SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fso'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4fso PROBABLE PORIN
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 249
TYR A 213
SER A 280
ARG A 247
ASP A 242
 None
 1.14A 2br4F-4fsoA:
undetectable		 2br4F-4fsoA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FO7_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4fso PROBABLE PORIN
(Pseudomonas
aeruginosa) 		4 / 5 HIS A 172
ASP A 286
TYR A 284
PRO A 290
 None
 1.44A 3fo7A-4fsoA:
undetectable		 3fo7A-4fsoA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H1X_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4fso PROBABLE PORIN
(Pseudomonas
aeruginosa) 		4 / 5 HIS A 172
ASP A 286
TYR A 284
PRO A 290
 None
 1.46A 3h1xA-4fsoA:
undetectable		 3h1xA-4fsoA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_0
(16S RRNA METHYLASE)		 4fso PROBABLE PORIN
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 222
GLY A 199
VAL A 196
ASN A 197
ALA A 220
 C8E  A 506 (-3.4A)
None
None
None
C8E  A 506 ( 3.9A)
 1.06A 3p2kC-4fsoA:
undetectable		 3p2kC-4fsoA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 4fso PROBABLE PORIN
(Pseudomonas
aeruginosa) 		4 / 7 ALA A 115
ALA A  98
LEU A 134
THR A 159
 None
C8E  A 507 ( 3.7A)
None
None
 0.95A 4du2A-4fsoA:
undetectable		 4du2A-4fsoA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_B_IMNB201_1
(TRANSTHYRETIN)		 4fso PROBABLE PORIN
(Pseudomonas
aeruginosa) 		4 / 6 LYS A 230
ALA A 263
SER A 270
THR A 268
 None
 0.82A 4ikiB-4fsoA:
undetectable		 4ikiB-4fsoA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA603_1
(SERUM ALBUMIN)		 4fso PROBABLE PORIN
(Pseudomonas
aeruginosa) 		5 / 10 ARG A 236
ALA A 293
SER A 232
LEU A 260
ALA A 261
 None
None
None
C8E  A 504 ( 4.7A)
None
 1.21A 4zbrA-4fsoA:
undetectable		 4zbrA-4fsoA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDZ_A_ADNA905_1
(ATP-CITRATE SYNTHASE)		 4fso PROBABLE PORIN
(Pseudomonas
aeruginosa) 		4 / 6 THR A  61
ASP A  60
ARG A  47
LEU A  46
 None
 1.10A 5tdzA-4fsoA:
undetectable		 5tdzA-4fsoA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJY_A_BEZA304_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 4fso PROBABLE PORIN
(Pseudomonas
aeruginosa) 		3 / 3 MET A 328
GLU A 349
ARG A 330
 None
 0.92A 5tjyA-4fsoA:
undetectable		 5tjyA-4fsoA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJZ_A_BEZA302_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 4fso PROBABLE PORIN
(Pseudomonas
aeruginosa) 		3 / 3 MET A 328
GLU A 349
ARG A 330
 None
 0.92A 5tjzA-4fsoA:
undetectable		 5tjzA-4fsoA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)		 4fso PROBABLE PORIN
(Pseudomonas
aeruginosa) 		5 / 12 PHE A 111
ARG A 154
GLY A 137
GLY A 114
MET A 104
 C8E  A 508 (-4.5A)
None
None
None
C8E  A 508 (-4.2A)
 1.18A 5ul4A-4fsoA:
undetectable		 5ul4A-4fsoA:
20.80