SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fnv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 4fnv HEPARINASE III
PROTEIN, HEPARITIN
SULFATE LYASE
(Bacteroides
thetaiotaomicron) 		5 / 12 ILE A 215
ALA A 270
LEU A 293
GLN A 208
LEU A 209
 None
 1.05A 1drfA-4fnvA:
undetectable		 1drfA-4fnvA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9J_H_TESH1010_1
(RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT HEAVY
CHAIN
RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT LIGHT
CHAIN)		 4fnv HEPARINASE III
PROTEIN, HEPARITIN
SULFATE LYASE
(Bacteroides
thetaiotaomicron) 		5 / 11 SER A 463
TYR A 490
GLU A 309
TYR A 314
VAL A 487
 None
 1.30A 1i9jH-4fnvA:
undetectable
1i9jL-4fnvA:
undetectable		 1i9jH-4fnvA:
14.53
1i9jL-4fnvA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4fnv HEPARINASE III
PROTEIN, HEPARITIN
SULFATE LYASE
(Bacteroides
thetaiotaomicron) 		5 / 10 SER A 264
ASN A 267
GLY A 317
GLU A 296
GLY A 259
 None
 1.31A 1mehA-4fnvA:
undetectable		 1mehA-4fnvA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRJ_A_ADNA300_1
(ALPHA-TRICHOSANTHIN)		 4fnv HEPARINASE III
PROTEIN, HEPARITIN
SULFATE LYASE
(Bacteroides
thetaiotaomicron) 		4 / 8 ILE A 514
GLY A 567
TYR A 655
ILE A 575
 None
 0.92A 1mrjA-4fnvA:
undetectable		 1mrjA-4fnvA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_1
(GLYCINE
N-METHYLTRANSFERASE)		 4fnv HEPARINASE III
PROTEIN, HEPARITIN
SULFATE LYASE
(Bacteroides
thetaiotaomicron) 		4 / 4 ILE A 627
ARG A 638
ASP A 468
ASN A 449
 None
 1.49A 1nbiC-4fnvA:
undetectable		 1nbiC-4fnvA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 4fnv HEPARINASE III
PROTEIN, HEPARITIN
SULFATE LYASE
(Bacteroides
thetaiotaomicron) 		4 / 4 ILE A 627
ARG A 638
ASP A 468
ASN A 449
 None
 1.49A 1nbiD-4fnvA:
undetectable		 1nbiD-4fnvA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 4fnv HEPARINASE III
PROTEIN, HEPARITIN
SULFATE LYASE
(Bacteroides
thetaiotaomicron) 		3 / 3 ASN A 605
ASN A 604
ARG A 479
 None
 0.81A 2rlcA-4fnvA:
undetectable		 2rlcA-4fnvA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_A_FOLA1188_0
(DIHYDROFOLATE
REDUCTASE)		 4fnv HEPARINASE III
PROTEIN, HEPARITIN
SULFATE LYASE
(Bacteroides
thetaiotaomicron) 		5 / 12 ILE A 215
ALA A 270
LEU A 293
GLN A 208
LEU A 209
 None
 1.08A 2w3mA-4fnvA:
undetectable		 2w3mA-4fnvA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_B_FOLB1188_0
(DIHYDROFOLATE
REDUCTASE)		 4fnv HEPARINASE III
PROTEIN, HEPARITIN
SULFATE LYASE
(Bacteroides
thetaiotaomicron) 		5 / 12 ILE A 215
ALA A 270
LEU A 293
GLN A 208
LEU A 209
 None
 1.08A 2w3mB-4fnvA:
undetectable		 2w3mB-4fnvA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_B_BEZB261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 4fnv HEPARINASE III
PROTEIN, HEPARITIN
SULFATE LYASE
(Bacteroides
thetaiotaomicron) 		4 / 8 HIS A 464
ASN A 260
ILE A 261
TRP A 207
 None
 0.90A 3ccfB-4fnvA:
undetectable		 3ccfB-4fnvA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZJ_A_ACRA405_1
(ACARBOSE/MALTOSE
BINDING PROTEIN GACH)		 4fnv HEPARINASE III
PROTEIN, HEPARITIN
SULFATE LYASE
(Bacteroides
thetaiotaomicron) 		5 / 12 GLU A 153
GLY A 317
ARG A 160
ALA A 268
ASN A 267
 None
 1.31A 3jzjA-4fnvA:
undetectable		 3jzjA-4fnvA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 4fnv HEPARINASE III
PROTEIN, HEPARITIN
SULFATE LYASE
(Bacteroides
thetaiotaomicron) 		4 / 5 ALA A 408
MET A 354
THR A 357
PHE A 362
 None
 1.37A 3vasB-4fnvA:
undetectable		 3vasB-4fnvA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 4fnv HEPARINASE III
PROTEIN, HEPARITIN
SULFATE LYASE
(Bacteroides
thetaiotaomicron) 		4 / 4 PHE A 675
VAL A 687
ALA A 685
PHE A 554
 None
 1.46A 4f3tA-4fnvA:
undetectable		 4f3tA-4fnvA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KEB_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 4fnv HEPARINASE III
PROTEIN, HEPARITIN
SULFATE LYASE
(Bacteroides
thetaiotaomicron) 		5 / 12 ILE A 215
ALA A 270
LEU A 293
GLN A 208
LEU A 209
 None
 1.07A 4kebB-4fnvA:
undetectable		 4kebB-4fnvA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4fnv HEPARINASE III
PROTEIN, HEPARITIN
SULFATE LYASE
(Bacteroides
thetaiotaomicron) 		4 / 4 PHE A 675
VAL A 687
ALA A 685
PHE A 554
 None
 1.49A 4w5qA-4fnvA:
undetectable		 4w5qA-4fnvA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4fnv HEPARINASE III
PROTEIN, HEPARITIN
SULFATE LYASE
(Bacteroides
thetaiotaomicron) 		4 / 4 PHE A 675
VAL A 687
ALA A 685
PHE A 554
 None
 1.49A 4w5rA-4fnvA:
undetectable		 4w5rA-4fnvA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_A_HISA302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4fnv HEPARINASE III
PROTEIN, HEPARITIN
SULFATE LYASE
(Bacteroides
thetaiotaomicron) 		5 / 10 GLY A 597
VAL A 610
VAL A 598
LEU A 577
LEU A 581
 None
 1.28A 4yb6A-4fnvA:
undetectable
4yb6E-4fnvA:
undetectable		 4yb6A-4fnvA:
15.91
4yb6E-4fnvA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4fnv HEPARINASE III
PROTEIN, HEPARITIN
SULFATE LYASE
(Bacteroides
thetaiotaomicron) 		5 / 10 GLY A 597
VAL A 610
VAL A 598
LEU A 577
LEU A 581
 None
 1.28A 4yb6B-4fnvA:
undetectable
4yb6C-4fnvA:
undetectable		 4yb6B-4fnvA:
15.91
4yb6C-4fnvA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_C_HISC302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4fnv HEPARINASE III
PROTEIN, HEPARITIN
SULFATE LYASE
(Bacteroides
thetaiotaomicron) 		5 / 10 GLY A 597
VAL A 610
VAL A 598
LEU A 577
LEU A 581
 None
 1.36A 4yb6C-4fnvA:
undetectable
4yb6F-4fnvA:
undetectable		 4yb6C-4fnvA:
15.91
4yb6F-4fnvA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_E_HISE302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4fnv HEPARINASE III
PROTEIN, HEPARITIN
SULFATE LYASE
(Bacteroides
thetaiotaomicron) 		5 / 10 LEU A 577
LEU A 581
GLY A 597
VAL A 610
VAL A 598
 None
 1.35A 4yb6D-4fnvA:
undetectable
4yb6E-4fnvA:
undetectable		 4yb6D-4fnvA:
15.91
4yb6E-4fnvA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_F_HISF302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4fnv HEPARINASE III
PROTEIN, HEPARITIN
SULFATE LYASE
(Bacteroides
thetaiotaomicron) 		5 / 10 LEU A 577
LEU A 581
GLY A 597
VAL A 610
VAL A 598
 None
 1.28A 4yb6B-4fnvA:
undetectable
4yb6F-4fnvA:
undetectable		 4yb6B-4fnvA:
15.91
4yb6F-4fnvA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4fnv HEPARINASE III
PROTEIN, HEPARITIN
SULFATE LYASE
(Bacteroides
thetaiotaomicron) 		4 / 4 PHE A 675
VAL A 687
ALA A 685
PHE A 554
 None
 1.49A 4z4gA-4fnvA:
undetectable		 4z4gA-4fnvA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4fnv HEPARINASE III
PROTEIN, HEPARITIN
SULFATE LYASE
(Bacteroides
thetaiotaomicron) 		5 / 12 GLY A 412
ILE A 446
LEU A 384
THR A 407
MET A 405
 None
 1.05A 4zdyA-4fnvA:
undetectable		 4zdyA-4fnvA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HJI_A_ADNA401_1
(TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A)		 4fnv HEPARINASE III
PROTEIN, HEPARITIN
SULFATE LYASE
(Bacteroides
thetaiotaomicron) 		5 / 11 LEU A  60
PHE A  50
ILE A  53
ASN A  54
VAL A  49
 None
 1.19A 5hjiA-4fnvA:
undetectable		 5hjiA-4fnvA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 4fnv HEPARINASE III
PROTEIN, HEPARITIN
SULFATE LYASE
(Bacteroides
thetaiotaomicron) 		5 / 12 ASP A 217
GLY A 216
ASN A  93
LEU A 328
ALA A 270
 None
 1.35A 5kc4E-4fnvA:
undetectable		 5kc4E-4fnvA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4fnv HEPARINASE III
PROTEIN, HEPARITIN
SULFATE LYASE
(Bacteroides
thetaiotaomicron) 		4 / 4 PHE A 675
VAL A 687
ALA A 685
PHE A 554
 None
 1.48A 5ki6A-4fnvA:
undetectable		 5ki6A-4fnvA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4fnv HEPARINASE III
PROTEIN, HEPARITIN
SULFATE LYASE
(Bacteroides
thetaiotaomicron) 		3 / 3 ASN A 374
VAL A 353
HIS A 315
 None
 0.80A 6a5yD-4fnvA:
undetectable		 6a5yD-4fnvA:
8.97