SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4frz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4frz KINESIN-LIKE
CALMODULIN-BINDING
PROTEIN
(Arabidopsis
thaliana) 		3 / 3 SER A1072
GLU A1073
GLU A1069
 None
 0.66A 1eqbD-4frzA:
undetectable		 1eqbD-4frzA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4frz KINESIN-LIKE
CALMODULIN-BINDING
PROTEIN
(Arabidopsis
thaliana) 		3 / 3 SER A1072
GLU A1073
GLU A1069
 None
 0.67A 1eqbB-4frzA:
undetectable		 1eqbB-4frzA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_B_BEZB1162_0
(PEROXIREDOXIN 5)		 4frz KINESIN-LIKE
CALMODULIN-BINDING
PROTEIN
(Arabidopsis
thaliana) 		4 / 8 THR A 990
PRO A 991
GLY A 988
THR A 977
 None
None
None
MG  A1301 ( 3.1A)
 0.87A 1h4oB-4frzA:
undetectable		 1h4oB-4frzA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OC3_A_BEZA201_0
(PEROXIREDOXIN 5)		 4frz KINESIN-LIKE
CALMODULIN-BINDING
PROTEIN
(Arabidopsis
thaliana) 		4 / 8 THR A 990
PRO A 991
GLY A 988
THR A 977
 None
None
None
MG  A1301 ( 3.1A)
 0.88A 1oc3A-4frzA:
undetectable		 1oc3A-4frzA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA501_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 4frz KINESIN-LIKE
CALMODULIN-BINDING
PROTEIN
(Arabidopsis
thaliana) 		5 / 12 ASP A1173
GLY A1176
ILE A1150
TYR A1203
ALA A1204
 None
 1.34A 1oltA-4frzA:
undetectable		 1oltA-4frzA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_B_BEZB12_0
(CES1 PROTEIN)		 4frz KINESIN-LIKE
CALMODULIN-BINDING
PROTEIN
(Arabidopsis
thaliana) 		4 / 4 GLY A1119
SER A1087
VAL A1123
LEU A1143
 None
EDO  A1306 ( 4.0A)
None
None
 1.27A 1yajB-4frzA:
undetectable		 1yajB-4frzA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)		 4frz KINESIN-LIKE
CALMODULIN-BINDING
PROTEIN
(Arabidopsis
thaliana) 		5 / 11 GLY A1151
SER A1155
ASP A1252
GLY A1156
GLN A1158
 None
 1.42A 2hmaA-4frzA:
undetectable		 2hmaA-4frzA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_2
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 4frz KINESIN-LIKE
CALMODULIN-BINDING
PROTEIN
(Arabidopsis
thaliana) 		4 / 6 ARG A 895
GLN A 944
ASN A 986
LEU A1068
 ADP  A1302 (-4.0A)
None
None
None
 1.26A 2nyrA-4frzA:
undetectable		 2nyrA-4frzA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA509_0
(CHORISMATE SYNTHASE)		 4frz KINESIN-LIKE
CALMODULIN-BINDING
PROTEIN
(Arabidopsis
thaliana) 		3 / 3 ARG A 897
GLN A 910
PRO A1189
 None
 0.96A 2qhfA-4frzA:
undetectable		 2qhfA-4frzA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKZ_A_ZMRA469_2
(NEURAMINIDASE)		 4frz KINESIN-LIKE
CALMODULIN-BINDING
PROTEIN
(Arabidopsis
thaliana) 		4 / 6 ASP A 950
ARG A 891
ARG A 895
SER A 943
 None
None
ADP  A1302 (-4.0A)
None
 1.13A 3ckzA-4frzA:
undetectable		 3ckzA-4frzA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 4frz KINESIN-LIKE
CALMODULIN-BINDING
PROTEIN
(Arabidopsis
thaliana) 		3 / 3 ARG A1007
ASP A 960
ASP A1004
 None
 0.91A 3jb3A-4frzA:
undetectable		 3jb3A-4frzA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4frz KINESIN-LIKE
CALMODULIN-BINDING
PROTEIN
(Arabidopsis
thaliana) 		4 / 7 ILE A 980
THR A 990
VAL A1185
ASP A 935
 None
 1.30A 4iarA-4frzA:
undetectable		 4iarA-4frzA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 4frz KINESIN-LIKE
CALMODULIN-BINDING
PROTEIN
(Arabidopsis
thaliana) 		5 / 9 SER A 974
ALA A 968
LEU A1117
GLY A1119
ALA A1152
 ADP  A1302 (-3.6A)
None
None
None
None
 1.37A 4l6va-4frzA:
undetectable
4l6vf-4frzA:
undetectable		 4l6va-4frzA:
17.28
4l6vf-4frzA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QKN_A_JMSA602_1
(ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO)		 4frz KINESIN-LIKE
CALMODULIN-BINDING
PROTEIN
(Arabidopsis
thaliana) 		4 / 8 THR A 994
LEU A1068
VAL A1095
SER A1094
 None
 1.10A 4qknA-4frzA:
undetectable		 4qknA-4frzA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_A_ADNA1002_1
(MYOSIN HEAVY CHAIN
KINASE A)		 4frz KINESIN-LIKE
CALMODULIN-BINDING
PROTEIN
(Arabidopsis
thaliana) 		5 / 11 GLY A 982
LEU A 954
LEU A1182
PHE A1184
THR A 951
 None
 1.13A 4zmeA-4frzA:
undetectable		 4zmeA-4frzA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4frz KINESIN-LIKE
CALMODULIN-BINDING
PROTEIN
(Arabidopsis
thaliana) 		3 / 3 THR A 990
HIS A1076
LEU A1027
 None
 0.74A 5axdA-4frzA:
undetectable		 5axdA-4frzA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0I_B_ACTB303_0
(SWI5-DEPENDENT HO
EXPRESSION PROTEIN 2)		 4frz KINESIN-LIKE
CALMODULIN-BINDING
PROTEIN
(Arabidopsis
thaliana) 		4 / 5 VAL A1207
THR A1181
ASN A1212
LEU A1175
 None
 1.33A 5m0iB-4frzA:
undetectable		 5m0iB-4frzA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M35_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4frz KINESIN-LIKE
CALMODULIN-BINDING
PROTEIN
(Arabidopsis
thaliana) 		4 / 5 PHE A1008
THR A1104
GLN A1103
ARG A1007
 None
 1.02A 5m35A-4frzA:
undetectable		 5m35A-4frzA:
20.41