SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fql'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_2
(POL POLYPROTEIN)		 4fql MONOCLONAL ANTIBODY
CR8033 HEAVY CHAIN
(Homo
sapiens) 		4 / 7 ASP H  61
VAL H  63
GLY H  50
ILE H  51
 None
 0.73A 1t7iB-4fqlH:
undetectable		 1t7iB-4fqlH:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA302_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 4fql MONOCLONAL ANTIBODY
CR8033 HEAVY CHAIN
(Homo
sapiens) 		4 / 6 LEU H 189
GLY H 190
ALA H 125
PRO H 126
 None
 0.47A 3huoA-4fqlH:
undetectable		 3huoA-4fqlH:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_1
(PROTEASE)		 4fql MONOCLONAL ANTIBODY
CR8033 HEAVY CHAIN
(Homo
sapiens) 		4 / 8 ASP H  61
VAL H  63
GLY H  50
ILE H  51
 None
 0.74A 3nu9A-4fqlH:
undetectable		 3nu9A-4fqlH:
15.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_C_MTXC2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4fql MONOCLONAL ANTIBODY
CR8033 HEAVY CHAIN
(Homo
sapiens) 		5 / 11 VAL H   2
ALA H  24
MET H  34
ARG H  71
ASN H  73
 None
 0.75A 3qxvC-4fqlH:
21.7		 3qxvC-4fqlH:
59.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 4fql MONOCLONAL ANTIBODY
CR8033 HEAVY CHAIN
(Homo
sapiens) 		5 / 10 PHE H 122
GLY H 118
THR H 205
VAL H 198
VAL H 207
 None
 1.21A 4jx1B-4fqlH:
undetectable		 4jx1B-4fqlH:
16.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CJK_B_ACTB302_0
(IMMUNOGLOBULIN FAB
HEAVY CHAIN)		 4fql MONOCLONAL ANTIBODY
CR8033 HEAVY CHAIN
(Homo
sapiens) 		3 / 3 TYR H  59
GLY H  65
THR H  68
 None
 0.17A 6cjkB-4fqlH:
24.7		 6cjkB-4fqlH:
60.17