3.4A)
None
 1.28A 1httB-4fnmA:
undetectable		 1httB-4fnmA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGS_A_SALA256_1
(MULTIPLE ANTIBIOTIC
RESISTANCE PROTEIN
MARR)		 4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE
(Lucilia
cuprina) 		4 / 7 PRO A 128
VAL A 158
LEU A 130
THR A 213
 None
 0.93A 1jgsA-4fnmA:
undetectable		 1jgsA-4fnmA:
12.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MAA_A_DMEA998_1
(ACETYLCHOLINESTERASE)		 4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE
(Lucilia
cuprina) 		5 / 12 GLY A 136
GLU A 217
SER A 218
PHE A 309
HIS A 471
 DPF  A 601 (-3.4A)
DPF  A 601 ( 4.2A)
DPF  A 601 (-1.5A)
None
DPF  A 601 (-4.2A)
 0.73A 1maaA-4fnmA:
38.2		 1maaA-4fnmA:
30.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MAA_C_DMEC997_1
(ACETYLCHOLINESTERASE)		 4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE
(Lucilia
cuprina) 		5 / 12 GLY A 136
TYR A 132
SER A 218
PHE A 309
HIS A 471
 DPF  A 601 (-3.4A)
None
DPF  A 601 (-1.5A)
None
DPF  A 601 (-4.2A)
 1.21A 1maaC-4fnmA:
38.2		 1maaC-4fnmA:
30.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MAA_C_DMEC997_1
(ACETYLCHOLINESTERASE)		 4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE
(Lucilia
cuprina) 		5 / 12 GLY A 136
TYR A 132
SER A 218
PHE A 354
HIS A 471
 DPF  A 601 (-3.4A)
None
DPF  A 601 (-1.5A)
None
DPF  A 601 (-4.2A)
 1.21A 1maaC-4fnmA:
38.2		 1maaC-4fnmA:
30.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MAA_C_DMEC997_1
(ACETYLCHOLINESTERASE)		 4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE
(Lucilia
cuprina) 		5 / 12 GLY A 136
TYR A 148
SER A 218
PHE A 309
HIS A 471
 DPF  A 601 (-3.4A)
None
DPF  A 601 (-1.5A)
None
DPF  A 601 (-4.2A)
 0.83A 1maaC-4fnmA:
38.2		 1maaC-4fnmA:
30.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MAA_D_DMED999_1
(ACETYLCHOLINESTERASE)		 4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE
(Lucilia
cuprina) 		4 / 8 GLY A 136
GLU A 217
SER A 218
HIS A 471
 DPF  A 601 (-3.4A)
DPF  A 601 ( 4.2A)
DPF  A 601 (-1.5A)
DPF  A 601 (-4.2A)
 0.38A 1maaD-4fnmA:
38.2		 1maaD-4fnmA:
30.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MAA_D_DMED999_1
(ACETYLCHOLINESTERASE)		 4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE
(Lucilia
cuprina) 		4 / 8 GLY A 137
GLU A 217
SER A 218
HIS A 471
 DPF  A 601 (-3.7A)
DPF  A 601 ( 4.2A)
DPF  A 601 (-1.5A)
DPF  A 601 (-4.2A)
 0.80A 1maaD-4fnmA:
38.2		 1maaD-4fnmA:
30.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_1
(LIVER
CARBOXYLESTERASE I)		 4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE
(Lucilia
cuprina) 		5 / 12 GLY A 136
GLY A 137
SER A 218
PHE A 421
HIS A 471
 DPF  A 601 (-3.4A)
DPF  A 601 (-3.7A)
DPF  A 601 (-1.5A)
None
DPF  A 601 (-4.2A)
 0.56A 1mx1D-4fnmA:
37.5		 1mx1D-4fnmA:
29.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_F_THAF6_1
(LIVER
CARBOXYLESTERASE I)		 4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE
(Lucilia
cuprina) 		5 / 12 GLY A 136
GLY A 137
SER A 218
PHE A 421
HIS A 471
 DPF  A 601 (-3.4A)
DPF  A 601 (-3.7A)
DPF  A 601 (-1.5A)
None
DPF  A 601 (-4.2A)
 0.48A 1mx1F-4fnmA:
37.3		 1mx1F-4fnmA:
29.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_1
(N,N-DIMETHYLGLYCINE
OXIDASE)		 4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE
(Lucilia
cuprina) 		3 / 3 ASP A 273
THR A 262
GLU A 302
 None
 0.83A 1pj7A-4fnmA:
undetectable		 1pj7A-4fnmA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE
(Lucilia
cuprina) 		5 / 10 TYR A 350
PHE A 375
LEU A 369
VAL A 402
VAL A 366
 None
 1.47A 1q23E-4fnmA:
undetectable		 1q23E-4fnmA:
17.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		 4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE
(Lucilia
cuprina) 		7 / 12 GLY A 135
GLY A 136
GLY A 137
GLU A 217
SER A 218
PHE A 309
HIS A 471
 DPF  A 601 ( 3.8A)
DPF  A 601 (-3.4A)
DPF  A 601 (-3.7A)
DPF  A 601 ( 4.2A)
DPF  A 601 (-1.5A)
None
DPF  A 601 (-4.2A)
 0.52A 1qtiA-4fnmA:
38.6		 1qtiA-4fnmA:
30.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		 4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE
(Lucilia
cuprina) 		6 / 12 GLY A 135
GLY A 136
GLY A 137
SER A 218
PHE A 354
HIS A 471
 DPF  A 601 ( 3.8A)
DPF  A 601 (-3.4A)
DPF  A 601 (-3.7A)
DPF  A 601 (-1.5A)
None
DPF  A 601 (-4.2A)
 1.08A 1qtiA-4fnmA:
38.6		 1qtiA-4fnmA:
30.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1W6R_A_GNTA1536_1
(ACETYLCHOLINESTERASE)		 4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE
(Lucilia
cuprina) 		5 / 12 GLY A 135
GLY A 136
GLY A 137
PHE A 309
PHE A 354
 DPF  A 601 ( 3.8A)
DPF  A 601 (-3.4A)
DPF  A 601 (-3.7A)
None
None
 0.72A 1w6rA-4fnmA:
39.2		 1w6rA-4fnmA:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1W6R_A_GNTA1536_1
(ACETYLCHOLINESTERASE)		 4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE
(Lucilia
cuprina) 		6 / 12 GLY A 135
GLY A 136
GLY A 137
SER A 218
PHE A 309
HIS A 471
 DPF  A 601 ( 3.8A)
DPF  A 601 (-3.4A)
DPF  A 601 (-3.7A)
DPF  A 601 (-1.5A)
None
DPF  A 601 (-4.2A)
 0.61A 1w6rA-4fnmA:
39.2		 1w6rA-4fnmA:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)		 4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE
(Lucilia
cuprina) 		6 / 11 GLY A 136
GLY A 137
GLU A 217
SER A 218
PHE A 309
HIS A 471
 DPF  A 601 (-3.4A)
DPF  A 601 (-3.7A)
DPF  A 601 ( 4.2A)
DPF  A 601 (-1.5A)
None
DPF  A 601 (-4.2A)
 0.55A 1w76A-4fnmA:
38.5		 1w76A-4fnmA:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		 4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE
(Lucilia
cuprina) 		6 / 10 GLY A 135
GLY A 136
GLU A 217
SER A 218
PHE A 309
HIS A 471
 DPF  A 601 ( 3.8A)
DPF  A 601 (-3.4A)
DPF  A 601 ( 4.2A)
DPF  A 601 (-1.5A)
None
DPF  A 601 (-4.2A)
 0.52A 1w76B-4fnmA:
38.5		 1w76B-4fnmA:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		 4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE
(Lucilia
cuprina) 		5 / 10 GLY A 135
GLY A 136
SER A 218
PHE A 354
HIS A 471
 DPF  A 601 ( 3.8A)
DPF  A 601 (-3.4A)
DPF  A 601 (-1.5A)
None
DPF  A 601 (-4.2A)
 1.01A 1w76B-4fnmA:
38.5		 1w76B-4fnmA:
30.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		 4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE
(Lucilia
cuprina) 		4 / 6 TYR A 444
GLY A 352
PHE A 421
SER A 417
 None
 1.37A 2a3cA-4fnmA:
undetectable		 2a3cA-4fnmA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		 4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE
(Lucilia
cuprina) 		4 / 6 TYR A 444
GLY A 352
PHE A 421
SER A 417
 None
 1.34A 2a3cB-4fnmA:
undetectable		 2a3cB-4fnmA:
22.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ACE_A_ACHA998_0
(ACETYLCHOLINESTERASE)		 4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE
(Lucilia
cuprina) 		5 / 9 GLY A 135
GLY A 136
SER A 218
ALA A 219
HIS A 471
 DPF  A 601 ( 3.8A)
DPF  A 601 (-3.4A)
DPF  A 601 (-1.5A)
DPF  A 601 (-3.3A)
DPF  A 601 (-4.2A)
 0.87A 2aceA-4fnmA:
10.7		 2aceA-4fnmA:
30.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ACE_A_ACHA998_0
(ACETYLCHOLINESTERASE)		 4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE
(Lucilia
cuprina) 		6 / 9 GLY A 136
GLY A 137
ALA A 219
TRP A 251
PHE A 309
PHE A   3
 DPF  A 601 (-3.4A)
DPF  A 601 (-3.7A)
DPF  A 601 (-3.3A)
DPF  A 601 ( 3.7A)
None
None
 1.37A 2aceA-4fnmA:
10.7		 2aceA-4fnmA:
30.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ACE_A_ACHA998_0
(ACETYLCHOLINESTERASE)		 4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE
(Lucilia
cuprina) 		7 / 9 GLY A 136
GLY A 137
SER A 218
ALA A 219
TRP A 251
PHE A 309
HIS A 471
 DPF  A 601 (-3.4A)
DPF  A 601 (-3.7A)
DPF  A 601 (-1.5A)
DPF  A 601 (-3.3A)
DPF  A 601 ( 3.7A)
None
DPF  A 601 (-4.2A)
 0.72A 2aceA-4fnmA:
10.7		 2aceA-4fnmA:
30.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ACK_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE
(Lucilia
cuprina) 		4 / 7 GLY A 136
GLU A 217
SER A 218
HIS A 471
 DPF  A 601 (-3.4A)
DPF  A 601 ( 4.2A)
DPF  A 601 (-1.5A)
DPF  A 601 (-4.2A)
 0.82A 2ackA-4fnmA:
39.0		 2ackA-4fnmA:
30.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A164_1
(BETA-LACTOGLOBULIN)		 4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE
(Lucilia
cuprina) 		4 / 5 LEU A 545
LYS A 546
MET A 521
ARG A 499
 None
 1.39A 2gj5A-4fnmA:
1.9		 2gj5A-4fnmA:
15.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HA4_A_ACTA544_0
(ACETYLCHOLINESTERASE)		 4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE
(Lucilia
cuprina) 		6 / 8 GLY A 136
GLY A 137
ALA A 219
TRP A 251
PHE A 309
HIS A 471
 DPF  A 601 (-3.4A)
DPF  A 601 (-3.7A)
DPF  A 601 (-3.3A)
DPF  A 601 ( 3.7A)
None
DPF  A 601 (-4.2A)
 0.78A 2ha4A-4fnmA:
38.3		 2ha4A-4fnmA:
30.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HA4_B_ACTB601_0
(ACETYLCHOLINESTERASE)		 4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE
(Lucilia
cuprina) 		6 / 7 GLY A 136
GLY A 137
ALA A 219
TRP A 251
PHE A 309
HIS A 471
 DPF  A 601 (-3.4A)
DPF  A 601 (-3.7A)
DPF  A 601 (-3.3A)
DPF  A 601 ( 3.7A)
None
DPF  A 601 (-4.2A)
 0.79A 2ha4B-4fnmA:
38.7		 2ha4B-4fnmA:
30.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_C_ACTC36_0
(GCN4 LEUCINE ZIPPER)		 4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE
(Lucilia
cuprina) 		5 / 10 ALA A 247
ASN A 253
ALA A 252
ALA A 222
SER A 223
 None
 1.39A 2r2vC-4fnmA:
undetectable
2r2vF-4fnmA:
undetectable
2r2vG-4fnmA:
undetectable		 2r2vC-4fnmA:
7.43
2r2vF-4fnmA:
7.43
2r2vG-4fnmA:
7.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_F_CSCF1383_2
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE
(Lucilia
cuprina) 		3 / 3 LEU A 353
MET A 413
MET A 425
 None
 0.84A 2vavF-4fnmA:
10.9		 2vavF-4fnmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XTK_B_AZMB1339_1
(CLASS III CHITINASE
CHIA1)		 4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE
(Lucilia
cuprina) 		5 / 10 TYR A 165
PHE A 172
GLY A 171
ALA A 186
TYR A  63
 None
 1.46A 2xtkB-4fnmA:
2.6		 2xtkB-4fnmA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_1
(UNCHARACTERIZED
PROTEIN MJ1557)		 4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE
(Lucilia
cuprina) 		3 / 3 MET A 227
GLU A 316
ASN A 181
 None
 1.00A 3a27A-4fnmA:
undetectable		 3a27A-4fnmA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE
(Lucilia
cuprina) 		4 / 7 HIS A 418
ASP A 549
TYR A 536
HIS A 401
 None
 1.21A 3abmN-4fnmA:
undetectable
3abmP-4fnmA:
undetectable		 3abmN-4fnmA:
20.56
3abmP-4fnmA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_1
(N,N-DIMETHYLTRANSFER
ASE)		 4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE
(Lucilia
cuprina) 		3 / 3 TYR A 165
GLU A 217
ASP A 473
 None
DPF  A 601 ( 4.2A)
None
 0.77A 3bxoA-4fnmA:
undetectable		 3bxoA-4fnmA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_1
(N,N-DIMETHYLTRANSFER
ASE)		 4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE
(Lucilia
cuprina) 		3 / 3 TYR A 165
GLU A 217
ASP A 473
 None
DPF  A 601 ( 4.2A)
None
 0.79A 3bxoB-4fnmA:
undetectable		 3bxoB-4fnmA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX94_0
(PROTEIN S100-B)		 4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE
(Lucilia
cuprina) 		3 / 3 PHE A 355
CYH A 416
PHE A 375
 None
 1.00A 3cr5X-4fnmA:
1.6		 3cr5X-4fnmA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE
(Lucilia
cuprina) 		4 / 6 ILE A 163
PHE A 153
PHE A 479
TYR A 132
 None
 1.19A 3elzB-4fnmA:
undetectable		 3elzB-4fnmA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I9J_B_NCAB302_0
(ADP-RIBOSYL CYCLASE)		 4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE
(Lucilia
cuprina) 		4 / 6 LEU A 365
GLU A 368
ASN A 374
PHE A 355
 None
 1.50A 3i9jB-4fnmA:
undetectable		 3i9jB-4fnmA:
20.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3O9M_A_BEZA999_0
(CHOLINESTERASE)		 4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE
(Lucilia
cuprina) 		6 / 7 GLY A 136
GLY A 137
SER A 218
TRP A 251
PHE A 421
HIS A 471
 DPF  A 601 (-3.4A)
DPF  A 601 (-3.7A)
DPF  A 601 (-1.5A)
DPF  A 601 ( 3.7A)
None
DPF  A 601 (-4.2A)
 0.66A 3o9mA-4fnmA:
38.7		 3o9mA-4fnmA:
32.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3O9M_B_BEZB999_0
(CHOLINESTERASE)		 4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE
(Lucilia
cuprina) 		5 / 6 GLY A 136
GLY A 137
SER A 218
TRP A 251
HIS A 471
 DPF  A 601 (-3.4A)
DPF  A 601 (-3.7A)
DPF  A 601 (-1.5A)
DPF  A 601 ( 3.7A)
DPF  A 601 (-4.2A)
 0.43A 3o9mB-4fnmA:
38.9		 3o9mB-4fnmA:
32.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_A_9PLA501_1
(CYTOCHROME P450 2A6)		 4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE
(Lucilia
cuprina) 		5 / 10 PHE A 153
PHE A 479
ASN A 162
THR A 213
ILE A 241
 None
 1.30A 3t3qA-4fnmA:
undetectable		 3t3qA-4fnmA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_B_9PLB501_1
(CYTOCHROME P450 2A6)		 4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE
(Lucilia
cuprina) 		5 / 10 PHE A 153
PHE A 479
ASN A 162
THR A 213
ILE A 241
 None
 1.35A 3t3qB-4fnmA:
undetectable		 3t3qB-4fnmA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_C_9PLC501_1
(CYTOCHROME P450 2A6)		 4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE
(Lucilia
cuprina) 		5 / 10 PHE A 153
PHE A 479
ASN A 162
THR A 213
ILE A 241
 None
 1.32A 3t3qC-4fnmA:
undetectable		 3t3qC-4fnmA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_0
(GLYCINE
N-METHYLTRANSFERASE)		 4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE
(Lucilia
cuprina) 		4 / 6 SER A 378
LEU A 380
HIS A 566
ARG A 385
 None
 1.38A 3thrB-4fnmA:
undetectable		 3thrB-4fnmA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VKX_A_T3A301_1
(PROLIFERATING CELL
NUCLEAR ANTIGEN)		 4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE
(Lucilia
cuprina) 		4 / 6 MET A 547
LEU A 539
GLN A 506
PRO A 513
 None
 1.12A 3vkxA-4fnmA:
undetectable		 3vkxA-4fnmA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE
(Lucilia
cuprina) 		5 / 12 ILE A 212
ALA A 508
LEU A 160
THR A 224
ILE A 133
 None
 1.02A 4ej1B-4fnmA:
undetectable		 4ej1B-4fnmA:
13.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		 4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE
(Lucilia
cuprina) 		6 / 12 GLY A 135
GLY A 136
GLY A 137
SER A 218
PHE A 309
HIS A 471
 DPF  A 601 ( 3.8A)
DPF  A 601 (-3.4A)
DPF  A 601 (-3.7A)
DPF  A 601 (-1.5A)
None
DPF  A 601 (-4.2A)
 0.54A 4ey6A-4fnmA:
38.7		 4ey6A-4fnmA:
30.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		 4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE
(Lucilia
cuprina) 		6 / 12 GLY A 135
GLY A 136
GLY A 137
GLU A 217
PHE A 354
HIS A 471
 DPF  A 601 ( 3.8A)
DPF  A 601 (-3.4A)
DPF  A 601 (-3.7A)
DPF  A 601 ( 4.2A)
None
DPF  A 601 (-4.2A)
 1.12A 4ey6B-4fnmA:
38.3		 4ey6B-4fnmA:
30.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		 4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE
(Lucilia
cuprina) 		7 / 12 GLY A 135
GLY A 136
GLY A 137
GLU A 217
SER A 218
PHE A 309
HIS A 471
 DPF  A 601 ( 3.8A)
DPF  A 601 (-3.4A)
DPF  A 601 (-3.7A)
DPF  A 601 ( 4.2A)
DPF  A 601 (-1.5A)
None
DPF  A 601 (-4.2A)
 0.52A 4ey6B-4fnmA:
38.3		 4ey6B-4fnmA:
30.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA505_0
(RNA POLYMERASE
3D-POL)		 4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE
(Lucilia
cuprina) 		3 / 3 CYH A 202
ASN A 208
LYS A 199
 None
 1.47A 4k50A-4fnmA:
undetectable		 4k50A-4fnmA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE
(Lucilia
cuprina) 		3 / 3 TYR A  55
ARG A 145
SER A  57
 None
 1.08A 4khpI-4fnmA:
undetectable
4khpJ-4fnmA:
undetectable		 4khpI-4fnmA:
12.41
4khpJ-4fnmA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_2
(FOLATE RECEPTOR BETA)		 4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE
(Lucilia
cuprina) 		3 / 3 TYR A 113
GLN A  65
TRP A 197
 None
 1.04A 4kn2C-4fnmA:
undetectable		 4kn2C-4fnmA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LS7_B_1X9B503_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE
(Lucilia
cuprina) 		5 / 12 MET A 227
ALA A 221
PHE A 138
HIS A 471
GLY A 245
 None
None
None
DPF  A 601 (-4.2A)
None
 1.02A 4ls7A-4fnmA:
undetectable
4ls7B-4fnmA:
undetectable		 4ls7A-4fnmA:
21.33
4ls7B-4fnmA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LS7_B_1X9B503_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE
(Lucilia
cuprina) 		5 / 12 MET A 227
ILE A 133
ALA A 221
PHE A 138
HIS A 471
 None
None
None
None
DPF  A 601 (-4.2A)
 1.07A 4ls7A-4fnmA:
undetectable
4ls7B-4fnmA:
undetectable		 4ls7A-4fnmA:
21.33
4ls7B-4fnmA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_A_ADNA501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE
(Lucilia
cuprina) 		3 / 3 PRO A 326
LEU A 325
HIS A 225
 None
 0.65A 4pevA-4fnmA:
3.0		 4pevA-4fnmA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE
(Lucilia
cuprina) 		5 / 12 ILE A 212
ALA A 508
LEU A 160
THR A 224
ILE A 133
 None
 1.01A 4x5jA-4fnmA:
undetectable		 4x5jA-4fnmA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP3_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE
(Lucilia
cuprina) 		4 / 6 ALA A  64
GLN A  65
LEU A 112
LEU A  71
 None
 1.22A 4xp3A-4fnmA:
undetectable		 4xp3A-4fnmA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE
(Lucilia
cuprina) 		4 / 5 GLY A 135
TYR A 226
SER A 223
GLU A 217
 DPF  A 601 ( 3.8A)
None
None
DPF  A 601 ( 4.2A)
 1.18A 4xueA-4fnmA:
2.2		 4xueA-4fnmA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_1
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE
(Lucilia
cuprina) 		4 / 4 ASP A 473
GLY A 468
ASP A 449
ASP A 452
 None
 1.01A 5e72A-4fnmA:
undetectable		 5e72A-4fnmA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		 4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE
(Lucilia
cuprina) 		4 / 8 SER A 378
PRO A 250
TYR A 420
ASN A 305
 None
 1.11A 5l1fA-4fnmA:
undetectable
5l1fB-4fnmA:
undetectable		 5l1fA-4fnmA:
22.24
5l1fB-4fnmA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM2_A_ACTA605_0
(SALICYLATE-AMP
LIGASE)		 4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE
(Lucilia
cuprina) 		3 / 3 THR A 439
THR A 436
ARG A 432
 None
 0.62A 5wm2A-4fnmA:
1.9		 5wm2A-4fnmA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_1
(CYTOCHROME P450 2C9)		 4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE
(Lucilia
cuprina) 		5 / 12 ALA A 194
GLN A 164
GLY A 220
ALA A 219
LEU A 167
 None
None
None
DPF  A 601 (-3.3A)
None
 1.07A 5xxiA-4fnmA:
undetectable		 5xxiA-4fnmA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE
(Lucilia
cuprina) 		4 / 7 HIS A 418
ASP A 549
TYR A 536
HIS A 401
 None
 1.29A 6nmfN-4fnmA:
undetectable
6nmfP-4fnmA:
undetectable		 6nmfN-4fnmA:
20.56
6nmfP-4fnmA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE
(Lucilia
cuprina) 		4 / 6 HIS A 418
ASP A 549
TYR A 536
HIS A 401
 None
 1.25A 6nmpA-4fnmA:
undetectable
6nmpC-4fnmA:
undetectable		 6nmpA-4fnmA:
20.56
6nmpC-4fnmA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE
(Lucilia
cuprina) 		4 / 7 HIS A 418
ASP A 549
TYR A 536
HIS A 401
 None
 1.25A 6nmpN-4fnmA:
undetectable
6nmpP-4fnmA:
undetectable		 6nmpN-4fnmA:
20.56
6nmpP-4fnmA:
17.53