SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fno'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4fno PEPTIDYL-TRNA
HYDROLASE
(Pseudomonas
aeruginosa) 		4 / 5 ASP A  95
GLY A 153
PRO A 141
ILE A 138
 None
 0.96A 2aoiA-4fnoA:
undetectable		 2aoiA-4fnoA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		 4fno PEPTIDYL-TRNA
HYDROLASE
(Pseudomonas
aeruginosa) 		4 / 8 TYR A  17
ASN A  12
GLY A  14
GLU A  16
 None
 0.99A 2ys6A-4fnoA:
undetectable		 2ys6A-4fnoA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)		 4fno PEPTIDYL-TRNA
HYDROLASE
(Pseudomonas
aeruginosa) 		5 / 11 LEU A  10
ILE A  64
SER A  75
VAL A 151
LEU A 152
 None
GOL  A 203 (-4.5A)
None
None
None
 1.40A 3a9eB-4fnoA:
undetectable		 3a9eB-4fnoA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_A_BEZA261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 4fno PEPTIDYL-TRNA
HYDROLASE
(Pseudomonas
aeruginosa) 		4 / 8 HIS A  22
GLY A  11
ASN A  23
TYR A  17
 None
None
GOL  A 203 ( 4.6A)
None
 1.34A 3ccfA-4fnoA:
undetectable		 3ccfA-4fnoA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_2
(PROTEASE)		 4fno PEPTIDYL-TRNA
HYDROLASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  97
GLY A  25
LEU A  10
VAL A 151
ILE A 138
 None
 0.94A 3em6B-4fnoA:
undetectable		 3em6B-4fnoA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4fno PEPTIDYL-TRNA
HYDROLASE
(Pseudomonas
aeruginosa) 		4 / 7 LEU A  40
ARG A  31
SER A  75
GLY A  25
 None
 1.06A 3hcrB-4fnoA:
4.1		 3hcrB-4fnoA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 4fno PEPTIDYL-TRNA
HYDROLASE
(Pseudomonas
aeruginosa) 		4 / 8 VAL A  38
GLN A   5
ILE A  64
GLY A  51
 None
None
GOL  A 203 (-4.5A)
None
 0.83A 3hjoA-4fnoA:
undetectable		 3hjoA-4fnoA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZJ_A_ACRA405_1
(ACARBOSE/MALTOSE
BINDING PROTEIN GACH)		 4fno PEPTIDYL-TRNA
HYDROLASE
(Pseudomonas
aeruginosa) 		5 / 12 PHE A 131
GLY A 109
ALA A 123
GLY A  73
ASN A 127
 None
 1.42A 3jzjA-4fnoA:
undetectable		 3jzjA-4fnoA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)		 4fno PEPTIDYL-TRNA
HYDROLASE
(Pseudomonas
aeruginosa) 		5 / 12 ILE A  85
PHE A  83
LEU A   6
VAL A   8
LEU A  40
 None
 0.96A 3ozuA-4fnoA:
undetectable		 3ozuA-4fnoA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD2_1
(CYTOCHROME P450 2D6)		 4fno PEPTIDYL-TRNA
HYDROLASE
(Pseudomonas
aeruginosa) 		5 / 9 PHE A  53
LEU A 178
VAL A   4
LEU A  32
ILE A   7
 None
 1.15A 3tbgD-4fnoA:
undetectable		 3tbgD-4fnoA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4fno PEPTIDYL-TRNA
HYDROLASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 118
GLY A   9
GLY A  11
ALA A  93
HIS A  94
 None
 1.13A 3uj7B-4fnoA:
undetectable		 3uj7B-4fnoA:
20.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QD3_A_5AEA201_1
(PEPTIDYL-TRNA
HYDROLASE)		 4fno PEPTIDYL-TRNA
HYDROLASE
(Pseudomonas
aeruginosa) 		9 / 9 HIS A  22
LEU A  97
GLY A 114
HIS A 115
ASN A 116
VAL A 147
SER A 148
VAL A 151
LEU A 152
 None
 0.39A 4qd3A-4fnoA:
39.4		 4qd3A-4fnoA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_A_ACTA802_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 4fno PEPTIDYL-TRNA
HYDROLASE
(Pseudomonas
aeruginosa) 		4 / 6 HIS A  22
ASP A  95
HIS A 115
MET A  69
 None
 1.48A 5m45A-4fnoA:
undetectable		 5m45A-4fnoA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD802_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 4fno PEPTIDYL-TRNA
HYDROLASE
(Pseudomonas
aeruginosa) 		4 / 6 HIS A  22
ASP A  95
HIS A 115
MET A  69
 None
 1.47A 5m45D-4fnoA:
undetectable		 5m45D-4fnoA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_G_ACTG802_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 4fno PEPTIDYL-TRNA
HYDROLASE
(Pseudomonas
aeruginosa) 		4 / 6 HIS A  22
ASP A  95
HIS A 115
MET A  69
 None
 1.48A 5m45G-4fnoA:
undetectable		 5m45G-4fnoA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ802_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 4fno PEPTIDYL-TRNA
HYDROLASE
(Pseudomonas
aeruginosa) 		4 / 6 HIS A  22
ASP A  95
HIS A 115
MET A  69
 None
 1.48A 5m45J-4fnoA:
0.0		 5m45J-4fnoA:
14.34