SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fry'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_0
(HYPOTHETICAL PROTEIN
RV2118C)		 4fry PUTATIVE
SIGNAL-TRANSDUCTION
PROTEIN WITH CBS
DOMAINS
(Burkholderia
ambifaria) 		5 / 12 ILE A   8
GLY A 118
GLY A  16
SER A  15
LEU A  44
 None
 1.24A 1i9gA-4fryA:
undetectable		 1i9gA-4fryA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO4_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 4fry PUTATIVE
SIGNAL-TRANSDUCTION
PROTEIN WITH CBS
DOMAINS
(Burkholderia
ambifaria) 		5 / 12 ALA A  31
VAL A  22
THR A  81
MET A  80
ASP A  59
 None
None
AMP  A 202 (-3.6A)
None
AMP  A 202 (-2.6A)
 1.28A 2qo4A-4fryA:
undetectable		 2qo4A-4fryA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_B_SAMB206_0
(UPF0217 PROTEIN
MJ1640)		 4fry PUTATIVE
SIGNAL-TRANSDUCTION
PROTEIN WITH CBS
DOMAINS
(Burkholderia
ambifaria) 		4 / 5 SER A  90
LEU A 108
GLU A  88
CYH A  96
 None
AMP  A 202 ( 4.9A)
None
None
 1.22A 3aiaA-4fryA:
undetectable
3aiaB-4fryA:
undetectable		 3aiaA-4fryA:
23.44
3aiaB-4fryA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 4fry PUTATIVE
SIGNAL-TRANSDUCTION
PROTEIN WITH CBS
DOMAINS
(Burkholderia
ambifaria) 		7 / 12 ILE A  54
THR A  56
ASP A  59
LYS A  63
THR A  81
VAL A  84
PRO A 109
 AMP  A 202 (-4.1A)
AMP  A 202 (-2.9A)
AMP  A 202 (-2.6A)
AMP  A 202 ( 4.1A)
AMP  A 202 (-3.6A)
AMP  A 202 (-3.8A)
AMP  A 202 (-4.7A)
 0.66A 3kpbA-4fryA:
16.7		 3kpbA-4fryA:
29.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 4fry PUTATIVE
SIGNAL-TRANSDUCTION
PROTEIN WITH CBS
DOMAINS
(Burkholderia
ambifaria) 		8 / 12 HIS A 107
ILE A  54
THR A  56
ASP A  59
LYS A  63
THR A  81
VAL A  84
PRO A 109
 AMP  A 202 ( 3.7A)
AMP  A 202 (-4.1A)
AMP  A 202 (-2.9A)
AMP  A 202 (-2.6A)
AMP  A 202 ( 4.1A)
AMP  A 202 (-3.6A)
AMP  A 202 (-3.8A)
AMP  A 202 (-4.7A)
 0.77A 3kpbC-4fryA:
16.4		 3kpbC-4fryA:
29.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_D_SAMD1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 4fry PUTATIVE
SIGNAL-TRANSDUCTION
PROTEIN WITH CBS
DOMAINS
(Burkholderia
ambifaria) 		6 / 10 ILE A  54
THR A  56
ASP A  59
LYS A  63
THR A  81
VAL A  84
 AMP  A 202 (-4.1A)
AMP  A 202 (-2.9A)
AMP  A 202 (-2.6A)
AMP  A 202 ( 4.1A)
AMP  A 202 (-3.6A)
AMP  A 202 (-3.8A)
 0.69A 3kpbD-4fryA:
16.2		 3kpbD-4fryA:
29.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPC_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 4fry PUTATIVE
SIGNAL-TRANSDUCTION
PROTEIN WITH CBS
DOMAINS
(Burkholderia
ambifaria) 		6 / 11 ILE A  54
THR A  56
ASP A  59
THR A  81
VAL A  84
PRO A 109
 AMP  A 202 (-4.1A)
AMP  A 202 (-2.9A)
AMP  A 202 (-2.6A)
AMP  A 202 (-3.6A)
AMP  A 202 (-3.8A)
AMP  A 202 (-4.7A)
 0.37A 3kpcA-4fryA:
17.4		 3kpcA-4fryA:
28.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 4fry PUTATIVE
SIGNAL-TRANSDUCTION
PROTEIN WITH CBS
DOMAINS
(Burkholderia
ambifaria) 		7 / 12 ILE A  54
THR A  56
ASP A  59
LYS A  63
THR A  81
VAL A  84
PRO A 109
 AMP  A 202 (-4.1A)
AMP  A 202 (-2.9A)
AMP  A 202 (-2.6A)
AMP  A 202 ( 4.1A)
AMP  A 202 (-3.6A)
AMP  A 202 (-3.8A)
AMP  A 202 (-4.7A)
 0.74A 3kpdB-4fryA:
17.0		 3kpdB-4fryA:
29.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 4fry PUTATIVE
SIGNAL-TRANSDUCTION
PROTEIN WITH CBS
DOMAINS
(Burkholderia
ambifaria) 		6 / 12 ILE A  54
THR A  56
ASP A  59
THR A  81
VAL A  84
PRO A 109
 AMP  A 202 (-4.1A)
AMP  A 202 (-2.9A)
AMP  A 202 (-2.6A)
AMP  A 202 (-3.6A)
AMP  A 202 (-3.8A)
AMP  A 202 (-4.7A)
 0.39A 3kpdC-4fryA:
17.2		 3kpdC-4fryA:
29.25