SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fo1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T03_P_TFOP822_1
(POL POLYPROTEIN
SYNTHETIC
OLIGONUCLEOTIDE
PRIMER)		 4fo1 LINCOSAMIDE
RESISTANCE PROTEIN
(Staphylococcus
haemolyticus) 		4 / 7 ASP A  48
TYR A  88
ASP A  90
ASP A  46
 EPE  A 201 (-3.6A)
None
None
None
 1.34A 1t03A-4fo1A:
undetectable		 1t03A-4fo1A:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA502_1
(CYTOCHROME P450 2C8)		 4fo1 LINCOSAMIDE
RESISTANCE PROTEIN
(Staphylococcus
haemolyticus) 		5 / 12 ILE A  49
ILE A  47
LEU A  27
VAL A   6
ILE A 132
 None
 1.06A 2nnhA-4fo1A:
undetectable		 2nnhA-4fo1A:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4fo1 LINCOSAMIDE
RESISTANCE PROTEIN
(Staphylococcus
haemolyticus) 		5 / 10 TYR A  68
ILE A  49
ILE A  47
VAL A   6
GLY A  87
 None
 1.26A 3em0A-4fo1A:
undetectable		 3em0A-4fo1A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_B_SAMB401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 4fo1 LINCOSAMIDE
RESISTANCE PROTEIN
(Staphylococcus
haemolyticus) 		5 / 12 ASP A  34
GLY A  30
THR A  37
ASP A  90
ASP A 150
 None
 1.28A 4pghB-4fo1A:
undetectable		 4pghB-4fo1A:
16.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 4fo1 LINCOSAMIDE
RESISTANCE PROTEIN
(Staphylococcus
haemolyticus) 		10 / 12 ASP A  28
GLY A  29
ASP A  48
ASP A  50
HIS A  92
PHE A 114
ALA A 136
GLN A 137
PHE A 140
HIS A 141
 EPE  A 201 (-3.2A)
EPE  A 201 (-3.6A)
EPE  A 201 (-3.6A)
EPE  A 201 (-3.2A)
EPE  A 201 (-3.4A)
EPE  A 201 (-4.1A)
None
None
EPE  A 201 (-3.7A)
None
 0.62A 4wh5A-4fo1A:
29.0		 4wh5A-4fo1A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 4fo1 LINCOSAMIDE
RESISTANCE PROTEIN
(Staphylococcus
haemolyticus) 		8 / 12 ASP A  28
GLY A  29
ASP A  48
ASP A  50
HIS A  92
PHE A 114
GLN A 137
HIS A 141
 EPE  A 201 (-3.2A)
EPE  A 201 (-3.6A)
EPE  A 201 (-3.6A)
EPE  A 201 (-3.2A)
EPE  A 201 (-3.4A)
EPE  A 201 (-4.1A)
None
None
 1.48A 4wh5A-4fo1A:
29.0		 4wh5A-4fo1A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 4fo1 LINCOSAMIDE
RESISTANCE PROTEIN
(Staphylococcus
haemolyticus) 		11 / 12 ASP A  28
GLY A  29
ASP A  48
ASP A  50
HIS A  92
PHE A 114
PHE A 119
ILE A 132
ALA A 136
GLN A 137
HIS A 141
 EPE  A 201 (-3.2A)
EPE  A 201 (-3.6A)
EPE  A 201 (-3.6A)
EPE  A 201 (-3.2A)
EPE  A 201 (-3.4A)
EPE  A 201 (-4.1A)
None
None
None
None
None
 0.37A 4wh5A-4fo1A:
29.0		 4wh5A-4fo1A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 4fo1 LINCOSAMIDE
RESISTANCE PROTEIN
(Staphylococcus
haemolyticus) 		6 / 12 GLY A  29
ASP A  48
HIS A  92
PHE A 119
PHE A 140
HIS A 141
 EPE  A 201 (-3.6A)
EPE  A 201 (-3.6A)
EPE  A 201 (-3.4A)
None
EPE  A 201 (-3.7A)
None
 1.38A 4wh5A-4fo1A:
29.0		 4wh5A-4fo1A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 4fo1 LINCOSAMIDE
RESISTANCE PROTEIN
(Staphylococcus
haemolyticus) 		5 / 12 GLY A  32
PHE A 119
ILE A 132
ALA A 136
GLN A 137
 None
 1.16A 4wh5A-4fo1A:
29.0		 4wh5A-4fo1A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WH5_B_3QBB203_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 4fo1 LINCOSAMIDE
RESISTANCE PROTEIN
(Staphylococcus
haemolyticus) 		9 / 11 ASP A  28
ASP A  48
ASP A  50
ARG A  78
ASP A  90
HIS A  92
GLN A 104
TRP A 118
PHE A 119
 EPE  A 201 (-3.2A)
EPE  A 201 (-3.6A)
EPE  A 201 (-3.2A)
None
None
EPE  A 201 (-3.4A)
EPE  A 201 (-2.7A)
None
None
 0.60A 4wh5A-4fo1A:
29.0
4wh5B-4fo1A:
29.1		 4wh5A-4fo1A:
100.00
4wh5B-4fo1A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WH5_B_3QBB203_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 4fo1 LINCOSAMIDE
RESISTANCE PROTEIN
(Staphylococcus
haemolyticus) 		7 / 11 ASP A  28
ASP A  48
ASP A  90
HIS A  92
GLN A 104
TRP A 118
PHE A 140
 EPE  A 201 (-3.2A)
EPE  A 201 (-3.6A)
None
EPE  A 201 (-3.4A)
EPE  A 201 (-2.7A)
None
EPE  A 201 (-3.7A)
 0.83A 4wh5A-4fo1A:
29.0
4wh5B-4fo1A:
29.1		 4wh5A-4fo1A:
100.00
4wh5B-4fo1A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WH5_B_3QBB203_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 4fo1 LINCOSAMIDE
RESISTANCE PROTEIN
(Staphylococcus
haemolyticus) 		5 / 11 ASP A  50
ASP A  90
HIS A  92
TRP A 118
PHE A 140
 EPE  A 201 (-3.2A)
None
EPE  A 201 (-3.4A)
None
EPE  A 201 (-3.7A)
 1.47A 4wh5A-4fo1A:
29.0
4wh5B-4fo1A:
29.1		 4wh5A-4fo1A:
100.00
4wh5B-4fo1A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB202_0
(HYDROXYNITRILE LYASE)		 4fo1 LINCOSAMIDE
RESISTANCE PROTEIN
(Staphylococcus
haemolyticus) 		4 / 7 VAL A  59
THR A  56
LEU A  89
MET A  75
 None
 0.94A 5e4dA-4fo1A:
undetectable
5e4dB-4fo1A:
undetectable		 5e4dA-4fo1A:
20.29
5e4dB-4fo1A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YSI_A_NCAA1001_0
(UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA)		 4fo1 LINCOSAMIDE
RESISTANCE PROTEIN
(Staphylococcus
haemolyticus) 		4 / 6 GLY A  32
SER A 133
THR A 122
VAL A  35
 None
 1.12A 5ysiA-4fo1A:
undetectable		 5ysiA-4fo1A:
17.79