SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fsp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_A_CCSA47_0
(GLUTATHIONE
S-TRANSFERASE)		 4fsp PROBABLE PORIN
(Pseudomonas
aeruginosa) 		4 / 7 THR A 135
LEU A 146
GLY A 185
LEU A 114
 None
None
C8E  A 406 ( 4.0A)
None
 0.81A 1gtiA-4fspA:
undetectable		 1gtiA-4fspA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_D_CCSD47_0
(GLUTATHIONE
S-TRANSFERASE)		 4fsp PROBABLE PORIN
(Pseudomonas
aeruginosa) 		4 / 7 THR A 135
LEU A 146
GLY A 185
LEU A 114
 None
None
C8E  A 406 ( 4.0A)
None
 0.94A 1gtiD-4fspA:
undetectable		 1gtiD-4fspA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_E_CCSE47_0
(GLUTATHIONE
S-TRANSFERASE)		 4fsp PROBABLE PORIN
(Pseudomonas
aeruginosa) 		4 / 7 THR A 135
LEU A 146
GLY A 185
LEU A 114
 None
None
C8E  A 406 ( 4.0A)
None
 0.86A 1gtiE-4fspA:
undetectable		 1gtiE-4fspA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_C_DESC129_1
(TRANSTHYRETIN)		 4fsp PROBABLE PORIN
(Pseudomonas
aeruginosa) 		4 / 6 LEU A  51
LEU A 100
SER A 103
SER A 136
 C8E  A 403 ( 4.6A)
None
None
None
 0.78A 1tz8C-4fspA:
undetectable
1tz8D-4fspA:
undetectable		 1tz8C-4fspA:
16.95
1tz8D-4fspA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_C_DESC129_1
(TRANSTHYRETIN)		 4fsp PROBABLE PORIN
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 186
LEU A 144
SER A 136
SER A 103
 C8E  A 408 (-4.5A)
None
None
None
 0.65A 1tz8C-4fspA:
undetectable
1tz8D-4fspA:
undetectable		 1tz8C-4fspA:
16.95
1tz8D-4fspA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		 4fsp PROBABLE PORIN
(Pseudomonas
aeruginosa) 		4 / 8 PRO A 112
LEU A 183
GLY A 201
LEU A 149
 None
 0.76A 1ya4A-4fspA:
undetectable		 1ya4A-4fspA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		 4fsp PROBABLE PORIN
(Pseudomonas
aeruginosa) 		4 / 7 PRO A 112
LEU A 183
GLY A 201
LEU A 149
 None
 0.77A 1ya4B-4fspA:
undetectable		 1ya4B-4fspA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4fsp PROBABLE PORIN
(Pseudomonas
aeruginosa) 		4 / 6 PRO A 115
ILE A 117
ASN A 145
LEU A 133
 None
 1.27A 2wekB-4fspA:
undetectable		 2wekB-4fspA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4fsp PROBABLE PORIN
(Pseudomonas
aeruginosa) 		5 / 12 TYR A 198
GLY A 213
SER A 197
LEU A 231
HIS A 210
 C8E  A 408 ( 3.9A)
None
None
None
C8E  A 408 ( 4.2A)
 1.27A 3ou7C-4fspA:
undetectable		 3ou7C-4fspA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHN_A_ACTA108_0
(PROTEIN P-30)		 4fsp PROBABLE PORIN
(Pseudomonas
aeruginosa) 		3 / 3 THR A 324
SER A 347
ARG A 345
 None
 0.82A 3phnA-4fspA:
undetectable		 3phnA-4fspA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TAJ_A_NBOA700_1
(LACTOTRANSFERRIN)		 4fsp PROBABLE PORIN
(Pseudomonas
aeruginosa) 		4 / 7 GLY A 355
TYR A 351
GLY A 362
THR A 386
 None
 0.72A 3tajA-4fspA:
undetectable		 3tajA-4fspA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		 4fsp PROBABLE PORIN
(Pseudomonas
aeruginosa) 		5 / 12 ASP A 236
HIS A 275
PHE A 172
ASP A 274
GLY A 273
 None
 1.41A 4bz6A-4fspA:
undetectable
4bz6B-4fspA:
undetectable		 4bz6A-4fspA:
20.34
4bz6B-4fspA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN)		 4fsp PROBABLE PORIN
(Pseudomonas
aeruginosa) 		5 / 12 ARG A 230
SER A 253
GLY A 267
GLN A 305
ALA A 297
 None
 1.16A 4r29A-4fspA:
undetectable		 4r29A-4fspA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN)		 4fsp PROBABLE PORIN
(Pseudomonas
aeruginosa) 		5 / 12 ARG A 366
ARG A  14
MET A  18
PHE A  16
TYR A 384
 None
 1.29A 4r29A-4fspA:
undetectable		 4r29A-4fspA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4fsp PROBABLE PORIN
(Pseudomonas
aeruginosa) 		4 / 4 GLY A 185
LEU A 149
PHE A 129
ILE A 117
 C8E  A 406 ( 4.0A)
None
None
None
 0.98A 4xv2A-4fspA:
undetectable		 4xv2A-4fspA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DWK_C_ACTC207_0
(DIACYLGLYCEROL
KINASE)		 4fsp PROBABLE PORIN
(Pseudomonas
aeruginosa) 		4 / 5 GLU A 342
ALA A 297
GLU A 298
ASN A 169
 None
 1.32A 5dwkC-4fspA:
undetectable		 5dwkC-4fspA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 4fsp PROBABLE PORIN
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 322
SER A 321
PHE A 312
ASP A 311
 C8E  A 405 (-4.8A)
None
C8E  A 405 (-3.9A)
None
 1.19A 5om3A-4fspA:
undetectable
5om3B-4fspA:
undetectable		 5om3A-4fspA:
11.69
5om3B-4fspA:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJY_A_BEZA304_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 4fsp PROBABLE PORIN
(Pseudomonas
aeruginosa) 		3 / 3 MET A 323
GLU A 344
ARG A 325
 None
 0.89A 5tjyA-4fspA:
undetectable		 5tjyA-4fspA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJZ_A_BEZA302_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 4fsp PROBABLE PORIN
(Pseudomonas
aeruginosa) 		3 / 3 MET A 323
GLU A 344
ARG A 325
 None
 0.88A 5tjzA-4fspA:
undetectable		 5tjzA-4fspA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4fsp PROBABLE PORIN
(Pseudomonas
aeruginosa) 		4 / 7 THR A 150
ARG A 148
PHE A 181
LEU A 280
 None
 1.31A 5uxcA-4fspA:
undetectable		 5uxcA-4fspA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_E_D16E402_1
(THYMIDYLATE SYNTHASE)		 4fsp PROBABLE PORIN
(Pseudomonas
aeruginosa) 		4 / 6 PHE A 129
ILE A 117
LEU A 133
GLY A 147
 None
 0.98A 5x5qE-4fspA:
undetectable		 5x5qE-4fspA:
21.53