SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fog'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AXW_A_MTXA732_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		9 / 12 LYS A  48
HIS A  51
ILE A  79
TRP A  83
LEU A 143
ASP A 169
GLY A 173
PHE A 176
TYR A 209
 C2F  A 302 ( 3.9A)
C2F  A 302 (-3.9A)
C2F  A 302 (-3.3A)
C2F  A 302 (-3.9A)
C2F  A 302 (-4.8A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
C2F  A 302 ( 4.6A)
 0.40A 1axwA-4fogA:
40.7		 1axwA-4fogA:
66.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AXW_B_MTXB733_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		8 / 11 LYS A  48
ILE A  79
TRP A  80
TRP A  83
ASP A 169
GLY A 173
PHE A 176
TYR A 209
 C2F  A 302 ( 3.9A)
C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 (-3.9A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
C2F  A 302 ( 4.6A)
 0.40A 1axwB-4fogA:
40.5		 1axwB-4fogA:
66.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1B02_A_C2FA281_0
(PROTEIN (THYMIDYLATE
SYNTHASE))		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		7 / 11 ILE A  79
TRP A  80
TRP A  83
LEU A 143
ASP A 169
GLY A 173
TYR A 209
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 (-3.9A)
C2F  A 302 (-4.8A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 ( 4.6A)
 0.48A 1b02A-4fogA:
34.1		 1b02A-4fogA:
36.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EUP_A_ASDA452_1
(CYTOCHROME P450ERYF)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 8 PHE A 150
LEU A 116
LEU A 184
LEU A 119
 None
 0.77A 1eupA-4fogA:
undetectable		 1eupA-4fogA:
22.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_A_D16A414_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		6 / 12 GLU A  58
ILE A  79
TRP A  80
ASP A 169
GLY A 173
TYR A 209
 None
C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 ( 4.6A)
 0.45A 1hvyA-4fogA:
38.0		 1hvyA-4fogA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_A_D16A414_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		6 / 12 ILE A  79
TRP A  80
ASP A 169
GLY A 173
PHE A 176
TYR A 209
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
C2F  A 302 ( 4.6A)
 0.81A 1hvyA-4fogA:
38.0		 1hvyA-4fogA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_B_D16B415_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		7 / 12 GLU A  58
ILE A  79
TRP A  80
ASP A 169
GLY A 173
PHE A 176
TYR A 209
 None
C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
C2F  A 302 ( 4.6A)
 0.75A 1hvyB-4fogA:
38.1		 1hvyB-4fogA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_C_D16C416_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		6 / 11 GLU A  58
ILE A  79
TRP A  80
ASP A 169
GLY A 173
TYR A 209
 None
C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 ( 4.6A)
 0.47A 1hvyC-4fogA:
38.2		 1hvyC-4fogA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_C_D16C416_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 11 ILE A  79
ASP A 169
GLY A 173
PHE A 176
TYR A 209
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
C2F  A 302 ( 4.6A)
 0.77A 1hvyC-4fogA:
38.2		 1hvyC-4fogA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_D_D16D417_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		7 / 12 GLU A  58
ILE A  79
TRP A  80
LEU A 143
ASP A 169
GLY A 173
TYR A 209
 None
C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 (-4.8A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 ( 4.6A)
 0.55A 1hvyD-4fogA:
38.3		 1hvyD-4fogA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_D_D16D417_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		6 / 12 ILE A  79
LEU A 143
ASP A 169
GLY A 173
PHE A 176
TYR A 209
 C2F  A 302 (-3.3A)
C2F  A 302 (-4.8A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
C2F  A 302 ( 4.6A)
 0.83A 1hvyD-4fogA:
38.3		 1hvyD-4fogA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I00_A_D16A315_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		6 / 9 GLU A  58
ILE A  79
TRP A  80
ASP A 169
GLY A 173
TYR A 209
 None
C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 ( 4.6A)
 0.57A 1i00A-4fogA:
36.5		 1i00A-4fogA:
49.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I00_A_D16A315_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		6 / 9 ILE A  79
TRP A  80
ASP A 169
GLY A 173
PHE A 176
TYR A 209
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
C2F  A 302 ( 4.6A)
 0.93A 1i00A-4fogA:
36.5		 1i00A-4fogA:
49.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I00_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 9 ILE A  79
ASP A 169
GLY A 173
PHE A 176
TYR A 209
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
C2F  A 302 ( 4.6A)
 0.98A 1i00B-4fogA:
22.0		 1i00B-4fogA:
49.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I00_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		6 / 9 ILE A  79
TRP A  80
ASP A 169
GLY A 173
ASN A 177
TYR A 209
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
UFP  A 301 (-2.8A)
C2F  A 302 ( 4.6A)
 0.80A 1i00B-4fogA:
22.0		 1i00B-4fogA:
49.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		6 / 11 ILE A  79
TRP A  80
ASP A 169
GLY A 173
PHE A 176
TYR A 209
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
C2F  A 302 ( 4.6A)
 0.54A 1ju6A-4fogA:
38.1		 1ju6A-4fogA:
46.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_B_LYAB315_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		6 / 9 LYS A  48
ILE A  79
TRP A  80
ASP A 169
GLY A 173
TYR A 209
 C2F  A 302 ( 3.9A)
C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 ( 4.6A)
 0.50A 1ju6B-4fogA:
38.1		 1ju6B-4fogA:
46.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		6 / 10 ILE A  79
TRP A  80
ASP A 169
GLY A 173
PHE A 176
TYR A 209
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
C2F  A 302 ( 4.6A)
 0.54A 1ju6C-4fogA:
38.1		 1ju6C-4fogA:
46.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		6 / 11 LYS A  48
ILE A  79
TRP A  80
ASP A 169
GLY A 173
TYR A 209
 C2F  A 302 ( 3.9A)
C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 ( 4.6A)
 0.51A 1ju6D-4fogA:
38.2		 1ju6D-4fogA:
46.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_A_LYAA315_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		7 / 10 LYS A  48
ILE A  79
TRP A  80
ASP A 169
GLY A 173
PHE A 176
TYR A 209
 C2F  A 302 ( 3.9A)
C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
C2F  A 302 ( 4.6A)
 0.47A 1jujA-4fogA:
37.5		 1jujA-4fogA:
46.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_B_LYAB315_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		7 / 10 LYS A  48
ILE A  79
TRP A  80
ASP A 169
GLY A 173
PHE A 176
TYR A 209
 C2F  A 302 ( 3.9A)
C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
C2F  A 302 ( 4.6A)
 0.47A 1jujB-4fogA:
37.5		 1jujB-4fogA:
46.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		7 / 10 LYS A  48
ILE A  79
TRP A  80
ASP A 169
GLY A 173
PHE A 176
TYR A 209
 C2F  A 302 ( 3.9A)
C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
C2F  A 302 ( 4.6A)
 0.47A 1jujC-4fogA:
37.5		 1jujC-4fogA:
46.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		7 / 10 LYS A  48
ILE A  79
TRP A  80
ASP A 169
GLY A 173
PHE A 176
TYR A 209
 C2F  A 302 ( 3.9A)
C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
C2F  A 302 ( 4.6A)
 0.47A 1jujD-4fogA:
37.5		 1jujD-4fogA:
46.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RTS_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 8 ILE A  79
ASP A 169
GLY A 173
TYR A 209
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 ( 4.6A)
 0.56A 1rtsA-4fogA:
36.6		 1rtsA-4fogA:
47.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RTS_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 7 ILE A  79
ASP A 169
GLY A 173
TYR A 209
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 ( 4.6A)
 0.42A 1rtsB-4fogA:
37.5		 1rtsB-4fogA:
47.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TLS_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		9 / 12 HIS A  51
SER A  54
ILE A  79
TRP A  80
TRP A  83
LEU A 143
GLY A 173
PHE A 176
TYR A 209
 C2F  A 302 (-3.9A)
C2F  A 302 (-3.4A)
C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 (-3.9A)
C2F  A 302 (-4.8A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
C2F  A 302 ( 4.6A)
 0.47A 1tlsA-4fogA:
40.8		 1tlsA-4fogA:
66.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		9 / 12 HIS A  51
SER A  54
ILE A  79
TRP A  80
TRP A  83
LEU A 143
GLY A 173
PHE A 176
TYR A 209
 C2F  A 302 (-3.9A)
C2F  A 302 (-3.4A)
C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 (-3.9A)
C2F  A 302 (-4.8A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
C2F  A 302 ( 4.6A)
 0.55A 1tlsB-4fogA:
40.7		 1tlsB-4fogA:
66.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		9 / 12 HIS A  51
SER A  54
ILE A  79
TRP A  80
TRP A  83
LEU A 143
GLY A 173
PHE A 176
TYR A 209
 C2F  A 302 (-3.9A)
C2F  A 302 (-3.4A)
C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 (-3.9A)
C2F  A 302 (-4.8A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
C2F  A 302 ( 4.6A)
 0.38A 1tsnA-4fogA:
40.7		 1tsnA-4fogA:
66.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1217_1
(LIPOPROTEIN LPPX)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 4 VAL A 196
LEU A  63
ILE A 112
LEU A 116
 None
 1.03A 2byoA-4fogA:
undetectable		 2byoA-4fogA:
22.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2KCE_A_D16A566_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		9 / 12 SER A  54
GLU A  58
TRP A  80
TRP A  83
LEU A 143
ASP A 169
GLY A 173
PHE A 176
TYR A 209
 C2F  A 302 (-3.4A)
None
C2F  A 302 ( 3.8A)
C2F  A 302 (-3.9A)
C2F  A 302 (-4.8A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
C2F  A 302 ( 4.6A)
 0.57A 2kceA-4fogA:
40.8		 2kceA-4fogA:
66.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2KCE_B_D16B568_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		8 / 12 SER A  54
TRP A  80
TRP A  83
LEU A 143
ASP A 169
GLY A 173
PHE A 176
TYR A 209
 C2F  A 302 (-3.4A)
C2F  A 302 ( 3.8A)
C2F  A 302 (-3.9A)
C2F  A 302 (-4.8A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
C2F  A 302 ( 4.6A)
 0.73A 2kceB-4fogA:
40.9		 2kceB-4fogA:
66.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 7 ILE A  79
ASP A 169
GLY A 173
TYR A 209
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 ( 4.6A)
 0.46A 2tsrA-4fogA:
36.8		 2tsrA-4fogA:
47.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_C_D16C509_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		6 / 10 GLU A  58
ILE A  79
TRP A  80
ASP A 169
GLY A 173
TYR A 209
 None
C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 ( 4.6A)
 0.71A 2tsrC-4fogA:
36.7		 2tsrC-4fogA:
47.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_D_D16D609_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 9 ILE A  79
TRP A  80
ASP A 169
GLY A 173
TYR A 209
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 ( 4.6A)
 0.77A 2tsrD-4fogA:
22.5		 2tsrD-4fogA:
47.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 9 GLN A 165
ALA A 168
LEU A  45
VAL A  50
ILE A 178
 UFP  A 301 (-4.1A)
UFP  A 301 ( 4.9A)
None
None
None
 1.17A 3claA-4fogA:
undetectable		 3claA-4fogA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		9 / 12 SER A  54
GLU A  58
ILE A  79
TRP A  80
LEU A 143
ASP A 169
GLY A 173
PHE A 176
TYR A 209
 C2F  A 302 (-3.4A)
None
C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 (-4.8A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
C2F  A 302 ( 4.6A)
 0.54A 3k2hA-4fogA:
37.3		 3k2hA-4fogA:
28.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		9 / 12 SER A  54
GLU A  58
ILE A  79
TRP A  80
LEU A 143
ASP A 169
GLY A 173
PHE A 176
TYR A 209
 C2F  A 302 (-3.4A)
None
C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 (-4.8A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
C2F  A 302 ( 4.6A)
 0.53A 3k2hB-4fogA:
37.9		 3k2hB-4fogA:
28.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		8 / 12 SER A  54
GLU A  58
ILE A  79
TRP A  80
ASP A 169
GLY A 173
PHE A 176
TYR A 209
 C2F  A 302 (-3.4A)
None
C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
C2F  A 302 ( 4.6A)
 0.50A 3nrrA-4fogA:
38.2		 3nrrA-4fogA:
28.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		8 / 12 SER A  54
GLU A  58
ILE A  79
TRP A  80
ASP A 169
GLY A 173
PHE A 176
TYR A 209
 C2F  A 302 (-3.4A)
None
C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
C2F  A 302 ( 4.6A)
 0.50A 3nrrB-4fogA:
38.3		 3nrrB-4fogA:
28.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QJ7_A_SPMA264_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		6 / 8 ARG A 120
ALA A 190
GLN A 191
LEU A 232
ASP A 234
TYR A 241
 None
 0.37A 3qj7A-4fogA:
42.9
3qj7D-4fogA:
42.1		 3qj7A-4fogA:
100.00
3qj7D-4fogA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  59
ILE A 238
MET A 188
PHE A 150
HIS A 147
 None
None
None
None
UFP  A 301 (-4.0A)
 1.20A 3qt0A-4fogA:
undetectable		 3qt0A-4fogA:
24.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		8 / 12 ILE A  79
TRP A  80
LEU A 143
HIS A 147
GLY A 173
PHE A 176
ASN A 177
TYR A 209
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 (-4.8A)
UFP  A 301 (-4.0A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
UFP  A 301 (-2.8A)
C2F  A 302 ( 4.6A)
 0.55A 3uwlB-4fogA:
40.1		 3uwlB-4fogA:
52.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UWL_D_FOZD316_0
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		8 / 12 TRP A  80
TRP A  83
LEU A 143
HIS A 147
GLY A 173
PHE A 176
ASN A 177
TYR A 209
 C2F  A 302 ( 3.8A)
C2F  A 302 (-3.9A)
C2F  A 302 (-4.8A)
UFP  A 301 (-4.0A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
UFP  A 301 (-2.8A)
C2F  A 302 ( 4.6A)
 0.58A 3uwlD-4fogA:
38.2		 3uwlD-4fogA:
52.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		6 / 12 ILE A  79
ASP A 169
GLY A 173
PHE A 176
ASN A 177
TYR A 209
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
UFP  A 301 (-2.8A)
C2F  A 302 ( 4.6A)
 0.92A 4eb4A-4fogA:
37.5		 4eb4A-4fogA:
48.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		6 / 12 ILE A  79
TRP A  80
ASP A 169
GLY A 173
ASN A 177
TYR A 209
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
UFP  A 301 (-2.8A)
C2F  A 302 ( 4.6A)
 0.61A 4eb4A-4fogA:
37.5		 4eb4A-4fogA:
48.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		6 / 12 ILE A  79
ASP A 169
GLY A 173
PHE A 176
ASN A 177
TYR A 209
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
UFP  A 301 (-2.8A)
C2F  A 302 ( 4.6A)
 0.89A 4eb4B-4fogA:
37.7		 4eb4B-4fogA:
48.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		6 / 12 ILE A  79
TRP A  80
ASP A 169
GLY A 173
ASN A 177
TYR A 209
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
UFP  A 301 (-2.8A)
C2F  A 302 ( 4.6A)
 0.59A 4eb4B-4fogA:
37.7		 4eb4B-4fogA:
48.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 9 ILE A  79
ASP A 169
GLY A 173
ASN A 177
TYR A 209
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
UFP  A 301 (-2.8A)
C2F  A 302 ( 4.6A)
 0.59A 4eb4C-4fogA:
36.4		 4eb4C-4fogA:
48.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 9 ILE A  79
GLY A 173
PHE A 176
ASN A 177
TYR A 209
 C2F  A 302 (-3.3A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
UFP  A 301 (-2.8A)
C2F  A 302 ( 4.6A)
 1.07A 4eb4C-4fogA:
36.4		 4eb4C-4fogA:
48.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		6 / 10 ILE A  79
ASP A 169
GLY A 173
PHE A 176
ASN A 177
TYR A 209
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
UFP  A 301 (-2.8A)
C2F  A 302 ( 4.6A)
 0.99A 4eb4D-4fogA:
37.8		 4eb4D-4fogA:
48.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		6 / 10 ILE A  79
TRP A  80
ASP A 169
GLY A 173
ASN A 177
TYR A 209
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
UFP  A 301 (-2.8A)
C2F  A 302 ( 4.6A)
 0.67A 4eb4D-4fogA:
37.8		 4eb4D-4fogA:
48.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_A_C2FA302_0
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		11 / 11 LYS A  48
HIS A  51
SER A  54
ILE A  79
TRP A  80
TRP A  83
LEU A 143
ASP A 169
GLY A 173
PHE A 176
TYR A 209
 C2F  A 302 ( 3.9A)
C2F  A 302 (-3.9A)
C2F  A 302 (-3.4A)
C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 (-3.9A)
C2F  A 302 (-4.8A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
C2F  A 302 ( 4.6A)
 0.01A 4fogA-4fogA:
46.9		 4fogA-4fogA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_C_C2FC302_0
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		9 / 11 HIS A  51
SER A  54
ILE A  79
TRP A  80
LEU A 143
ASP A 169
GLY A 173
PHE A 176
TYR A 209
 C2F  A 302 (-3.9A)
C2F  A 302 (-3.4A)
C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 (-4.8A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
C2F  A 302 ( 4.6A)
 0.34A 4fogC-4fogA:
43.5		 4fogC-4fogA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_D_C2FD302_0
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		8 / 11 LYS A  48
ILE A  79
TRP A  80
LEU A 143
ASP A 169
GLY A 173
PHE A 176
TYR A 209
 C2F  A 302 ( 3.9A)
C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 (-4.8A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
C2F  A 302 ( 4.6A)
 0.33A 4fogD-4fogA:
43.2		 4fogD-4fogA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_A_D16A301_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		10 / 12 HIS A  51
SER A  54
GLU A  58
ILE A  79
TRP A  80
LEU A 143
ASP A 169
GLY A 173
PHE A 176
TYR A 209
 C2F  A 302 (-3.9A)
C2F  A 302 (-3.4A)
None
C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 (-4.8A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
C2F  A 302 ( 4.6A)
 0.43A 4foxA-4fogA:
43.7		 4foxA-4fogA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_B_D16B302_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		9 / 12 HIS A  51
GLU A  58
ILE A  79
TRP A  80
TRP A  83
LEU A 143
GLY A 173
PHE A 176
TYR A 209
 C2F  A 302 (-3.9A)
None
C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 (-3.9A)
C2F  A 302 (-4.8A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
C2F  A 302 ( 4.6A)
 1.01A 4foxB-4fogA:
43.5		 4foxB-4fogA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_B_D16B302_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		10 / 12 SER A  54
GLU A  58
ILE A  79
TRP A  80
TRP A  83
LEU A 143
ASP A 169
GLY A 173
PHE A 176
TYR A 209
 C2F  A 302 (-3.4A)
None
C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 (-3.9A)
C2F  A 302 (-4.8A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
C2F  A 302 ( 4.6A)
 0.39A 4foxB-4fogA:
43.5		 4foxB-4fogA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_C_D16C301_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		9 / 11 HIS A  51
SER A  54
GLU A  58
TRP A  80
LEU A 143
ASP A 169
GLY A 173
PHE A 176
TYR A 209
 C2F  A 302 (-3.9A)
C2F  A 302 (-3.4A)
None
C2F  A 302 ( 3.8A)
C2F  A 302 (-4.8A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
C2F  A 302 ( 4.6A)
 0.46A 4foxC-4fogA:
42.8		 4foxC-4fogA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		9 / 12 SER A  54
GLU A  58
ILE A  79
TRP A  80
TRP A  83
ASP A 169
GLY A 173
PHE A 176
TYR A 209
 C2F  A 302 (-3.4A)
None
C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 (-3.9A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
C2F  A 302 ( 4.6A)
 0.44A 4foxD-4fogA:
43.5		 4foxD-4fogA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_E_D16E301_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		10 / 12 LYS A  48
HIS A  51
SER A  54
GLU A  58
ILE A  79
TRP A  80
ASP A 169
GLY A 173
PHE A 176
TYR A 209
 C2F  A 302 ( 3.9A)
C2F  A 302 (-3.9A)
C2F  A 302 (-3.4A)
None
C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
C2F  A 302 ( 4.6A)
 0.35A 4foxE-4fogA:
43.9		 4foxE-4fogA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_F_D16F301_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		9 / 11 HIS A  51
GLU A  58
ILE A  79
TRP A  80
LEU A 143
ASP A 169
GLY A 173
PHE A 176
TYR A 209
 C2F  A 302 (-3.9A)
None
C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 (-4.8A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
C2F  A 302 ( 4.6A)
 0.47A 4foxF-4fogA:
43.1		 4foxF-4fogA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_G_D16G301_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		11 / 12 HIS A  51
SER A  54
GLU A  58
ILE A  79
TRP A  80
TRP A  83
LEU A 143
ASP A 169
GLY A 173
PHE A 176
TYR A 209
 C2F  A 302 (-3.9A)
C2F  A 302 (-3.4A)
None
C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 (-3.9A)
C2F  A 302 (-4.8A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
C2F  A 302 ( 4.6A)
 0.43A 4foxG-4fogA:
43.6		 4foxG-4fogA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_H_D16H301_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		10 / 11 HIS A  51
SER A  54
GLU A  58
ILE A  79
TRP A  80
TRP A  83
ASP A 169
GLY A 173
PHE A 176
TYR A 209
 C2F  A 302 (-3.9A)
C2F  A 302 (-3.4A)
None
C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 (-3.9A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
C2F  A 302 ( 4.6A)
 0.46A 4foxH-4fogA:
43.1		 4foxH-4fogA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		9 / 12 HIS A  51
GLU A  58
ILE A  79
TRP A  80
TRP A  83
ASP A 169
GLY A 173
PHE A 176
TYR A 209
 C2F  A 302 (-3.9A)
None
C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 (-3.9A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
C2F  A 302 ( 4.6A)
 0.45A 4fqsA-4fogA:
43.4		 4fqsA-4fogA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		9 / 12 HIS A  51
GLU A  58
ILE A  79
TRP A  80
TRP A  83
ASP A 169
GLY A 173
PHE A 176
TYR A 209
 C2F  A 302 (-3.9A)
None
C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 (-3.9A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
C2F  A 302 ( 4.6A)
 0.45A 4fqsB-4fogA:
43.5		 4fqsB-4fogA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 6 TYR A  94
TYR A 181
LEU A 184
PHE A 150
 None
 1.39A 4twdF-4fogA:
undetectable
4twdG-4fogA:
undetectable		 4twdF-4fogA:
19.33
4twdG-4fogA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 6 TYR A  94
TYR A 181
LEU A 184
PHE A 150
 None
 1.30A 4twdI-4fogA:
undetectable
4twdJ-4fogA:
undetectable		 4twdI-4fogA:
19.33
4twdJ-4fogA:
19.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		6 / 11 ILE A  79
TRP A  80
LEU A 143
ASP A 169
GLY A 173
TYR A 209
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 (-4.8A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 ( 4.6A)
 0.55A 5fctA-4fogA:
38.1		 5fctA-4fogA:
48.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FCT_B_C2FB402_0
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		7 / 12 LYS A  48
VAL A  50
ILE A  79
TRP A  80
LEU A 143
CYH A 146
TYR A 209
 C2F  A 302 ( 3.9A)
None
C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 (-4.8A)
UFP  A 301 (-2.9A)
C2F  A 302 ( 4.6A)
 0.45A 5fctB-4fogA:
38.2		 5fctB-4fogA:
48.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H3A_A_D16A401_1
(ORF70)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 7 ILE A  79
ASP A 169
GLY A 173
TYR A 209
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 ( 4.6A)
 0.56A 5h3aA-4fogA:
21.4		 5h3aA-4fogA:
49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H3A_B_D16B401_1
(ORF70)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 7 ILE A  79
ASP A 169
GLY A 173
TYR A 209
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 ( 4.6A)
 0.47A 5h3aB-4fogA:
36.6		 5h3aB-4fogA:
49.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_2
(CDL2.2)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 246
LEU A 232
VAL A 196
LEU A  38
GLY A 197
 None
 1.16A 5ienA-4fogA:
undetectable		 5ienA-4fogA:
19.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J7W_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		8 / 12 GLU A  58
ILE A  79
TRP A  83
LEU A 143
ASP A 169
GLY A 173
PHE A 176
TYR A 209
 None
C2F  A 302 (-3.3A)
C2F  A 302 (-3.9A)
C2F  A 302 (-4.8A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
C2F  A 302 ( 4.6A)
 0.49A 5j7wC-4fogA:
39.9		 5j7wC-4fogA:
52.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J7W_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		9 / 12 GLU A  58
ILE A  79
TRP A  80
TRP A  83
LEU A 143
ASP A 169
GLY A 173
PHE A 176
TYR A 209
 None
C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 (-3.9A)
C2F  A 302 (-4.8A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
C2F  A 302 ( 4.6A)
 0.48A 5j7wD-4fogA:
39.6		 5j7wD-4fogA:
52.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NOO_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 7 ILE A  79
ASP A 169
GLY A 173
TYR A 209
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 ( 4.6A)
 0.57A 5nooA-4fogA:
35.8		 5nooA-4fogA:
43.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NOO_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 7 ILE A  79
ASP A 169
GLY A 173
TYR A 209
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 ( 4.6A)
 0.65A 5nooB-4fogA:
35.6		 5nooB-4fogA:
43.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  75
GLU A  74
TRP A  71
 None
 0.76A 5odiD-4fogA:
undetectable		 5odiD-4fogA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  75
GLU A  74
TRP A  71
 None
 0.60A 5odqD-4fogA:
undetectable		 5odqD-4fogA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODR_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  75
GLU A  74
TRP A  71
 None
 0.72A 5odrD-4fogA:
undetectable		 5odrD-4fogA:
20.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		6 / 12 GLU A  58
ILE A  79
TRP A  80
ASP A 169
GLY A 173
TYR A 209
 None
C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 ( 4.6A)
 0.61A 5x5qB-4fogA:
37.8		 5x5qB-4fogA:
50.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 7 ILE A  79
ASP A 169
GLY A 173
TYR A 209
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 ( 4.6A)
 0.56A 5x5qC-4fogA:
36.6		 5x5qC-4fogA:
50.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 8 ILE A  79
ASP A 169
GLY A 173
TYR A 209
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 ( 4.6A)
 0.49A 5x5qD-4fogA:
22.3		 5x5qD-4fogA:
50.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_E_D16E402_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 6 ILE A  79
ASP A 169
GLY A 173
TYR A 209
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 ( 4.6A)
 0.50A 5x5qE-4fogA:
36.8		 5x5qE-4fogA:
50.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_F_D16F402_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 8 ILE A  79
ASP A 169
GLY A 173
TYR A 209
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 ( 4.6A)
 0.51A 5x5qF-4fogA:
36.6		 5x5qF-4fogA:
50.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_A_MTXA402_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		6 / 12 ILE A  79
ASP A 169
GLY A 173
PHE A 176
ASN A 177
TYR A 209
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
UFP  A 301 (-2.8A)
C2F  A 302 ( 4.6A)
 0.96A 5x66A-4fogA:
37.7
5x66B-4fogA:
37.9		 5x66A-4fogA:
50.52
5x66B-4fogA:
50.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		6 / 9 ILE A  79
ASP A 169
GLY A 173
PHE A 176
ASN A 177
TYR A 209
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
UFP  A 301 (-2.8A)
C2F  A 302 ( 4.6A)
 0.93A 5x66C-4fogA:
37.9		 5x66C-4fogA:
50.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		6 / 10 ILE A  79
ASP A 169
GLY A 173
PHE A 176
ASN A 177
TYR A 209
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
UFP  A 301 (-2.8A)
C2F  A 302 ( 4.6A)
 0.92A 5x66D-4fogA:
38.1		 5x66D-4fogA:
50.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  79
ASP A 169
GLY A 173
PHE A 176
TYR A 209
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
C2F  A 302 ( 4.6A)
 0.87A 5x66F-4fogA:
38.2		 5x66F-4fogA:
50.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 LYS A  48
ILE A  79
ASP A 169
GLY A 173
TYR A 209
 C2F  A 302 ( 3.9A)
C2F  A 302 (-3.3A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 ( 4.6A)
 0.40A 5x66F-4fogA:
38.2		 5x66F-4fogA:
50.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_B_TRPB502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 179
LEU A  44
LEU A  45
TYR A   4
VAL A  50
 None
 1.44A 6g2pB-4fogA:
undetectable		 6g2pB-4fogA:
23.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		8 / 12 ILE A  79
TRP A  80
TRP A  83
LEU A 143
GLY A 173
PHE A 176
ASN A 177
TYR A 209
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 (-3.9A)
C2F  A 302 (-4.8A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
UFP  A 301 (-2.8A)
C2F  A 302 ( 4.6A)
 0.50A 6qxsB-4fogA:
38.1		 6qxsB-4fogA:
52.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		7 / 12 ILE A  79
TRP A  80
TRP A  83
LEU A 143
ASP A 169
GLY A 173
ASN A 177
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 (-3.9A)
C2F  A 302 (-4.8A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
UFP  A 301 (-2.8A)
 0.51A 6qxsD-4fogA:
38.0		 6qxsD-4fogA:
52.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QYA_B_FOZB401_0
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		8 / 12 ILE A  79
TRP A  80
TRP A  83
LEU A 143
HIS A 147
GLY A 173
PHE A 176
TYR A 209
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 (-3.9A)
C2F  A 302 (-4.8A)
UFP  A 301 (-4.0A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
C2F  A 302 ( 4.6A)
 0.50A 6qyaB-4fogA:
37.5		 6qyaB-4fogA:
52.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		8 / 12 ILE A  79
TRP A  80
LEU A 143
HIS A 147
GLY A 173
PHE A 176
ASN A 177
TYR A 209
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 (-4.8A)
UFP  A 301 (-4.0A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
UFP  A 301 (-2.8A)
C2F  A 302 ( 4.6A)
 0.48A 6qyaD-4fogA:
37.6		 6qyaD-4fogA:
52.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		8 / 12 ILE A  79
TRP A  80
LEU A 143
ASP A 169
GLY A 173
PHE A 176
ASN A 177
TYR A 209
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 (-4.8A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
UFP  A 301 (-2.8A)
C2F  A 302 ( 4.6A)
 0.69A 6r2eA-4fogA:
37.8		 6r2eA-4fogA:
44.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_B_FFOB403_0
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		6 / 10 ILE A  79
TRP A  80
LEU A 143
ASP A 169
GLY A 173
ASN A 177
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 (-4.8A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
UFP  A 301 (-2.8A)
 0.63A 6r2eB-4fogA:
37.7		 6r2eB-4fogA:
44.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_C_FFOC404_0
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		6 / 10 ILE A  79
TRP A  80
LEU A 143
ASP A 169
GLY A 173
ASN A 177
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 (-4.8A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
UFP  A 301 (-2.8A)
 0.67A 6r2eC-4fogA:
37.8		 6r2eC-4fogA:
44.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_D_FFOD403_0
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		6 / 10 ILE A  79
TRP A  80
LEU A 143
ASP A 169
GLY A 173
ASN A 177
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 (-4.8A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
UFP  A 301 (-2.8A)
 0.60A 6r2eD-4fogA:
37.8		 6r2eD-4fogA:
44.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		7 / 12 ILE A  79
TRP A  80
TYR A  94
LEU A 143
GLY A 173
PHE A 176
ASN A 177
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
None
C2F  A 302 (-4.8A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
UFP  A 301 (-2.8A)
 0.51A 6r2eE-4fogA:
37.8		 6r2eE-4fogA:
44.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_F_FFOF403_0
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		6 / 11 ILE A  79
TRP A  80
LEU A 143
ASP A 169
GLY A 173
ASN A 177
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 (-4.8A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
UFP  A 301 (-2.8A)
 0.64A 6r2eF-4fogA:
37.8		 6r2eF-4fogA:
44.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		7 / 11 ILE A  79
TRP A  80
LEU A 143
ASP A 169
GLY A 173
PHE A 176
ASN A 177
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 (-4.8A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
UFP  A 301 (-2.8A)
 0.59A 6r2eG-4fogA:
37.8		 6r2eG-4fogA:
44.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		7 / 12 ILE A  79
TRP A  80
TYR A  94
LEU A 143
ASP A 169
GLY A 173
ASN A 177
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
None
C2F  A 302 (-4.8A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
UFP  A 301 (-2.8A)
 0.75A 6r2eH-4fogA:
37.8		 6r2eH-4fogA:
44.92