SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4frf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BRP_A_RTLA183_0
(RETINOL BINDING
PROTEIN)		 4frf INOSITOL
POLYPHOSPHATE
MULTIKINASE ALPHA
(Arabidopsis
thaliana) 		5 / 12 PHE A  46
PHE A  50
TYR A  63
LEU A 202
GLN A 201
 None
 1.41A 1brpA-4frfA:
undetectable		 1brpA-4frfA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HO5_A_ADNA1604_1
(5'-NUCLEOTIDASE)		 4frf INOSITOL
POLYPHOSPHATE
MULTIKINASE ALPHA
(Arabidopsis
thaliana) 		5 / 11 ILE A 258
ASN A 261
GLY A 254
ASN A 218
GLY A 256
 None
SO4  A 302 ( 4.8A)
None
SO4  A 302 (-4.2A)
None
 1.04A 1ho5A-4frfA:
undetectable		 1ho5A-4frfA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O01_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4frf INOSITOL
POLYPHOSPHATE
MULTIKINASE ALPHA
(Arabidopsis
thaliana) 		4 / 8 PHE A 269
SER A 268
ALA A 163
LEU A 167
 None
 0.96A 2o01A-4frfA:
undetectable		 2o01A-4frfA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)		 4frf INOSITOL
POLYPHOSPHATE
MULTIKINASE ALPHA
(Arabidopsis
thaliana) 		5 / 12 GLY A 265
GLY A 264
LEU A 202
MET A  97
CYH A 220
 None
 1.12A 3h52B-4frfA:
undetectable		 3h52B-4frfA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B304_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 4frf INOSITOL
POLYPHOSPHATE
MULTIKINASE ALPHA
(Arabidopsis
thaliana) 		4 / 5 ASN A 261
THR A 125
SER A 135
ARG A 156
 SO4  A 302 ( 4.8A)
None
None
None
 1.36A 3hlwB-4frfA:
undetectable		 3hlwB-4frfA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4frf INOSITOL
POLYPHOSPHATE
MULTIKINASE ALPHA
(Arabidopsis
thaliana) 		5 / 12 LEU A 155
SER A 135
GLY A 162
ALA A 163
LEU A 167
 None
 1.15A 5ikrA-4frfA:
undetectable		 5ikrA-4frfA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4frf INOSITOL
POLYPHOSPHATE
MULTIKINASE ALPHA
(Arabidopsis
thaliana) 		4 / 5 MET A 224
TYR A 192
GLY A 193
GLY A 194
 None
 1.10A 5x7pA-4frfA:
undetectable		 5x7pA-4frfA:
11.73