SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fp9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_A_SAMA301_0
(RRNA
METHYLTRANSFERASE)		 4fp9 MTERF
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 11 GLY B 174
GLY B 135
ILE B 186
SER B 163
LEU B 166
 None
 1.00A 1x7pA-4fp9B:
undetectable
1x7pB-4fp9B:
undetectable		 1x7pA-4fp9B:
21.23
1x7pB-4fp9B:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q9R_A_BEZA203_0
(PROTEIN OF UNKNOWN
FUNCTION)		 4fp9 MTERF
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 5 LEU B  99
GLY B 103
PRO B 138
ILE B 132
ILE B 128
 None
 1.42A 2q9rA-4fp9B:
undetectable		 2q9rA-4fp9B:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CD2_A_MTXA307_1
(DIHYDROFOLATE
REDUCTASE)		 4fp9 MTERF
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 12 ILE B 194
LEU B 154
SER B 164
LEU B 176
ILE B 186
 None
 1.14A 3cd2A-4fp9B:
undetectable		 3cd2A-4fp9B:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_2
(HIV-1 PROTEASE)		 4fp9 MTERF
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		3 / 3 ARG B 162
VAL B 222
THR B 197
 SO4  B 401 ( 4.7A)
None
None
 0.66A 3cyxA-4fp9B:
undetectable		 3cyxA-4fp9B:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4fp9 MTERF
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 12 ILE B 127
LEU B 151
LEU B 180
LEU B 176
ILE B 186
 None
 1.05A 3uvvA-4fp9B:
undetectable		 3uvvA-4fp9B:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_L_CHDL103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4fp9 MTERF
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		4 / 7 LEU B 216
GLU B 203
LYS B 202
LEU B 201
 None
 0.82A 4wg0L-4fp9B:
undetectable
4wg0M-4fp9B:
undetectable		 4wg0L-4fp9B:
4.00
4wg0M-4fp9B:
4.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F5U_A_CQNA610_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 4fp9 MTERF
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 10 LEU B 180
LEU B 176
LEU B 154
MET B 159
LEU B 151
 None
 0.99A 6f5uA-4fp9B:
undetectable
6f5uB-4fp9B:
undetectable		 6f5uA-4fp9B:
11.52
6f5uB-4fp9B:
15.44