SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fs3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4001_1
(SERUM ALBUMIN)		 4fs3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADPH] FABI
(Staphylococcus
aureus) 		5 / 9 LEU A 208
ILE A 207
ASN A 205
VAL A 201
GLY A 202
 None
0WE  A 302 ( 4.8A)
None
0WE  A 302 ( 4.4A)
None
 1.04A 1e7aA-4fs3A:
undetectable		 1e7aA-4fs3A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4001_1
(SERUM ALBUMIN)		 4fs3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADPH] FABI
(Staphylococcus
aureus) 		5 / 9 LEU A 208
ILE A 207
ASN A 205
VAL A 201
GLY A 202
 None
0WE  A 302 ( 4.8A)
None
0WE  A 302 ( 4.4A)
None
 1.02A 1e7aB-4fs3A:
undetectable		 1e7aB-4fs3A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_C_CCSC47_0
(GLUTATHIONE
S-TRANSFERASE)		 4fs3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADPH] FABI
(Staphylococcus
aureus) 		4 / 6 LEU A 234
GLY A 140
LYS A   7
TYR A   9
 None
 1.19A 1gtiC-4fs3A:
undetectable		 1gtiC-4fs3A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_F_CCSF47_0
(GLUTATHIONE
S-TRANSFERASE)		 4fs3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADPH] FABI
(Staphylococcus
aureus) 		4 / 5 LEU A 234
GLY A 140
LYS A   7
TYR A   9
 None
 1.19A 1gtiF-4fs3A:
undetectable		 1gtiF-4fs3A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1121_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 4fs3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADPH] FABI
(Staphylococcus
aureus) 		4 / 5 VAL A 241
SER A 141
VAL A 185
SER A 238
 None
 1.21A 2j9cA-4fs3A:
undetectable
2j9cB-4fs3A:
undetectable
2j9cC-4fs3A:
undetectable		 2j9cA-4fs3A:
24.00
2j9cB-4fs3A:
24.00
2j9cC-4fs3A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 4fs3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADPH] FABI
(Staphylococcus
aureus) 		5 / 12 VAL A 154
PHE A 204
LEU A 208
ALA A 190
SER A 189
 None
None
None
0WD  A 301 (-3.5A)
None
 1.41A 3apvA-4fs3A:
undetectable		 3apvA-4fs3A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_2
(DIHYDROFOLATE
REDUCTASE)		 4fs3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADPH] FABI
(Staphylococcus
aureus) 		4 / 4 ILE A  20
ARG A 219
ILE A 193
THR A 146
 0WD  A 301 (-3.9A)
None
None
None
 1.24A 3ia4C-4fs3A:
undetectable		 3ia4C-4fs3A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_A_KANA2001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4fs3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADPH] FABI
(Staphylococcus
aureus) 		5 / 11 VAL A  67
GLN A 118
ALA A 163
SER A 166
ASN A 170
 0WD  A 301 (-3.6A)
None
None
None
None
 1.09A 3kp5A-4fs3A:
undetectable		 3kp5A-4fs3A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3007_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4fs3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADPH] FABI
(Staphylococcus
aureus) 		5 / 9 ALA A 117
GLN A 118
ALA A 163
SER A 166
ASN A 170
 None
 1.25A 3kp6B-4fs3A:
undetectable		 3kp6B-4fs3A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_B_SAMB6735_0
(N-LYSINE
METHYLTRANSFERASE
SETD6
TRANSCRIPTION FACTOR
P65)		 4fs3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADPH] FABI
(Staphylococcus
aureus) 		5 / 11 VAL A 248
GLY A 191
TYR A 147
ALA A  21
TYR A  91
 None
None
0WE  A 302 ( 3.8A)
None
None
 1.34A 3qxyB-4fs3A:
undetectable
3qxyQ-4fs3A:
undetectable		 3qxyB-4fs3A:
20.59
3qxyQ-4fs3A:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_0
(METHYLTRANSFERASE
MPPJ)		 4fs3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADPH] FABI
(Staphylococcus
aureus) 		5 / 12 ILE A  11
GLY A  23
ILE A 188
ALA A 230
ALA A 190
 None
None
None
None
0WD  A 301 (-3.5A)
 1.10A 4kicB-4fs3A:
6.0		 4kicB-4fs3A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 4fs3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADPH] FABI
(Staphylococcus
aureus) 		3 / 3 ASN A  86
PHE A  77
TYR A  63
 None
 0.81A 4u15A-4fs3A:
undetectable		 4u15A-4fs3A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4fs3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADPH] FABI
(Staphylococcus
aureus) 		4 / 6 ILE A 120
GLN A  68
ILE A 127
ASP A  70
 0WD  A 301 (-3.8A)
0WD  A 301 ( 4.8A)
None
None
 1.15A 4w5qA-4fs3A:
2.8		 4w5qA-4fs3A:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4fs3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADPH] FABI
(Staphylococcus
aureus) 		4 / 6 ILE A 120
GLN A  68
ILE A 127
ASP A  70
 0WD  A 301 (-3.8A)
0WD  A 301 ( 4.8A)
None
None
 1.04A 4z4cA-4fs3A:
2.4		 4z4cA-4fs3A:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4fs3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADPH] FABI
(Staphylococcus
aureus) 		5 / 12 GLY A 240
PHE A  77
ILE A  80
LEU A 234
THR A 242
 None
 1.11A 4zdyA-4fs3A:
undetectable		 4zdyA-4fs3A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_2
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)		 4fs3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADPH] FABI
(Staphylococcus
aureus) 		3 / 3 VAL A  73
LYS A 133
MET A 136
 None
 1.05A 5nknA-4fs3A:
undetectable		 5nknA-4fs3A:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4fs3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADPH] FABI
(Staphylococcus
aureus) 		4 / 7 SER A 189
VAL A 221
PRO A 192
ILE A 207
 None
None
0WD  A 301 (-4.8A)
0WE  A 302 ( 4.8A)
 1.23A 5vkqA-4fs3A:
undetectable
5vkqB-4fs3A:
undetectable		 5vkqA-4fs3A:
9.74
5vkqB-4fs3A:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4fs3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADPH] FABI
(Staphylococcus
aureus) 		4 / 7 SER A 189
VAL A 221
PRO A 192
ILE A 207
 None
None
0WD  A 301 (-4.8A)
0WE  A 302 ( 4.8A)
 1.22A 5vkqC-4fs3A:
undetectable
5vkqD-4fs3A:
undetectable		 5vkqC-4fs3A:
9.74
5vkqD-4fs3A:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_1
(REGULATORY PROTEIN
TETR)		 4fs3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADPH] FABI
(Staphylococcus
aureus) 		4 / 8 GLN A 223
GLY A 227
ILE A  11
GLN A  57
 None
 0.89A 5vlmH-4fs3A:
undetectable		 5vlmH-4fs3A:
23.46