SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fom'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_A_DVAA6_0
(GRAMICIDIN A)		 4fom POLIOVIRUS
RECEPTOR-RELATED
PROTEIN 3
(Homo
sapiens) 		3 / 3 ALA A  68
VAL A 168
TRP A  70
 None
NAG  A 415 ( 4.6A)
NAG  A 415 ( 4.1A)
 0.96A 1av2A-4fomA:
undetectable
1av2B-4fomA:
undetectable		 1av2A-4fomA:
4.86
1av2B-4fomA:
4.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4fom POLIOVIRUS
RECEPTOR-RELATED
PROTEIN 3
(Homo
sapiens) 		3 / 3 VAL A 102
ALA A 103
HIS A 105
 None
 0.69A 1q23C-4fomA:
undetectable		 1q23C-4fomA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4fom POLIOVIRUS
RECEPTOR-RELATED
PROTEIN 3
(Homo
sapiens) 		3 / 3 VAL A 102
ALA A 103
HIS A 105
 None
 0.71A 1q23H-4fomA:
undetectable		 1q23H-4fomA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4fom POLIOVIRUS
RECEPTOR-RELATED
PROTEIN 3
(Homo
sapiens) 		3 / 3 VAL A 102
ALA A 103
HIS A 105
 None
 0.74A 1q23G-4fomA:
undetectable		 1q23G-4fomA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4fom POLIOVIRUS
RECEPTOR-RELATED
PROTEIN 3
(Homo
sapiens) 		3 / 3 VAL A 102
ALA A 103
HIS A 105
 None
 0.70A 1q23L-4fomA:
undetectable		 1q23L-4fomA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_A_DVAA6_0
(GRAMICIDIN D)		 4fom POLIOVIRUS
RECEPTOR-RELATED
PROTEIN 3
(Homo
sapiens) 		3 / 3 ALA A  68
VAL A 168
TRP A  70
 None
NAG  A 415 ( 4.6A)
NAG  A 415 ( 4.1A)
 0.95A 1w5uA-4fomA:
undetectable
1w5uB-4fomA:
undetectable		 1w5uA-4fomA:
4.86
1w5uB-4fomA:
4.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB6_0
(GRAMICIDIN D)		 4fom POLIOVIRUS
RECEPTOR-RELATED
PROTEIN 3
(Homo
sapiens) 		3 / 3 TRP A  70
ALA A  68
VAL A 168
 NAG  A 415 ( 4.1A)
None
NAG  A 415 ( 4.6A)
 0.93A 1w5uA-4fomA:
undetectable
1w5uB-4fomA:
undetectable		 1w5uA-4fomA:
4.86
1w5uB-4fomA:
4.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_B_BEZB1352_0
(D-AMINO-ACID OXIDASE)		 4fom POLIOVIRUS
RECEPTOR-RELATED
PROTEIN 3
(Homo
sapiens) 		4 / 6 LEU A 289
TYR A 336
ILE A 353
GLY A 314
 None
 0.92A 2du8B-4fomA:
undetectable		 2du8B-4fomA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA6_0
(GRAMICIDIN D)		 4fom POLIOVIRUS
RECEPTOR-RELATED
PROTEIN 3
(Homo
sapiens) 		3 / 3 ALA A  68
VAL A 168
TRP A  70
 None
NAG  A 415 ( 4.6A)
NAG  A 415 ( 4.1A)
 0.99A 2izqA-4fomA:
undetectable
2izqB-4fomA:
undetectable		 2izqA-4fomA:
4.86
2izqB-4fomA:
4.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_D_DVAD6_0
(GRAMICIDIN D)		 4fom POLIOVIRUS
RECEPTOR-RELATED
PROTEIN 3
(Homo
sapiens) 		3 / 3 TRP A  70
ALA A  68
VAL A 168
 NAG  A 415 ( 4.1A)
None
NAG  A 415 ( 4.6A)
 0.83A 2izqC-4fomA:
undetectable
2izqD-4fomA:
undetectable		 2izqC-4fomA:
4.86
2izqD-4fomA:
4.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 4fom POLIOVIRUS
RECEPTOR-RELATED
PROTEIN 3
(Homo
sapiens) 		5 / 10 THR A 188
GLU A 187
LEU A 181
LEU A 263
ILE A 265
 FUC  A 411 ( 4.9A)
None
None
None
None
 1.35A 3kvrB-4fomA:
undetectable		 3kvrB-4fomA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB6_0
(GRAMICIDIN D)		 4fom POLIOVIRUS
RECEPTOR-RELATED
PROTEIN 3
(Homo
sapiens) 		3 / 3 TRP A  70
ALA A  68
VAL A 168
 NAG  A 415 ( 4.1A)
None
NAG  A 415 ( 4.6A)
 0.96A 3l8lA-4fomA:
undetectable
3l8lB-4fomA:
undetectable		 3l8lA-4fomA:
4.86
3l8lB-4fomA:
4.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD6_0
(GRAMICIDIN D)		 4fom POLIOVIRUS
RECEPTOR-RELATED
PROTEIN 3
(Homo
sapiens) 		3 / 3 TRP A  70
ALA A  68
VAL A 168
 NAG  A 415 ( 4.1A)
None
NAG  A 415 ( 4.6A)
 0.85A 3l8lC-4fomA:
undetectable
3l8lD-4fomA:
undetectable		 3l8lC-4fomA:
4.86
3l8lD-4fomA:
4.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4fom POLIOVIRUS
RECEPTOR-RELATED
PROTEIN 3
(Homo
sapiens) 		4 / 6 VAL A 172
VAL A 201
ILE A 228
ARG A 258
 None
 1.12A 3mssA-4fomA:
undetectable		 3mssA-4fomA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_A_URFA400_1
(URIDINE
PHOSPHORYLASE 1)		 4fom POLIOVIRUS
RECEPTOR-RELATED
PROTEIN 3
(Homo
sapiens) 		5 / 9 THR A 188
GLU A 187
LEU A 181
LEU A 263
ILE A 265
 FUC  A 411 ( 4.9A)
None
None
None
None
 1.33A 3nbqA-4fomA:
undetectable		 3nbqA-4fomA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4fom POLIOVIRUS
RECEPTOR-RELATED
PROTEIN 3
(Homo
sapiens) 		4 / 7 ILE A 175
PRO A 178
ILE A 228
THR A 216
 None
 0.92A 6cduF-4fomA:
undetectable
6cduG-4fomA:
undetectable		 6cduF-4fomA:
22.48
6cduG-4fomA:
22.48