SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fqg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9H_A_RAPA108_1
(FKBP12.6)		 4fqg TRANSCRIPTION
ELONGATION REGULATOR
1
(Homo
sapiens) 		5 / 12 TYR A 116
ASP A  75
GLU A  88
VAL A  89
ILE A  93
 None
 1.06A 1c9hA-4fqgA:
undetectable		 1c9hA-4fqgA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKB_A_RAPA108_1
(FK506 BINDING
PROTEIN)		 4fqg TRANSCRIPTION
ELONGATION REGULATOR
1
(Homo
sapiens) 		5 / 12 TYR A 116
ASP A  75
GLU A  88
VAL A  89
ILE A  93
 None
 1.08A 1fkbA-4fqgA:
undetectable		 1fkbA-4fqgA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_E_ADNE4260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 4fqg TRANSCRIPTION
ELONGATION REGULATOR
1
(Homo
sapiens) 		5 / 12 ARG A  67
THR A  63
GLU A 112
SER A  23
ASP A  24
 None
 1.34A 1jdvE-4fqgA:
undetectable
1jdvF-4fqgA:
undetectable		 1jdvE-4fqgA:
20.56
1jdvF-4fqgA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4fqg TRANSCRIPTION
ELONGATION REGULATOR
1
(Homo
sapiens) 		4 / 8 LEU A 160
GLN A 161
PHE A 128
LEU A 132
 None
 0.83A 1v54P-4fqgA:
undetectable
1v54W-4fqgA:
undetectable		 1v54P-4fqgA:
18.08
1v54W-4fqgA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4fqg TRANSCRIPTION
ELONGATION REGULATOR
1
(Homo
sapiens) 		5 / 12 LEU A  54
LEU A  16
GLY A  43
ARG A   5
ALA A   8
 None
 1.19A 2bm9D-4fqgA:
undetectable		 2bm9D-4fqgA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4fqg TRANSCRIPTION
ELONGATION REGULATOR
1
(Homo
sapiens) 		5 / 12 LEU A  54
LEU A  16
GLY A  43
ARG A   5
ALA A   8
 None
 1.06A 2br4A-4fqgA:
undetectable		 2br4A-4fqgA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4fqg TRANSCRIPTION
ELONGATION REGULATOR
1
(Homo
sapiens) 		5 / 12 LEU A  54
LEU A  16
GLY A  43
ARG A   5
ALA A   8
 None
 1.06A 2br4C-4fqgA:
undetectable		 2br4C-4fqgA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4fqg TRANSCRIPTION
ELONGATION REGULATOR
1
(Homo
sapiens) 		5 / 12 LEU A  54
LEU A  16
GLY A  43
ARG A   5
ALA A   8
 None
 1.09A 2br4D-4fqgA:
undetectable		 2br4D-4fqgA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4fqg TRANSCRIPTION
ELONGATION REGULATOR
1
(Homo
sapiens) 		5 / 12 LEU A  54
LEU A  16
GLY A  43
ARG A   5
ALA A   8
 None
 1.15A 2br4E-4fqgA:
undetectable		 2br4E-4fqgA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG3_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 4fqg TRANSCRIPTION
ELONGATION REGULATOR
1
(Homo
sapiens) 		5 / 11 TYR A 116
ASP A  75
GLU A  88
VAL A  89
ILE A  93
 None
 1.11A 2dg3A-4fqgA:
undetectable		 2dg3A-4fqgA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG4_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 4fqg TRANSCRIPTION
ELONGATION REGULATOR
1
(Homo
sapiens) 		5 / 11 TYR A 116
ASP A  75
GLU A  88
VAL A  89
ILE A  93
 None
 1.14A 2dg4A-4fqgA:
undetectable		 2dg4A-4fqgA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4fqg TRANSCRIPTION
ELONGATION REGULATOR
1
(Homo
sapiens) 		4 / 7 LEU A 160
GLN A 161
PHE A 128
LEU A 132
 None
 0.84A 2eikC-4fqgA:
undetectable
2eikJ-4fqgA:
undetectable		 2eikC-4fqgA:
18.08
2eikJ-4fqgA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4fqg TRANSCRIPTION
ELONGATION REGULATOR
1
(Homo
sapiens) 		4 / 8 LEU A 160
GLN A 161
PHE A 128
LEU A 132
 None
 0.77A 2eikP-4fqgA:
undetectable
2eikW-4fqgA:
undetectable		 2eikP-4fqgA:
18.08
2eikW-4fqgA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4fqg TRANSCRIPTION
ELONGATION REGULATOR
1
(Homo
sapiens) 		4 / 8 LEU A 160
GLN A 161
PHE A 128
LEU A 132
 None
 0.81A 2eilC-4fqgA:
undetectable
2eilJ-4fqgA:
undetectable		 2eilC-4fqgA:
18.08
2eilJ-4fqgA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 4fqg TRANSCRIPTION
ELONGATION REGULATOR
1
(Homo
sapiens) 		4 / 7 LEU A 160
GLN A 161
PHE A 128
LEU A 132
 None
 0.79A 3ag2C-4fqgA:
undetectable		 3ag2C-4fqgA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4fqg TRANSCRIPTION
ELONGATION REGULATOR
1
(Homo
sapiens) 		4 / 7 LEU A 160
GLN A 161
PHE A 128
LEU A 132
 None
 0.78A 3ag2P-4fqgA:
undetectable
3ag2W-4fqgA:
undetectable		 3ag2P-4fqgA:
18.08
3ag2W-4fqgA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4fqg TRANSCRIPTION
ELONGATION REGULATOR
1
(Homo
sapiens) 		4 / 8 LEU A 160
GLN A 161
PHE A 128
LEU A 132
 None
 0.79A 3ag4C-4fqgA:
undetectable
3ag4J-4fqgA:
undetectable		 3ag4C-4fqgA:
18.08
3ag4J-4fqgA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4fqg TRANSCRIPTION
ELONGATION REGULATOR
1
(Homo
sapiens) 		4 / 7 LEU A 160
GLN A 161
PHE A 128
LEU A 132
 None
 0.74A 3ag4P-4fqgA:
undetectable
3ag4W-4fqgA:
undetectable		 3ag4P-4fqgA:
18.08
3ag4W-4fqgA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4)		 4fqg TRANSCRIPTION
ELONGATION REGULATOR
1
(Homo
sapiens) 		5 / 11 TYR A 116
ASP A  75
GLU A  88
VAL A  89
ILE A  93
 None
 1.03A 4drjA-4fqgA:
undetectable		 4drjA-4fqgA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QT2_A_RAPA202_1
(FK506-BINDING
PROTEIN (FKBP)-TYPE
PEPTIDYL-PROPYL
ISOMERASE)		 4fqg TRANSCRIPTION
ELONGATION REGULATOR
1
(Homo
sapiens) 		5 / 10 TYR A 116
ASP A  75
GLU A  88
VAL A  89
ILE A  93
 None
 1.07A 4qt2A-4fqgA:
undetectable		 4qt2A-4fqgA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QT3_A_RAPA202_1
(FK506-BINDING
PROTEIN (FKBP)-TYPE
PEPTIDYL-PROPYL
ISOMERASE)		 4fqg TRANSCRIPTION
ELONGATION REGULATOR
1
(Homo
sapiens) 		5 / 10 TYR A 116
ASP A  75
GLU A  88
VAL A  89
ILE A  93
 None
 1.06A 4qt3A-4fqgA:
undetectable		 4qt3A-4fqgA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA302_0
(THAUMATIN-1)		 4fqg TRANSCRIPTION
ELONGATION REGULATOR
1
(Homo
sapiens) 		3 / 3 ARG A  98
GLN A  72
GLU A  76
 None
 0.78A 4tvtA-4fqgA:
undetectable		 4tvtA-4fqgA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HKG_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1B)		 4fqg TRANSCRIPTION
ELONGATION REGULATOR
1
(Homo
sapiens) 		5 / 12 TYR A 116
ASP A  75
GLU A  88
VAL A  89
ILE A  93
 None
 1.14A 5hkgA-4fqgA:
undetectable		 5hkgA-4fqgA:
19.17