SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fo9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CD2_A_MTXA307_1
(DIHYDROFOLATE
REDUCTASE)		 4fo9 E3 SUMO-PROTEIN
LIGASE PIAS2
(Homo
sapiens) 		5 / 12 ILE A 263
ILE A 279
SER A 278
PRO A 227
LEU A 241
 None
 1.12A 3cd2A-4fo9A:
undetectable		 3cd2A-4fo9A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_E_CHDE401_0
(BILE SALT HYDROLASE)		 4fo9 E3 SUMO-PROTEIN
LIGASE PIAS2
(Homo
sapiens) 		4 / 8 ILE A 279
LEU A 213
LEU A 215
ALA A 216
 None
 0.60A 5y7pE-4fo9A:
undetectable		 5y7pE-4fo9A:
21.80