SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4frx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_B_ACAB90_1
(PLASMINOGEN)		 4frx ANAEROBICALLY-INDUCE
D OUTER MEMBRANE
PORIN OPRE
(Pseudomonas
aeruginosa) 		4 / 7 ASP A 245
ASP A 212
TYR A 208
TYR A 190
 None
 1.32A 1ceaB-4frxA:
undetectable		 1ceaB-4frxA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXV_B_PNNB1001_0
(PENICILLIN ACYLASE)		 4frx ANAEROBICALLY-INDUCE
D OUTER MEMBRANE
PORIN OPRE
(Pseudomonas
aeruginosa) 		4 / 7 PHE A 306
SER A 172
SER A 242
PHE A 304
 None
 1.15A 1fxvA-4frxA:
undetectable
1fxvB-4frxA:
0.9		 1fxvA-4frxA:
20.05
1fxvB-4frxA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_1
(MINERALOCORTICOID
RECEPTOR)		 4frx ANAEROBICALLY-INDUCE
D OUTER MEMBRANE
PORIN OPRE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  59
LEU A  62
ALA A  98
LEU A 132
THR A 117
 None
C8E  A 502 ( 4.3A)
C8E  A 502 ( 3.8A)
None
None
 1.31A 1ya3A-4frxA:
undetectable		 1ya3A-4frxA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_B_STRB302_1
(MINERALOCORTICOID
RECEPTOR)		 4frx ANAEROBICALLY-INDUCE
D OUTER MEMBRANE
PORIN OPRE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  59
LEU A  62
ALA A  98
LEU A 132
THR A 117
 None
C8E  A 502 ( 4.3A)
C8E  A 502 ( 3.8A)
None
None
 1.30A 2aa5B-4frxA:
undetectable		 2aa5B-4frxA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_B_NCAB1246_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 4frx ANAEROBICALLY-INDUCE
D OUTER MEMBRANE
PORIN OPRE
(Pseudomonas
aeruginosa) 		4 / 7 ARG A 163
GLY A 130
SER A 315
ARG A 421
 None
 1.09A 2c8aB-4frxA:
undetectable		 2c8aB-4frxA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE802_0
(GLUTAMATE RECEPTOR 2)		 4frx ANAEROBICALLY-INDUCE
D OUTER MEMBRANE
PORIN OPRE
(Pseudomonas
aeruginosa) 		3 / 3 ASP A 311
ASN A 164
SER A 179
 None
 0.94A 3lsfB-4frxA:
undetectable
3lsfE-4frxA:
undetectable		 3lsfB-4frxA:
19.91
3lsfE-4frxA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 4frx ANAEROBICALLY-INDUCE
D OUTER MEMBRANE
PORIN OPRE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  38
PHE A  16
ASP A 129
GLY A  63
PHE A  85
 None
 1.16A 3ps9A-4frxA:
undetectable		 3ps9A-4frxA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ0_X_DXCX75_0
(CYTOCHROME C7)		 4frx ANAEROBICALLY-INDUCE
D OUTER MEMBRANE
PORIN OPRE
(Pseudomonas
aeruginosa) 		4 / 7 ILE A  18
LYS A 161
PHE A  85
GLY A  63
 None
 1.07A 3sj0X-4frxA:
undetectable		 3sj0X-4frxA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4frx ANAEROBICALLY-INDUCE
D OUTER MEMBRANE
PORIN OPRE
(Pseudomonas
aeruginosa) 		4 / 7 ARG A 276
ALA A 277
ILE A 297
GLY A 332
 None
 0.80A 3v4tH-4frxA:
undetectable		 3v4tH-4frxA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W37_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 4frx ANAEROBICALLY-INDUCE
D OUTER MEMBRANE
PORIN OPRE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 277
ASN A 275
ILE A 223
ASP A 236
PHE A 219
 None
 1.48A 3w37A-4frxA:
undetectable		 3w37A-4frxA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEL_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 4frx ANAEROBICALLY-INDUCE
D OUTER MEMBRANE
PORIN OPRE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 277
ASN A 275
ILE A 223
ASP A 236
PHE A 219
 None
 1.46A 3welA-4frxA:
undetectable		 3welA-4frxA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG306_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4frx ANAEROBICALLY-INDUCE
D OUTER MEMBRANE
PORIN OPRE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 238
ARG A 339
ASP A 322
 None
 1.01A 3wipG-4frxA:
undetectable
3wipH-4frxA:
undetectable		 3wipG-4frxA:
20.22
3wipH-4frxA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR4_C_AICC401_1
(OUTER MEMBRANE
PROTEIN F)		 4frx ANAEROBICALLY-INDUCE
D OUTER MEMBRANE
PORIN OPRE
(Pseudomonas
aeruginosa) 		4 / 8 ARG A 163
ARG A 131
ASP A 377
ARG A 421
 None
 1.35A 4kr4C-4frxA:
14.1		 4kr4C-4frxA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_C_SAMC301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 4frx ANAEROBICALLY-INDUCE
D OUTER MEMBRANE
PORIN OPRE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 154
GLY A 194
ASP A 195
ALA A 192
TYR A 318
 None
 1.13A 4lg1C-4frxA:
undetectable		 4lg1C-4frxA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T44A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4frx ANAEROBICALLY-INDUCE
D OUTER MEMBRANE
PORIN OPRE
(Pseudomonas
aeruginosa) 		4 / 6 SER A 160
GLU A 138
VAL A 125
THR A 126
 None
 1.11A 4lnxA-4frxA:
undetectable		 4lnxA-4frxA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OJ0_A_9WTA801_0
(PENICILLIN-BINDING
PROTEIN 2X)		 4frx ANAEROBICALLY-INDUCE
D OUTER MEMBRANE
PORIN OPRE
(Pseudomonas
aeruginosa) 		5 / 12 ASN A 128
ASN A 308
GLN A 329
SER A 179
GLY A 178
 None
 1.45A 5oj0A-4frxA:
undetectable		 5oj0A-4frxA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4frx ANAEROBICALLY-INDUCE
D OUTER MEMBRANE
PORIN OPRE
(Pseudomonas
aeruginosa) 		4 / 8 THR A 145
THR A 143
ARG A 114
GLN A 141
 None
 1.24A 5tzoA-4frxA:
undetectable		 5tzoA-4frxA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4frx ANAEROBICALLY-INDUCE
D OUTER MEMBRANE
PORIN OPRE
(Pseudomonas
aeruginosa) 		4 / 8 THR A 151
THR A 143
ARG A 114
GLN A 141
 None
 1.37A 5tzoA-4frxA:
undetectable		 5tzoA-4frxA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4frx ANAEROBICALLY-INDUCE
D OUTER MEMBRANE
PORIN OPRE
(Pseudomonas
aeruginosa) 		4 / 8 THR A 145
THR A 143
ARG A 114
GLN A 141
 None
 1.29A 5tzoC-4frxA:
undetectable		 5tzoC-4frxA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7P_A_SAMA501_0
(OXAC)		 4frx ANAEROBICALLY-INDUCE
D OUTER MEMBRANE
PORIN OPRE
(Pseudomonas
aeruginosa) 		5 / 12 GLU A 333
GLY A 326
LEU A 319
PHE A 306
ASP A 303
 None
 1.20A 5w7pA-4frxA:
undetectable		 5w7pA-4frxA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_B_SALB203_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 4frx ANAEROBICALLY-INDUCE
D OUTER MEMBRANE
PORIN OPRE
(Pseudomonas
aeruginosa) 		4 / 6 GLY A 155
TYR A 190
LEU A 118
VAL A 125
 None
 0.89A 5x80A-4frxA:
undetectable
5x80B-4frxA:
undetectable		 5x80A-4frxA:
17.22
5x80B-4frxA:
17.22