SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fqz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 4fqz GALECTIN-8
(Homo
sapiens) 		4 / 7 PHE A 267
PHE A 261
PHE A 239
VAL A 203
 None
 0.89A 1lh6A-4fqzA:
undetectable		 1lh6A-4fqzA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1866_0
(FPRA)		 4fqz GALECTIN-8
(Homo
sapiens) 		4 / 4 ARG A  36
LEU A   3
ASN A 192
VAL A  34
 None
 1.07A 1lqtA-4fqzA:
undetectable		 1lqtA-4fqzA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1875_0
(FPRA)		 4fqz GALECTIN-8
(Homo
sapiens) 		4 / 4 ARG A  36
LEU A   3
ASN A 192
VAL A  34
 None
 1.09A 1lqtB-4fqzA:
undetectable		 1lqtB-4fqzA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1423_0
(FPRA)		 4fqz GALECTIN-8
(Homo
sapiens) 		4 / 4 ARG A  36
LEU A   3
ASN A 192
VAL A  34
 None
 1.08A 1lquA-4fqzA:
undetectable		 1lquA-4fqzA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1432_0
(FPRA)		 4fqz GALECTIN-8
(Homo
sapiens) 		4 / 4 ARG A  36
LEU A   3
ASN A 192
VAL A  34
 None
 1.10A 1lquB-4fqzA:
undetectable		 1lquB-4fqzA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4fqz GALECTIN-8
(Homo
sapiens) 		3 / 3 VAL A  62
ALA A  63
HIS A 128
 None
 0.66A 1q23H-4fqzA:
undetectable		 1q23H-4fqzA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4fqz GALECTIN-8
(Homo
sapiens) 		3 / 3 VAL A  62
ALA A  63
HIS A 128
 None
 0.77A 1q23G-4fqzA:
undetectable		 1q23G-4fqzA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4fqz GALECTIN-8
(Homo
sapiens) 		3 / 3 VAL A  62
ALA A  63
HIS A 128
 None
 0.63A 1q23J-4fqzA:
undetectable		 1q23J-4fqzA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QCA_A_FUAA221_1
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4fqz GALECTIN-8
(Homo
sapiens) 		4 / 7 CYH A  78
PHE A  46
PHE A  64
LEU A 138
 EDO  A 404 (-3.6A)
None
None
None
 1.06A 1qcaA-4fqzA:
undetectable		 1qcaA-4fqzA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 4fqz GALECTIN-8
(Homo
sapiens) 		5 / 12 GLY A 139
GLY A  21
ILE A 149
SER A  54
PRO A  18
 None
EDO  A 412 (-3.1A)
None
EDO  A 412 ( 4.8A)
None
 0.76A 1sg9B-4fqzA:
undetectable		 1sg9B-4fqzA:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BL9_A_CP6A1240_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4fqz GALECTIN-8
(Homo
sapiens) 		5 / 12 ILE A 107
LEU A   8
SER A 148
ILE A  12
ILE A  35
 None
 1.17A 2bl9A-4fqzA:
undetectable		 2bl9A-4fqzA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 4fqz GALECTIN-8
(Homo
sapiens) 		4 / 5 PHE A 267
PHE A 261
PHE A 239
VAL A 203
 None
 0.88A 2lh6A-4fqzA:
undetectable		 2lh6A-4fqzA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 4fqz GALECTIN-8
(Homo
sapiens) 		3 / 3 ASP A  44
THR A  95
PRO A  96
 None
 0.62A 2pynB-4fqzA:
undetectable		 2pynB-4fqzA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_4
(PROTEASE RETROPEPSIN)		 4fqz GALECTIN-8
(Homo
sapiens) 		3 / 3 ASP A  44
THR A  95
PRO A  96
 None
 0.62A 2q64B-4fqzA:
undetectable		 2q64B-4fqzA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 4fqz GALECTIN-8
(Homo
sapiens) 		3 / 3 ASP A  44
THR A  95
PRO A  96
 None
 0.63A 2qakB-4fqzA:
undetectable		 2qakB-4fqzA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_A_1GNA998_1
(GALECTIN-7)		 4fqz GALECTIN-8
(Homo
sapiens) 		4 / 6 HIS A  65
ASN A  67
ARG A  45
TRP A  86
 GAL  A 401 (-4.0A)
GAL  A 401 (-4.2A)
GAL  A 401 (-2.8A)
GAL  A 401 (-3.5A)
 1.16A 3galA-4fqzA:
22.6		 3galA-4fqzA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_A_1GNA998_1
(GALECTIN-7)		 4fqz GALECTIN-8
(Homo
sapiens) 		6 / 6 HIS A  65
ASN A  67
ARG A  69
ASN A  79
TRP A  86
GLU A  89
 GAL  A 401 (-4.0A)
GAL  A 401 (-4.2A)
BGC  A 402 ( 2.5A)
GAL  A 401 (-3.8A)
GAL  A 401 (-3.5A)
BGC  A 402 ( 3.3A)
 0.41A 3galA-4fqzA:
22.6		 3galA-4fqzA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_A_1GNA998_1
(GALECTIN-7)		 4fqz GALECTIN-8
(Homo
sapiens) 		6 / 6 HIS A 229
ASN A 231
ARG A 233
ASN A 242
TRP A 249
GLU A 252
 None
 0.38A 3galA-4fqzA:
22.6		 3galA-4fqzA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_B_1GNB999_1
(GALECTIN-7)		 4fqz GALECTIN-8
(Homo
sapiens) 		4 / 6 HIS A  65
ASN A  67
ARG A  45
TRP A  86
 GAL  A 401 (-4.0A)
GAL  A 401 (-4.2A)
GAL  A 401 (-2.8A)
GAL  A 401 (-3.5A)
 1.12A 3galB-4fqzA:
22.3		 3galB-4fqzA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_B_1GNB999_1
(GALECTIN-7)		 4fqz GALECTIN-8
(Homo
sapiens) 		6 / 6 HIS A  65
ASN A  67
ARG A  69
ASN A  79
TRP A  86
GLU A  89
 GAL  A 401 (-4.0A)
GAL  A 401 (-4.2A)
BGC  A 402 ( 2.5A)
GAL  A 401 (-3.8A)
GAL  A 401 (-3.5A)
BGC  A 402 ( 3.3A)
 0.39A 3galB-4fqzA:
22.3		 3galB-4fqzA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_B_1GNB999_1
(GALECTIN-7)		 4fqz GALECTIN-8
(Homo
sapiens) 		6 / 6 HIS A 229
ASN A 231
ARG A 233
ASN A 242
TRP A 249
GLU A 252
 None
 0.44A 3galB-4fqzA:
22.3		 3galB-4fqzA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 4fqz GALECTIN-8
(Homo
sapiens) 		4 / 6 PHE A  46
VAL A 116
THR A 123
PHE A  97
 None
 1.33A 3ltwA-4fqzA:
undetectable		 3ltwA-4fqzA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_F_PXLF400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 4fqz GALECTIN-8
(Homo
sapiens) 		5 / 11 VAL A  62
HIS A  65
GLN A  47
VAL A  20
TYR A 141
 None
GAL  A 401 (-4.0A)
GAL  A 401 ( 4.5A)
None
None
 1.44A 3mbhF-4fqzA:
undetectable		 3mbhF-4fqzA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_2
(PROTEASE)		 4fqz GALECTIN-8
(Homo
sapiens) 		5 / 11 LEU A  27
ALA A  63
ASP A  61
ILE A  23
ILE A 135
 None
 1.13A 3s53B-4fqzA:
undetectable		 3s53B-4fqzA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_3
(PROTEASE)		 4fqz GALECTIN-8
(Homo
sapiens) 		3 / 3 ASP A  44
THR A  95
PRO A  96
 None
 0.61A 3tkgD-4fqzA:
undetectable		 3tkgD-4fqzA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4fqz GALECTIN-8
(Homo
sapiens) 		5 / 9 LEU A 138
VAL A  48
ILE A 149
GLY A 150
PHE A  97
 None
 0.95A 5vkqC-4fqzA:
undetectable
5vkqD-4fqzA:
undetectable		 5vkqC-4fqzA:
10.60
5vkqD-4fqzA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC605_0
(ALPHA-AMYLASE)		 4fqz GALECTIN-8
(Homo
sapiens) 		4 / 8 GLY A 142
ILE A  17
LYS A 143
ASP A  42
 None
 1.00A 6ag0C-4fqzA:
undetectable		 6ag0C-4fqzA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B8K_A_W9TA300_0
(GALECTIN-3)		 4fqz GALECTIN-8
(Homo
sapiens) 		5 / 7 HIS A  65
ASN A  67
ARG A  45
ASN A  79
TRP A  86
 GAL  A 401 (-4.0A)
GAL  A 401 (-4.2A)
GAL  A 401 (-2.8A)
GAL  A 401 (-3.8A)
GAL  A 401 (-3.5A)
 1.33A 6b8kA-4fqzA:
22.1		 6b8kA-4fqzA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B8K_A_W9TA300_0
(GALECTIN-3)		 4fqz GALECTIN-8
(Homo
sapiens) 		6 / 7 HIS A  65
ASN A  67
ARG A  69
ASN A  79
TRP A  86
GLU A  89
 GAL  A 401 (-4.0A)
GAL  A 401 (-4.2A)
BGC  A 402 ( 2.5A)
GAL  A 401 (-3.8A)
GAL  A 401 (-3.5A)
BGC  A 402 ( 3.3A)
 0.30A 6b8kA-4fqzA:
22.1		 6b8kA-4fqzA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B8K_A_W9TA300_0
(GALECTIN-3)		 4fqz GALECTIN-8
(Homo
sapiens) 		7 / 7 HIS A 229
ASN A 231
ARG A 233
ASN A 242
TRP A 249
GLU A 252
ARG A 254
 None
 0.43A 6b8kA-4fqzA:
22.1		 6b8kA-4fqzA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_A_W9TA201_0
(GALECTIN-1)		 4fqz GALECTIN-8
(Homo
sapiens) 		5 / 8 HIS A  65
ASN A  67
ARG A  45
ASN A  79
TRP A  86
 GAL  A 401 (-4.0A)
GAL  A 401 (-4.2A)
GAL  A 401 (-2.8A)
GAL  A 401 (-3.8A)
GAL  A 401 (-3.5A)
 1.27A 6b94A-4fqzA:
18.2		 6b94A-4fqzA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_A_W9TA201_0
(GALECTIN-1)		 4fqz GALECTIN-8
(Homo
sapiens) 		6 / 8 HIS A  65
ASN A  67
ARG A  69
ASN A  79
TRP A  86
GLU A  89
 GAL  A 401 (-4.0A)
GAL  A 401 (-4.2A)
BGC  A 402 ( 2.5A)
GAL  A 401 (-3.8A)
GAL  A 401 (-3.5A)
BGC  A 402 ( 3.3A)
 0.46A 6b94A-4fqzA:
18.2		 6b94A-4fqzA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_A_W9TA201_0
(GALECTIN-1)		 4fqz GALECTIN-8
(Homo
sapiens) 		7 / 8 HIS A 229
ASN A 231
ARG A 233
ASN A 242
TRP A 249
GLU A 252
ARG A 254
 None
 0.39A 6b94A-4fqzA:
18.2		 6b94A-4fqzA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_B_W9TB201_0
(GALECTIN-1)		 4fqz GALECTIN-8
(Homo
sapiens) 		5 / 10 HIS A  65
ASN A  67
ARG A  45
ASN A  79
TRP A  86
 GAL  A 401 (-4.0A)
GAL  A 401 (-4.2A)
GAL  A 401 (-2.8A)
GAL  A 401 (-3.8A)
GAL  A 401 (-3.5A)
 1.33A 6b94A-4fqzA:
18.2
6b94B-4fqzA:
17.8		 6b94A-4fqzA:
16.25
6b94B-4fqzA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_B_W9TB201_0
(GALECTIN-1)		 4fqz GALECTIN-8
(Homo
sapiens) 		6 / 10 HIS A  65
ASN A  67
ARG A  69
ASN A  79
TRP A  86
GLU A  89
 GAL  A 401 (-4.0A)
GAL  A 401 (-4.2A)
BGC  A 402 ( 2.5A)
GAL  A 401 (-3.8A)
GAL  A 401 (-3.5A)
BGC  A 402 ( 3.3A)
 0.42A 6b94A-4fqzA:
18.2
6b94B-4fqzA:
17.8		 6b94A-4fqzA:
16.25
6b94B-4fqzA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_B_W9TB201_0
(GALECTIN-1)		 4fqz GALECTIN-8
(Homo
sapiens) 		7 / 10 HIS A 229
ASN A 231
ARG A 233
ASN A 242
TRP A 249
GLU A 252
ARG A 254
 None
 0.48A 6b94A-4fqzA:
18.2
6b94B-4fqzA:
17.8		 6b94A-4fqzA:
16.25
6b94B-4fqzA:
16.25