SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fqn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_C_CHDC1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4fqn MALCAVERNIN
(Homo
sapiens) 		4 / 5 ARG A 354
PHE A 348
LEU A 369
PHE A 365
 None
 1.36A 2y69C-4fqnA:
undetectable
2y69J-4fqnA:
undetectable		 2y69C-4fqnA:
14.18
2y69J-4fqnA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4fqn MALCAVERNIN
(Homo
sapiens) 		5 / 7 ARG A 354
LEU A 351
PHE A 348
LEU A 369
PHE A 365
 None
 1.44A 2zxwC-4fqnA:
undetectable
2zxwJ-4fqnA:
undetectable		 2zxwC-4fqnA:
14.18
2zxwJ-4fqnA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4fqn MALCAVERNIN
(Homo
sapiens) 		5 / 6 ARG A 354
LEU A 351
PHE A 348
LEU A 369
PHE A 365
 None
 1.50A 2zxwP-4fqnA:
undetectable
2zxwW-4fqnA:
undetectable		 2zxwP-4fqnA:
14.18
2zxwW-4fqnA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4fqn MALCAVERNIN
(Homo
sapiens) 		4 / 5 ARG A 354
PHE A 348
LEU A 369
PHE A 365
 None
 1.41A 3ablC-4fqnA:
undetectable
3ablJ-4fqnA:
undetectable		 3ablC-4fqnA:
14.18
3ablJ-4fqnA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4fqn MALCAVERNIN
(Homo
sapiens) 		4 / 5 ARG A 354
PHE A 348
LEU A 369
PHE A 365
 None
 1.36A 3abmC-4fqnA:
undetectable
3abmJ-4fqnA:
undetectable		 3abmC-4fqnA:
14.18
3abmJ-4fqnA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4fqn MALCAVERNIN
(Homo
sapiens) 		4 / 5 ARG A 354
PHE A 348
LEU A 369
PHE A 365
 None
 1.35A 3abmP-4fqnA:
undetectable
3abmW-4fqnA:
undetectable		 3abmP-4fqnA:
14.18
3abmW-4fqnA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4fqn MALCAVERNIN
(Homo
sapiens) 		5 / 6 ARG A 354
LEU A 351
PHE A 348
LEU A 369
PHE A 365
 None
 1.47A 3ag1C-4fqnA:
undetectable
3ag1J-4fqnA:
undetectable		 3ag1C-4fqnA:
14.18
3ag1J-4fqnA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4fqn MALCAVERNIN
(Homo
sapiens) 		4 / 4 ARG A 354
PHE A 348
LEU A 369
PHE A 365
 None
 1.38A 3ag1P-4fqnA:
0.0
3ag1W-4fqnA:
0.0		 3ag1P-4fqnA:
14.18
3ag1W-4fqnA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4fqn MALCAVERNIN
(Homo
sapiens) 		4 / 4 ARG A 354
PHE A 348
LEU A 369
PHE A 365
 None
 1.42A 3ag3P-4fqnA:
1.0
3ag3W-4fqnA:
undetectable		 3ag3P-4fqnA:
14.18
3ag3W-4fqnA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_A_LURA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4fqn MALCAVERNIN
(Homo
sapiens) 		5 / 12 TYR A 342
LEU A 338
LEU A 299
TYR A 302
ALA A 319
 None
 1.09A 4rrxA-4fqnA:
undetectable		 4rrxA-4fqnA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYM_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 4fqn MALCAVERNIN
(Homo
sapiens) 		5 / 12 LEU A 338
TYR A 325
PHE A 356
LEU A 353
TYR A 342
 None
 1.44A 5cymA-4fqnA:
undetectable		 5cymA-4fqnA:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYQ_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 4fqn MALCAVERNIN
(Homo
sapiens) 		5 / 12 LEU A 338
TYR A 325
PHE A 356
LEU A 353
TYR A 342
 None
 1.46A 5cyqA-4fqnA:
undetectable		 5cyqA-4fqnA:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4fqn MALCAVERNIN
(Homo
sapiens) 		5 / 6 ARG A 354
LEU A 351
PHE A 348
LEU A 369
PHE A 365
 None
 1.50A 5w97C-4fqnA:
undetectable
5w97J-4fqnA:
undetectable		 5w97C-4fqnA:
14.18
5w97J-4fqnA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 4fqn MALCAVERNIN
(Homo
sapiens) 		5 / 5 ARG A 354
LEU A 351
PHE A 348
LEU A 369
PHE A 365
 None
 1.49A 5xdxC-4fqnA:
undetectable
5xdxJ-4fqnA:
undetectable		 5xdxC-4fqnA:
14.62
5xdxJ-4fqnA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ELI_A_T27A701_1
(REVERSE
TRANSCRIPTASE)		 4fqn MALCAVERNIN
(Homo
sapiens) 		5 / 12 LEU A 338
TYR A 325
PHE A 356
LEU A 353
TYR A 342
 None
 1.41A 6eliA-4fqnA:
undetectable		 6eliA-4fqnA:
19.19