SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fr4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A
(Homo
sapiens) 		8 / 12 GLY A  30
VAL A  37
ALA A  50
VAL A  84
ASN A 151
LEU A 153
THR A 163
ASP A 164
 STU  A 401 (-3.3A)
STU  A 401 ( 4.9A)
STU  A 401 (-3.2A)
None
STU  A 401 ( 4.8A)
STU  A 401 (-4.7A)
STU  A 401 (-3.8A)
STU  A 401 ( 3.9A)
 0.67A 1fmoE-4fr4A:
31.7		 1fmoE-4fr4A:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A
(Homo
sapiens) 		4 / 7 LYS A  52
VAL A  84
ARG A 145
LEU A 153
 None
None
None
STU  A 401 (-4.7A)
 0.92A 1iepB-4fr4A:
21.0		 1iepB-4fr4A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A
(Homo
sapiens) 		7 / 12 ILE A  29
VAL A  37
VAL A  84
ASP A 107
ASN A 151
LEU A 153
ASP A 164
 STU  A 401 (-4.1A)
STU  A 401 ( 4.9A)
None
STU  A 401 (-3.3A)
STU  A 401 ( 4.8A)
STU  A 401 (-4.7A)
STU  A 401 ( 3.9A)
 0.76A 2eufB-4fr4A:
26.2		 2eufB-4fr4A:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_D_SC2D1290_1
(FICOLIN-2)		 4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A
(Homo
sapiens) 		4 / 5 TRP A 206
TRP A 207
ARG A 268
LEU A 260
 None
 1.37A 2j2pD-4fr4A:
undetectable
2j2pF-4fr4A:
undetectable		 2j2pD-4fr4A:
18.78
2j2pF-4fr4A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A
(Homo
sapiens) 		6 / 12 ILE A  29
VAL A  37
ALA A  50
LEU A 102
GLY A 106
LEU A 153
 STU  A 401 (-4.1A)
STU  A 401 ( 4.9A)
STU  A 401 (-3.2A)
STU  A 401 (-4.4A)
STU  A 401 ( 3.7A)
STU  A 401 (-4.7A)
 0.46A 2y7jA-4fr4A:
29.8		 2y7jA-4fr4A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A
(Homo
sapiens) 		6 / 10 ILE A  29
VAL A  37
ALA A  50
LEU A 102
GLY A 106
LEU A 153
 STU  A 401 (-4.1A)
STU  A 401 ( 4.9A)
STU  A 401 (-3.2A)
STU  A 401 (-4.4A)
STU  A 401 ( 3.7A)
STU  A 401 (-4.7A)
 0.57A 2y7jB-4fr4A:
29.8		 2y7jB-4fr4A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A
(Homo
sapiens) 		6 / 10 ILE A  29
VAL A  37
ALA A  50
LEU A 102
GLY A 106
LEU A 153
 STU  A 401 (-4.1A)
STU  A 401 ( 4.9A)
STU  A 401 (-3.2A)
STU  A 401 (-4.4A)
STU  A 401 ( 3.7A)
STU  A 401 (-4.7A)
 0.57A 2y7jC-4fr4A:
29.6		 2y7jC-4fr4A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A
(Homo
sapiens) 		6 / 10 ILE A  29
VAL A  37
ALA A  50
LEU A 102
GLY A 106
LEU A 153
 STU  A 401 (-4.1A)
STU  A 401 ( 4.9A)
STU  A 401 (-3.2A)
STU  A 401 (-4.4A)
STU  A 401 ( 3.7A)
STU  A 401 (-4.7A)
 0.61A 2y7jD-4fr4A:
29.4		 2y7jD-4fr4A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A
(Homo
sapiens) 		6 / 12 VAL A  37
ALA A  50
LEU A  86
LEU A 102
GLY A 106
THR A 163
 STU  A 401 ( 4.9A)
STU  A 401 (-3.2A)
None
STU  A 401 (-4.4A)
STU  A 401 ( 3.7A)
STU  A 401 (-3.8A)
 0.70A 3bbtB-4fr4A:
19.8		 3bbtB-4fr4A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A
(Homo
sapiens) 		7 / 12 VAL A  37
ALA A  50
LEU A 102
GLY A 106
LEU A 153
THR A 163
PHE A 165
 STU  A 401 ( 4.9A)
STU  A 401 (-3.2A)
STU  A 401 (-4.4A)
STU  A 401 ( 3.7A)
STU  A 401 (-4.7A)
STU  A 401 (-3.8A)
None
 0.81A 3bbtB-4fr4A:
19.8		 3bbtB-4fr4A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A
(Homo
sapiens) 		6 / 12 GLY A  30
ALA A  50
VAL A  84
VAL A 100
GLY A 106
LEU A 153
 STU  A 401 (-3.3A)
STU  A 401 (-3.2A)
None
None
STU  A 401 ( 3.7A)
STU  A 401 (-4.7A)
 0.36A 3c7qA-4fr4A:
20.3		 3c7qA-4fr4A:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXZ_A_0LIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A
(Homo
sapiens) 		6 / 12 ALA A  50
GLU A  71
LEU A  83
VAL A  84
GLY A 106
HIS A 144
 STU  A 401 (-3.2A)
None
None
None
STU  A 401 ( 3.7A)
None
 0.88A 3oxzA-4fr4A:
20.5		 3oxzA-4fr4A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)		 4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A
(Homo
sapiens) 		5 / 9 ILE A  29
ALA A  50
VAL A  84
ASP A 107
LEU A 153
 STU  A 401 (-4.1A)
STU  A 401 (-3.2A)
None
STU  A 401 (-3.3A)
STU  A 401 (-4.7A)
 0.56A 3ti1A-4fr4A:
23.6		 3ti1A-4fr4A:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U52_A_CUA515_0
(PHENOL HYDROXYLASE
COMPONENT PHL
PHENOL HYDROXYLASE
COMPONENT PHN)		 4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A
(Homo
sapiens) 		3 / 3 HIS A 157
HIS A 159
ILE A 295
 None
 0.78A 3u52A-4fr4A:
undetectable
3u52C-4fr4A:
undetectable		 3u52A-4fr4A:
18.38
3u52C-4fr4A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A
(Homo
sapiens) 		6 / 12 ILE A  29
GLY A  32
GLY A  35
VAL A  37
ALA A  50
LYS A  52
 STU  A 401 (-4.1A)
None
None
STU  A 401 ( 4.9A)
STU  A 401 (-3.2A)
None
 0.70A 3v5wA-4fr4A:
9.1		 3v5wA-4fr4A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A
(Homo
sapiens) 		6 / 12 ILE A  29
GLY A  32
GLY A  35
VAL A  37
ALA A  50
VAL A  84
 STU  A 401 (-4.1A)
None
None
STU  A 401 ( 4.9A)
STU  A 401 (-3.2A)
None
 0.79A 3v5wA-4fr4A:
9.1		 3v5wA-4fr4A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A
(Homo
sapiens) 		6 / 12 ALA A  50
LEU A 102
GLY A 106
ASP A 107
LEU A 153
ASP A 164
 STU  A 401 (-3.2A)
STU  A 401 (-4.4A)
STU  A 401 ( 3.7A)
STU  A 401 (-3.3A)
STU  A 401 (-4.7A)
STU  A 401 ( 3.9A)
 0.66A 3zbfA-4fr4A:
22.4		 3zbfA-4fr4A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A
(Homo
sapiens) 		5 / 9 ILE A  74
MET A  75
LEU A  78
MET A  98
ILE A 162
 None
 1.08A 3zosA-4fr4A:
20.7		 3zosA-4fr4A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A
(Homo
sapiens) 		5 / 9 ILE A  74
MET A  75
LEU A  78
MET A  98
ILE A 162
 None
 1.08A 3zosB-4fr4A:
20.7		 3zosB-4fr4A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A
(Homo
sapiens) 		5 / 11 ALA A  50
VAL A  84
VAL A 100
GLY A 106
LEU A 153
 STU  A 401 (-3.2A)
None
None
STU  A 401 ( 3.7A)
STU  A 401 (-4.7A)
 0.41A 4agdA-4fr4A:
20.2		 4agdA-4fr4A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_A_STIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A
(Homo
sapiens) 		7 / 12 VAL A  37
ALA A  50
GLU A  71
ILE A  74
MET A  75
MET A  98
LEU A 153
 STU  A 401 ( 4.9A)
STU  A 401 (-3.2A)
None
None
None
None
STU  A 401 (-4.7A)
 1.05A 4bkjA-4fr4A:
20.5		 4bkjA-4fr4A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A
(Homo
sapiens) 		6 / 12 VAL A  37
ALA A  50
GLU A  71
ILE A  74
MET A  98
LEU A 153
 STU  A 401 ( 4.9A)
STU  A 401 (-3.2A)
None
None
None
STU  A 401 (-4.7A)
 0.95A 4bkjB-4fr4A:
20.6		 4bkjB-4fr4A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A
(Homo
sapiens) 		8 / 12 VAL A  37
ALA A  50
ASP A 107
ASP A 146
LYS A 148
ASN A 151
LEU A 153
ASP A 164
 STU  A 401 ( 4.9A)
STU  A 401 (-3.2A)
STU  A 401 (-3.3A)
None
None
STU  A 401 ( 4.8A)
STU  A 401 (-4.7A)
STU  A 401 ( 3.9A)
 0.46A 4i41A-4fr4A:
25.3		 4i41A-4fr4A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A
(Homo
sapiens) 		6 / 11 VAL A  37
ALA A  50
LYS A  52
ASP A 107
LEU A 153
ASP A 164
 STU  A 401 ( 4.9A)
STU  A 401 (-3.2A)
None
STU  A 401 (-3.3A)
STU  A 401 (-4.7A)
STU  A 401 ( 3.9A)
 1.00A 4iaaA-4fr4A:
25.2		 4iaaA-4fr4A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		 4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A
(Homo
sapiens) 		6 / 10 ILE A  29
ALA A  50
VAL A  84
LEU A 103
GLY A 106
LEU A 153
 STU  A 401 (-4.1A)
STU  A 401 (-3.2A)
None
STU  A 401 (-4.3A)
STU  A 401 ( 3.7A)
STU  A 401 (-4.7A)
 0.56A 4ks8A-4fr4A:
27.5		 4ks8A-4fr4A:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A
(Homo
sapiens) 		7 / 12 VAL A  37
ALA A  50
LEU A 102
GLY A 106
ASP A 107
LEU A 153
ASP A 164
 STU  A 401 ( 4.9A)
STU  A 401 (-3.2A)
STU  A 401 (-4.4A)
STU  A 401 ( 3.7A)
STU  A 401 (-3.3A)
STU  A 401 (-4.7A)
STU  A 401 ( 3.9A)
 0.51A 4mkcA-4fr4A:
21.1		 4mkcA-4fr4A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A
(Homo
sapiens) 		7 / 8 ILE A  29
VAL A  37
ALA A  50
ASP A 107
ASN A 151
LEU A 153
ASP A 164
 STU  A 401 (-4.1A)
STU  A 401 ( 4.9A)
STU  A 401 (-3.2A)
STU  A 401 (-3.3A)
STU  A 401 ( 4.8A)
STU  A 401 (-4.7A)
STU  A 401 ( 3.9A)
 0.69A 4ogrA-4fr4A:
27.1		 4ogrA-4fr4A:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A
(Homo
sapiens) 		5 / 7 ALA A  50
ASP A 107
ASN A 151
LEU A 153
ASP A 164
 STU  A 401 (-3.2A)
STU  A 401 (-3.3A)
STU  A 401 ( 4.8A)
STU  A 401 (-4.7A)
STU  A 401 ( 3.9A)
 0.51A 4ogrE-4fr4A:
11.9		 4ogrE-4fr4A:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A
(Homo
sapiens) 		5 / 7 GLY A  30
ALA A  50
ASP A 107
LEU A 153
ASP A 164
 STU  A 401 (-3.3A)
STU  A 401 (-3.2A)
STU  A 401 (-3.3A)
STU  A 401 (-4.7A)
STU  A 401 ( 3.9A)
 0.90A 4ogrE-4fr4A:
11.9		 4ogrE-4fr4A:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A
(Homo
sapiens) 		7 / 9 ILE A  29
VAL A  37
ALA A  50
ASP A 107
ASN A 151
LEU A 153
ASP A 164
 STU  A 401 (-4.1A)
STU  A 401 ( 4.9A)
STU  A 401 (-3.2A)
STU  A 401 (-3.3A)
STU  A 401 ( 4.8A)
STU  A 401 (-4.7A)
STU  A 401 ( 3.9A)
 0.75A 4ogrI-4fr4A:
26.8		 4ogrI-4fr4A:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A
(Homo
sapiens) 		6 / 11 ILE A  29
ALA A  50
GLU A  71
LEU A 103
LEU A 153
ASP A 164
 STU  A 401 (-4.1A)
STU  A 401 (-3.2A)
None
STU  A 401 (-4.3A)
STU  A 401 (-4.7A)
STU  A 401 ( 3.9A)
 0.70A 4qmsA-4fr4A:
28.9		 4qmsA-4fr4A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A
(Homo
sapiens) 		6 / 12 ILE A  29
GLY A  30
VAL A  37
ALA A  50
LEU A 103
LEU A 153
 STU  A 401 (-4.1A)
STU  A 401 (-3.3A)
STU  A 401 ( 4.9A)
STU  A 401 (-3.2A)
STU  A 401 (-4.3A)
STU  A 401 (-4.7A)
 0.61A 4qmzA-4fr4A:
28.5		 4qmzA-4fr4A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A
(Homo
sapiens) 		5 / 12 ALA A  50
GLU A  71
VAL A 100
LEU A 137
ARG A 145
 STU  A 401 (-3.2A)
None
None
None
None
 0.60A 4qrcA-4fr4A:
21.4		 4qrcA-4fr4A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A
(Homo
sapiens) 		5 / 10 ILE A  29
ALA A  50
LYS A  52
LEU A 102
LEU A 153
 STU  A 401 (-4.1A)
STU  A 401 (-3.2A)
None
STU  A 401 (-4.4A)
STU  A 401 (-4.7A)
 0.81A 4rz7A-4fr4A:
9.4		 4rz7A-4fr4A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A
(Homo
sapiens) 		4 / 7 VAL A  37
LYS A  52
ARG A 145
ILE A 162
 STU  A 401 ( 4.9A)
None
None
None
 0.73A 4uxqA-4fr4A:
20.7		 4uxqA-4fr4A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A
(Homo
sapiens) 		5 / 12 ALA A  50
GLU A  71
VAL A 100
LEU A 137
HIS A 144
 STU  A 401 (-3.2A)
None
None
None
None
 0.81A 4v01A-4fr4A:
20.3		 4v01A-4fr4A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A
(Homo
sapiens) 		5 / 12 ALA A  50
GLU A  71
VAL A 100
LEU A 137
HIS A 144
 STU  A 401 (-3.2A)
None
None
None
None
 0.77A 4v01B-4fr4A:
20.8		 4v01B-4fr4A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A
(Homo
sapiens) 		6 / 12 VAL A  37
ALA A  50
GLU A  71
VAL A 100
LEU A 137
HIS A 144
 STU  A 401 ( 4.9A)
STU  A 401 (-3.2A)
None
None
None
None
 0.79A 4v04A-4fr4A:
13.2		 4v04A-4fr4A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A
(Homo
sapiens) 		5 / 12 ALA A  50
GLU A  71
VAL A 100
LEU A 137
HIS A 144
 STU  A 401 (-3.2A)
None
None
None
None
 0.77A 4v04B-4fr4A:
21.1		 4v04B-4fr4A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A
(Homo
sapiens) 		4 / 7 ASN A  85
TYR A  88
LEU A  72
PHE A  69
 None
 1.25A 4yv5B-4fr4A:
undetectable		 4yv5B-4fr4A:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A
(Homo
sapiens) 		4 / 5 GLU A 215
THR A 212
THR A 122
LEU A 154
 None
 1.25A 5axaA-4fr4A:
undetectable		 5axaA-4fr4A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A
(Homo
sapiens) 		4 / 5 GLU A 215
THR A 212
THR A 122
LEU A 154
 None
 1.25A 5axaC-4fr4A:
undetectable		 5axaC-4fr4A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A
(Homo
sapiens) 		4 / 5 GLU A 215
THR A 212
THR A 122
LEU A 154
 None
 1.23A 5hm8A-4fr4A:
undetectable		 5hm8A-4fr4A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_B_ADNB501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A
(Homo
sapiens) 		4 / 5 GLU A 215
THR A 212
THR A 122
LEU A 154
 None
 1.24A 5hm8B-4fr4A:
undetectable		 5hm8B-4fr4A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_C_ADNC501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A
(Homo
sapiens) 		4 / 5 GLU A 215
THR A 212
THR A 122
LEU A 154
 None
 1.24A 5hm8C-4fr4A:
undetectable		 5hm8C-4fr4A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_D_ADND501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A
(Homo
sapiens) 		4 / 5 GLU A 215
THR A 212
THR A 122
LEU A 154
 None
 1.23A 5hm8D-4fr4A:
undetectable		 5hm8D-4fr4A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_E_ADNE501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A
(Homo
sapiens) 		4 / 5 GLU A 215
THR A 212
THR A 122
LEU A 154
 None
 1.24A 5hm8E-4fr4A:
undetectable		 5hm8E-4fr4A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_F_ADNF501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A
(Homo
sapiens) 		4 / 5 GLU A 215
THR A 212
THR A 122
LEU A 154
 None
 1.24A 5hm8F-4fr4A:
undetectable		 5hm8F-4fr4A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_G_ADNG501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A
(Homo
sapiens) 		4 / 5 GLU A 215
THR A 212
THR A 122
LEU A 154
 None
 1.23A 5hm8G-4fr4A:
undetectable		 5hm8G-4fr4A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_H_ADNH501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A
(Homo
sapiens) 		4 / 5 GLU A 215
THR A 212
THR A 122
LEU A 154
 None
 1.24A 5hm8H-4fr4A:
undetectable		 5hm8H-4fr4A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)		 4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A
(Homo
sapiens) 		5 / 7 GLY A  30
GLY A  32
SER A  33
GLY A  35
VAL A  37
 STU  A 401 (-3.3A)
None
None
None
STU  A 401 ( 4.9A)
 0.60A 5izjB-4fr4A:
32.3		 5izjB-4fr4A:
29.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)		 4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A
(Homo
sapiens) 		4 / 7 GLY A  30
GLY A  32
SER A  33
ASP A 164
 STU  A 401 (-3.3A)
None
None
STU  A 401 ( 3.9A)
 0.48A 5j5xA-4fr4A:
32.1		 5j5xA-4fr4A:
29.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A
(Homo
sapiens) 		7 / 12 ILE A  29
GLY A  30
VAL A  37
ALA A  50
VAL A  84
ASP A 107
LEU A 153
 STU  A 401 (-4.1A)
STU  A 401 (-3.3A)
STU  A 401 ( 4.9A)
STU  A 401 (-3.2A)
None
STU  A 401 (-3.3A)
STU  A 401 (-4.7A)
 0.74A 5l2iA-4fr4A:
6.9		 5l2iA-4fr4A:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A
(Homo
sapiens) 		4 / 8 ALA A  50
GLU A  71
LEU A 153
ASP A 164
 STU  A 401 (-3.2A)
None
STU  A 401 (-4.7A)
STU  A 401 ( 3.9A)
 0.34A 5owrA-4fr4A:
23.3		 5owrA-4fr4A:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_A_ADNA502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A
(Homo
sapiens) 		4 / 4 GLU A 215
THR A 212
THR A 122
LEU A 154
 None
 1.24A 5v96A-4fr4A:
undetectable		 5v96A-4fr4A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_B_ADNB502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A
(Homo
sapiens) 		4 / 4 GLU A 215
THR A 212
THR A 122
LEU A 154
 None
 1.26A 5v96B-4fr4A:
undetectable		 5v96B-4fr4A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_D_ADND502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A
(Homo
sapiens) 		4 / 4 GLU A 215
THR A 212
THR A 122
LEU A 154
 None
 1.25A 5v96D-4fr4A:
undetectable		 5v96D-4fr4A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_2
(WEE1-LIKE PROTEIN
KINASE)		 4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A
(Homo
sapiens) 		4 / 4 VAL A  37
LYS A  52
VAL A  84
ASN A 151
 STU  A 401 ( 4.9A)
None
None
STU  A 401 ( 4.8A)
 0.46A 5vc3A-4fr4A:
24.6		 5vc3A-4fr4A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A
(Homo
sapiens) 		4 / 4 VAL A  84
LEU A 102
ASN A 151
ASP A 164
 None
STU  A 401 (-4.4A)
STU  A 401 ( 4.8A)
STU  A 401 ( 3.9A)
 0.86A 5vcyA-4fr4A:
24.9		 5vcyA-4fr4A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A
(Homo
sapiens) 		7 / 12 VAL A  37
ALA A  50
LYS A  52
GLU A  71
LEU A 102
GLY A 106
LEU A 153
 STU  A 401 ( 4.9A)
STU  A 401 (-3.2A)
None
None
STU  A 401 (-4.4A)
STU  A 401 ( 3.7A)
STU  A 401 (-4.7A)
 0.72A 5y7zA-4fr4A:
24.6		 5y7zA-4fr4A:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A
(Homo
sapiens) 		7 / 12 VAL A  37
ALA A  50
LYS A  52
GLU A  71
LEU A 102
GLY A 106
LEU A 153
 STU  A 401 ( 4.9A)
STU  A 401 (-3.2A)
None
None
STU  A 401 (-4.4A)
STU  A 401 ( 3.7A)
STU  A 401 (-4.7A)
 0.72A 5y7zA-4fr4A:
24.6		 5y7zA-4fr4A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A
(Homo
sapiens) 		7 / 12 ALA A  50
LYS A  52
GLU A  71
LEU A 102
GLY A 106
LEU A 153
ASP A 164
 STU  A 401 (-3.2A)
None
None
STU  A 401 (-4.4A)
STU  A 401 ( 3.7A)
STU  A 401 (-4.7A)
STU  A 401 ( 3.9A)
 0.65A 5y7zB-4fr4A:
24.6		 5y7zB-4fr4A:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A
(Homo
sapiens) 		8 / 12 VAL A  37
ALA A  50
LYS A  52
GLU A  71
LEU A 102
GLY A 106
LEU A 153
ASP A 164
 STU  A 401 ( 4.9A)
STU  A 401 (-3.2A)
None
None
STU  A 401 (-4.4A)
STU  A 401 ( 3.7A)
STU  A 401 (-4.7A)
STU  A 401 ( 3.9A)
 0.55A 5y80A-4fr4A:
23.6		 5y80A-4fr4A:
13.68