SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fo0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_B_CAMB502_0
(CYTOCHROME P450-CAM)		 4fo0 ACTIN-RELATED
PROTEIN 8
(Homo
sapiens) 		4 / 5 TYR A 240
VAL A 263
VAL A 268
ASP A 238
 None
 1.49A 1dz6B-4fo0A:
undetectable		 1dz6B-4fo0A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4fo0 ACTIN-RELATED
PROTEIN 8
(Homo
sapiens) 		5 / 10 THR A 574
PHE A 393
LEU A 392
VAL A 314
VAL A 284
 None
 1.39A 1q23K-4fo0A:
undetectable		 1q23K-4fo0A:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4fo0 ACTIN-RELATED
PROTEIN 8
(Homo
sapiens) 		5 / 11 THR A 574
PHE A 393
LEU A 392
VAL A 314
VAL A 284
 None
 1.37A 1q23L-4fo0A:
undetectable		 1q23L-4fo0A:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U1J_A_C2FA773_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 4fo0 ACTIN-RELATED
PROTEIN 8
(Homo
sapiens) 		4 / 8 ARG A 575
HIS A  52
ARG A 582
VAL A 538
 None
None
ATP  A 702 ( 4.3A)
None
 1.18A 1u1jA-4fo0A:
undetectable		 1u1jA-4fo0A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_A_RBFA300_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4fo0 ACTIN-RELATED
PROTEIN 8
(Homo
sapiens) 		5 / 11 GLY A 273
SER A 274
LEU A 536
HIS A  52
ALA A 590
 None
 1.49A 2a58A-4fo0A:
undetectable
2a58E-4fo0A:
undetectable		 2a58A-4fo0A:
14.53
2a58E-4fo0A:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_D_RBFD303_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4fo0 ACTIN-RELATED
PROTEIN 8
(Homo
sapiens) 		5 / 11 HIS A  52
ALA A 590
GLY A 273
SER A 274
LEU A 536
 None
 1.48A 2a58C-4fo0A:
undetectable
2a58D-4fo0A:
undetectable		 2a58C-4fo0A:
14.53
2a58D-4fo0A:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQY_A_ADNA400_1
(MEMBRANE LIPOPROTEIN
TMPC)		 4fo0 ACTIN-RELATED
PROTEIN 8
(Homo
sapiens) 		5 / 12 ASP A 283
GLY A 539
PHE A 544
GLY A 310
VAL A 314
 MG  A 701 ( 3.9A)
ATP  A 702 (-3.6A)
ATP  A 702 (-4.0A)
None
None
 1.44A 2fqyA-4fo0A:
2.2		 2fqyA-4fo0A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A164_1
(BETA-LACTOGLOBULIN)		 4fo0 ACTIN-RELATED
PROTEIN 8
(Homo
sapiens) 		4 / 5 ASP A 383
LEU A 386
LYS A 385
MET A 390
 None
None
GOL  A 707 (-2.7A)
None
 1.40A 2gj5A-4fo0A:
undetectable		 2gj5A-4fo0A:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA502_0
(FERROCHELATASE)		 4fo0 ACTIN-RELATED
PROTEIN 8
(Homo
sapiens) 		4 / 8 MET A 579
PRO A  68
GLY A 589
TRP A 586
 None
 1.09A 2qd3A-4fo0A:
undetectable		 2qd3A-4fo0A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APT_B_ACTB311_0
(METHYLENETETRAHYDROF
OLATE REDUCTASE)		 4fo0 ACTIN-RELATED
PROTEIN 8
(Homo
sapiens) 		5 / 9 LEU A 220
ASP A  65
PRO A  68
ALA A  69
ILE A  60
 None
 1.24A 3aptB-4fo0A:
0.3		 3aptB-4fo0A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		 4fo0 ACTIN-RELATED
PROTEIN 8
(Homo
sapiens) 		3 / 3 GLU A 295
HIS A 300
THR A 527
 None
 0.71A 3hkuA-4fo0A:
undetectable		 3hkuA-4fo0A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_H_DHIH3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 4fo0 ACTIN-RELATED
PROTEIN 8
(Homo
sapiens) 		3 / 3 LEU A 583
TRP A 586
GLY A  61
 CL  A 711 ( 4.7A)
None
None
 0.78A 3l35A-4fo0A:
undetectable
3l35H-4fo0A:
undetectable		 3l35A-4fo0A:
5.70
3l35H-4fo0A:
2.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_K_DHIK3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 4fo0 ACTIN-RELATED
PROTEIN 8
(Homo
sapiens) 		3 / 3 LEU A 583
TRP A 586
GLY A  61
 CL  A 711 ( 4.7A)
None
None
 0.68A 3l35B-4fo0A:
undetectable
3l35K-4fo0A:
undetectable		 3l35B-4fo0A:
5.70
3l35K-4fo0A:
2.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LW5_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4fo0 ACTIN-RELATED
PROTEIN 8
(Homo
sapiens) 		5 / 10 ILE A 252
PHE A 622
ARG A 617
LEU A 616
ALA A 620
 None
 1.41A 3lw5B-4fo0A:
undetectable		 3lw5B-4fo0A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_C_MIYC392_1
(TETX2 PROTEIN)		 4fo0 ACTIN-RELATED
PROTEIN 8
(Homo
sapiens) 		5 / 12 TYR A 230
PRO A  68
ILE A  71
TYR A 219
GLU A 221
 None
 1.44A 4a99A-4fo0A:
undetectable
4a99C-4fo0A:
undetectable		 4a99A-4fo0A:
20.03
4a99C-4fo0A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_ACTA303_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4fo0 ACTIN-RELATED
PROTEIN 8
(Homo
sapiens) 		3 / 3 TYR A 180
HIS A 162
ARG A  78
 None
 1.01A 4htfA-4fo0A:
undetectable		 4htfA-4fo0A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		 4fo0 ACTIN-RELATED
PROTEIN 8
(Homo
sapiens) 		5 / 12 LEU A 346
PHE A 318
TYR A 319
PRO A 328
ASP A 383
 None
 1.36A 4j7xF-4fo0A:
2.1		 4j7xF-4fo0A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		 4fo0 ACTIN-RELATED
PROTEIN 8
(Homo
sapiens) 		5 / 12 LEU A 346
PHE A 318
TYR A 319
PRO A 328
ASP A 383
 None
 1.32A 4j7xJ-4fo0A:
2.4		 4j7xJ-4fo0A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4fo0 ACTIN-RELATED
PROTEIN 8
(Homo
sapiens) 		4 / 8 LEU A 172
TYR A 173
VAL A  74
HIS A 369
 None
GOL  A 704 (-4.0A)
None
None
 1.00A 4l1xA-4fo0A:
undetectable		 4l1xA-4fo0A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M51_A_BEZA501_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 4fo0 ACTIN-RELATED
PROTEIN 8
(Homo
sapiens) 		4 / 6 ILE A 236
ILE A 261
PHE A 622
LEU A 616
 None
 0.96A 4m51A-4fo0A:
undetectable		 4m51A-4fo0A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4fo0 ACTIN-RELATED
PROTEIN 8
(Homo
sapiens) 		4 / 8 THR A 574
GLY A 541
GLY A 540
ASP A 580
 None
ATP  A 702 (-3.8A)
ATP  A 702 (-3.1A)
None
 0.79A 4qvvK-4fo0A:
undetectable
4qvvL-4fo0A:
undetectable		 4qvvK-4fo0A:
18.91
4qvvL-4fo0A:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4fo0 ACTIN-RELATED
PROTEIN 8
(Homo
sapiens) 		4 / 8 THR A 574
GLY A 541
GLY A 540
ASP A 580
 None
ATP  A 702 (-3.8A)
ATP  A 702 (-3.1A)
None
 0.78A 4qvvY-4fo0A:
undetectable
4qvvZ-4fo0A:
undetectable		 4qvvY-4fo0A:
18.91
4qvvZ-4fo0A:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z7F_A_FOLA201_0
(FOLATE ECF
TRANSPORTER)		 4fo0 ACTIN-RELATED
PROTEIN 8
(Homo
sapiens) 		5 / 12 LEU A 386
LYS A 385
ALA A 325
TYR A 139
ARG A 128
 None
GOL  A 707 (-2.7A)
None
None
None
 1.28A 4z7fA-4fo0A:
0.0		 4z7fA-4fo0A:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_D_6ZPD902_1
(GLUTAMATE RECEPTOR 2)		 4fo0 ACTIN-RELATED
PROTEIN 8
(Homo
sapiens) 		5 / 10 PHE A 379
ASP A 362
LEU A 360
SER A 138
ASN A 140
 None
 1.33A 5l1fD-4fo0A:
2.5		 5l1fD-4fo0A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4fo0 ACTIN-RELATED
PROTEIN 8
(Homo
sapiens) 		5 / 10 ARG A  77
LEU A 191
PRO A 185
GLY A 198
THR A 202
 None
 1.04A 5o96G-4fo0A:
undetectable
5o96H-4fo0A:
undetectable		 5o96G-4fo0A:
19.46
5o96H-4fo0A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4fo0 ACTIN-RELATED
PROTEIN 8
(Homo
sapiens) 		4 / 6 GLN A 323
PHE A 327
PHE A 379
LEU A 381
 None
 1.09A 5z85P-4fo0A:
undetectable
5z85W-4fo0A:
undetectable		 5z85P-4fo0A:
18.32
5z85W-4fo0A:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		 4fo0 ACTIN-RELATED
PROTEIN 8
(Homo
sapiens) 		4 / 6 ASP A 520
ASN A 302
LEU A 408
PHE A 504
 None
 1.11A 6ekuA-4fo0A:
undetectable		 6ekuA-4fo0A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4fo0 ACTIN-RELATED
PROTEIN 8
(Homo
sapiens) 		4 / 6 GLY A 109
VAL A 314
PHE A 393
PHE A 544
 None
None
None
ATP  A 702 (-4.0A)
 1.02A 6h7lA-4fo0A:
undetectable		 6h7lA-4fo0A:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_B_Y00B405_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4fo0 ACTIN-RELATED
PROTEIN 8
(Homo
sapiens) 		4 / 6 GLY A 109
VAL A 314
PHE A 393
PHE A 544
 None
None
None
ATP  A 702 (-4.0A)
 1.02A 6h7lB-4fo0A:
undetectable		 6h7lB-4fo0A:
10.54